EKS-OTG-00268

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-OTG-00268

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
Other/PLK	417.8	1.6E-125	62	314	253

Status

Unreviewed

Ensembl Protein

ENSOGAP00000006201

UniProt Accession

H0WV81;

Protein Name

Protein Synonyms/Alias

Gene Name

PLK3

Gene Synonyms/Alias

PLK3;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSOGAG00000006927	ENSOGAP00000006201	ENSOGAT00000006931

Organism

Otolemur garnettii

Functional Description

Protein Length

646

Protein Sequence
(FASTA)

MEPAAGFLSP RPFPRAATPP APHAGPGPPP SALPGLELEM LAGPPAPDPG RLITDPRNGR 60

TYIKGRLLGK GGFARCYEAT DTETGSAYAV KVIPQSRVAK PHQREKILNE IELHRDLQHR 120

HIVRFLHHFE DSDNIYIFLE LCSRKSLAHI WKARHTLLEP EVRYYLRQIL SGLKYLHQRS 180

ILHRDLKLGN FFITENMELK VGDFGLAARL EPPEERKKTI CGTPNYVAPE VLMRQGHGPE 240

ADVWSLGCVM YTLLCGSPPF ETADLKETYR CIKQVHYTLP ASLSLPARQL LAAILRASPR 300

DRPSIDQILR HDFFTKGYTP DRLPVCSCVT VPDLTSPNPA RSLFAKVTKS LFGRKKKSKK 360

HPQERDEVSC LVSGLMHTSI GHQDATPEAP AASGLAPVSL VETAPEDSSP RGTLASSGDG 420

FEEGLTVATV VESALCALRN CVAFMPPAEQ NPAPLAQPEP LVWVSKWVDY SNKFGFGYQL 480

SSRRVAVLFN DGTHMALSAN RKTVHYNPTS TKHFSFSVGA VPRALQPQLG ILRYFASYME 540

QHLMKGGDLP SVEEVEMPAL PLLLQWVKTD QALLMLFSDG TVQVNFYGDH TKLILSGWDP 600

LLVTFVARNR SACTYLASHL RQLGCSPDLR QRLRYALHLL QDRSPA 646

Nucleotide Sequence
(FASTA)

