EKS-OTG-00167
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-OTG-00167
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
CAMK/RSKb493.81.0E-148411668258
StatusUnreviewed
Ensembl ProteinENSOGAP00000005635
UniProt AccessionH0WTX4;
Protein NameRibosomal protein S6 kinase
Protein Synonyms/Alias
Gene NameRPS6KA2
Gene Synonyms/Alias RPS6KA2;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSOGAG00000006306ENSOGAP00000005635ENSOGAT00000006310
OrganismOtolemur garnettii
Functional Description
Protein Length729
Protein Sequence
(FASTA)
MKKFAVRRFF SVYLRKKSRS KSSSLSRLEE EGIVKEIDIS HHVKEGFEKA DPSQFELLKV 60
LGQGSYGKVF LVRKIKGSDA GQLYAMKVLK KATLKVRDRV RSKMERDILA EVNHPFIVKL 120
HYAFQTEGKL YLILDFLRGG DLFTRLSKEV MFTEEDVKFY LAELALALDH LHGLGIIYRD 180
LKPENILLDE EGHIKITDFG LSKEAIDHDK RAYSFCGTIE YMAPEVVNRR GHTQSADWWS 240
FGVLMFEMLT GSLPFQGKDR KETMALILKA KLGMPQFLST EAQGLLRALF KRNPCNRLGA 300
GIDGVEEIKR HPFFVTIDWN KLYRKEIKPP FKPAVGRPED TFHFDPEFTA RTPTDSPGVP 360
PSANAHHLFR GFSFVASSLV QEPAQQGPHK VPVHPIVQQL HGNNVHFTDG YEIKEDIGVG 420
SYSVCKRCVH KATDTEYAVK IIDKSKRDPS EEIEILLRYG QHPNIISLKD VYDDGKYVYL 480
VMELMRGGEL LDRILRQRCF SEREASDVLC TIAKTMDYLH SQGVVHRDLK PSNILYMDES 540
GNPESIRICD FGFAKQLRAE NGLLMTPCYT ANFVAPEVLK RQGYDAACDV WSLGILLYTM 600
LAGFTPFANG PDDTPEEILA RIGSGKYALS GGNWDSISDA AKDVVSKMLH VDPHQRLTAV 660
QVLRHPWIVN REYLSQNQLS RQDVHLVKGA MAATYFALNR TPQAPRLEPV LSSNLAQRRG 720
MKRLTSTRL 729
Nucleotide Sequence
(FASTA)
ATGAAGAAGT TCGCCGTCCG CAGGTTCTTC TCCGTGTACC TGCGCAAGAA GTCACGCTCC 60
AAGAGCTCCA GCCTAAGTCG GCTCGAGGAA GAAGGCATCG TCAAGGAGAT CGACATCAGC 120
CACCATGTGA AGGAAGGATT TGAAAAGGCA GACCCTTCCC AGTTCGAACT GCTGAAAGTC 180
TTAGGACAAG GATCGTACGG GAAGGTGTTC CTGGTGAGGA AGATCAAGGG GTCCGACGCC 240
GGCCAGCTCT ACGCCATGAA AGTCCTCAAG AAAGCAACGC TGAAAGTCCG GGACCGAGTC 300
CGATCAAAGA TGGAGAGAGA CATCTTGGCA GAAGTGAATC ACCCTTTCAT TGTAAAGCTT 360
CATTATGCCT TTCAGACGGA AGGAAAGCTC TACCTGATCC TGGACTTCCT GAGGGGAGGG 420
GACCTCTTCA CCAGACTCTC CAAGGAGGTG ATGTTCACGG AGGAGGACGT CAAGTTCTAC 480
CTGGCCGAGC TGGCCCTGGC GCTGGACCAT CTCCACGGGC TGGGGATCAT CTATAGGGAC 540
CTGAAACCCG AGAACATCCT CCTGGATGAA GAGGGACATA TTAAGATCAC AGATTTCGGC 600
CTGAGTAAGG AGGCCATTGA CCACGACAAG AGGGCCTATT CCTTCTGCGG GACCATCGAG 660
TACATGGCAC CCGAGGTGGT GAACCGGCGG GGGCACACTC AGAGCGCTGA CTGGTGGTCC 720
TTCGGCGTGC TCATGTTTGA GATGCTCACG GGGTCCCTGC CGTTCCAGGG GAAGGACAGG 780
