EKS-OTG-00374

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-OTG-00374

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TK/Src	429.5	3.8E-129	245	494	250

Status

Unreviewed

Ensembl Protein

ENSOGAP00000005099

UniProt Accession

H0WSN1;

Protein Name

Protein Synonyms/Alias

Gene Name

LCK

Gene Synonyms/Alias

LCK;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSOGAG00000005705	ENSOGAP00000005099	ENSOGAT00000005708

Organism

Otolemur garnettii

Functional Description

Protein Length

509

Protein Sequence
(FASTA)

MGCGCSSNPE DDWMESIDVC ENCHYPIVPL DGKATLPMRN GSDVRDPLVT YEGSNPPASP 60

LQDNLVIALH SYEPSHDGDL GFQKGEQLRI LEQSGEWWKA QSLTTGLEGF IPFNFVAKAN 120

SLEPEPWFFK NLSRKDAERQ LLAPGNTHGS FLIRESESTA GSFSLSVRDF DQNQGEVVKH 180

YKIRNLDKGG FYISPRITFP GLHELVRHYT NASDGLCTRL SRPCQTQKPQ KPWWEDEWEV 240

PRETLKLVER LGAGQFGEVW MGFYNGHTKV AVKSLKQGSM SPDAFLAEAN LMKQLQHQRL 300

VRLYAVVTQE PIYIITEYME NGSLVDFLKT PPGIKLTISK LLDMAAQIAE GMAFIEERNY 360

IHRDLRAANI LVSGTLSCKI ADFGLARLIE DNEYTAREGA KFPIKWTAPE AINYGTFTIK 420

SDVWSFGILL TEIVTHGRIP YPGMTNPEVI QNLERGYRMV RPDNCPEELY DLMMLCWKEH 480

PEDRPTFDYL RSVLEDFFTA TEGQYQPQP 509

Nucleotide Sequence
(FASTA)

