EKS-OTG-00290

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-OTG-00290

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TKL/STKR	388.9	1.3E-116	202	500	299

Status

Unreviewed

Ensembl Protein

ENSOGAP00000006952

UniProt Accession

H0WX01;

Protein Name

Protein Synonyms/Alias

Gene Name

BMPR2

Gene Synonyms/Alias

BMPR2;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSOGAG00000007765	ENSOGAP00000006952	ENSOGAT00000007769

Organism

Otolemur garnettii

Functional Description

Protein Length

1037

Protein Sequence
(FASTA)

ASPIYRRWQV QIWPWTLGFI SYILASQNQE RLCAFKDPYQ QDLGIGESRI SHENGTILCS 60

KGSTCYGLWE KSKGDINLVK QGCWSHIGDP QECHYEECVV TTTPPSIQNG TYRFCCCSTD 120

LCNVNFTENF PPPDTTPLSP PHSFNRDETI IIALASVSVL AVLIVALCFG YRMLTGDRKQ 180

GLHSMNMMEA AASEPSLDLD NLKLLELIGR GRYGAVYKGS LDERPVAVKV FSFANRQNFI 240

NEKNIYRVPL MEHDNIARFI VGDERVTADG RMEYLLVMEY YPNGSLCKYL SLHTSDWVSS 300

CRLAHSVTRG LAYLHTELPR GDHYKPAISH RDLNSRNVLV KNDGTCVISD FGLSMRLTGN 360

RLVRPGEEDN AAISEVGTIR YMAPEVLEGA VNLRDCESAL KQVDMYALGL IYWEIFMRCT 420

DLFPGESVPE YQMAFQTEVG NHPTFEDMQV LVSREKQRPK FPEAWKENSL AVRSLKETIE 480

DCWDQDAEAR LTAQCAEERM AELMMIWERN KSVSPTVNPM STAMQNERNL SHNRRVPKIG 540

PYPDYSSSSY IEDSIHHTDS IVKNISSEHS MSSTPLTIGE KNRNSINYER QQAQARIPSP 600

ETSVTSLSTN TTTTNTTGLT PSTGMTTISE MPYPDETNLH ATNVAQSIGP TPVCLQLTEE 660

DLETNKLDPK EVDKNLKESS DENLMEHSLK QFSGPDPLSS TSSSLLYPLI KLAVEVTGQQ 720

DFTQAANGQA CLIPDVLPTQ IYPLPKQQNL PKRPTSLPLN TKNSTKEPRL KFGSKHKSNL 780

KQVETGVAKM NTINAAEPHV VTVTMNGVAG RNHSVNSHAA TAQYANGTVP SGQTTNIVAH 840

RTQEMLQNQF IGEDTRLNIN SSPDEHEPLL RREQQAGHDE GVLDRLVDRR ERPLEGGRTN 900

SNNNNSNPCS EQDVLTQGIP STVADPGPSK PRRAQRPNSL DLSATNVLDG SSMQIGESIQ 960

DGKSGSGEKI KKRVKTPYSL KRWRPSTWVI STEPLDCEVN NNGSDRAVHS KSSTAVYLAE 1020

GGTATTMVSK DMGMNCL 1037

Nucleotide Sequence
(FASTA)

