EKS-OTG-00269

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-OTG-00269

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
Other/PLK	388.5	1.4E-116	12	265	254

Status

Unreviewed

Ensembl Protein

ENSOGAP00000005150

UniProt Accession

H0WSS6;

Protein Name

Protein Synonyms/Alias

Gene Name

PLK4

Gene Synonyms/Alias

PLK4;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSOGAG00000005757	ENSOGAP00000005150	ENSOGAT00000005761

Organism

Otolemur garnettii

Functional Description

Protein Length

971

Protein Sequence
(FASTA)

MATCIGEKIE DFKVGSLLGK GSFAGVYRAE SIHTGLEVAI KMIDKKAMYK AGMVQRVQNE 60

VKIHCQLKHP SILELYNYFE DNNYVYLVLE MCHNGEMNRY LKNRMKPFSE NEARHFMHQI 120

ITGMLYLHSH GILHRDLTLS NLLLTRNMNI KIADFGLATQ LKMPHEKHYT LCGTPNYISP 180

EIATRSAHGL ESDVWSLGCM FYTLLIGRPP FDTDTVKNTL NKVVLADYEM PTFLSREAKD 240

LIHQLLRRNP ADRLSLSSIL DHPFMSRNSS TKSKDLGTVE DSIDSGHATI STAITASSST 300

SISGSLFDRR RLLIGQPLPN KMTVFPKTKN ASDFSSSGDG NSFYNQWGNQ EQEISNRGRG 360

KVIQDAEERP HSRYLRRAHS SDRSSTSNSQ SRAKTCVMER CHSAEVLSKP KRSGVDENEE 420

RYSPTNNNVN VFPFFKEKTS NSSGSFDQPG TNQALANHLC PGKTPFPFSD QTPQTEMVQQ 480

WFGNLQINAH LRETTEYNSL AQTKITGHPH LQKDMSRSAW TDRKPKKNSN ASDNAHSVKH 540

LNTIKHMTVL HSKPEIIQQE SVFGLDPLSE QRRTKGVEPS LGYQKRTLRS ITSPLVAHRL 600

KPIRQKTKKA VVSILDSEEV CVELLKDYTS QEYVKEVLQI SSDGNMITIY YPNDGRGFPL 660

TDRPPSPTDN ISRYSFDNLP EKYWRKYQYA SRFVQLVRSK SPKITYFTRY AKCILMENSP 720

DADFEVWFYD GAKIHKTEDL IHVIEKTGKS YTLKGESEVN SLKEEMKMYM DHVNEGHRVC 780

LTLESIISEE ERKSRNASFF PIIIGRKPGC ISSPTALSPP SVDSNYSVRD RPALSRMMMN 840

SAASEEKCSV KEMGEMVINE GLGLTTIASG TNISSTSLKD SLPKSAQLLK SVFVKNVGWA 900

TQLSSGAVWV QFNDGSQLVV QAGVSSISYT SPDGQTTRYG EDEKLPEYIR QKLQCLSSIL 960

LMFSNPTPSF H 971

Nucleotide Sequence
(FASTA)