ATGGGCTGTG GCTGCAGCTC AAACCCTGAA GACGACTGGA TGGAAAGCAT CGATGTTTGT 60

GAGAACTGCC ATTATCCCAT AGTCCCACTG GATGGCAAGG CCACGCTGCC CATGCGAAAT 120

GGCTCTGACG TGCGGGACCC ACTGGTCACC TATGAGGGCT CCAATCCACC AGCCTCCCCA 180

CTGCAAGACA ACCTGGTTAT TGCTCTGCAC AGCTATGAGC CCTCTCATGA TGGAGACCTG 240

GGCTTCCAAA AGGGTGAACA GCTCCGGATC CTGGAGCAGA GCGGCGAGTG GTGGAAGGCG 300

CAGTCCCTGA CCACCGGCCT GGAAGGCTTC ATCCCCTTCA ACTTTGTGGC CAAAGCCAAC 360

AGCCTGGAGC CTGAACCCTG GTTCTTTAAA AACCTGAGCC GCAAGGATGC AGAGCGACAG 420

CTCCTAGCGC CTGGGAACAC ACATGGCTCT TTCCTGATCC GGGAGAGCGA GAGCACTGCG 480

GGATCGTTTT CACTATCGGT CCGGGACTTC GACCAGAACC AGGGAGAGGT GGTAAAACAT 540

TACAAGATCC GTAACCTGGA TAAAGGCGGC TTCTACATCT CCCCTCGCAT CACCTTTCCC 600

GGCCTGCATG AACTGGTCCG CCATTACACC AATGCTTCAG ATGGGCTGTG CACCCGGTTG 660

AGTCGCCCCT GCCAGACCCA GAAGCCCCAG AAGCCTTGGT GGGAGGACGA GTGGGAGGTT 720

CCCAGAGAGA CGCTGAAATT GGTTGAGCGG CTGGGGGCTG GCCAGTTCGG GGAAGTGTGG 780

ATGGGGTTCT ACAATGGGCA CACAAAGGTG GCAGTGAAGA GCCTGAAGCA GGGCAGCATG 840

TCCCCTGATG CCTTCCTGGC TGAGGCCAAC CTCATGAAGC AGCTGCAACA CCAGCGGCTG 900

GTCCGGCTCT ATGCAGTGGT CACCCAGGAG CCCATCTATA TCATCACTGA ATACATGGAG 960

AATGGGAGTC TGGTGGATTT TCTCAAGACC CCACCAGGTA TCAAGTTGAC CATCAGTAAA 1020

CTCCTGGACA TGGCAGCCCA AATCGCAGAG GGCATGGCAT TCATTGAAGA GCGGAATTAT 1080

ATCCACCGTG ACCTTCGGGC TGCCAACATT CTGGTGTCTG GCACCCTGAG CTGCAAGATT 1140

GCAGACTTTG GCTTAGCACG CCTCATTGAA GACAACGAAT ATACAGCCAG GGAGGGAGCC 1200

AAGTTTCCCA TTAAGTGGAC AGCACCAGAA GCCATTAACT ATGGGACATT CACCATCAAG 1260

TCGGATGTGT GGTCTTTCGG GATTCTGCTG ACAGAGATTG TCACTCATGG GCGCATCCCT 1320

TACCCAGGGA TGACCAATCC TGAGGTGATT CAGAACCTGG AGCGAGGCTA CCGTATGGTG 1380

CGACCTGATA ACTGTCCCGA GGAACTGTAC GACCTCATGA TGCTGTGCTG GAAGGAGCAC 1440

CCAGAGGACC GGCCCACCTT TGACTACTTG CGCAGTGTAC TGGAGGACTT CTTCACAGCC 1500

ACAGAGGGCC AATACCAGCC TCAGCCTTGA 1530

Domain Profile

S: 1     lklvkklGeGqfGevwlgkwkgsvkvavktlkegtlspeafleeaqilkklrheklvkly  60

         lklv++lG+GqfGevw+g ++g++kvavk+lk+g++sp+afl+ea+++k+l+h++lv+ly

Q: 245   LKLVERLGAGQFGEVWMGFYNGHTKVAVKSLKQGSMSPDAFLAEANLMKQLQHQRLVRLY  304

         6899********************************************************

S: 61    avvseeePiyivtelmakGslldflkeeegkklklpklvdlaaqvaeGmayleeknlihr  120

         avv++ ePiyi+te+m++Gsl+dflk+  g kl+++kl+d+aaq+aeGma++ee+n+ihr

Q: 305   AVVTQ-EPIYIITEYMENGSLVDFLKTPPGIKLTISKLLDMAAQIAEGMAFIEERNYIHR  363

         ****9.******************************************************

S: 121   dlaarnvlvgeslvvkvadfGlarlieddeytakegaklPikWtaPeaiklgkftiksdv  180

         dl+a+n+lv+ +l +k+adfGlarlied+eyta+egak+PikWtaPeai++g+ftiksdv

Q: 364   DLRAANILVSGTLSCKIADFGLARLIEDNEYTAREGAKFPIKWTAPEAINYGTFTIKSDV  423

         ************************************************************

S: 181   WsfGillteivtkGkvPypGmtneevleqvergyrlprpeecpeelyelllecwkkdpee  240

         WsfGillteivt+G++PypGmtn ev++++ergyr+ rp++cpeely+l++ cwk++pe+

Q: 424   WSFGILLTEIVTHGRIPYPGMTNPEVIQNLERGYRMVRPDNCPEELYDLMMLCWKEHPED  483

         ************************************************************

S: 241   rPtfetlqevl  251

         rPtf++l++vl

Q: 484   RPTFDYLRSVL  494

         *******9876

Domain Sequence
(FASTA)

LKLVERLGAG QFGEVWMGFY NGHTKVAVKS LKQGSMSPDA FLAEANLMKQ LQHQRLVRLY 60

AVVTQEPIYI ITEYMENGSL VDFLKTPPGI KLTISKLLDM AAQIAEGMAF IEERNYIHRD 120

LRAANILVSG TLSCKIADFG LARLIEDNEY TAREGAKFPI KWTAPEAINY GTFTIKSDVW 180

SFGILLTEIV THGRIPYPGM TNPEVIQNLE RGYRMVRPDN CPEELYDLMM LCWKEHPEDR 240

PTFDYLRSVL 250

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; SH3 domain; Transferase; Tyrosine-protein kinase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Dipodomys ordii"; ?>Equus caballus"; ?>Erinaceus europaeus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Meleagris gallopavo"; ?>Microcebus murinus"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sorex araneus"; ?>Sus scrofa"; ?>Takifugu rubripes"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004713	; F:protein tyrosine kinase activity

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR000980	; SH2.
IPR001452	; SH3_domain.
IPR008266	; Tyr_kinase_AS.
IPR020635	; Tyr_kinase_cat_dom.

Pfam

PF07714	; Pkinase_Tyr; 1.
PF00017	; SH2; 1.
PF00018	; SH3_1; 1.

SMARTs

SM00252	; SH2; 1.
SM00326	; SH3; 1.
SM00219	; TyrKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00109	; PROTEIN_KINASE_TYR; 1.
PS50001	; SH2; 1.
PS50002	; SH3; 1.

Prints

PR00401	; SH2DOMAIN.
PR00452	; SH3DOMAIN.
PR00109	; TYRKINASE.

Created Date

20-Feb-2013