EKS-OTG-00344

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-OTG-00344

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
Other/PEK	369.3	1.3E-110	590	1002	413

Status

Unreviewed

Ensembl Protein

ENSOGAP00000007957

UniProt Accession

H0WZE3;

Protein Name

Protein Synonyms/Alias

Gene Name

EIF2AK4

Gene Synonyms/Alias

EIF2AK4;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSOGAG00000008865	ENSOGAP00000007957	ENSOGAT00000008878

Organism

Otolemur garnettii

Functional Description

Protein Length

1653

Protein Sequence
(FASTA)

MVGGRGATGR GRDEPPESYP QRQDHELQAL EAIYGADFQD LRQHSRGPVK GPPEINLVLY 60

PQGLTGEEVY VKVELRVKCP PTYPDVVPEI DLQNAKGLSN ESVNLLKSRL EELAKKHCGE 120

VMIFELAYHV QSFLSEHNKP PPKSFHEEML ERRAQEEQQR LLEARRKEEQ EQREILHEIQ 180

RRKEEIKEEK KRKEMAKQER LEIASLSNQD HMSKKDPGGH RTAAILHGSS PDFVGNGKHR 240

ANSLGRARRE RQYSVCSSED SPGSCEILYF YMGSPDQLMV HKGKCTGDDE QLGKLIYNAL 300

ETTSGSFVLL YEWVLQWQKR MGPFLTNQER EKIDKCKKQI QGAEAEFNSL VKLNHPNIVR 360

YLAMNLKEQD DSIVVDILAE HISGVSLAAH LSHSGPVPVH QLRRYAAQLL SGLDYLHSNS 420

VVHKVLSASN VLVDAEGTIK ITDYSISKRL ADICKEDVFE QTRVRFSDNA LPYKTGKKGD 480

VWRLGLLLLS LSQGHECGEY PVAIPSDLPA DFQDFLKKCV CLDDKERWSP QQLLKHSFIN 540

PQPKMPLVEQ SPEDSGGQDY VETVIPSNRL PSAAFFSETQ RQFSRYFIEF EELQLLGKGA 600

FGAVIKVQNK LDGCCYAVKR IPINPASRHF RRIKGEVTLL SRLHHENIVR YYNAWIERHE 660

RPAGPGTPPP DSGPLAKDGR ATGQPAGDSG SPDSVEAAAP PPILSSSVEW STSGERSASA 720

RFPAAGPGSS SDEDDDDEDE HNGVFSQSFL PASDSESDII FDNEDENSKS QNQDEDCDEK 780

NGCRESEPSV TTEAVHYLYI QMEYCEKSTL RDTIDQGLYR DTIRLWRLFR EILDGLAYIH 840

EKGMIHRDLK PVNIFLDSDD HVKIGDFGLA TDHLAFSADG KQDDQAGDHS IKSDPSGHLT 900

GMVGTALYVS PEVQGSTKSA YNQKVDLFSL GIIFFEMSYH PMITASERIF VLNQLRDPTS 960

PKFPEDFDDG EHAKQKSVIS WLLNHDPAKR PTATELLKSE LLPPPQMEES ELHEVLHHTL 1020

ANVDGKAYRT MMAHIFSQRI SPAIDYTYDS DILKGNFSIG TAKIQQHVCE TIIRIFKRHG 1080

AVQLCTPLLL PRNRQIYEHN EAALFMDHSG MLVMLPFDLR VPFARYVARN NIMNLKRYCI 1140

ERVFRPRKLD RFHPKELLEC AFDIVTSTTN SSLPTAEIIY TIYEIIQEFP ALQERNYSIY 1200

LNHAMLLKAI LLHCGIPEDK LSQVYVILYD AVTEKLTRRE VEAKFCNLSL SSNSLCRLYK 1260

FIEQKGDLQD VMPTINSLIK QKTGVAQLVK YGLKDLEEVV GLLKKLGIKL QVLINLGLVY 1320

KVQQHSGIIF QFVAFIRRRQ RAVPEILAAG GRYDLLIPQF RGPQALGPVP TAIGVSIAID 1380

KISAAVLNME EPVTISSCDL LVVSVGQMSM SRAINLTQKL WTAGITAEIM YDWSQSQEEL 1440

QEYCRHHEIT YVALVSDKEG SHVKVKSFEK ERQTEKRVLE SDLVDHVVQK LRTKVSDERS 1500

IREASDNLAV QNLKGSFSNA SGLFEIHGAT VVPIVSVIAP EKLSASTRRR YETQVHQARF 1560

LPTSLTWWLL KVSSTLSISV VDLPKETILQ FLSLEWDADE QAFNTTVKQL LSRLPKQRYL 1620

KLVCDEIYNI KVEKKVSVLF LYSYRDDYYR ILF 1653

Nucleotide Sequence
(FASTA)

