EKS-OTG-00384

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-OTG-00384

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TKL/MLK	314.5	5.1E-94	36	283	248

Status

Unreviewed

Ensembl Protein

ENSOGAP00000005397

UniProt Accession

H0WTC8;

Protein Name

Protein Synonyms/Alias

Gene Name

MAP3K7

Gene Synonyms/Alias

MAP3K7;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSOGAG00000006039	ENSOGAP00000005397	ENSOGAT00000006041

Organism

Otolemur garnettii

Functional Description

Protein Length

579

Protein Sequence
(FASTA)

MSTASAASSS SSSSAGEMIE APSQVLNFEE IDYKEIEVEE VVGRGAFGVV CKAKWRAKDV 60

AIKQIESESE RKAFIVELRQ LSRVNHPNIV KLYGACLNPV CLVMEYAEGG SLYNVLHGAE 120

PLPYYTAAHA MSWCLQCSQG VAYLHSMQPK ALIHRDLKPP NLLLVAGGTV LKICDFGTAC 180

DIQTHMTNNK GSAAWMAPEV FEGSNYSEKC DVFSWGIILW EVITRRKPFD EIGGPAFRIM 240

WAVHNGTRPP LIKNLPKPIE SLMTRCWSKD PSQRPSMEEI VKIMTHLMRY FPGADEPLQY 300

PCQYSDEGQS NSATSTGSFM DIASTNTSNK SDTNLEQLPA TNDTIKRLES KLLKNQAKQQ 360

NESGRLSLGA SRGSSVESLP PTSEGKRMSA DMSEIEARIA ATTGNGQPRR RSIQDLTITG 420

TEPGQVSSRS SSPSVRMITT SGPTSEKPTW SHPWTPDDST DTNGSDNSIP MAYLTLDHQL 480

QPLAPCPNSK ESMAVFEQHC KMAQEYMKVQ TEIALLLQRK QELVAELDQD EKDQQNTSRL 540

VQEHKKLLDE NKSLSTYYQQ CKKQLEVIRS QQQKRQGTS 579

Nucleotide Sequence
(FASTA)

