EKS-OTG-00371
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-OTG-00371
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TK/Src437.71.1E-131241490250
StatusUnreviewed
Ensembl ProteinENSOGAP00000004919
UniProt AccessionH0WS71;
Protein Name
Protein Synonyms/Alias
Gene NameHCK
Gene Synonyms/Alias HCK;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSOGAG00000005498ENSOGAP00000004919ENSOGAT00000005501
OrganismOtolemur garnettii
Functional Description
Protein Length505
Protein Sequence
(FASTA)
RMGCVKSRFL RNGGKSSKTE SSANPHSPVG TQDLPSVAKL GPNSYNGNPP GSMEAGSEEI 60
VVVALYDYEA IHHEDLSFQK GDKMVVLEES GEWWKARSLA TRKEGYIPSN YVARVDSLET 120
EEWFFKGISR KDAERQLLAP GNVLGSFMIR DSETTKGSYS LSVRDYDPRQ GDAVKHYKIR 180
TLDNGGFYIS PRSTFSTLQE LVAHYKKNND GLCQKLSVAC MSPKPQKPWE KDAWEIPRES 240
LKLEKRLGAG QFGEVWMATY NKHTKVAVKT MKPGSMSVEA FLAEANLMKT LQHDKLVKLH 300
AVVTEEPIYI ITEFMAKGSL LDFLKSDEGS KQPLPKLIDF SAQIAEGMAF IEQRNYIHRD 360
LRAANILVSA SLVCKIADFG LARIIEDNEY TAREGAKFPI KWTAPEAINF GSFTIKSDVW 420
SFGILLMEIV TYGRIPYPGM SNPEVIRALE RGYRMPRPEH CPEALYSIMT RCWKNRPEER 480
PTFEYIQSVL DDFYTATESQ YQQQP 505
Nucleotide Sequence
(FASTA)
AGGATGGGGT GCGTGAAGTC CAGGTTCCTA CGGAATGGAG GCAAGAGCTC GAAAACTGAG 60
TCCAGCGCCA ACCCACACAG CCCTGTGGGC ACACAGGATC TTCCATCTGT GGCCAAGCTG 120
GGGCCTAACA GCTACAATGG CAACCCGCCA GGGTCTATGG AGGCAGGCTC TGAGGAAATC 180
GTCGTGGTCG CCCTGTACGA TTACGAGGCC ATTCACCATG AAGACCTCAG CTTCCAGAAA 240
GGGGACAAGA TGGTGGTCCT GGAGGAGTCT GGGGAGTGGT GGAAGGCTCG ATCCCTGGCC 300
ACCCGGAAAG AGGGCTACAT CCCGAGCAAC TATGTCGCCC GTGTTGACTC TCTGGAGACA 360
GAGGAGTGGT TCTTCAAGGG CATCAGCAGG AAGGATGCAG AGCGCCAACT CCTAGCTCCC 420
GGCAATGTGC TAGGCTCGTT CATGATCCGA GACAGCGAGA CCACCAAAGG GAGCTACTCG 480
TTGTCTGTGC GAGACTACGA CCCCCGGCAA GGAGATGCAG TGAAGCATTA CAAGATCCGG 540
ACCCTGGACA ACGGAGGCTT CTATATCTCC CCGAGGAGCA CCTTCAGCAC CCTGCAGGAG 600
CTGGTGGCCC ACTACAAGAA GAATAACGAT GGTCTCTGCC AGAAGTTGTC GGTGGCCTGC 660
ATGTCCCCCA AGCCACAGAA GCCTTGGGAG AAAGATGCCT GGGAGATCCC CCGGGAATCC 720
CTCAAACTGG AGAAAAGACT TGGAGCTGGA CAGTTTGGGG AAGTGTGGAT GGCCACCTAC 780
AACAAGCACA CCAAGGTGGC AGTGAAGACG ATGAAGCCCG GCAGCATGTC GGTGGAGGCC 840
TTCCTGGCTG AGGCCAACCT GATGAAAACC CTGCAGCACG ACAAGCTGGT GAAGCTGCAC 900
GCAGTGGTCA CGGAGGAGCC CATCTACATC ATCACAGAGT TCATGGCCAA AGGAAGCCTG 960
CTGGACTTTC TGAAAAGTGA CGAAGGCAGC AAGCAGCCCT TGCCCAAGCT CATCGACTTC 1020
TCAGCCCAGA TTGCAGAAGG CATGGCCTTC ATTGAGCAAA GGAACTACAT TCACCGAGAC 1080
CTCCGAGCTG CCAACATCTT GGTCTCTGCA TCCCTGGTGT GTAAGATTGC TGACTTCGGG 1140
CTGGCACGGA TCATCGAAGA CAATGAGTAC ACGGCTCGGG AAGGGGCCAA GTTCCCCATC 1200
AAGTGGACGG CTCCGGAAGC CATCAACTTT GGCTCCTTCA CCATCAAGTC TGACGTCTGG 1260
TCCTTTGGTA TCCTGCTGAT GGAGATCGTC ACCTACGGCC GGATCCCTTA CCCAGGGATG 1320
TCAAACCCAG AGGTGATCCG AGCACTGGAG CGTGGATACC GGATGCCTCG ACCGGAGCAC 1380
TGCCCCGAGG CGCTGTACAG CATCATGACA CGCTGCTGGA AGAACCGCCC AGAGGAGCGG 1440
CCCACCTTTG AATACATCCA GAGTGTGCTG GATGACTTTT ACACGGCCAC CGAGAGCCAG 1500
TACCAACAGC AGCCATGA 1518
Domain Profile
