EKS-OTG-00297

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-OTG-00297

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
Other/BUB	368.7	1.3E-110	787	1053	267

Status

Unreviewed

Ensembl Protein

ENSOGAP00000007020

UniProt Accession

H0WX62;

Protein Name

Protein Synonyms/Alias

Gene Name

BUB1

Gene Synonyms/Alias

BUB1;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSOGAG00000007837	ENSOGAP00000007020	ENSOGAT00000007843

Organism

Otolemur garnettii

Functional Description

Protein Length

1085

Protein Sequence
(FASTA)

MDNPEDVFQM FEAHMRSYKG DDPLGEWESY MQWVEENFPE NKEYLTTLLQ HLMKEFLDKK 60

RYHNDPRFIN YCLKFAEFNS DLHQFFEFLY NHGVGTLSSL LYIAWAEHLE TQGELQHASA 120

VFRRGIQNQA EPRELLQQQY RLFQTRLTEP RLPAQARASE PLNDQIVNQI TSKSNPGNNS 180

ACIPKNQGSE LSGVISSTRD KESNMEKRVI MISKSEYSAH PSLAAKADVQ QVVMYCKEKL 240

IHGESEFSFE ELRAQKYNQR RKHEQWVNED RHYMKKKEAN AFEEQLLKQK MDELHKKLHQ 300

VAETSHEDLP TFQEGSKVNP ACTGPNVGSQ PELRAPCLPA INQQISAHIR ENLREAPPIA 360

PLMTNAIPAA LVSPAVSQSI PPPVPLTAQS VTDSMFAVAR KGPGCVSKST QEFKPHSGAD 420

IKEGCDVQKV ANTSSFHTTP NTSLGMVQAT PSKGQPSPTV HTKEALGFIM NMFQAPTLPD 480

ISDDKDEWQS LDQNEDAFEA QFQKNTGSSG AWGVNKIIYS LSSGFPVFED GNKENYGLPQ 540

PKNKPTGART FGERSVSRFP SKANEVPHTE EFLDDSTVWG IRCNKTLAPS PKSPGDFTSA 600

AQLASTPFHK LLAESVHILE DKENVVAKQY SHMTLDSCEE NMVPSKDRKF SISSPILEKN 660

PEQAFPSDTC SASSLRLNQP TAGGVLTCEA ERGLEACKLT DTAIAIAEDP PDAIAGLQAE 720

QMQTGSRGNV DAPNFSVENP WDDQLILKLL SGLSKPMSSY PNAFEWQCKL PAIKPRSEFQ 780

LGSMLVYVHH LLGEGAFAQV YEVTQGDVND PKNKQKFVLK VQKPANRWEF YIGTQLMERL 840

KPTVQHLFIK FYSAHLFQNG SVLVGDLYSY GTLLNAINLY KNTPEKVMPQ GLVISFAMRM 900

LYMVEQVHAC EIIHGDIKPD NFILGGGFLE QDAEDDDFSA GLALIDLGQS IDMKLFPKGT 960

TFTAKCETSG FQCTEMLSNK PWNYQIDYFG VAATIYCMLF GTYMKVKNEG GVWKPEGLFR 1020

RLPHLDMWNE FFHIMLNIPD SHHLPSLNLL RQKLKEVFQQ HYTNKIRALR NRLIVLLLEY 1080

KRSRK 1085

Nucleotide Sequence
(FASTA)