ATGTCTACAG CCTCCGCCGC CTCGTCCTCC TCCTCGTCTT CGGCCGGTGA GATGATCGAA 60

GCCCCCTCCC AGGTCCTCAA CTTCGAAGAG ATCGACTACA AGGAGATCGA GGTGGAAGAG 120

GTTGTTGGAA GAGGAGCCTT TGGAGTAGTT TGCAAAGCTA AATGGAGAGC AAAAGATGTT 180

GCTATTAAAC AAATAGAAAG TGAGTCTGAG AGGAAAGCTT TCATTGTAGA GCTTCGGCAG 240

TTATCCCGTG TGAACCATCC TAACATTGTA AAGCTGTATG GAGCCTGCTT GAACCCAGTG 300

TGTCTCGTGA TGGAATATGC TGAAGGGGGC TCTTTGTATA ATGTGCTGCA CGGTGCTGAG 360

CCACTTCCCT ATTACACCGC CGCCCATGCA ATGAGCTGGT GTTTACAGTG CTCCCAAGGG 420

GTGGCTTATC TTCACAGCAT GCAGCCCAAA GCGCTAATTC ACAGGGACCT GAAACCACCC 480

AACTTACTGC TGGTTGCAGG GGGCACAGTT CTAAAAATTT GTGATTTTGG CACAGCCTGT 540

GACATTCAGA CACACATGAC CAATAACAAG GGAAGTGCTG CTTGGATGGC ACCTGAAGTT 600

TTTGAAGGTA GTAATTACAG TGAAAAATGT GATGTCTTCA GCTGGGGTAT TATCCTTTGG 660

GAAGTGATAA CCCGTCGGAA ACCTTTTGAT GAGATTGGTG GCCCAGCTTT CAGGATCATG 720

TGGGCTGTGC ACAATGGTAC TCGACCACCA CTGATCAAAA ATTTACCTAA GCCCATTGAG 780

AGCCTGATGA CTCGCTGTTG GTCTAAAGAT CCTTCTCAGC GCCCGTCAAT GGAGGAAATT 840

GTGAAGATAA TGACTCACTT AATGCGGTAT TTTCCAGGAG CAGATGAGCC ATTACAGTAT 900

CCCTGTCAGT ATTCAGATGA AGGGCAGAGC AACTCTGCTA CCAGCACAGG CTCATTTATG 960

GACATTGCAT CTACAAATAC CAGTAATAAA AGTGACACTA ACCTGGAGCA GCTTCCTGCT 1020

ACCAATGATA CTATTAAACG CTTGGAATCA AAATTGTTGA AAAATCAGGC AAAGCAACAG 1080

AACGAATCTG GACGTTTAAG CTTGGGGGCT TCTCGGGGGA GCAGCGTGGA GAGCTTGCCC 1140

CCAACCTCTG AGGGCAAGAG AATGAGTGCT GACATGTCGG AAATAGAAGC GAGGATCGCC 1200

GCAACCACAG GCAACGGACA GCCAAGACGT AGGTCCATCC AAGATTTGAC TATAACTGGA 1260

ACAGAACCTG GTCAGGTAAG CAGTAGGTCA TCCAGTCCCA GTGTTAGAAT GATCACTACC 1320

TCAGGACCAA CCTCAGAAAA GCCAACTTGG AGTCATCCAT GGACACCTGA TGATTCCACA 1380

GATACCAATG GGTCAGATAA CTCCATCCCA ATGGCTTACC TTACCTTGGA TCACCAGCTG 1440

CAGCCTCTAG CACCGTGCCC AAACTCCAAA GAATCTATGG CAGTGTTTGA ACAGCATTGT 1500

AAAATGGCGC AAGAATATAT GAAAGTTCAA ACAGAGATTG CATTACTATT ACAGAGAAAG 1560

CAAGAACTAG TTGCAGAACT GGACCAGGAT GAAAAGGACC AGCAAAATAC ATCTCGTCTG 1620

GTACAGGAAC ATAAAAAGCT TTTAGATGAA AACAAAAGCC TTTCAACGTA CTATCAGCAA 1680

TGCAAAAAAC AACTAGAGGT CATCAGAAGT CAGCAGCAGA AACGACAAGG CACTTCATGA 1740

Domain Profile

S: 1     ieleeligsgafgkvykakwrkkevavKklreeaeekekleklereakllsklshpniie  60

         ie+ee++g+gafg v+kakwr+k+va+K++++e+e+    +++  e+++ls+++hpni++

Q: 36    IEVEEVVGRGAFGVVCKAKWRAKDVAIKQIESESER----KAFIVELRQLSRVNHPNIVK  91

         5789****************************9888....********************

S: 61    llGvcleepnlllvmeyveggsLsnvlhe.kskreidlevlvswalqiArGmaYLhseap  119

         l+G+cl++  ++lvmey+eggsL+nvlh+ +  + ++ ++++sw+lq+++G+aYLhs++p

Q: 92    LYGACLNP--VCLVMEYAEGGSLYNVLHGaEPLPYYTAAHAMSWCLQCSQGVAYLHSMQP  149

         *******9..89*****************778899*************************

S: 120   kkiihrdLksknvLlseekktlkicdFGtarelskstkmsaagtlawmaPEvlkeekvse  179

         k++ihrdLk++n+Ll +  ++lkicdFGta++++ +++++++g++awmaPEv++ +++se

Q: 150   KALIHRDLKPPNLLLVAGGTVLKICDFGTACDIQ-THMTNNKGSAAWMAPEVFEGSNYSE  208

         ********************************99.9************************

S: 180   ksDvwSygvvLWelltrevPykdlse..laiaykvalkglrlpipsscpeklkkLmkecw  237

         k+Dv+S+g++LWe++tr++P++++    ++i+++v ++g+r+p+++++p+++++Lm++cw

Q: 209   KCDVFSWGIILWEVITRRKPFDEIGGpaFRIMWAV-HNGTRPPLIKNLPKPIESLMTRCW  267

         **********************9987447889999.99**********************

S: 238   nedpekRpsfseivks  253

         ++dp++Rps++eivk+

Q: 268   SKDPSQRPSMEEIVKI  283

         *************986

Domain Sequence
(FASTA)

IEVEEVVGRG AFGVVCKAKW RAKDVAIKQI ESESERKAFI VELRQLSRVN HPNIVKLYGA 60

CLNPVCLVME YAEGGSLYNV LHGAEPLPYY TAAHAMSWCL QCSQGVAYLH SMQPKALIHR 120

DLKPPNLLLV AGGTVLKICD FGTACDIQTH MTNNKGSAAW MAPEVFEGSN YSEKCDVFSW 180

GIILWEVITR RKPFDEIGGP AFRIMWAVHN GTRPPLIKNL PKPIESLMTR CWSKDPSQRP 240

SMEEIVKI 248

Keyword

Complete proteome; Kinase; Reference proteome; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Echinops telfairi"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0000287	; F:magnesium ion binding
GO:0004709	; F:MAP kinase kinase kinase activity
GO:0000186	; P:activation of MAPKK activity
GO:0000165	; P:MAPK cascade

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR017421	; MAPKKK7.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF07714

; Pkinase_Tyr; 1.

SMARTs

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

PR00109

; TYRKINASE.

Created Date

20-Feb-2013