S: 1     lklvkklGeGqfGevwlgkwkgsvkvavktlkegtlspeafleeaqilkklrheklvkly  60
         lkl+k+lG+GqfGevw++++++++kvavkt+k+g++s eafl+ea+++k+l+h+klvkl+
Q: 241   LKLEKRLGAGQFGEVWMATYNKHTKVAVKTMKPGSMSVEAFLAEANLMKTLQHDKLVKLH  300
         689*********************************************************
S: 61    avvseeePiyivtelmakGslldflkeeegkklklpklvdlaaqvaeGmayleeknlihr  120
         avv+e ePiyi+te+makGslldflk++eg+k++lpkl+d++aq+aeGma++e++n+ihr
Q: 301   AVVTE-EPIYIITEFMAKGSLLDFLKSDEGSKQPLPKLIDFSAQIAEGMAFIEQRNYIHR  359
         ****9.******************************************************
S: 121   dlaarnvlvgeslvvkvadfGlarlieddeytakegaklPikWtaPeaiklgkftiksdv  180
         dl+a+n+lv+ slv+k+adfGlar+ied+eyta+egak+PikWtaPeai++g+ftiksdv
Q: 360   DLRAANILVSASLVCKIADFGLARIIEDNEYTAREGAKFPIKWTAPEAINFGSFTIKSDV  419
         ************************************************************
S: 181   WsfGillteivtkGkvPypGmtneevleqvergyrlprpeecpeelyelllecwkkdpee  240
         WsfGill+eivt+G++PypGm+n ev++++ergyr+prpe+cpe ly+++++cwk++pee
Q: 420   WSFGILLMEIVTYGRIPYPGMSNPEVIRALERGYRMPRPEHCPEALYSIMTRCWKNRPEE  479
         ************************************************************
S: 241   rPtfetlqevl  251
         rPtfe++q+vl
Q: 480   RPTFEYIQSVL  490
         *******9976
Domain Sequence
(FASTA)
LKLEKRLGAG QFGEVWMATY NKHTKVAVKT MKPGSMSVEA FLAEANLMKT LQHDKLVKLH 60
AVVTEEPIYI ITEFMAKGSL LDFLKSDEGS KQPLPKLIDF SAQIAEGMAF IEQRNYIHRD 120
LRAANILVSA SLVCKIADFG LARIIEDNEY TAREGAKFPI KWTAPEAINF GSFTIKSDVW 180
SFGILLMEIV TYGRIPYPGM SNPEVIRALE RGYRMPRPEH CPEALYSIMT RCWKNRPEER 240
PTFEYIQSVL 250
KeywordATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; SH3 domain; Transferase; Tyrosine-protein kinase.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Pan troglodytes"; ?>Petromyzon marinus"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Xiphophorus maculatus"; ?>
EKS-AIM-00343
EKS-ANC-00359
EKS-BOT-00369
EKS-CAJ-00373
EKS-CAF-00370
EKS-CAP-00404
EKS-DAR-00749
EKS-EQC-00360
EKS-FEC-00356
EKS-GAG-00313
EKS-GAA-00451
EKS-GOG-00360
EKS-HOS-00375
EKS-ICT-00350
EKS-LOA-00378
EKS-MAM-00369
EKS-MEG-00306
EKS-MOD-00358
EKS-MUM-00401
EKS-MUP-00363
EKS-MYL-00369
EKS-NOL-00337
EKS-OCP-00073
EKS-ORN-00478
EKS-ORC-00347
EKS-ORL-00440
EKS-PAT-00354
EKS-PEM-00194
EKS-PTV-00094
EKS-RAN-00383
EKS-SAH-00339
EKS-TAG-00442
EKS-TAR-00474
EKS-XIM-00467
Gene Ontology
GO:0005524; F:ATP binding
GO:0004713; F:protein tyrosine kinase activity
KEGG
InterPros
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
IPR000980; SH2.
IPR001452; SH3_domain.
IPR008266; Tyr_kinase_AS.
IPR020635; Tyr_kinase_cat_dom.
Pfam
PF07714; Pkinase_Tyr; 1.
PF00017; SH2; 1.
PF00018; SH3_1; 1.
SMARTs
SM00252; SH2; 1.
SM00326; SH3; 1.
SM00219; TyrKc; 1.
Prosites
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00109; PROTEIN_KINASE_TYR; 1.
PS50001; SH2; 1.
PS50002; SH3; 1.
Prints
PR00401; SH2DOMAIN.
PR00452; SH3DOMAIN.
PR00109; TYRKINASE.
Created Date20-Feb-2013