EKS-OTG-00496

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-OTG-00496

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
Other/TBCK	431.7	7.0E-130	18	273	256

Status

Unreviewed

Ensembl Protein

ENSOGAP00000004934

UniProt Accession

H0WS84;

Protein Name

Protein Synonyms/Alias

Gene Name

TBCK

Gene Synonyms/Alias

TBCK;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSOGAG00000005510	ENSOGAP00000004934	ENSOGAT00000005518

Organism

Otolemur garnettii

Functional Description

Protein Length

891

Protein Sequence
(FASTA)

MFPLKDTDMG AFTFFASALP HDVCGSNGLP LTPNSIKILG RFQILKTITH PRLCQYVDIS 60

RGKHERLVVV AEHCERSLED LLRERKPVSY SKVLCIAFEV LQGLQYMNKH GIVHRALSLH 120

NILLDRKGHV KLAKFGLYHM TAHGDDVDFP IGYPSYLAPE VIAQGIFKTT DHVPSEKPLP 180

SGPKSDVWSL GIILFELCVG RKLFQSLDIS ERLKFVLTLD CVDDTVIVLA EEHGCLDIIK 240

ELPENVIDLL KKCLTFHPSK RPTPDELMKD KVFSEVSPLY PPFNKPAGLF SSSLRCADLT 300

LPEDISQLCK DINNDYLAER SIEEVYYLWC LAGGDLEKEL VNKEIIRSKP PICTLPNFLF 360

EDGESFGQDR DRSSLLDDTT VTLSLCQLRN RLKDVGGEAF YPLLEDDQSN LPHSNSNNEL 420

SAAATLPLII RERDTEYQLN RIILFDRLLK AYPYKKNQIW KEARVDIPPL MRGLTWAALL 480

GVEGAIHAKY EAIDKDTPIP TDRQIEVDIP RCHQYDELLS SPEGHAKFRR VLKAWVVSHP 540

DLVYWQGLDS LCAPFLYLNF NNEALAYACM SAFIPKYLYN FFLKDNSHVI QEYLTVFSQM 600

IAFHDPELSN HLNEIGFIPD LYAIPWFLTM FTHVFPLHKI FHLWDTLLLG NSSFPFCIGV 660

AILQQLRDRL LANGFNECIL LFSDLPEIDI ERCVRESINL FCWTPKSATY RQHAQPPKPA 720

PDSTGVRSSA PFFSSECPDP PKSDLVFIEI PGQSLKLSPW VECCGITACS NLQLLGSNES 780

PASTSQVAGT TILVLSLGNR PIFIRGHISG SINIPFSAAF TAEGELTQGP YSTMLQNYKG 840

KVIVIVGHVA KHTAEFAAHL VKMKYPRICI LDGGINKIKP TGLLTVPSPQ I 891

Nucleotide Sequence
(FASTA)