ATGGTTGGGG GCCGAGGGGC CACCGGGCGC GGTCGGGACG AGCCTCCGGA GAGCTACCCG 60

CAGCGGCAGG ACCACGAGCT GCAGGCTCTA GAGGCCATCT ACGGCGCCGA CTTCCAGGAC 120

CTGCGGCAAC ACTCGCGCGG ACCGGTCAAA GGGCCTCCTG AAATCAATTT AGTTCTATAC 180

CCGCAAGGCC TAACTGGTGA AGAAGTATAC GTGAAAGTGG AGCTAAGGGT TAAATGTCCA 240

CCTACCTATC CAGATGTAGT TCCTGAAATA GACTTACAGA ATGCCAAAGG TCTATCAAAT 300

GAAAGTGTTA ATTTATTAAA ATCCCGCCTG GAAGAACTAG CCAAAAAACA CTGCGGGGAG 360

GTGATGATAT TTGAACTGGC TTACCATGTC CAGTCATTTC TCAGCGAGCA TAACAAGCCC 420

CCTCCCAAAT CTTTCCACGA AGAAATGCTG GAAAGGCGGG CCCAGGAGGA GCAACAGAGG 480

CTGCTGGAAG CCAGGCGGAA GGAGGAGCAG GAGCAACGTG AAATCCTTCA TGAGATTCAG 540

AGAAGGAAAG AAGAGATCAA AGAAGAGAAA AAAAGGAAAG AAATGGCGAA GCAGGAACGT 600

TTGGAAATTG CTAGTTTGTC AAACCAAGAT CATATGTCTA AGAAAGACCC AGGAGGACAC 660

AGAACAGCTG CCATTCTACA CGGAAGCTCT CCTGACTTTG TAGGGAATGG TAAACATCGG 720

GCAAACTCCT TGGGAAGGGC TAGGCGAGAA CGTCAGTATT CCGTATGTAG TAGTGAAGAT 780

TCTCCTGGCT CCTGTGAAAT CCTGTATTTC TATATGGGAA GTCCTGATCA ACTCATGGTG 840

CACAAAGGGA AATGTACTGG TGACGATGAG CAGCTTGGAA AATTAATTTA CAACGCTTTG 900

GAAACAACCT CTGGCAGCTT CGTCTTGTTA TATGAGTGGG TCCTTCAGTG GCAGAAAAGA 960

ATGGGTCCAT TCCTTACAAA TCAAGAGAGA GAGAAGATTG ATAAGTGCAA AAAACAGATT 1020

CAAGGGGCAG AAGCAGAATT CAACTCACTG GTGAAATTGA ACCACCCGAA CATAGTGCGC 1080

TACTTAGCAA TGAATCTCAA AGAGCAGGAT GACTCCATCG TGGTGGACAT TTTAGCAGAG 1140

CACATTAGTG GGGTCTCTCT TGCCGCACAC CTGAGCCATT CGGGCCCCGT CCCCGTGCAT 1200

CAGCTTCGCA GGTATGCAGC TCAGCTCTTG TCGGGTCTCG ACTATCTGCA CAGCAATTCG 1260

GTGGTGCACA AGGTCCTGAG CGCATCAAAT GTCTTGGTGG ACGCTGAGGG CACCATCAAG 1320

ATTACCGACT ACAGCATTTC TAAGCGCCTC GCGGACATCT GCAAGGAGGA TGTGTTCGAA 1380

CAAACCCGAG TTCGTTTTAG TGACAATGCC CTGCCTTATA AAACGGGGAA GAAAGGGGAT 1440

GTTTGGCGTC TTGGTCTTCT GCTGCTGTCC CTCAGCCAAG GACATGAATG TGGAGAGTAT 1500

CCCGTGGCTA TCCCTAGTGA CTTACCAGCT GACTTTCAAG ATTTTCTAAA GAAGTGCGTT 1560

TGCTTGGATG ACAAGGAAAG ATGGAGTCCT CAGCAATTGT TGAAACACAG CTTTATAAAT 1620

CCGCAGCCAA AAATGCCTTT AGTGGAACAA AGTCCTGAAG ATTCTGGAGG ACAAGATTAT 1680

GTTGAGACTG TTATTCCTAG CAACCGGCTA CCCAGCGCAG CGTTCTTTAG TGAGACACAG 1740

AGACAGTTTT CCCGATACTT CATTGAATTT GAAGAATTGC AGCTGCTTGG CAAAGGAGCT 1800

TTTGGAGCTG TCATCAAGGT GCAGAACAAA CTGGACGGCT GCTGCTACGC GGTGAAGCGC 1860

