EKS-OTG-00168
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-OTG-00168
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
CAMK/RSKb428.96.4E-129415674260
StatusUnreviewed
Ensembl ProteinENSOGAP00000006420
UniProt AccessionH0WVS0;
Protein NameRibosomal protein S6 kinase
Protein Synonyms/Alias
Gene NameRPS6KA4
Gene Synonyms/Alias RPS6KA4;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSOGAG00000007168ENSOGAP00000006420ENSOGAT00000007172
OrganismOtolemur garnettii
Functional Description
Protein Length764
Protein Sequence
(FASTA)
MGDEDEDEGC ALELWITEAN LTGHEEKVSV ENFELLKVLG TGAYGKVFLV RKAGGHDAGK 60
LYAMKVLRKA ALVQRAKTQE HTRTERSVLE LVRQAPFLVT LHYAFQTDAK LHLILDYVSG 120
GEMFTHLYQR QYFKEAEVRV YGGEIVLALE YLHKLGIIYR DLKLENVLLD SEGHIVLTDF 180
GLSKEFLTEE KERTFSFCGT IEYMAPEIIR SKAGHGKAVD WWSLGILLFE LLTGASPFTL 240
EGERNTQAEV SRRILKCSPP FPPRIGPVAQ DLLQRLLCKE PKKRLGAGPQ GAQEVKNHPF 300
FQGLDWAALA TRKIPAPFRP QIRSELDVSN FAEEFTRLEP VYSPPGSPPP GDPRIFQGYS 360
FVAPSILFDH NNAVMTDVLE APGTGDRPGR AAVARSAMMQ DSSFFQQYEL DLREPALGQG 420
SFSVCRRCRQ RQSGQEFAVK ILSRRLEANT QREVAALRLC QSHPNVVNLH EVHQDQLHTY 480
LVLELLQGGE LLEHIRKKRH FSESEASQIL RSLVSAVSFM HEEAGVVHRD LKPENILYAD 540
DTPGAPVKII DFGFARLRPQ SPGRPMQTPC FTLQYAAPEL LAQQGYDESC DLWSLGVILY 600
MMLSGQVPFQ GASGQGGQSQ AAEIMCKIRE GRFSLDGEAW QGVSEEAKEL VRGLLTVDPA 660
KRLKLEGLRG SSWLQDGSAR SSPPLRTPDV LESSGPAVRS GLNATFMAFN RGKREGFFLK 720
SVENAPLAKR RKQKLRSATA SRRGSPVPTT KGPPRRANGP LPPS 764
Nucleotide Sequence
(FASTA)
ATGGGAGACG AGGACGAGGA TGAGGGCTGT GCCCTGGAGC TGTGGATCAC GGAAGCCAAC 60
CTGACCGGGC ATGAGGAGAA GGTGAGCGTG GAGAACTTCG AGCTGCTCAA GGTGCTGGGA 120
ACGGGAGCCT ACGGGAAAGT GTTCCTGGTG CGGAAGGCAG GCGGGCACGA TGCGGGGAAG 180
CTGTATGCCA TGAAGGTGCT GCGCAAGGCG GCGCTGGTGC AGCGTGCCAA GACGCAGGAG 240
CACACGCGCA CCGAGCGCTC GGTTTTGGAG CTCGTGCGCC AGGCACCCTT CCTGGTCACA 300
CTCCACTATG CCTTCCAGAC TGATGCCAAG CTGCACCTCA TCCTGGACTA CGTGAGTGGT 360
GGTGAGATGT TCACCCACCT TTACCAGCGC CAATACTTCA AGGAGGCTGA AGTGCGTGTG 420
TATGGGGGTG AGATTGTGCT GGCCCTGGAA TACCTGCACA AGCTTGGCAT CATCTACCGA 480
GACCTGAAGC TGGAGAACGT GCTGCTGGAC TCGGAGGGCC ACATTGTCCT CACAGACTTT 540
GGGCTAAGCA AGGAGTTCCT GACAGAGGAG AAAGAGCGGA CCTTCTCCTT CTGTGGCACC 600
ATTGAGTACA TGGCCCCTGA AATCATCCGC AGCAAGGCAG GCCATGGCAA GGCTGTGGAC 660
TGGTGGAGCC TGGGCATCCT GCTCTTTGAG CTGCTGACGG GAGCCTCACC CTTCACACTG 720
GAGGGTGAGA GGAACACGCA GGCTGAGGTG TCCCGACGGA TCCTGAAGTG CTCCCCTCCC 780