ATGTTTCCCT TGAAGGATAC TGATATGGGT GCCTTTACCT TCTTTGCCTC AGCTCTGCCA 60

CATGATGTTT GTGGAAGCAA TGGGCTTCCT CTCACACCTA ATTCCATCAA AATTTTAGGG 120

CGCTTTCAAA TCCTTAAGAC TATCACCCAT CCCAGACTGT GCCAGTACGT GGATATATCT 180

AGGGGAAAGC ATGAAAGACT GGTGGTGGTG GCTGAACACT GTGAACGGAG CCTAGAAGAC 240

TTGCTTCGAG AAAGAAAACC AGTGAGTTAT TCAAAAGTTT TGTGCATAGC ATTCGAGGTA 300

CTTCAAGGCT TGCAGTATAT GAACAAACAT GGTATAGTAC ACCGGGCACT GTCTCTTCAT 360

AATATCCTGT TGGACCGAAA GGGACATGTT AAATTGGCTA AATTTGGTCT TTATCACATG 420

ACGGCTCATG GTGATGATGT TGATTTCCCT ATAGGGTATC CATCATACTT GGCACCTGAG 480

GTAATTGCAC AAGGAATTTT CAAAACCACT GATCATGTGC CAAGTGAAAA ACCACTGCCG 540

TCTGGCCCCA AATCAGATGT GTGGTCTCTT GGAATTATTT TGTTTGAGCT TTGTGTGGGA 600

AGAAAATTAT TTCAAAGCTT GGATATTTCT GAAAGACTAA AATTTGTGCT TACTTTAGAC 660

TGCGTAGATG ACACTGTAAT AGTTCTGGCT GAAGAGCATG GTTGTCTGGA CATTATAAAG 720

GAGCTTCCTG AAAATGTGAT AGATCTTTTG AAGAAGTGCC TCACCTTCCA TCCTTCTAAA 780

AGGCCAACCC CAGATGAATT GATGAAGGAC AAAGTGTTCA GTGAAGTGTC CCCTCTATAT 840

CCTCCCTTTA ACAAACCTGC CGGTCTGTTT TCATCTTCTC TGAGATGTGC TGATTTAACC 900

TTGCCTGAGG ATATCAGTCA GTTGTGTAAA GATATAAACA ATGATTATCT GGCAGAAAGA 960

TCTATTGAAG AAGTTTATTA TCTTTGGTGT TTGGCTGGAG GAGACTTGGA GAAAGAGCTT 1020

GTCAATAAGG AAATCATTCG ATCCAAACCA CCTATCTGCA CACTCCCCAA TTTTCTCTTT 1080

GAAGATGGTG AAAGCTTTGG ACAAGATCGA GACAGAAGCT CCCTTTTAGA TGATACCACT 1140

GTGACGTTGT CATTATGTCA GCTAAGAAAT AGATTAAAAG ATGTTGGTGG AGAAGCATTT 1200

TACCCATTAC TTGAAGATGA CCAGTCTAAT TTACCTCATT CAAACAGCAA TAACGAGTTG 1260

TCTGCAGCTG CTACTCTCCC TTTGATCATC AGAGAGAGGG ACACAGAGTA CCAACTAAAC 1320

AGAATTATTC TCTTTGACAG GCTGCTAAAG GCTTATCCAT ATAAAAAAAA TCAAATCTGG 1380

AAGGAAGCAA GAGTTGACAT TCCTCCTCTT ATGAGAGGTC TGACCTGGGC TGCTCTTCTG 1440

GGAGTTGAGG GCGCCATTCA TGCCAAGTAT GAAGCAATTG ATAAAGACAC TCCAATTCCT 1500

ACAGATAGAC AGATTGAAGT GGATATTCCT CGCTGCCATC AGTATGATGA ACTGTTATCG 1560

TCACCAGAAG GTCATGCAAA ATTTAGGCGT GTATTAAAAG CCTGGGTAGT ATCTCATCCT 1620

GATCTTGTGT ATTGGCAAGG TCTTGACTCA CTTTGTGCTC CATTTCTGTA TCTAAATTTC 1680

AATAATGAAG CCTTGGCATA TGCATGCATG TCTGCTTTTA TTCCCAAGTA CCTGTATAAC 1740

TTCTTCTTAA AAGACAACTC ACATGTGATA CAAGAGTATC TGACCGTGTT CTCTCAGATG 1800

ATTGCATTCC ACGATCCAGA GCTGAGTAAT CATCTCAATG AGATTGGCTT TATTCCAGAT 1860

CTCTATGCCA TCCCTTGGTT TCTCACCATG TTTACTCATG TATTTCCTCT GCACAAAATT 1920

TTTCACCTCT GGGATACCTT ACTCCTTGGG AATTCTTCTT TCCCATTTTG TATTGGAGTG 1980

GCAATTCTTC AGCAGCTGCG GGACCGGCTT TTGGCTAATG GTTTTAATGA GTGCATTCTT 2040

CTCTTCTCTG ATTTACCAGA AATTGACATT GAACGCTGTG TGCGAGAATC GATCAACCTG 2100

TTCTGTTGGA CTCCTAAGAG TGCTACGTAC AGGCAGCATG CTCAGCCTCC AAAGCCAGCT 2160

CCTGACAGCA CTGGAGTCAG AAGCTCAGCT CCTTTTTTCT CTTCTGAGTG TCCAGACCCT 2220

CCAAAGTCAG ATCTGGTATT TATAGAAATC CCTGGACAGA GCCTCAAGCT GTCCCCCTGG 2280

GTAGAGTGCT GTGGCATCAC AGCTTGCAGC AACCTCCAAC TCCTGGGCTC AAACGAGTCT 2340