AAGGAGACCA TGGCCCTCAT CCTCAAAGCC AAGCTGGGCA TGCCTCAGTT CCTCAGCACT 840
GAGGCTCAGG GTTTGCTGCG AGCCCTCTTC AAGCGGAATC CCTGCAACCG GCTAGGTGCC 900
GGCATTGATG GAGTGGAGGA AATTAAGCGT CATCCTTTCT TTGTTACCAT AGACTGGAAC 960
AAGCTGTACC GGAAGGAGAT CAAGCCTCCG TTCAAGCCAG CGGTGGGCAG GCCTGAGGAC 1020
ACCTTCCACT TTGACCCTGA GTTCACAGCA CGGACCCCCA CAGACTCTCC AGGTGTGCCC 1080
CCAAGTGCCA ACGCTCACCA TCTGTTTAGA GGATTCAGTT TCGTGGCATC GAGCCTGGTG 1140
CAGGAGCCCG CACAGCAAGG CCCACACAAA GTCCCAGTTC ACCCGATCGT GCAGCAATTA 1200
CATGGGAACA ACGTCCACTT TACTGATGGC TACGAGATCA AAGAGGATAT TGGGGTGGGC 1260
TCCTACTCCG TGTGCAAGCG ATGTGTGCAC AAGGCAACTG ACACAGAGTA CGCCGTGAAG 1320
ATCATCGACA AGAGTAAAAG AGACCCCTCA GAAGAGATCG AGATTCTCCT GAGGTACGGC 1380
CAGCACCCGA ACATCATCTC CCTCAAGGAC GTCTATGACG ATGGCAAGTA TGTGTACCTG 1440
GTGATGGAGC TGATGCGTGG CGGGGAGCTC CTGGACCGAA TTCTTCGGCA GAGATGCTTC 1500
TCAGAGCGCG AGGCCAGTGA CGTGCTGTGC ACCATTGCCA AGACCATGGA CTACCTGCAC 1560
TCCCAGGGGG TGGTCCATCG AGATCTGAAG CCGAGTAACA TTCTGTACAT GGATGAGTCT 1620
GGAAACCCTG AATCCATTCG CATCTGTGAC TTTGGGTTTG CCAAGCAGCT GCGAGCAGAG 1680
AATGGGCTGC TGATGACACC GTGCTACACG GCCAACTTTG TGGCCCCAGA GGTTCTGAAG 1740
CGTCAGGGCT ATGATGCAGC ATGTGACGTC TGGAGCTTGG GGATCCTGCT GTACACCATG 1800
CTGGCAGGAT TTACCCCGTT TGCAAACGGA CCAGATGATA CTCCAGAGGA GATCTTGGCA 1860
CGGATCGGCA GTGGGAAGTA CGCCCTTTCT GGGGGAAACT GGGACTCAAT ATCCGATGCA 1920
GCAAAGGATG TCGTATCCAA GATGCTCCAT GTGGACCCAC ATCAGCGCCT CACTGCAGTG 1980
CAGGTGCTCA GACACCCATG GATTGTCAAC AGGGAGTACC TGTCCCAAAA CCAGCTCAGC 2040
AGACAAGACG TGCACCTGGT GAAGGGTGCC ATGGCCGCCA CCTACTTTGC CCTGAACAGA 2100
ACACCTCAGG CTCCGCGGCT GGAGCCAGTG CTGTCATCCA ACCTGGCCCA GCGCCGGGGC 2160
ATGAAGAGGC TCACATCCAC CAGGCTGTAG 2190
Domain Profile
S: 1     yevkedlGvGsysvckrcvhkatnqefavkiidkskrdtseeieillryeqhpnivtlkd  60
         ye+ked+GvGsysvckrcvhkat++e+avkiidkskrd+seeieillry+qhpni++lkd
Q: 411   YEIKEDIGVGSYSVCKRCVHKATDTEYAVKIIDKSKRDPSEEIEILLRYGQHPNIISLKD  470
         789*********************************************************
S: 61    vyddgkyvylvlellkGGelldrikkkkffsereasailrtlvkaveylheqGvvhrdlk  120
         vyddgkyvylv+el++GGelldri+++++fsereas++l+t++k+++ylh+qGvvhrdlk
Q: 471   VYDDGKYVYLVMELMRGGELLDRILRQRCFSEREASDVLCTIAKTMDYLHSQGVVHRDLK  530
         ************************************************************
