EKS-OTG-00267

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-OTG-00267

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
Other/PLK	426.6	3.3E-128	53	305	253

Status

Unreviewed

Ensembl Protein

ENSOGAP00000004986

UniProt Accession

H0WSC6;

Protein Name

Protein Synonyms/Alias

Gene Name

PLK1

Gene Synonyms/Alias

PLK1;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSOGAG00000005574	ENSOGAP00000004986	ENSOGAT00000005578

Organism

Otolemur garnettii

Functional Description

Protein Length

604

Protein Sequence
(FASTA)

MSTAATAGKL ARAPADPGKA GVPGPAAPGA PAAALPAKEI PEVLVDQRSR RRYVRGRFLG 60

KGGFAKCFEI SDADTKEVFA GKIVPKSLLL KPHQKEKMSM EISIHRSLAH QHVVGFHGFF 120

EDNDFVFVVL ELCRRRSLLE LHKRRKALTE PEARYYLRQI VLGCQYLHRN RVIHRDLKLG 180

NLFLNEDLEV KIGDFGLATK VEYDGERKKT LCGTPNYIAP EVLSKKGHSF EVDVWSIGCI 240

MYTLLVGKPP FETSCLKETY LRIKKNEYSI PKHINPVAAS LIQKMLQTDP TARPTINELL 300

NDEFFTSGYI PARLPITCLT IPPRFSIAPS TLDPSSRKPL TVLNKGMENP LPERPREKEE 360

PVVRETGEVV DCHLSDLLQQ LHSVNASKPS ERGLVRQEEA EDPACIPIFW VSKWVDYSDK 420

YGLGYQLCDN SVGVLFNDST RLILYNDGDS LQYIERDGAE SYLTVSSHPN SLLKKITLLK 480

YFRNYMSEHL LKAGANITPR EGDELARLPY LRTWFRTRSA IILHLSNGSV QINFFQDHTK 540

LILCPLMAAV TYIDEKRDFR TYRLSLLEEY GCCKELASRL RYARTMVDKL LSSRSANNRL 600

KASS 604

Nucleotide Sequence
(FASTA)

