EKS-OTG-00244

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-OTG-00244

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CAMK/CAMKL	388.8	9.3E-117	56	307	252

Status

Unreviewed

Ensembl Protein

ENSOGAP00000007403

UniProt Accession

H0WY38;

Protein Name

Protein Synonyms/Alias

Gene Name

MARK3

Gene Synonyms/Alias

MARK3;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSOGAG00000008270	ENSOGAP00000007403	ENSOGAT00000008272

Organism

Otolemur garnettii

Functional Description

Protein Length

783

Protein Sequence
(FASTA)

MSTRTPLPTV NERDTENHTS HGDGRQEVTS RTGRSGAWCR NSIASCADEQ PVIGNYRLLK 60

TIGKGNFAKV KLARHILTGR EVAIKIIDKT QLNPTSLQKL FREVRIMKIL NHPNIVKLFE 120

VIETEKTLYL IMEYASGGEV FDYLVAHGRM KEKEARAKFR QIVSAVQYCH QKRIVHRDLK 180

AENLLLDADM NIKIADFGFS NEFTVGSKLD TFCGSPPYAA PELFQGKKYD GPEVDVWSLG 240

VILYTLVSGS LPFDGQNLKE LRERVLRGKY RIPFYMSTDC ENLLKRFLVL NPIKRGTLEQ 300

IMKDRWINAG HEEDELKPFV EPELDISDQK RIGILVGMGY SQEEIQESLS KMKYDEITAT 360

YLLLGRKSSE LDASDSSSSS NLSLAKVRPS SDLNNSTGQS PHHKVQRSVS SSQKQRRYSD 420

HAGPAVPTVV AYPKRSQTSA ADSDLKEDGI PSRKSSGIAV GGKGIAPASP MLGNASNPNK 480

ADIPERKKSS TVPSSNTASG GMTRRNTYVC SERTTADRHS VIQNGKENSL TEMFAYAASP 540

ASVCTTSSTC RLRHQKSMSM SASGHPKMML PPIDSEGDNF KAITIPDQRT PVASTHSISS 600

ATTPDRIRFP RGTASRSTFH GQPRERRTAT YNGPPASPSL SHEATPLSQT RSRGSTNLFS 660

KLTSKLTRSR NVSAEQKDEN KEAKPRSLRF TWSMKTTSSM DPGDMMREIR KVLDANNCDY 720

EQRERFLLFC VHGDGHAESL VQWEMEVCKL PRLSLNGVRF KRISGTSIAF KNIASKIANE 780

LKL 783

Nucleotide Sequence
(FASTA)