ATGGCGACCT GCATCGGGGA GAAGATCGAG GATTTTAAAG TTGGAAGTCT GCTGGGTAAA 60

GGATCATTTG CTGGTGTCTA CAGAGCTGAG TCCATTCACA CTGGTTTGGA AGTTGCAATC 120

AAAATGATAG ATAAGAAAGC CATGTACAAA GCGGGAATGG TACAGAGAGT CCAAAATGAG 180

GTGAAAATAC ATTGCCAATT GAAACATCCT TCTATCTTGG AGCTTTATAA CTATTTTGAA 240

GATAACAATT ATGTGTATCT GGTATTAGAA ATGTGCCATA ATGGAGAAAT GAACAGGTAT 300

CTAAAGAACA GAATGAAACC CTTCTCAGAA AATGAAGCTC GACATTTCAT GCACCAAATC 360

ATCACAGGAA TGTTATATCT TCATTCTCAT GGTATATTAC ACCGGGACCT CACACTTTCT 420

AACCTCTTAC TAACTCGTAA TATGAACATC AAGATAGCTG ATTTTGGATT GGCAACTCAG 480

TTGAAAATGC CACATGAAAA GCACTATACG TTATGTGGAA CTCCTAATTA TATTTCACCA 540

GAAATTGCAA CTCGAAGTGC GCATGGACTT GAATCTGATG TTTGGTCCTT GGGGTGTATG 600

TTTTATACGT TACTTATTGG GAGACCACCT TTTGACACTG ACACAGTCAA GAACACGTTA 660

AATAAAGTAG TATTGGCAGA TTATGAAATG CCAACTTTTT TGTCAAGGGA AGCCAAGGAC 720

CTTATTCACC AGTTACTTCG TAGAAATCCA GCAGATCGTT TAAGTCTGTC TTCAATATTA 780

GACCATCCTT TTATGTCCCG AAATTCTTCA ACAAAAAGTA AAGATTTAGG AACTGTAGAA 840

GACTCAATTG ATAGTGGGCA TGCCACGATT TCTACTGCAA TTACAGCTTC TTCTAGTACC 900

AGTATAAGTG GTAGTTTATT TGACAGAAGA AGACTTTTGA TTGGTCAGCC ACTCCCAAAT 960

AAAATGACTG TATTTCCAAA GACTAAAAAT GCAAGTGATT TTTCTTCTTC AGGAGATGGA 1020

AACAGTTTTT ATAATCAGTG GGGAAATCAA GAACAAGAAA TCAGTAATCG TGGAAGGGGC 1080

AAAGTAATCC AAGATGCAGA AGAAAGACCA CATTCTCGTT ACCTTCGTAG AGCCCATTCT 1140

TCTGATAGGT CCAGCACTTC TAACAGTCAA TCTCGAGCAA AAACATGTGT AATGGAAAGA 1200

TGTCACTCAG CTGAAGTGCT TTCAAAACCC AAAAGATCAG GAGTAGATGA AAATGAAGAG 1260

AGATACTCAC CCACAAACAA CAATGTCAAT GTTTTTCCCT TCTTTAAAGA AAAGACATCT 1320

AATAGTTCTG GATCTTTTGA CCAACCTGGT ACCAATCAAG CACTCGCCAA TCATCTTTGT 1380

CCAGGAAAAA CTCCTTTTCC ATTCTCAGAC CAGACACCTC AGACTGAAAT GGTACAACAA 1440

TGGTTTGGGA ATCTACAAAT AAATGCTCAT TTAAGAGAAA CTACTGAATA CAACAGCTTA 1500

GCTCAAACCA AGATTACTGG CCATCCACAT TTGCAGAAGG ACATGTCAAG AAGTGCTTGG 1560

ACTGATAGAA AACCCAAAAA GAACTCTAAT GCTTCTGATA ATGCACATTC TGTAAAACAT 1620

CTGAATACCA TCAAACATAT GACTGTACTT CATAGTAAAC CTGAGATAAT TCAACAAGAA 1680

TCTGTTTTTG GCCTAGATCC GCTTTCTGAA CAAAGGAGGA CTAAGGGTGT GGAGCCATCA 1740

TTGGGTTATC AGAAACGTAC ATTACGAAGC ATTACATCTC CTTTGGTTGC TCACAGGTTA 1800

AAACCAATCA GACAGAAAAC CAAAAAGGCT GTGGTGAGCA TACTTGATTC AGAGGAGGTA 1860

TGTGTGGAGC TTCTAAAGGA CTATACATCT CAAGAATATG TGAAAGAAGT TCTTCAGATA 1920

TCTAGTGATG GAAATATGAT CACTATTTAT TATCCAAATG ATGGAAGAGG TTTTCCTCTT 1980

ACTGATAGAC CACCCTCACC TACTGACAAC ATCAGTAGGT ACAGCTTTGA TAATTTACCA 2040

GAAAAGTACT GGAGAAAATA CCAATATGCT TCCAGGTTTG TACAGCTTGT AAGATCCAAA 2100

TCTCCCAAAA TCACTTATTT TACAAGATAT GCTAAATGTA TTTTGATGGA GAATTCTCCT 2160

GATGCTGATT TTGAAGTTTG GTTTTATGAT GGAGCAAAAA TACACAAAAC AGAAGATTTA 2220

ATTCATGTAA TTGAAAAGAC TGGGAAATCG TACACTTTAA AAGGTGAAAG TGAAGTTAAT 2280

AGCTTGAAAG AGGAAATGAA AATGTATATG GACCATGTTA ATGAGGGTCA TCGTGTTTGT 2340

TTAACACTGG AATCCATAAT TTCAGAAGAG GAAAGGAAAA GTAGGAATGC TTCCTTTTTC 2400

