EKS-OTG-00084

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-OTG-00084

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CMGC/GSK	448.5	8.9E-135	120	403	284

Status

Unreviewed

Ensembl Protein

ENSOGAP00000007623

UniProt Accession

H0WYM7;

Protein Name

Protein Synonyms/Alias

Gene Name

GSK3A

Gene Synonyms/Alias

GSK3A;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSOGAG00000008509	ENSOGAP00000007623	ENSOGAT00000008514

Organism

Otolemur garnettii

Functional Description

Protein Length

495

Protein Sequence
(FASTA)

MSGGGPSGGG PGGSGRARTS SFAEPGGGGG GGGGGPGGSA SGPGGSSSGK PSVGAMGGGV 60

GASSSGGGPS GSGGGGSGGP GAGTSFPPPG VKLGRDSGKV TTVVATLGQG PERSQEVAYT 120

DIKVIGNGSF GVVYQARLAE TRELVAIKKV LQDKRFKNRE LQIMRKLDHC NIVRLRYFFY 180

SSGEKKDELY LNLVLEYVPE TVYRVARHFT KAKLTIPIIY VKVYMYQLFR SLAYIHSQGV 240

CHRDIKPQNL LVDPDTAVLK LCDFGSAKQL VRGEPNVSYI CSRYYRAPEL IFGATDYTSS 300

IDVWSAGCVL AELLLGQPIF PGDSGVDQLV EIIKVLGTPT REQIREMNPN YTEFKFPQIK 360

AHPWTKVFKS RTPPEAIALC SSLLEYTPSS RLSPLEACAH SFFDELRCLG TQLPNNRPLP 420

PLFNFSPGEL SIQPSLNAIL IPPHLRSTAG TPTLTQSSQA LTETQTGSDW QSPEAPPLLP 480

PGLHLLQPPP LLVSL 495

Nucleotide Sequence
(FASTA)