ATGTCCACTA GGACTCCATT GCCAACAGTG AATGAACGGG ACACTGAAAA CCACACGTCA 60

CACGGAGATG GGCGTCAAGA AGTTACCTCT CGCACTGGCC GCTCTGGAGC TTGGTGTAGA 120

AACTCTATAG CTTCCTGTGC AGATGAACAA CCTGTCATCG GAAACTACAG ACTGTTGAAA 180

ACAATTGGCA AGGGGAATTT TGCAAAAGTG AAATTGGCAA GACATATCCT TACAGGCAGA 240

GAGGTTGCTA TAAAAATAAT TGACAAAACT CAATTGAACC CAACAAGTCT ACAAAAGCTC 300

TTCAGAGAAG TAAGAATAAT GAAGATTTTA AATCATCCAA ACATAGTGAA GTTATTCGAA 360

GTCATTGAAA CTGAAAAAAC ACTCTACCTA ATCATGGAAT ATGCAAGTGG AGGTGAAGTG 420

TTTGACTATT TGGTTGCACA TGGAAGGATG AAGGAAAAAG AAGCAAGAGC TAAATTTAGA 480

CAGATTGTGT CTGCAGTCCA GTACTGCCAT CAAAAACGGA TTGTTCACAG AGACTTGAAG 540

GCTGAAAATC TATTGTTAGA TGCTGATATG AACATTAAAA TAGCAGATTT TGGTTTTAGC 600

AATGAATTTA CTGTTGGCAG TAAACTGGAC ACGTTTTGTG GCAGTCCTCC ATACGCAGCC 660

CCTGAGCTCT TCCAGGGCAA GAAGTACGAT GGGCCTGAGG TGGATGTGTG GAGTCTTGGG 720

GTCATCCTGT ACACACTTGT CAGTGGCTCA CTTCCCTTTG ATGGGCAAAA CCTGAAGGAA 780

CTGAGAGAGA GAGTATTAAG AGGGAAATAT AGAATCCCTT TCTACATGTC TACAGACTGT 840

GAAAACCTTC TCAAACGTTT CCTGGTGCTA AATCCAATTA AACGAGGCAC TCTAGAGCAA 900

ATCATGAAGG ACAGGTGGAT AAATGCAGGG CATGAGGAAG ATGAACTTAA ACCATTTGTT 960

GAACCAGAAC TAGACATCTC AGACCAGAAA CGAATAGGCA TTTTGGTGGG AATGGGGTAT 1020

TCACAAGAAG AAATTCAAGA ATCTCTGAGT AAAATGAAAT ATGATGAAAT CACAGCCACG 1080

TATTTATTGT TGGGGAGAAA ATCCTCAGAG CTGGATGCTA GTGATTCCAG TTCTAGCAGC 1140

AATCTTTCAC TTGCTAAGGT TAGGCCAAGC AGTGATCTCA ACAATAGCAC TGGCCAGTCT 1200

CCTCATCACA AAGTGCAGAG AAGTGTTTCT TCAAGCCAGA AGCAGAGACG TTACAGTGAC 1260

CATGCTGGAC CAGCTGTTCC TACAGTTGTG GCATATCCAA AAAGGAGTCA GACCAGCGCT 1320

GCAGATAGTG ACCTCAAAGA AGATGGAATT CCCTCCCGGA AATCAAGTGG CATTGCTGTT 1380

GGAGGAAAGG GAATTGCTCC GGCCAGTCCC ATGCTTGGGA ATGCAAGTAA TCCCAATAAG 1440

GCAGATATTC CTGAACGAAA GAAAAGTTCC ACTGTCCCTA GTAGTAACAC AGCATCTGGT 1500

GGAATGACAC GGCGAAATAC CTATGTTTGC AGTGAGAGAA CCACAGCTGA TAGACACTCA 1560

GTGATTCAGA ATGGCAAAGA AAACAGCCTG ACAGAAATGT TCGCTTATGC AGCTAGCCCT 1620

GCCTCAGTTT GTACCACATC TTCTACCTGT CGGCTGAGAC ATCAGAAGTC GATGTCCATG 1680

TCAGCCTCTG GGCACCCCAA GATGATGTTA CCTCCAATAG ACAGTGAAGG AGATAACTTC 1740

AAGGCTATCA CTATTCCTGA TCAGAGAACA CCAGTTGCCT CAACACACAG TATTAGCAGT 1800

GCAACCACCC CAGATCGAAT CCGCTTCCCA AGAGGCACTG CCAGTCGTAG CACTTTCCAT 1860

GGCCAGCCAC GGGAGCGGCG AACTGCAACA TATAATGGCC CTCCTGCCTC TCCCAGCCTG 1920

TCCCATGAAG CCACACCTTT GTCTCAGACG CGAAGCCGAG GCTCCACTAA TCTTTTTAGT 1980

AAATTAACTT CAAAACTCAC AAGGAGTCGC AACGTATCTG CTGAGCAAAA GGACGAGAAC 2040

AAAGAAGCAA AACCTCGTTC CCTGCGCTTC ACTTGGAGCA TGAAAACCAC TAGTTCCATG 2100

GATCCTGGGG ACATGATGCG GGAAATCCGC AAAGTGCTGG ACGCCAATAA CTGCGACTAT 2160

GAGCAGCGGG AGCGCTTCTT GCTGTTCTGC GTCCATGGTG ATGGGCACGC GGAGAGCCTC 2220

GTGCAGTGGG AGATGGAGGT CTGCAAGCTG CCAAGACTGT CTCTGAATGG GGTCCGGTTT 2280

AAGCGGATAT CAGGGACATC CATAGCCTTC AAAAATATTG CATCCAAAAT TGCCAATGAG 2340

CTAAAGCTGT AA 2352

Domain Profile

S: 1     ykllktlGegsfgkVklakhketkekvavKiikkkklseeslekikrEieilkklkhpni  60

         y+llkt+G+g+f+kVkla+h +t+++va+Kii+k++l+ +sl+k++rE++i+k+l+hpni

Q: 56    YRLLKTIGKGNFAKVKLARHILTGREVAIKIIDKTQLNPTSLQKLFREVRIMKILNHPNI  115

         99**********************************************************

S: 61    ikllevietkkklylvleyasggeLfdyieekgrlkekearklfkqlvsavkYlhskgiv  120

         +kl+eviet+k+lyl++eyasgge+fdy++++gr+kekear+ f+q+vsav+Y+h+k+iv

Q: 116   VKLFEVIETEKTLYLIMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQYCHQKRIV  175

         ************************************************************

S: 121   HrDlKpeNllldkkenikiaDFGlanlfkegklletfcGsppYaaPellkgkkYegpkvD  180

         HrDlK+eNllld+++nikiaDFG++n+f+ g++l+tfcGsppYaaPel++gkkY+gp+vD

Q: 176   HRDLKAENLLLDADMNIKIADFGFSNEFTVGSKLDTFCGSPPYAAPELFQGKKYDGPEVD  235

         ************************************************************

S: 181   vWslGvvLyalvtgklPfdeenlkellekilkgkleipkklskelesLlrklLvvdpekR  240

         vWslGv+Ly+lv+g+lPfd++nlkel+e++l+gk++ip+++s+++e+Ll+++Lv +p kR

Q: 236   VWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLKRFLVLNPIKR  295

         ************************************************************

S: 241   atieeilkhewl  252

          t+e+i+k++w+

Q: 296   GTLEQIMKDRWI  307

         ***********7

Domain Sequence
(FASTA)

YRLLKTIGKG NFAKVKLARH ILTGREVAIK IIDKTQLNPT SLQKLFREVR IMKILNHPNI 60

VKLFEVIETE KTLYLIMEYA SGGEVFDYLV AHGRMKEKEA RAKFRQIVSA VQYCHQKRIV 120

HRDLKAENLL LDADMNIKIA DFGFSNEFTV GSKLDTFCGS PPYAAPELFQ GKKYDGPEVD 180

VWSLGVILYT LVSGSLPFDG QNLKELRERV LRGKYRIPFY MSTDCENLLK RFLVLNPIKR 240

GTLEQIMKDR WI 252

Keyword

ATP-binding; Complete proteome; Nucleotide-binding; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Choloepus hoffmanni"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tarsius syrichta"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity

KEGG

InterPros

IPR001772	; Kinase-assoc_KA1.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.
IPR015940	; UBA/transl_elong_EF1B_N_euk.

Pfam

PF02149	; KA1; 1.
PF00069	; Pkinase; 1.

SMARTs

SM00220	; S_TKc; 1.
SM00165	; UBA; 1.

Prosites

PS50032	; KA1; 1.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.
PS50030	; UBA; 1.

Prints

Created Date

20-Feb-2013