ATGAGTACAG CGGCGACTGC AGGGAAGCTG GCCCGGGCAC CGGCCGACCC GGGGAAAGCT 60

GGGGTCCCAG GCCCTGCAGC TCCGGGGGCG CCGGCGGCAG CTCTTCCAGC GAAAGAGATC 120

CCGGAGGTCC TAGTGGACCA ACGCAGCCGG CGGCGCTATG TGCGGGGCCG CTTTTTGGGC 180

AAGGGCGGCT TCGCCAAGTG TTTTGAGATC TCGGATGCGG ACACCAAGGA GGTGTTCGCA 240

GGCAAGATCG TGCCTAAGTC TCTGCTGCTC AAGCCGCACC AGAAGGAGAA GATGTCCATG 300

GAGATTTCCA TTCACCGCAG CCTTGCCCAT CAACACGTCG TAGGCTTTCA TGGCTTTTTC 360

GAGGACAACG ACTTCGTGTT CGTGGTGTTG GAGCTCTGTC GCAGGAGGTC TCTCCTGGAG 420

CTGCACAAGA GGAGGAAAGC CCTGACTGAG CCTGAGGCCA GATACTACCT GAGGCAAATC 480

GTCCTTGGCT GCCAATACCT GCACAGAAAC CGAGTTATTC ACCGGGACCT TAAGCTGGGC 540

AACCTCTTCC TGAATGAGGA CCTGGAAGTG AAAATAGGGG ATTTTGGACT GGCAACCAAA 600

GTCGAATATG ATGGGGAGCG GAAGAAGACC CTGTGTGGGA CTCCTAATTA CATAGCTCCT 660

GAGGTGCTGA GCAAGAAAGG GCACAGTTTC GAGGTGGATG TGTGGTCCAT TGGGTGCATC 720

ATGTATACCT TGTTAGTGGG CAAACCACCT TTCGAGACTT CTTGCCTAAA AGAGACCTAC 780

CTCCGGATCA AGAAGAATGA ATACAGTATT CCCAAGCACA TCAACCCTGT GGCCGCCTCC 840

CTTATCCAGA AGATGCTTCA GACAGATCCT ACTGCCCGCC CAACCATTAA TGAGCTGCTG 900

AACGATGAGT TCTTTACTTC TGGCTACATC CCTGCCCGTC TTCCCATCAC CTGTCTCACC 960

ATTCCACCGA GGTTTTCCAT TGCTCCCAGC ACCCTGGACC CCAGCAGCCG GAAACCTCTC 1020

ACAGTCCTCA ATAAAGGGAT GGAGAACCCC CTGCCTGAGC GACCCCGGGA GAAAGAGGAA 1080

CCAGTGGTTC GAGAAACAGG TGAGGTGGTC GACTGCCACC TCAGTGACTT GCTACAGCAG 1140

CTACACAGTG TCAATGCTTC CAAACCCTCT GAGCGAGGGC TGGTGAGGCA AGAGGAGGCT 1200

GAGGATCCTG CCTGCATCCC CATCTTCTGG GTCAGCAAGT GGGTGGACTA TTCGGACAAG 1260

TATGGCCTCG GGTACCAGCT GTGTGACAAC AGTGTGGGGG TGCTCTTCAA TGACTCGACA 1320

CGCCTTATCC TCTACAATGA TGGTGACAGC TTGCAGTACA TAGAACGTGA TGGTGCTGAG 1380

TCTTACCTCA CTGTGAGTTC CCATCCCAAC TCTTTGTTGA AGAAGATCAC TCTCCTTAAG 1440

TATTTCCGGA ATTACATGAG CGAACACTTG TTGAAGGCGG GTGCCAACAT CACGCCACGG 1500

GAAGGTGATG AGCTAGCCCG GCTGCCCTAC CTGCGTACCT GGTTCCGCAC CCGCAGTGCC 1560

ATCATCCTGC ACCTCAGTAA TGGCAGTGTG CAGATCAACT TCTTCCAGGA CCATACGAAA 1620

CTCATCCTGT GCCCACTGAT GGCAGCTGTA ACATACATCG ATGAGAAACG TGACTTCCGC 1680

ACATACCGCC TGAGCCTCCT TGAGGAGTAT GGCTGCTGCA AGGAGCTGGC CAGCCGGCTG 1740

CGCTATGCTC GCACCATGGT GGACAAGCTG CTGAGCTCAC GCTCAGCTAA CAACCGCCTC 1800

AAGGCCTCTT CATAG 1815

Domain Profile

S: 1     yergkllGkGgfakcyelkdletkevfavkvvpksllakekqrekvekeieihrslkhkn  60

         y rg++lGkGgfakc+e++d++tkevfa k+vpksll k++q+ek+++ei+ihrsl+h++

Q: 53    YVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQKEKMSMEISIHRSLAHQH  112

         89**********************************************************

S: 61    ivklyeffedkenvylvlelcsrrslaellkrrkaltepevryylrqivsglkylhekri  120

         +v ++ ffed+++v++vlelc+rrsl el+krrkaltepe+ryylrqiv g++ylh++r+

Q: 113   VVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRV  172

         ************************************************************

S: 121   lhrdlklgnlflneelevkigdfGlatrlekeeerkktlcGtPnyiaPevlskkghslev  180

         +hrdlklgnlflne+levkigdfGlat++e+++erkktlcGtPnyiaPevlskkghs+ev

Q: 173   IHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEV  232

         ************************************************************

S: 181   diWslGcilytllvGkPPfetkelketyekikkaeyslPsslskeaksliakllkkePee  240

         d+Ws+Gci+ytllvGkPPfet++lkety +ikk+eys+P+++++ a+sli+k+l+++P++

Q: 233   DVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTA  292

         ************************************************************

S: 241   rpsleevlkdefl  253

         rp+++e+l+def+

Q: 293   RPTINELLNDEFF  305

         ************8

Domain Sequence
(FASTA)

YVRGRFLGKG GFAKCFEISD ADTKEVFAGK IVPKSLLLKP HQKEKMSMEI SIHRSLAHQH 60

VVGFHGFFED NDFVFVVLEL CRRRSLLELH KRRKALTEPE ARYYLRQIVL GCQYLHRNRV 120

IHRDLKLGNL FLNEDLEVKI GDFGLATKVE YDGERKKTLC GTPNYIAPEV LSKKGHSFEV 180

DVWSIGCIMY TLLVGKPPFE TSCLKETYLR IKKNEYSIPK HINPVAASLI QKMLQTDPTA 240

RPTINELLND EFF 253

Keyword

ATP-binding; Complete proteome; Nucleotide-binding; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Echinops telfairi"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Macropus eugenii"; ?>Meleagris gallopavo"; ?>Microcebus murinus"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tupaia belangeri"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000959	; POLO_box_duplicated_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069	; Pkinase; 1.
PF00659	; POLO_box; 2.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS50078	; POLO_BOX; 2.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013