CCAATAATTA TAGGAAGAAA ACCTGGTTGT ATTAGTTCAC CCACAGCTTT ATCACCACCT 2460

TCTGTGGATT CAAACTACTC AGTAAGGGAT AGACCAGCTT TGAGTAGAAT GATGATGAAT 2520

AGTGCTGCCA GTGAAGAAAA ATGCAGTGTT AAAGAAATGG GGGAGATGGT TATAAATGAA 2580

GGACTTGGTC TTACAACTAT AGCTTCTGGA ACAAACATCT CTTCTACTAG TCTAAAAGAT 2640

TCTCTTCCTA AATCAGCACA ACTTTTGAAA TCTGTTTTTG TGAAAAATGT TGGTTGGGCT 2700

ACACAGTTAA GTAGTGGAGC TGTATGGGTT CAGTTTAATG ATGGGTCCCA GTTGGTCGTG 2760

CAGGCAGGAG TATCTTCTAT CAGTTATACA TCACCAGATG GTCAAACAAC CAGGTATGGA 2820

GAAGATGAAA AATTACCAGA ATACATCAGA CAGAAATTAC AGTGTCTTTC TTCCATCCTT 2880

CTGATGTTTT CTAATCCAAC TCCTAGCTTT CATTAA 2916

Domain Profile

S: 1     yergkllGkGgfakcyelkdletkevfavkvvpksllakekqrekvekeieihrslkhkn  60

         +++g llGkG+fa +y++++++t+ ++a+k+++k++++k+ + ++v++e++ih++lkh++

Q: 12    FKVGSLLGKGSFAGVYRAESIHTGLEVAIKMIDKKAMYKAGMVQRVQNEVKIHCQLKHPS  71

         6899********************************************************

S: 61    ivklyeffedkenvylvlelcsrrslaellkrr.kaltepevryylrqivsglkylhekr  119

         i++ly++fed+++vylvle+c++++++++lk+r k+++e+e+r++++qi++g++ylh++

Q: 72    ILELYNYFEDNNYVYLVLEMCHNGEMNRYLKNRmKPFSENEARHFMHQIITGMLYLHSHG  131

         ********************************99**************************

S: 120   ilhrdlklgnlflneelevkigdfGlatrlekeeerkktlcGtPnyiaPevlskkghsle  179

         ilhrdl+l+nl+l++++++ki+dfGlat+l++++e+++tlcGtPnyi+Pe++++++h+le

Q: 132   ILHRDLTLSNLLLTRNMNIKIADFGLATQLKMPHEKHYTLCGTPNYISPEIATRSAHGLE  191

         ************************************************************

S: 180   vdiWslGcilytllvGkPPfetkelketyekikkaeyslPsslskeaksliakllkkePe  239

         +d+WslGc++ytll+G+PPf+t+++k+t++k++ a+y++P+ ls+eak+li++ll+++P+

Q: 192   SDVWSLGCMFYTLLIGRPPFDTDTVKNTLNKVVLADYEMPTFLSREAKDLIHQLLRRNPA  251

         ************************************************************

S: 240   erpsleevlkdefl  253

         +r+sl+++l+++f+

Q: 252   DRLSLSSILDHPFM  265

         ************98

Domain Sequence
(FASTA)

FKVGSLLGKG SFAGVYRAES IHTGLEVAIK MIDKKAMYKA GMVQRVQNEV KIHCQLKHPS 60

ILELYNYFED NNYVYLVLEM CHNGEMNRYL KNRMKPFSEN EARHFMHQII TGMLYLHSHG 120

ILHRDLTLSN LLLTRNMNIK IADFGLATQL KMPHEKHYTL CGTPNYISPE IATRSAHGLE 180

SDVWSLGCMF YTLLIGRPPF DTDTVKNTLN KVVLADYEMP TFLSREAKDL IHQLLRRNPA 240

DRLSLSSILD HPFM 254

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Dipodomys ordii"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004713	; F:protein tyrosine kinase activity

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000959	; POLO_box_duplicated_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008266	; Tyr_kinase_AS.

Pfam

PF00069	; Pkinase; 1.
PF00659	; POLO_box; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS50078	; POLO_BOX; 1.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00109	; PROTEIN_KINASE_TYR; 1.

Prints

Created Date

20-Feb-2013