ATCCCCATCA ACCCGGCCAG CAGGCACTTT CGCAGGATCA AGGGTGAGGT GACGCTGCTG 1920

TCCCGCCTGC ACCATGAGAA CATTGTGCGC TACTACAACG CCTGGATAGA GCGCCATGAG 1980

CGCCCGGCGG GCCCGGGGAC CCCGCCCCCG GACTCGGGAC CCCTGGCTAA GGACGGGCGA 2040

GCCACCGGGC AGCCGGCAGG CGACAGTGGC AGCCCAGACA GCGTGGAGGC TGCGGCGCCG 2100

CCGCCCATCC TCAGCAGCTC GGTGGAGTGG AGCACGTCGG GCGAGCGCTC GGCCAGCGCC 2160

CGCTTCCCCG CCGCTGGCCC GGGCTCCAGC AGTGACGAGG ACGACGACGA CGAGGACGAG 2220

CACAACGGTG TCTTCTCGCA GTCCTTCCTA CCTGCTTCAG ATTCTGAGAG TGATATCATC 2280

TTTGACAATG AAGATGAGAA CAGTAAAAGC CAGAATCAGG ATGAAGACTG CGATGAAAAG 2340

AATGGTTGCC GTGAAAGTGA GCCGTCAGTG ACGACTGAGG CTGTGCATTA CCTGTATATC 2400

CAGATGGAGT ACTGTGAAAA GAGCACTTTA CGTGACACCA TTGACCAGGG ACTGTACCGA 2460

GACACCATCA GACTCTGGAG GCTTTTTCGA GAGATTCTGG ATGGATTAGC TTATATCCAT 2520

GAGAAAGGAA TGATTCACCG GGATCTGAAG CCTGTCAACA TTTTTTTGGA TTCTGATGAC 2580

CATGTGAAAA TAGGTGATTT TGGTTTGGCA ACAGACCATC TAGCCTTTTC TGCTGACGGC 2640

AAGCAAGACG ATCAGGCAGG AGATCACTCA ATTAAATCAG ACCCTTCAGG TCATTTGACT 2700

GGGATGGTTG GCACTGCTCT GTATGTGAGC CCAGAGGTCC AAGGAAGCAC CAAATCTGCA 2760

TACAACCAGA AAGTGGATCT CTTCAGCCTG GGAATTATCT TCTTTGAGAT GTCCTATCAC 2820

CCCATGATTA CAGCGTCAGA AAGGATCTTT GTTCTCAACC AACTCAGAGA TCCCACTTCG 2880

CCGAAGTTTC CAGAAGACTT CGATGATGGA GAGCATGCAA AGCAGAAATC TGTCATCTCC 2940

TGGCTGTTGA ACCATGATCC TGCCAAACGG CCCACAGCCA CAGAACTGCT CAAGAGCGAG 3000

CTGCTGCCTC CGCCCCAGAT GGAGGAGTCG GAGCTTCACG AGGTGCTGCA CCACACCCTG 3060

GCCAATGTGG ATGGGAAGGC CTATCGCACC ATGATGGCCC ACATCTTCTC CCAGCGCATC 3120

TCCCCTGCCA TCGATTACAC CTATGACAGC GACATACTGA AGGGCAACTT TTCAATCGGT 3180

ACAGCCAAGA TACAGCAACA TGTGTGTGAA ACCATCATCC GCATCTTTAA AAGACATGGA 3240

GCTGTCCAAT TGTGTACCCC ACTACTGCTT CCCCGAAACA GGCAAATATA CGAGCACAAT 3300

GAAGCTGCCT TATTCATGGA CCACAGCGGG ATGCTGGTGA TGCTTCCTTT TGACCTGCGG 3360

GTCCCTTTTG CAAGATACGT GGCAAGAAAT AACATAATGA ATTTAAAACG ATACTGCATA 3420

GAACGTGTAT TCAGACCTCG CAAGTTGGAT CGATTTCATC CCAAAGAACT TCTGGAATGT 3480

GCATTTGATA TTGTCACTTC TACCACCAAC AGCTCTCTGC CCACTGCTGA AATCATCTAC 3540

ACTATCTACG AAATCATCCA AGAGTTCCCA GCACTCCAGG AAAGAAATTA CAGTATTTAC 3600

TTGAACCATG CTATGTTATT GAAAGCAATC CTCTTACACT GTGGGATCCC AGAAGATAAA 3660

CTCAGTCAAG TCTATGTTAT TTTGTATGAT GCTGTGACGG AGAAGCTGAC GAGGAGAGAA 3720