ATGAGCGGCG GCGGGCCTTC GGGAGGCGGC CCGGGGGGCT CGGGCCGGGC GCGGACCAGC 60

TCGTTCGCGG AGCCAGGAGG CGGAGGCGGC GGAGGCGGAG GCGGCCCTGG GGGTTCGGCC 120

TCCGGCCCGG GCGGCAGCAG CAGCGGGAAG CCGTCGGTCG GGGCTATGGG TGGGGGCGTG 180

GGGGCCTCAA GCTCCGGGGG TGGCCCCAGC GGCAGCGGCG GAGGAGGCAG CGGCGGCCCT 240

GGCGCGGGCA CTAGCTTCCC GCCGCCCGGA GTGAAGCTGG GCCGTGACAG TGGGAAGGTG 300

ACCACAGTGG TAGCCACCCT AGGCCAAGGC CCAGAGCGTT CTCAAGAGGT GGCTTACACA 360

GACATCAAAG TGATTGGCAA TGGCTCATTT GGGGTTGTGT ACCAGGCACG GCTGGCAGAG 420

ACCAGGGAAT TGGTCGCCAT CAAGAAGGTT CTCCAGGACA AGAGGTTCAA GAACCGAGAG 480

CTTCAGATTA TGCGTAAGCT GGATCACTGC AATATTGTGA GGCTGAGATA CTTTTTCTAC 540

TCCAGTGGGG AGAAGAAAGA CGAGCTTTAC CTAAATCTGG TGCTGGAATA TGTGCCCGAG 600

ACAGTCTACC GGGTGGCCCG CCATTTCACC AAGGCCAAAT TGACCATCCC TATCATCTAT 660

GTCAAGGTAT ACATGTACCA GCTCTTTCGG AGCTTGGCCT ATATCCACTC CCAGGGGGTG 720

TGTCACCGTG ACATCAAGCC CCAGAACCTG CTGGTGGATC CTGACACTGC TGTCCTCAAG 780

CTCTGTGATT TTGGCAGTGC AAAGCAGTTG GTCCGGGGGG AGCCCAATGT CTCCTACATC 840

TGTTCTCGCT ACTACCGGGC CCCGGAGCTC ATCTTTGGAG CCACTGATTA CACCTCGTCC 900

ATTGATGTGT GGTCAGCTGG CTGTGTACTG GCTGAGCTTC TCCTTGGCCA GCCCATCTTC 960

CCTGGGGACA GTGGGGTAGA CCAGCTGGTG GAGATCATCA AGGTGCTGGG AACACCAACC 1020

AGGGAACAAA TCCGAGAGAT GAACCCCAAT TACACGGAGT TCAAGTTTCC CCAGATTAAA 1080

GCTCATCCCT GGACAAAGGT GTTCAAATCT CGAACGCCGC CAGAGGCCAT CGCTCTCTGC 1140

TCTAGCCTGC TGGAGTACAC ACCGTCCTCA AGGCTCTCCC CACTAGAGGC CTGTGCCCAC 1200

AGCTTCTTTG ATGAACTGCG ATGTCTTGGA ACCCAGCTCC CCAACAACCG CCCGCTCCCT 1260

CCCCTCTTCA ATTTCAGTCC TGGTGAACTC TCCATCCAAC CATCTCTCAA TGCCATTCTC 1320

ATCCCTCCTC ACTTGAGGTC CACAGCGGGC ACTCCTACCC TCACCCAGTC CTCACAAGCT 1380

TTAACTGAGA CTCAGACCGG CTCAGATTGG CAGTCACCCG AAGCGCCCCC TCTCCTCCCA 1440

CCTGGCCTCC ACCTCCTTCA ACCCCCTCCC CTCCTTGTGT CCCTT 1485

Domain Profile

S: 2     eelkligsGsFgnVyqavlseesekevaiKkvlqdkklknlEleilrklkHknivrLlyf  61

         +++k+ig+GsFg+Vyqa+l+e++e  vaiKkvlqdk++kn+El+i+rkl+H+nivrL+yf

Q: 120   TDIKVIGNGSFGVVYQARLAETREL-VAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYF  178

         789**********************.**********************************

S: 62    fsksaekkdkvylnlvleylPetlakvlrelkdkkkkldvlevklytyQlfrglaylhsl  121

         f++s ekkd++ylnlvley+Pet+++v+r+++++k ++++++vk+y+yQlfr+lay+hs+

Q: 179   FYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPIIYVKVYMYQLFRSLAYIHSQ  238

         ************************************************************

S: 122   eivHrDiKPqNllvdeetgvlKlcDfGsakrleknepnvsYivsRyYRaPELllgakeyt  181

         +++HrDiKPqNllvd++t+vlKlcDfGsak+l+++epnvsYi+sRyYRaPEL++ga++yt

Q: 239   GVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYT  298

         ************************************************************

S: 182   tkiDvWsagcvlaEllkgkvlfkgksakdqlelivkvlGtptkedikemnvkykekkfkk  241

         ++iDvWsagcvlaEll+g+++f+g+s++dql++i+kvlGtpt+e+i+emn++y+e+kf++

Q: 299   SSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQ  358

         ************************************************************

S: 242   ikkvslakvlkkkedkeavdllkkilkyepkkRlsalellahpff  286

         ik+++++kv+k+++++ea++l++++l+y+p++Rls+le++ah+ff

Q: 359   IKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFF  403

         ********************************************9

Domain Sequence
(FASTA)

TDIKVIGNGS FGVVYQARLA ETRELVAIKK VLQDKRFKNR ELQIMRKLDH CNIVRLRYFF 60

YSSGEKKDEL YLNLVLEYVP ETVYRVARHF TKAKLTIPII YVKVYMYQLF RSLAYIHSQG 120

VCHRDIKPQN LLVDPDTAVL KLCDFGSAKQ LVRGEPNVSY ICSRYYRAPE LIFGATDYTS 180

SIDVWSAGCV LAELLLGQPI FPGDSGVDQL VEIIKVLGTP TREQIREMNP NYTEFKFPQI 240

KAHPWTKVFK SRTPPEAIAL CSSLLEYTPS SRLSPLEACA HSFF 284

Keyword

ATP-binding; Complete proteome; Nucleotide-binding; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Macropus eugenii"; ?>Meleagris gallopavo"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Pan troglodytes"; ?>Pongo abelii"; ?>Procavia capensis"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>Saccharomyces cerevisiae"; ?>Schizosaccharomyces pombe"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069

; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013