EKS-OTG-00160

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-OTG-00160

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
AGC/RSK	368.1	2.8E-110	91	352	262

Status

Unreviewed

Ensembl Protein

ENSOGAP00000006995

UniProt Accession

H0WX39;

Protein Name

Protein Synonyms/Alias

Gene Name

RPS6KB1

Gene Synonyms/Alias

RPS6KB1;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSOGAG00000007813	ENSOGAP00000006995	ENSOGAT00000007816

Organism

Otolemur garnettii

Functional Description

Protein Length

525

Protein Sequence
(FASTA)

MRRRRRRDGF YPAPDFRDRE AEDMAGVFDI DLDQPEDAGS EDELEEGGQL NESMDHGGVG 60

PYELGMEHCE KFEISETSVN RGPEKIRPEC FELLRVLGKG GYGKVFQVRK VTGANTGKIF 120

AMKVLKKAMI VRNAKDTAHT KAERNILEEV KHPFIVDLIY AFQTGGKLYL ILEYLSGGEL 180

FMQLEREGIF MEDTACFYLA EISMALGHLH QKGIIYRDLK PENIMLNHQG HVKLTDFGLC 240

KESIHDGTVT HTFCGTIEYM APEILMRSGH NRAVDWWSLG ALMYDMLTGA PPFTGENRKK 300

TIDKILKCKL NLPPYLTQEA RDLLKKLLKR NAASRLGAGP GDAGEVQAHP FFRHINWEDL 360

LARKVEPPFK PLLQSEEDVS QFDSKFTRQT PVDSPDDSTL SESANQVFLG FTYVAPSVLE 420

SVKEKFSFEP KIRSPRRFIG SPRTPVSPVK FSPGDFWGRG ASASTANPQT PVEYPMETSG 480

IEQMDVTMSG EASAPLPIRQ PNSGPYKKQA FPMISKRPEH LRMNL 525

Nucleotide Sequence
(FASTA)