GTGGAAGCTA AATTTTGTAA TCTGTCTTTG TCTTCTAATA GTCTGTGTCG ACTCTACAAG 3780

TTTATTGAGC AGAAGGGAGA TTTGCAAGAT GTAATGCCAA CAATAAATTC ATTAATAAAA 3840

CAGAAAACAG GTGTCGCCCA GTTGGTGAAG TATGGCTTAA AAGATCTAGA GGAGGTTGTT 3900

GGACTGTTGA AGAAACTTGG CATCAAATTA CAGGTCTTGA TCAATTTGGG CTTGGTTTAC 3960

AAGGTGCAGC AACACAGCGG CATCATCTTC CAGTTTGTGG CGTTCATTAG ACGAAGGCAG 4020

AGAGCTGTAC CTGAAATCCT TGCAGCCGGT GGCAGATATG ACCTGCTGAT CCCCCAGTTT 4080

AGAGGACCAC AGGCTTTGGG GCCCGTTCCC ACTGCTATCG GGGTCAGCAT AGCTATAGAC 4140

AAGATATCTG CTGCTGTCCT CAACATGGAA GAACCTGTTA CAATAAGCTC TTGTGACCTC 4200

CTGGTTGTAA GTGTCGGCCA GATGTCCATG TCCAGGGCCA TTAACCTGAC CCAGAAACTC 4260

TGGACAGCAG GAATCACAGC AGAAATCATG TACGACTGGT CACAGTCCCA AGAGGAATTG 4320

CAAGAGTATT GCAGACATCA TGAAATCACC TACGTGGCCC TTGTCTCAGA TAAAGAGGGA 4380

AGCCATGTGA AGGTTAAGTC TTTTGAGAAG GAAAGGCAGA CAGAGAAGCG TGTGCTGGAG 4440

TCTGACCTTG TGGACCATGT TGTGCAGAAA CTGAGGACTA AAGTCAGTGA TGAAAGGAGT 4500

ATCAGAGAAG CTTCCGATAA TCTTGCAGTG CAAAATCTGA AGGGGTCATT TTCTAATGCT 4560

TCAGGTTTGT TTGAAATCCA TGGAGCAACG GTTGTTCCCA TTGTGAGTGT GATAGCCCCG 4620

GAGAAGCTGT CAGCCAGCAC TAGGAGGCGA TATGAAACGC AGGTACACCA AGCCCGGTTT 4680

CTTCCCACTT CTTTAACTTG GTGGCTTCTG AAAGTTTCAT CAACACTAAG CATCTCTGTG 4740

GTGGATTTAC CCAAAGAAAC AATCTTACAG TTTTTGTCAT TAGAGTGGGA TGCTGATGAA 4800

CAAGCATTTA ACACAACTGT GAAGCAGCTG CTGTCACGCC TGCCAAAGCA AAGATACCTC 4860

AAATTAGTCT GTGATGAAAT TTATAACATC AAAGTAGAAA AAAAAGTATC TGTGCTATTC 4920

CTGTACAGCT ACAGAGATGA CTACTACAGA ATCTTATTTT AA 4962

Domain Profile

S: 1     feeikvlGkGgfgvVlkaknkldkkeyaikriklnkakkelekverevkaLaklehpniv  60

         fee+++lGkG+fg+V+k++nkld+++ya+kri++n a++++++++ ev++L++l+h+niv

Q: 590   FEELQLLGKGAFGAVIKVQNKLDGCCYAVKRIPINPASRHFRRIKGEVTLLSRLHHENIV  649

         89**********************************************************

S: 61    rYfaawleekeesl..............................................  74

         rY++aw+e++e+++

Q: 650   RYYNAWIERHERPAgpgtpppdsgplakdgratgqpagdsgspdsveaaapppilsssve  709

         **************************************9866655555555555555555

S: 75    ...........................................tdsseveaeaeleeses  91

Q: 710   wstsgersasarfpaagpgsssdeddddedehngvfsqsflpaS----------------  753

         55555555555555555555555555555555555555555551................