ATGGATAACC CAGAAGACGT CTTTCAAATG TTTGAAGCCC ATATGCGGAG TTATAAGGGT 60

GATGATCCAC TTGGAGAATG GGAAAGCTAC ATGCAATGGG TAGAAGAGAA TTTTCCTGAA 120

AATAAAGAAT ACTTGACAAC TTTGTTACAA CATTTAATGA AGGAGTTTTT AGATAAGAAG 180

AGATACCACA ATGACCCAAG ATTCATTAAT TATTGTTTAA AATTTGCTGA GTTCAATAGC 240

GACCTTCATC AGTTTTTTGA GTTTCTGTAC AACCATGGGG TTGGAACCCT GTCATCCCTT 300

CTGTACATAG CATGGGCAGA GCATCTGGAG ACCCAGGGAG AGCTGCAGCA TGCCAGTGCT 360

GTTTTCCGGA GAGGAATTCA AAACCAAGCG GAACCCAGGG AGCTGCTGCA ACAGCAGTAC 420

AGGTTATTTC AGACACGCCT CACTGAACCC CGTTTGCCTG CTCAAGCTAG AGCCTCAGAA 480

CCTCTAAATG ATCAGATTGT AAACCAGATA ACATCAAAAT CAAACCCAGG AAACAACTCG 540

GCCTGCATTC CTAAGAATCA GGGTTCAGAA CTTTCTGGAG TGATATCTTC AACTCGTGAT 600

AAAGAGTCAA ATATGGAAAA AAGGGTGATC ATGATTTCTA AGTCAGAATA TTCTGCACAC 660

CCGTCTTTGG CAGCCAAAGC AGATGTTCAG CAGGTTGTTA TGTATTGCAA GGAGAAGCTT 720

ATTCATGGAG AATCAGAATT TTCCTTTGAA GAACTGAGAG CCCAGAAATA TAATCAACGG 780

AGAAAGCATG AGCAGTGGGT AAATGAGGAC AGACATTATA TGAAAAAGAA AGAAGCAAAT 840

GCTTTTGAAG AACAACTATT AAAACAGAAA ATGGATGAAC TTCACAAGAA GTTGCATCAA 900

GTGGCAGAAA CATCCCATGA GGACCTGCCC ACTTTCCAGG AAGGGTCCAA GGTTAATCCA 960

GCGTGTACGG GGCCAAATGT AGGCTCTCAG CCGGAACTGA GAGCTCCATG TCTTCCAGCC 1020

ATCAATCAGC AGATCTCAGC ACACATAAGA GAGAATCTAA GAGAGGCACC TCCTATTGCT 1080

CCTCTGATGA CAAACGCTAT TCCTGCAGCT TTGGTGTCTC CAGCCGTCAG CCAAAGCATA 1140

CCTCCTCCCG TTCCTTTGAC AGCCCAATCA GTGACAGACT CCATGTTTGC AGTGGCCAGA 1200

AAAGGTCCTG GATGTGTGAG TAAAAGTACT CAGGAGTTCA AGCCACACAG TGGAGCAGAT 1260

ATAAAAGAAG GATGTGACGT GCAGAAGGTT GCCAACACAA GTTCTTTTCA CACAACTCCA 1320

AACACATCAC TGGGAATGGT TCAGGCAACC CCATCCAAAG GGCAGCCCTC ACCCACGGTG 1380

CATACAAAAG AAGCATTAGG TTTCATCATG AATATGTTTC AGGCTCCTAC GCTTCCTGAT 1440

ATTTCTGATG ACAAAGATGA ATGGCAATCT CTAGATCAAA ATGAAGATGC ATTTGAAGCC 1500

CAGTTTCAAA AAAATACAGG GTCTTCGGGA GCTTGGGGAG TCAATAAGAT TATCTATTCT 1560

CTGTCATCTG GTTTTCCTGT GTTCGAAGAT GGAAACAAAG AAAATTATGG ATTACCACAG 1620

CCTAAAAATA AGCCCACAGG AGCCAGGACC TTTGGAGAAC GCTCTGTCAG CAGATTTCCT 1680

TCAAAAGCAA ATGAAGTGCC TCACACTGAA GAGTTTTTGG ACGATTCAAC TGTCTGGGGT 1740

ATTCGCTGCA ACAAAACCCT GGCACCCAGT CCTAAGAGCC CAGGAGACTT TACATCTGCC 1800

GCACAGCTGG CATCTACACC ATTCCACAAA CTTCTAGCAG AGTCGGTGCA CATTCTAGAA 1860

GACAAAGAAA ATGTGGTAGC AAAACAATAC AGCCATATGA CTTTGGATTC TTGTGAAGAA 1920

AACATGGTGC CTTCAAAGGA CAGAAAATTC AGCATATCCA GTCCAATTCT AGAGAAAAAC 1980

CCGGAACAAG CATTTCCCTC TGACACATGT TCAGCATCAT CACTCCGTCT GAACCAGCCC 2040

ACTGCAGGTG GTGTACTTAC GTGTGAGGCA GAACGGGGCC TTGAGGCCTG TAAACTCACA 2100

GACACTGCCA TTGCCATTGC AGAGGATCCA CCAGATGCTA TCGCTGGGCT GCAAGCAGAA 2160

CAAATGCAAA CAGGTTCACG TGGGAATGTC GATGCTCCAA ACTTCTCTGT TGAGAACCCA 2220

TGGGATGATC AATTGATTCT CAAACTTTTA TCTGGGCTTT CTAAACCAAT GAGTTCCTAT 2280

CCAAATGCTT TTGAATGGCA ATGTAAACTT CCAGCCATCA AGCCCAGGAG TGAATTTCAA 2340

TTGGGGTCTA TGCTGGTCTA TGTCCATCAC CTTCTTGGAG AAGGAGCTTT TGCCCAGGTC 2400

TATGAAGTTA CCCAGGGAGA TGTGAATGAT CCTAAAAATA AACAGAAATT TGTTTTAAAG 2460

GTCCAGAAGC CTGCCAACCG CTGGGAGTTC TACATTGGAA CCCAGCTGAT GGAGAGACTA 2520

AAGCCAACTG TGCAACACCT GTTTATCAAA TTCTATTCTG CCCACTTGTT CCAGAATGGC 2580