ATGGAGCCCG CCGCCGGCTT CCTGTCCCCG CGCCCCTTCC CGCGTGCGGC CACTCCGCCC 60

GCGCCCCACG CCGGGCCCGG ACCTCCTCCG AGTGCCTTGC CCGGACTTGA ACTGGAAATG 120

CTGGCGGGGC CACCGGCGCC AGACCCTGGG CGCCTCATTA CCGACCCGCG CAATGGCCGC 180

ACCTACATCA AAGGCCGCTT GTTGGGCAAG GGGGGCTTCG CCCGCTGCTA TGAGGCCACT 240

GACACAGAGA CCGGCAGCGC TTATGCTGTC AAAGTCATCC CGCAGAGCCG TGTCGCCAAG 300

CCGCATCAGC GCGAGAAGAT CCTAAATGAG ATTGAATTGC ACCGAGACTT GCAGCACCGC 360

CACATCGTGC GTTTTTTGCA CCACTTTGAG GACTCCGACA ACATATACAT TTTTCTGGAG 420

CTCTGCAGCC GAAAGTCCCT GGCCCATATC TGGAAGGCCC GCCACACCCT GTTAGAGCCC 480

GAGGTTCGCT ACTACCTGCG GCAGATCCTT TCTGGTCTCA AGTACTTGCA CCAGCGGAGC 540

ATCCTGCATC GGGACCTCAA GCTGGGAAAC TTTTTCATCA CTGAGAACAT GGAACTGAAG 600

GTGGGGGATT TTGGGCTGGC AGCCCGGTTG GAGCCTCCGG AAGAGAGGAA GAAGACCATC 660

TGTGGCACCC CCAACTATGT GGCTCCAGAA GTGCTAATGA GACAGGGCCA TGGCCCTGAG 720

GCAGATGTGT GGTCACTGGG CTGTGTCATG TACACACTGC TCTGTGGTAG CCCACCCTTT 780

GAGACAGCTG ACTTGAAGGA GACATACCGC TGCATCAAGC AGGTTCACTA CACGCTGCCT 840

GCCAGCCTCT CACTGCCTGC CCGGCAGCTC TTGGCTGCTA TCCTTCGGGC CTCACCCCGA 900

GACCGCCCTT CTATTGACCA GATCCTGCGC CATGACTTCT TTACCAAGGG CTACACCCCC 960

GATCGGCTCC CTGTGTGCAG CTGTGTGACA GTCCCAGACC TGACATCTCC CAACCCAGCT 1020

AGGAGTCTGT TTGCCAAAGT TACCAAGAGC CTCTTTGGCA GGAAGAAGAA GAGTAAGAAG 1080

CATCCCCAGG AGCGGGATGA GGTCTCCTGT TTGGTGAGTG GCCTCATGCA CACGTCCATT 1140

GGCCATCAGG ATGCCACGCC TGAGGCTCCA GCAGCTTCTG GTCTAGCCCC TGTCAGCCTA 1200

GTAGAGACAG CACCTGAAGA CAGCTCACCC CGTGGGACAT TGGCAAGCAG TGGAGATGGG 1260

TTTGAAGAAG GTCTCACTGT GGCCACAGTG GTGGAGTCAG CCCTCTGTGC TCTGAGAAAC 1320

TGTGTGGCCT TCATGCCTCC AGCGGAACAG AACCCAGCTC CCCTGGCCCA GCCAGAGCCT 1380

CTGGTGTGGG TTAGCAAGTG GGTTGACTAC TCCAACAAGT TTGGCTTTGG GTATCAACTG 1440

TCTAGCCGCC GTGTAGCTGT GCTCTTCAAT GATGGCACAC ATATGGCCCT TTCGGCCAAT 1500

AGAAAGACTG TGCACTACAA CCCCACCAGC ACAAAGCACT TCTCCTTCTC TGTGGGTGCT 1560

GTACCTCGGG CCCTGCAACC TCAGCTAGGC ATCCTGCGGT ACTTTGCCTC CTACATGGAG 1620

CAGCATCTCA TGAAAGGTGG GGATCTGCCC AGTGTGGAAG AGGTGGAGAT GCCTGCTCTA 1680

CCCTTGCTGC TGCAGTGGGT CAAGACAGAT CAGGCCCTAC TTATGCTGTT TAGTGATGGC 1740

ACTGTTCAGG TGAACTTCTA TGGGGACCAC ACCAAGCTGA TCCTCAGTGG CTGGGACCCC 1800

CTCCTTGTGA CTTTCGTGGC CCGAAATCGC AGTGCTTGTA CTTACCTTGC TTCCCACCTT 1860

CGGCAGCTGG GCTGCTCCCC AGACCTGCGG CAGCGACTCC GCTACGCTCT GCACCTACTC 1920

CAGGACCGCA GCCCAGCCTA G 1941

Domain Profile

S: 1     yergkllGkGgfakcyelkdletkevfavkvvpksllakekqrekvekeieihrslkhkn  60

         y +g+llGkGgfa+cye++d+et++++avkv+p+s++ak++qrek+ +eie+hr+l+h++

Q: 62    YIKGRLLGKGGFARCYEATDTETGSAYAVKVIPQSRVAKPHQREKILNEIELHRDLQHRH  121

         889*********************************************************

S: 61    ivklyeffedkenvylvlelcsrrslaellkrrkaltepevryylrqivsglkylhekri  120

         iv++ ++fed++n+y++lelcsr+sla+++k+r++l epevryylrqi+sglkylh+++i

Q: 122   IVRFLHHFEDSDNIYIFLELCSRKSLAHIWKARHTLLEPEVRYYLRQILSGLKYLHQRSI  181

         ************************************************************

S: 121   lhrdlklgnlflneelevkigdfGlatrlekeeerkktlcGtPnyiaPevlskkghslev  180

         lhrdlklgn+f++e++e+k+gdfGla+rle++eerkkt+cGtPny+aPevl ++gh+ e+

Q: 182   LHRDLKLGNFFITENMELKVGDFGLAARLEPPEERKKTICGTPNYVAPEVLMRQGHGPEA  241

         ************************************************************

S: 181   diWslGcilytllvGkPPfetkelketyekikkaeyslPsslskeaksliakllkkePee  240

         d+WslGc++ytll+G+PPfet++lkety++ik+ +y+lP+sls +a++l+a++l+++P++

Q: 242   DVWSLGCVMYTLLCGSPPFETADLKETYRCIKQVHYTLPASLSLPARQLLAAILRASPRD  301

         ************************************************************

S: 241   rpsleevlkdefl  253

         rps++++l+++f+

Q: 302   RPSIDQILRHDFF  314

         ************8

Domain Sequence
(FASTA)

YIKGRLLGKG GFARCYEATD TETGSAYAVK VIPQSRVAKP HQREKILNEI ELHRDLQHRH 60

IVRFLHHFED SDNIYIFLEL CSRKSLAHIW KARHTLLEPE VRYYLRQILS GLKYLHQRSI 120

LHRDLKLGNF FITENMELKV GDFGLAARLE PPEERKKTIC GTPNYVAPEV LMRQGHGPEA 180

DVWSLGCVMY TLLCGSPPFE TADLKETYRC IKQVHYTLPA SLSLPARQLL AAILRASPRD 240

RPSIDQILRH DFF 253

Keyword

ATP-binding; Complete proteome; Nucleotide-binding; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Macropus eugenii"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Pan troglodytes"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000959	; POLO_box_duplicated_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.
IPR020658	; Ser/Thr_kinase_Plk3.

Pfam

PF00069	; Pkinase; 1.
PF00659	; POLO_box; 2.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS50078	; POLO_BOX; 2.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013