S: 121   penilyvdesdnaesikiidfGfaklkraengllktpcytlnfvapevlkrqGydeacdl  180
         p+nily+des+n+esi+i+dfGfak++raengll+tpcyt+nfvapevlkrqGyd+acd+
Q: 531   PSNILYMDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDV  590
         ************************************************************
S: 181   wslGvllytmlaGyvpfangpedtaeeilakikeGkfslsGeawdsvseeakdlvskllt  240
         wslG+llytmlaG++pfangp+dt+eeila+i++Gk++lsG++wds+s++akd+vsk+l+
Q: 591   WSLGILLYTMLAGFTPFANGPDDTPEEILARIGSGKYALSGGNWDSISDAAKDVVSKMLH  650
         ************************************************************
S: 241   vdpakrlkleqllkhswl  258
         vdp++rl++ q+l+h+w+
Q: 651   VDPHQRLTAVQVLRHPWI  668
         *****************8
Domain Sequence
(FASTA)
YEIKEDIGVG SYSVCKRCVH KATDTEYAVK IIDKSKRDPS EEIEILLRYG QHPNIISLKD 60
VYDDGKYVYL VMELMRGGEL LDRILRQRCF SEREASDVLC TIAKTMDYLH SQGVVHRDLK 120
PSNILYMDES GNPESIRICD FGFAKQLRAE NGLLMTPCYT ANFVAPEVLK RQGYDAACDV 180
WSLGILLYTM LAGFTPFANG PDDTPEEILA RIGSGKYALS GGNWDSISDA AKDVVSKMLH 240
VDPHQRLTAV QVLRHPWI 258
KeywordATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Equus caballus"; ?>Gallus gallus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Oryctolagus cuniculus"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Xenopus tropicalis"; ?>
EKS-AIM-00154
EKS-ANC-00156
EKS-BOT-00161
EKS-CAJ-00165
EKS-CAF-00168
EKS-CAP-00161
EKS-DAR-00449
EKS-EQC-00163
EKS-GAG-00139
EKS-GOG-00162
EKS-HOS-00167
EKS-ICT-00156
EKS-LAC-00170
EKS-LOA-00159
EKS-MAM-00161
EKS-MEG-00128
EKS-MOD-00158
EKS-MUM-00167
EKS-MUP-00165
EKS-ORC-00150
EKS-PES-00142
EKS-POA-00158
EKS-RAN-00159
EKS-SAH-00153
EKS-SUS-00139
EKS-XET-00150
Gene Ontology
GO:0005524; F:ATP binding
GO:0000287; F:magnesium ion binding
GO:0004674; F:protein serine/threonine kinase activity
GO:0007243; P:intracellular protein kinase cascade
KEGG
InterPros
IPR000961; AGC-kinase_C.
IPR011009; Kinase-like_dom.
IPR017892; Pkinase_C.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR016239; Ribosomal_S6_kinase_II.
IPR002290; Ser/Thr_dual-sp_kinase_dom.
IPR008271; Ser/Thr_kinase_AS.
Pfam
PF00069; Pkinase; 2.
PF00433; Pkinase_C; 1.
SMARTs
SM00133; S_TK_X; 1.
SM00220; S_TKc; 2.
Prosites
PS51285; AGC_KINASE_CTER; 1.
PS00107; PROTEIN_KINASE_ATP; 2.
PS50011; PROTEIN_KINASE_DOM; 2.
PS00108; PROTEIN_KINASE_ST; 2.
Prints
Created Date20-Feb-2013