AGTGTATTAG TAGGAGACCT CTATAGCTAT GGAACATTGT TAAATGCCAT AAACCTCTAT 2640

AAAAATACCC CTGAAAAAGT AATGCCTCAA GGTCTCGTGA TCTCTTTTGC AATGAGAATG 2700

CTTTACATGG TGGAACAAGT GCACGCCTGT GAAATCATTC ATGGAGACAT TAAGCCAGAC 2760

AATTTCATAC TTGGAGGCGG ATTTTTGGAA CAGGATGCTG AAGATGATGA TTTCTCTGCT 2820

GGCTTGGCAC TGATTGACCT GGGTCAGAGT ATAGATATGA AGCTTTTCCC AAAAGGAACT 2880

ACATTCACAG CCAAATGTGA AACTTCTGGT TTTCAGTGTA CTGAGATGCT CAGTAACAAA 2940

CCATGGAACT ACCAGATTGA CTACTTTGGG GTGGCTGCAA CAATATACTG CATGCTTTTT 3000

GGCACATACA TGAAAGTAAA AAATGAAGGA GGAGTCTGGA AGCCTGAAGG GCTTTTTAGA 3060

AGGCTTCCTC ATTTGGATAT GTGGAATGAA TTTTTTCACA TCATGTTGAA TATACCAGAT 3120

AGTCATCATC TACCCTCTTT GAATTTATTA AGGCAAAAGT TGAAGGAAGT ATTTCAACAA 3180

CACTATACTA ACAAGATTAG GGCCCTACGT AACAGGCTAA TTGTATTGCT CTTAGAATAT 3240

AAGCGTTCGC GAAAATAA 3258

Domain Profile

S: 2     eiekeigeGayakvykaeh....dsksgelvalKvekpansWefYIclqlkeRlkeeell  57

         ++++++geGa+a+vy+ ++    d k++++++lKv+kpan WefYI +ql+eRlk ++++

Q: 787   YVHHLLGEGAFAQVYEVTQgdvnDPKNKQKFVLKVQKPANRWEFYIGTQLMERLK-PTVQ  845

         79****************99998999*****************************.89**

S: 58    ksiieissallfqdasllvleyasygtlldlinkvkevtnkvmdeelvvllivqllkive  117

         + +i+++sa+lfq++s+lv +++sygtll++in++k++ +kvm++ lv+++++++l++ve

Q: 846   HLFIKFYSAHLFQNGSVLVGDLYSYGTLLNAINLYKNTPEKVMPQGLVISFAMRMLYMVE  905

         ************************************************************

S: 118   klHeveIiHgDlkPdnfllgnrimdkad.kdkeekglkliDfgrsiDmkllpdgtkfkgk  176

         ++H++eIiHgD+kPdnf+lg  + ++   +d+ ++gl+liD+g+siDmkl+p+gt+f++k

Q: 906   QVHACEIIHGDIKPDNFILGGGFLEQDAeDDDFSAGLALIDLGQSIDMKLFPKGTTFTAK  965

         ***********************9998725556778************************

S: 177   aktdafeciemlagkswsYqvDlfglaavihvllfgkyleviqeggswklkqkikrllkk  236

         ++t++f+c+eml++k+w+Yq+D+fg+aa+i+++lfg+y++v++egg wk++  ++rl++

Q: 966   CETSGFQCTEMLSNKPWNYQIDYFGVAATIYCMLFGTYMKVKNEGGVWKPEGLFRRLPHL  1025

         ************************************************************

S: 237   elwekiferlLNisdastlpsleelveek  265

         ++w+++f+ +LNi+d ++lpsl+ l++ k

Q: 1026  DMWNEFFHIMLNIPDSHHLPSLNLLRQ-K  1053

         *************************95.4

Domain Sequence
(FASTA)

YVHHLLGEGA FAQVYEVTQG DVNDPKNKQK FVLKVQKPAN RWEFYIGTQL MERLKPTVQH 60

LFIKFYSAHL FQNGSVLVGD LYSYGTLLNA INLYKNTPEK VMPQGLVISF AMRMLYMVEQ 120

VHACEIIHGD IKPDNFILGG GFLEQDAEDD DFSAGLALID LGQSIDMKLF PKGTTFTAKC 180

ETSGFQCTEM LSNKPWNYQI DYFGVAATIY CMLFGTYMKV KNEGGVWKPE GLFRRLPHLD 240

MWNEFFHIML NIPDSHHLPS LNLLRQK 267

Keyword

Complete proteome; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Pan troglodytes"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Saccharomyces cerevisiae"; ?>Schizosaccharomyces pombe"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR013212	; Mad3_BUB1_I.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR008271	; Ser/Thr_kinase_AS.
IPR015661	; Ser/Thr_kinase_Bub1.

Pfam

PF08311	; Mad3_BUB1_I; 1.
PF00069	; Pkinase; 1.

SMARTs

SM00777

; Mad3_BUB1_I; 1.

Prosites

PS51489	; BUB1_N; 1.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013