ATGAGGCGAC GACGGAGGCG GGACGGCTTT TACCCAGCGC CGGACTTCCG AGACAGGGAA 60

GCTGAGGATA TGGCAGGAGT GTTTGACATA GACCTGGACC AGCCAGAGGA CGCGGGCTCT 120

GAAGATGAGC TGGAGGAGGG GGGTCAGTTA AATGAAAGCA TGGACCATGG GGGAGTTGGA 180

CCATATGAAC TTGGCATGGA ACATTGTGAG AAATTTGAAA TCTCAGAAAC TAGTGTGAAC 240

AGAGGGCCAG AAAAAATCAG ACCAGAATGT TTTGAACTAC TTCGGGTACT TGGTAAAGGG 300

GGCTATGGAA AGGTTTTTCA AGTACGAAAA GTAACAGGAG CAAATACTGG GAAAATATTT 360

GCCATGAAGG TGCTTAAAAA GGCAATGATA GTAAGAAATG CTAAAGATAC AGCTCATACA 420

AAAGCAGAAC GGAATATTCT GGAGGAAGTA AAGCATCCCT TCATTGTGGA TTTAATTTAT 480

GCCTTTCAGA CCGGTGGAAA ACTCTACCTC ATCCTTGAGT ATCTCAGTGG AGGAGAACTA 540

TTTATGCAGT TAGAAAGAGA GGGAATATTT ATGGAAGACA CAGCCTGCTT TTACTTGGCA 600

GAAATCTCCA TGGCTTTGGG GCATTTACAT CAAAAGGGGA TCATCTACAG AGACCTGAAG 660

CCGGAGAATA TCATGCTTAA TCACCAAGGT CATGTGAAGC TGACAGACTT TGGACTATGC 720

AAAGAATCTA TTCATGATGG AACAGTCACA CACACATTTT GTGGAACAAT AGAATACATG 780

GCCCCTGAAA TCTTGATGAG AAGCGGCCAC AATCGTGCTG TGGATTGGTG GAGTTTGGGA 840

GCATTAATGT ATGACATGCT GACTGGAGCA CCCCCCTTTA CTGGGGAGAA TAGAAAGAAA 900

ACAATTGACA AAATCCTCAA ATGTAAACTC AATTTGCCTC CCTACCTCAC ACAAGAAGCC 960

CGAGATCTGC TTAAAAAGCT GCTGAAAAGA AATGCTGCTT CTCGTCTTGG AGCTGGTCCT 1020

GGGGATGCTG GAGAAGTTCA AGCTCATCCA TTCTTTAGAC ACATTAATTG GGAAGATCTT 1080

CTGGCTCGGA AGGTGGAGCC CCCCTTTAAA CCTCTGTTGC AATCTGAAGA GGATGTGAGT 1140

CAGTTTGATT CCAAGTTTAC ACGTCAGACA CCTGTTGATA GCCCAGATGA CTCAACTCTC 1200

AGTGAAAGTG CCAACCAGGT CTTTCTGGGT TTTACATATG TGGCTCCATC TGTACTTGAA 1260

AGTGTGAAAG AGAAGTTTTC CTTTGAACCA AAAATCCGAT CACCTCGAAG ATTTATTGGC 1320

AGCCCACGAA CACCTGTCAG CCCAGTCAAA TTCTCTCCTG GGGATTTCTG GGGAAGAGGT 1380

GCTTCAGCCA GCACAGCAAA TCCTCAGACA CCTGTGGAAT ACCCAATGGA AACAAGTGGA 1440

ATAGAGCAGA TGGACGTGAC AATGAGTGGG GAAGCATCAG CACCACTTCC GATACGACAG 1500

CCGAACTCCG GGCCATACAA AAAACAAGCT TTCCCCATGA TCTCCAAACG GCCAGAGCAC 1560

CTGCGTATGA ATCTATGA 1578

Domain Profile

S: 1     fellkvlgkGaygkvflvrkvekkdtgklyavKvlkkaelvk..kkkertkeereiLeev  58

         fell+vlgkG+ygkvf+vrkv++ +tgk++a+Kvlkka +v+  k++++tk+er+iLeev

Q: 91    FELLRVLGKGGYGKVFQVRKVTGANTGKIFAMKVLKKAMIVRnaKDTAHTKAERNILEEV  150

         89***********************************9999999****************

S: 59    ehpfivklheafqdekklylvlellkGgeLlerlkkkklfseeeasfilaelvlaleylH  118

         +hpfiv+l +afq+  klyl+le+l+GgeL+++l+++++f+e++a+f+lae+++al +lH

Q: 151   KHPFIVDLIYAFQTGGKLYLILEYLSGGELFMQLEREGIFMEDTACFYLAEISMALGHLH  210

         ************************************************************

S: 119   skgvvyrDLkpeNilldeeghvkltDfglakekiaeneekaysfcgTleyvaPevlkrkg  178

         +kg++yrDLkpeNi+l+++ghvkltDfgl+ke+i ++++ +++fcgT+ey+aPe+l+r+g

Q: 211   QKGIIYRDLKPENIMLNHQGHVKLTDFGLCKESI-HDGTVTHTFCGTIEYMAPEILMRSG  269

         *********************************9.9999999******************

S: 179   ydeavDlwslGvllyemLtGktPftgeerketlarilkgkfslklpaweelseeakdlvk  238

         +++avD+wslG+l+y+mLtG++Pftge+rk+t+++ilk+k  l+lp +  l++ea+dl+k

Q: 270   HNRAVDWWSLGALMYDMLTGAPPFTGENRKKTIDKILKCK--LNLPPY--LTQEARDLLK  325

         ****************************************..9*****..**********

S: 239   klLkkdpakRlga...taeeikehkfl  262

         klLk++ a+Rlga   +a e+++h+f+

Q: 326   KLLKRNAASRLGAgpgDAGEVQAHPFF  352

         *************9*9*********97

Domain Sequence
(FASTA)

FELLRVLGKG GYGKVFQVRK VTGANTGKIF AMKVLKKAMI VRNAKDTAHT KAERNILEEV 60

KHPFIVDLIY AFQTGGKLYL ILEYLSGGEL FMQLEREGIF MEDTACFYLA EISMALGHLH 120

QKGIIYRDLK PENIMLNHQG HVKLTDFGLC KESIHDGTVT HTFCGTIEYM APEILMRSGH 180

NRAVDWWSLG ALMYDMLTGA PPFTGENRKK TIDKILKCKL NLPPYLTQEA RDLLKKLLKR 240

NAASRLGAGP GDAGEVQAHP FF 262

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Choloepus hoffmanni"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryzias latipes"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sorex araneus"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>Schizosaccharomyces pombe"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity
GO:0007165	; P:signal transduction

KEGG

InterPros

IPR000961	; AGC-kinase_C.
IPR011009	; Kinase-like_dom.
IPR017892	; Pkinase_C.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR016238	; Ribosomal_S6_kinase.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069	; Pkinase; 1.
PF00433	; Pkinase_C; 1.

SMARTs

SM00133	; S_TK_X; 1.
SM00220	; S_TKc; 1.

Prosites

PS51285	; AGC_KINASE_CTER; 1.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013