S: 92    seesdtk..........................................llyiqmelcek  109

               +                                          +lyiqme+cek

Q: 754   ------DsesdiifdnedensksqnqdedcdekngcresepsvtteavhYLYIQMEYCEK  807

         ......0555555555555555555555556788888888888888999***********

S: 110   etLkdwiderkllesrselvmrlfkqllegleylHskgliHrdLkpsniFldsddqvKig  169

         +tL+d+id+  l++++ +l+ rlf+++l+gl+y+H+kg+iHrdLkp+niFldsdd+vKig

Q: 808   STLRDTIDQG-LYRDTIRLW-RLFREILDGLAYIHEKGMIHRDLKPVNIFLDSDDHVKIG  865

         **********.9********.***************************************

S: 170   DFgLatalaealkedvkqdaqske........akhtgqvgtklymsPeql..eksqYnkk  219

         DFgLat+ + a+++d kqd+q+++        ++ tg+vgt+ly+sPe++  +ks+Yn+k

Q: 866   DFGLATD-HLAFSADGKQDDQAGDhsiksdpsGHLTGMVGTALYVSPEVQgsTKSAYNQK  924

         ******9.8899999***999999777777766*****************999*******

S: 220   vDifsLGlilfeLly.pfstemervetltelrd...gkipedfdd.kvpkekkllqklls  274

         vD+fsLG+i+fe++y p+ t++er+ +l++lrd    k+pedfdd ++ k+k+++++ll+

Q: 925   VDLFSLGIIFFEMSYhPMITASERIFVLNQLRDptsPKFPEDFDDgEHAKQKSVISWLLN  984

         *********************************9999***********************

S: 275   rdpkeRpsasellksell  292

         +dp++Rp+a+ellksell

Q: 985   HDPAKRPTATELLKSELL  1002

         ***************986

Domain Sequence
(FASTA)

FEELQLLGKG AFGAVIKVQN KLDGCCYAVK RIPINPASRH FRRIKGEVTL LSRLHHENIV 60

RYYNAWIERH ERPAGPGTPP PDSGPLAKDG RATGQPAGDS GSPDSVEAAA PPPILSSSVE 120

WSTSGERSAS ARFPAAGPGS SSDEDDDDED EHNGVFSQSF LPASDSESDI IFDNEDENSK 180

SQNQDEDCDE KNGCRESEPS VTTEAVHYLY IQMEYCEKST LRDTIDQGLY RDTIRLWRLF 240

REILDGLAYI HEKGMIHRDL KPVNIFLDSD DHVKIGDFGL ATDHLAFSAD GKQDDQAGDH 300

SIKSDPSGHL TGMVGTALYV SPEVQGSTKS AYNQKVDLFS LGIIFFEMSY HPMITASERI 360

FVLNQLRDPT SPKFPEDFDD GEHAKQKSVI SWLLNHDPAK RPTATELLKS ELL 413

Keyword

ATP-binding; Complete proteome; Nucleotide-binding; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>Saccharomyces cerevisiae"; ?>Schizosaccharomyces pombe"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004694	; F:eukaryotic translation initiation factor 2alpha kinase activity
GO:0000049	; F:tRNA binding
GO:0006446	; P:regulation of translational initiation

KEGG

InterPros

IPR004154	; Anticodon-bd.
IPR026920	; EIF2AK4.
IPR024435	; GCN2_anticodon-bd_dom.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR006575	; RWD-domain.
IPR008271	; Ser/Thr_kinase_AS.
IPR016255	; Ser/Thr_kinase_GCN2.
IPR016135	; UBQ-conjugating_enzyme/RWD.

Pfam

PF12745	; HGTP_anticodon2; 1.
PF00069	; Pkinase; 3.
PF05773	; RWD; 1.

SMARTs

SM00591

; RWD; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 2.
PS00108	; PROTEIN_KINASE_ST; 1.
PS50908	; RWD; 1.

Prints

Created Date

20-Feb-2013