TTCCCCCCAC GGATCGGGCC CGTGGCGCAG GACCTGCTGC AGCGGCTGCT TTGCAAGGAG 840
CCCAAGAAGC GATTAGGTGC GGGGCCCCAA GGGGCACAAG AAGTCAAGAA CCACCCTTTC 900
TTCCAGGGTT TAGATTGGGC TGCTCTGGCT ACCAGGAAGA TTCCCGCCCC ATTTCGGCCC 960
CAGATACGCT CAGAGCTGGA TGTGAGCAAC TTTGCAGAGG AATTTACTCG GCTAGAGCCT 1020
GTCTACTCAC CCCCTGGAAG TCCCCCTCCT GGGGACCCTC GAATCTTTCA GGGATACTCA 1080
TTCGTGGCGC CATCCATACT GTTTGATCAC AACAATGCGG TGATGACTGA TGTTCTGGAA 1140
GCGCCTGGCA CTGGAGACCG GCCTGGTCGG GCAGCCGTGG CCAGGAGTGC CATGATGCAG 1200
GACTCGTCCT TCTTCCAGCA GTACGAGCTG GACCTGCGGG AACCTGCGCT GGGCCAGGGC 1260
AGCTTCTCTG TGTGTCGCCG CTGCCGTCAG CGCCAAAGCG GCCAGGAGTT CGCTGTGAAG 1320
ATCCTCAGTC GTAGGCTGGA GGCGAACACG CAGCGCGAAG TGGCAGCCCT GCGCTTGTGC 1380
CAGTCACACC CCAACGTGGT GAATTTGCAC GAGGTGCACC AGGACCAGCT GCACACATAC 1440
CTAGTCTTGG AGCTGCTGCA GGGCGGGGAG CTGCTGGAGC ATATCCGCAA GAAGCGGCAC 1500
TTCAGCGAGT CAGAAGCCAG CCAGATTCTG CGGAGCCTAG TGTCAGCCGT GAGCTTTATG 1560
CATGAGGAGG CGGGCGTTGT GCACCGCGAC CTCAAGCCAG AGAACATCTT GTACGCCGAC 1620
GACACTCCCG GAGCCCCGGT GAAGATCATT GACTTTGGTT TCGCGCGGCT GCGGCCCCAG 1680
AGTCCAGGGA GGCCCATGCA GACACCCTGC TTCACGCTGC AGTACGCGGC CCCCGAGCTG 1740
CTGGCGCAGC AGGGCTACGA CGAGTCCTGT GACCTCTGGA GCCTAGGCGT CATTCTGTAC 1800
ATGATGCTGT CGGGGCAGGT CCCCTTCCAG GGGGCCTCAG GCCAGGGCGG GCAGAGCCAA 1860
GCGGCCGAGA TCATGTGCAA GATCCGCGAG GGGCGCTTCT CCCTTGACGG GGAGGCCTGG 1920
CAGGGTGTGT CAGAGGAAGC CAAGGAGCTG GTCCGAGGGC TCCTGACTGT GGACCCTGCA 1980
AAGCGGCTGA AACTAGAGGG GCTGCGGGGC AGCTCGTGGT TGCAGGATGG CAGCGCGCGC 2040
TCCTCGCCCC CACTCCGGAC CCCAGATGTG CTCGAATCTT CCGGGCCCGC AGTGCGCTCT 2100
GGGCTGAACG CCACATTCAT GGCGTTCAAC CGGGGCAAGC GTGAGGGTTT CTTCCTGAAG 2160
AGCGTGGAGA ATGCGCCCCT GGCCAAGCGG CGGAAGCAGA AGCTGCGGAG CGCCACGGCC 2220
TCCCGTCGCG GCTCACCAGT GCCCACCACC AAGGGGCCCC CCCGCCGAGC CAACGGTCCC 2280
CTACCCCCTT CCTAG 2295
Domain Profile
S: 5     edlGvGsysvckrcvhkatnqefavkiidks.krdtseeieillryeqhpnivtlkdvyd  63
           lG+Gs+svc+rc++++++qefavki++++ +++t++e+++l+++++hpn+v+l++v++
Q: 415   PALGQGSFSVCRRCRQRQSGQEFAVKILSRRlEANTQREVAALRLCQSHPNVVNLHEVHQ  474
         579*********************************************************
S: 64    dgkyvylvlellkGGelldrikkkkffsereasailrtlvkaveylheq.Gvvhrdlkpe  122
         d++++ylvlell+GGell++i+kk++fse+eas+ilr+lv+av+++he+ Gvvhrdlkpe
Q: 475   DQLHTYLVLELLQGGELLEHIRKKRHFSESEASQILRSLVSAVSFMHEEaGVVHRDLKPE  534
         ***********************************************999**********