GCCAGCCCCA TATACCGGAG GTGGCAGGTT CAAATCTGGC CCTGGACCTT AGGTTTTATT 60

TCCTATATTT TAGCTTCCCA GAATCAAGAA CGGCTATGTG CATTTAAAGA CCCCTATCAG 120

CAAGACCTTG GGATAGGTGA GAGTCGAATC TCTCATGAAA ATGGGACAAT ATTATGCTCA 180

AAAGGTAGCA CCTGCTATGG CCTTTGGGAG AAATCAAAAG GGGACATAAA TCTTGTGAAA 240

CAAGGATGTT GGTCTCACAT TGGAGATCCC CAAGAGTGTC ACTATGAAGA ATGTGTCGTA 300

ACTACCACTC CTCCCTCAAT TCAGAACGGA ACATACCGTT TCTGCTGTTG TAGCACAGAT 360

TTATGTAATG TCAACTTTAC TGAGAATTTT CCACCTCCTG ACACAACACC ACTCAGTCCA 420

CCTCATTCAT TTAACCGAGA TGAGACAATA ATCATTGCTT TGGCATCAGT CTCTGTATTA 480

GCTGTTTTGA TAGTTGCCTT ATGTTTTGGA TACAGAATGT TGACAGGAGA TCGTAAACAA 540

GGTCTTCACA GTATGAACAT GATGGAGGCA GCAGCATCAG AGCCCTCTCT TGACCTAGAT 600

AATCTCAAAC TGTTGGAGCT GATTGGCCGG GGTAGATACG GAGCAGTATA TAAAGGTTCC 660

TTGGATGAGC GTCCAGTTGC TGTAAAAGTG TTTTCTTTTG CAAACCGTCA GAATTTTATC 720

AATGAGAAAA ACATTTACAG AGTGCCTTTG ATGGAACATG ACAATATAGC TCGCTTTATA 780

GTTGGAGATG AGAGAGTCAC TGCAGATGGA CGCATGGAGT ATTTACTTGT GATGGAGTAT 840

TATCCCAATG GATCTTTATG CAAGTATTTG AGTCTCCATA CAAGTGATTG GGTAAGCTCT 900

TGCCGCCTGG CTCATTCTGT GACTAGAGGA CTGGCTTATC TTCATACTGA ATTACCACGA 960

GGAGATCATT ATAAACCTGC AATTTCCCAC CGAGATTTAA ATAGCAGAAA TGTTCTGGTG 1020

AAAAATGATG GAACCTGTGT TATTAGTGAC TTTGGGTTGT CCATGAGGCT GACTGGAAAT 1080

AGACTGGTGC GCCCAGGAGA AGAAGATAAT GCAGCTATAA GTGAGGTTGG CACAATTAGA 1140

TATATGGCAC CAGAAGTGCT AGAAGGAGCT GTGAACCTGA GGGACTGTGA ATCAGCTTTG 1200

AAACAAGTAG ATATGTATGC GCTTGGACTA ATCTATTGGG AGATATTTAT GAGATGTACA 1260

GACCTCTTCC CAGGGGAATC TGTACCAGAA TACCAGATGG CTTTTCAGAC AGAAGTTGGA 1320

AACCATCCTA CTTTTGAGGA TATGCAGGTT CTTGTGTCTA GGGAAAAACA GAGACCCAAA 1380

TTCCCAGAAG CCTGGAAAGA AAATAGCCTG GCAGTGAGAT CACTCAAGGA GACAATCGAA 1440

GACTGCTGGG ATCAGGATGC AGAAGCTCGG CTTACTGCAC AGTGTGCTGA GGAGAGGATG 1500

GCTGAACTTA TGATGATATG GGAAAGAAAC AAATCTGTGA GCCCAACAGT CAATCCAATG 1560

TCTACTGCTA TGCAGAATGA ACGCAACCTT TCACATAATA GGCGTGTGCC AAAAATTGGT 1620

CCTTATCCAG ATTATTCTTC CTCCTCATAT ATCGAAGACT CTATTCATCA CACTGACAGC 1680

ATTGTGAAGA ATATTTCCTC TGAGCATTCA ATGTCTAGCA CACCTTTGAC AATAGGGGAA 1740

AAGAACCGAA ACTCAATTAA TTATGAACGT CAGCAAGCAC AAGCTCGAAT CCCTAGCCCT 1800

GAAACGAGTG TCACCAGCCT GTCCACCAAC ACAACAACCA CAAACACCAC TGGCCTCACT 1860

CCAAGTACTG GCATGACCAC TATATCTGAG ATGCCATACC CAGATGAAAC AAATCTGCAT 1920

GCCACAAATG TTGCACAGTC AATTGGGCCA ACCCCTGTCT GCTTACAGCT GACAGAAGAA 1980

GACTTAGAGA CTAACAAGTT AGACCCAAAA GAAGTTGATA AGAACCTCAA GGAGAGCTCA 2040

GATGAGAATC TCATGGAGCA TTCTCTTAAA CAGTTTAGTG GGCCAGACCC ACTGAGCAGT 2100

ACCAGTTCTA GCTTACTTTA CCCACTCATA AAGCTTGCAG TAGAAGTGAC TGGACAGCAG 2160

GACTTCACAC AGGCTGCAAA TGGCCAAGCA TGTTTAATTC CTGATGTTCT GCCTACTCAG 2220

ATCTATCCTC TCCCCAAGCA ACAGAACCTT CCTAAGAGAC CTACTAGTTT GCCTTTGAAC 2280

ACCAAAAATT CAACAAAGGA GCCCCGGCTA AAATTTGGCA GCAAGCACAA ATCAAACTTG 2340

AAACAAGTAG AAACTGGAGT TGCCAAAATG AATACAATCA ATGCAGCAGA ACCTCATGTG 2400

GTGACAGTCA CCATGAATGG TGTGGCAGGT AGAAATCACA GTGTTAACTC TCATGCTGCC 2460

ACAGCCCAAT ATGCCAATGG GACAGTACCA TCTGGCCAGA CAACCAACAT AGTGGCACAT 2520

AGGACCCAAG AAATGCTACA GAATCAATTT ATTGGTGAGG ACACCCGGCT GAATATTAAT 2580

TCTAGTCCTG ATGAGCATGA ACCTTTACTG AGACGAGAGC AGCAGGCTGG CCATGATGAA 2640