CCTGCCTCCA CCTCCCAAGT AGCTGGGACC ACAATACTAG TTTTATCTCT TGGGAACAGG 2400

CCTATTTTTA TTCGAGGTCA CATTTCAGGT AGCATCAACA TTCCATTCAG TGCTGCATTC 2460

ACTGCGGAAG GGGAGCTTAC CCAGGGCCCT TACTCTACTA TGCTCCAGAA CTACAAGGGG 2520

AAGGTCATTG TCATCGTGGG GCATGTGGCA AAGCACACAG CCGAGTTTGC AGCTCATCTT 2580

GTGAAGATGA AATATCCAAG AATCTGTATT TTAGATGGAG GCATTAACAA GATCAAGCCA 2640

ACAGGCCTCC TCACTGTGCC ATCCCCTCAA ATATGA 2676

Domain Profile

S: 1     llaqdkdGsnGlplasnakkilGrfqiLkelqhdrLcqYldisrgkhervivvaehlels  60

         +l++d++GsnGlpl++n++kilGrfqiLk+++h+rLcqY+disrgkher++vvaeh+e+s

Q: 18    ALPHDVCGSNGLPLTPNSIKILGRFQILKTITHPRLCQYVDISRGKHERLVVVAEHCERS  77

         589*********************************************************

S: 61    LeDllkerkpvseslvlriayevlsgldylnkhnivhralepksilldrkgqkvkLakyG  120

         LeDll+erkpvs s+vl+ia+evl+gl+y+nkh+ivhral++++illdrkg+ vkLak+G

Q: 78    LEDLLRERKPVSYSKVLCIAFEVLQGLQYMNKHGIVHRALSLHNILLDRKGH-VKLAKFG  136

         ****************************************************.*******

S: 121   LyhltayGkdvdfpigygsylaPerilqd.........edkllaatvksDvWsLglille  171

         Lyh+ta+G+dvdfpigy+sylaPe+i+q+         ++k+l++++ksDvWsLg+il+e

Q: 137   LYHMTAHGDDVDFPIGYPSYLAPEVIAQGifkttdhvpSEKPLPSGPKSDVWSLGIILFE  196

         ************************************************************

S: 172   lilgikLfaeldlserlkillklstvdetliklaeekkcldiikklderleallkkCLtl  231

         l++g+kLf++ld+serlk++l+l++vd+t+i+laee++cldiik+l+e++++llkkCLt+

Q: 197   LCVGRKLFQSLDISERLKFVLTLDCVDDTVIVLAEEHGCLDIIKELPENVIDLLKKCLTF  256

         ************************************************************

S: 232   lpskRpspdellkekvf  248

         +pskRp+pdel+k+kvf

Q: 257   HPSKRPTPDELMKDKVF  273

         ***************98

Domain Sequence
(FASTA)

ALPHDVCGSN GLPLTPNSIK ILGRFQILKT ITHPRLCQYV DISRGKHERL VVVAEHCERS 60

LEDLLRERKP VSYSKVLCIA FEVLQGLQYM NKHGIVHRAL SLHNILLDRK GHVKLAKFGL 120

YHMTAHGDDV DFPIGYPSYL APEVIAQGIF KTTDHVPSEK PLPSGPKSDV WSLGIILFEL 180

CVGRKLFQSL DISERLKFVL TLDCVDDTVI VLAEEHGCLD IIKELPENVI DLLKKCLTFH 240

PSKRPTPDEL MKDKVF 256

Keyword

Complete proteome; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Pan troglodytes"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005622	; C:intracellular
GO:0005524	; F:ATP binding
GO:0004672	; F:protein kinase activity
GO:0005097	; F:Rab GTPase activator activity
GO:0032851	; P:positive regulation of Rab GTPase activity

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR000195	; Rab-GTPase-TBC_dom.
IPR001763	; Rhodanese-like_dom.

Pfam

PF00069	; Pkinase; 1.
PF00566	; RabGAP-TBC; 1.
PF00581	; Rhodanese; 1.

SMARTs

SM00450	; RHOD; 1.
SM00164	; TBC; 1.

Prosites

PS50011	; PROTEIN_KINASE_DOM; 1.
PS50206	; RHODANESE_3; 1.
PS50086	; TBC_RABGAP; 1.

Prints

Created Date

20-Feb-2013