S: 123   nilyvdesdnaesikiidfGfaklkraeng.llktpcytlnfvapevlkrqGydeacdlw  181
         nily+d++++a+ +kiidfGfa+l+++++g +++tpc+tl+++ape+l++qGyde+cdlw
Q: 535   NILYADDTPGAP-VKIIDFGFARLRPQSPGrPMQTPCFTLQYAAPELLAQQGYDESCDLW  593
         ************.****************99*****************************
S: 182   slGvllytmlaGyvpf....angpedtaeeilakikeGkfslsGeawdsvseeakdlvsk  237
         slGv+ly+ml+G+vpf    ++g++++a+ei++ki+eG+fsl+Geaw++vseeak+lv++
Q: 594   SLGVILYMMLSGQVPFqgasGQGGQSQAAEIMCKIREGRFSLDGEAWQGVSEEAKELVRG  653
         ****************999889**************************************
S: 238   lltvdpakrlkleqllkhswl  258
         lltvdpakrlkle+l+ +swl
Q: 654   LLTVDPAKRLKLEGLRGSSWL  674
         ********************7
Domain Sequence
(FASTA)
PALGQGSFSV CRRCRQRQSG QEFAVKILSR RLEANTQREV AALRLCQSHP NVVNLHEVHQ 60
DQLHTYLVLE LLQGGELLEH IRKKRHFSES EASQILRSLV SAVSFMHEEA GVVHRDLKPE 120
NILYADDTPG APVKIIDFGF ARLRPQSPGR PMQTPCFTLQ YAAPELLAQQ GYDESCDLWS 180
LGVILYMMLS GQVPFQGASG QGGQSQAAEI MCKIREGRFS LDGEAWQGVS EEAKELVRGL 240
LTVDPAKRLK LEGLRGSSWL 260
KeywordATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gasterosteus aculeatus"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Macropus eugenii"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xiphophorus maculatus"; ?>
EKS-AIM-00156
EKS-ANC-00159
EKS-BOT-00164
EKS-CAE-00125
EKS-CAJ-00168
EKS-CAF-00171
EKS-CAP-00163
EKS-CII-00093
EKS-CIS-00194
EKS-DAR-00453
EKS-EQC-00155
EKS-FEC-00154
EKS-GAA-00194
EKS-HOS-00170
EKS-ICT-00159
EKS-LOA-00163
EKS-MAM-00162
EKS-MAE-00060
EKS-MUM-00169
EKS-MUP-00168
EKS-NOL-00157
EKS-ORN-00204
EKS-PAT-00154
EKS-PES-00145
EKS-RAN-00161
EKS-SAH-00158
EKS-SUS-00141
EKS-TAR-00211
EKS-TEN-00204
EKS-XIM-00199
Gene Ontology
GO:0005524; F:ATP binding
GO:0000287; F:magnesium ion binding
GO:0004674; F:protein serine/threonine kinase activity
GO:0007243; P:intracellular protein kinase cascade
KEGG
InterPros
IPR000961; AGC-kinase_C.
IPR011009; Kinase-like_dom.
IPR017892; Pkinase_C.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR016239; Ribosomal_S6_kinase_II.
IPR002290; Ser/Thr_dual-sp_kinase_dom.
IPR008271; Ser/Thr_kinase_AS.
Pfam
PF00069; Pkinase; 2.
PF00433; Pkinase_C; 1.
SMARTs
SM00133; S_TK_X; 1.
SM00220; S_TKc; 2.
Prosites
PS51285; AGC_KINASE_CTER; 1.
PS00107; PROTEIN_KINASE_ATP; 2.
PS50011; PROTEIN_KINASE_DOM; 2.
PS00108; PROTEIN_KINASE_ST; 2.
Prints
Created Date20-Feb-2013