GGTGTTCTAG ATCGTCTTGT GGACAGGAGG GAACGGCCAC TAGAAGGTGG CCGAACTAAT 2700

TCCAATAACA ACAACAGCAA TCCATGTTCA GAACAAGATG TTCTTACACA GGGTATTCCA 2760

AGCACAGTAG CAGATCCTGG GCCATCAAAG CCCAGAAGAG CACAGAGGCC TAATTCTCTG 2820

GATCTGTCAG CCACAAATGT CCTGGATGGC AGCAGTATGC AGATAGGCGA GTCAATACAA 2880

GATGGCAAAT CAGGATCAGG TGAAAAGATC AAGAAACGTG TGAAAACTCC CTACTCTCTT 2940

AAGCGGTGGC GCCCCTCTAC CTGGGTCATC TCCACTGAAC CACTGGACTG TGAGGTCAAC 3000

AACAATGGCA GTGACAGGGC AGTTCATTCC AAATCCAGCA CTGCTGTTTA CCTTGCAGAA 3060

GGAGGCACTG CCACAACCAT GGTGTCTAAA GATATGGGAA TGAACTGTCT GTGA 3114

Domain Profile

S: 1     lklleligkGrygeVwkaklrgeevAvKifstedeaswkrEkeiyqtvllrhenilqfia  60

         lkllelig+Gryg+V+k++l+++ vAvK+fs ++++++ +Ek+iy+++l++h+ni +fi+

Q: 202   LKLLELIGRGRYGAVYKGSLDERPVAVKVFSFANRQNFINEKNIYRVPLMEHDNIARFIV  261

         6899********************************************************

S: 61    adk.keedsltelllvteyhekgsLsdyLkretldveellrlalslasGlahLHeeivgt  119

          d+  ++d ++e+llv+ey+++gsL++yL+ +t+d+ +++rla+s+++Gla+LH+e++

Q: 262   GDErVTADGRMEYLLVMEYYPNGSLCKYLSLHTSDWVSSCRLAHSVTRGLAYLHTELPRG  321

         **9999**************************************************9766

S: 120   kgkkKpaiaHRDlkskNilvkkdltcciaDlGLalkleeekee....ldlaansqvGtkR  175

          +++Kpai+HRDl+s+N+lvk+d+tc+i+D+GL+++l+ ++ +    +d+aa+s+vGt R

Q: 322   -DHYKPAISHRDLNSRNVLVKNDGTCVISDFGLSMRLTGNRLVrpgeEDNAAISEVGTIR  380

         .46***********************************999877787999**********

S: 176   YmaPEvleealnlkdfe.afkraDvYslgLvlWEvasRcee..vdeeveeyklpfeevvg  232

         YmaPEvle+a+nl+d+e a+k++D+Y+lgL++WE+++Rc++  ++e+v+ey+++f+++vg

Q: 381   YMAPEVLEGAVNLRDCEsALKQVDMYALGLIYWEIFMRCTDlfPGESVPEYQMAFQTEVG  440

         *****************99*****************************************

S: 233   sdPsleemkevvvekklrPkipeawkkke.alkelsklleecWdadpeaRltalrvkkrl  291

         ++P++e+m+ +v ++k+rPk+peawk+++ a+++l++++e+cWd+d+eaRlta++ ++r+

Q: 441   NHPTFEDMQVLVSREKQRPKFPEAWKENSlAVRSLKETIEDCWDQDAEARLTAQCAEERM  500

         ***************************9999*************************9987

Domain Sequence
(FASTA)

LKLLELIGRG RYGAVYKGSL DERPVAVKVF SFANRQNFIN EKNIYRVPLM EHDNIARFIV 60

GDERVTADGR MEYLLVMEYY PNGSLCKYLS LHTSDWVSSC RLAHSVTRGL AYLHTELPRG 120

DHYKPAISHR DLNSRNVLVK NDGTCVISDF GLSMRLTGNR LVRPGEEDNA AISEVGTIRY 180

MAPEVLEGAV NLRDCESALK QVDMYALGLI YWEIFMRCTD LFPGESVPEY QMAFQTEVGN 240

HPTFEDMQVL VSREKQRPKF PEAWKENSLA VRSLKETIED CWDQDAEARL TAQCAEERM 299

Keyword

ATP-binding; Complete proteome; Nucleotide-binding; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Procavia capensis"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tarsius syrichta"; ?>Tetraodon nigroviridis"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0016020	; C:membrane
GO:0005524	; F:ATP binding
GO:0005024	; F:transforming growth factor beta-activated receptor activity
GO:0007178	; P:transmembrane receptor protein serine/threonine kinase signaling pathway

KEGG

InterPros

IPR000472	; Activin_rcpt.
IPR015770	; BMPRII.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.

Pfam

PF01064	; Activin_recp; 1.
PF00069	; Pkinase; 1.

SMARTs

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.

Prints

Created Date

20-Feb-2013