EKS-OTG-00257

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-OTG-00257

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CAMK/CAMKL	316.7	9.3E-95	11	263	253

Status

Unreviewed

Ensembl Protein

ENSOGAP00000008053

UniProt Accession

H0WZM5;

Protein Name

Protein Synonyms/Alias

Gene Name

MELK

Gene Synonyms/Alias

MELK;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSOGAG00000008982	ENSOGAP00000008053	ENSOGAT00000008986

Organism

Otolemur garnettii

Functional Description

Protein Length

654

Protein Sequence
(FASTA)

MKDYDELLKY YELYETIGTG GFAKVKLACH ILTGEMVAIK IMDKNALGSD LPRIKTEIDA 60

LKNLRHQHIC QLYHVLETAN KIFMVLEYCP GGELFDYIIS QDRLSEEETR VVFRQIVSAV 120

AYVHSQGYAH RDLKPENLLF DEYHKLKLID FGLCAKPKGD KDYHLQTCCG SLAYAAPELI 180

QGKSYLGSEA DVWSMGILLY VLMCGFLPFD DDNVMALYKK IMKGKYDVPK WLSPSSILLL 240

QQMLQVDPKK RISLKNLLNH PWIMQDYNCP VEWQSKNPFI HLDDDCVTEL SVHHRTNRQT 300

MADLISLWQY DHLTATYLLL LTKKARGKPV RLRLPSFSCG QVSASPFIDI KSKNLSLEDV 360

TTSDERNVAG LIDYEWCEDY LSTGLSTPQT PQVVVIVVYL AGAGFEPASL SVCGWRHNQV 420

LWLWYCYGAT GAKLSFDNQP SLLFGGPGLG IRTRHLSFED PCSNLLLPLM APARNKCLKE 480

TPIKTPIYST GADKLMAGVI SPERRCRSVE LDLNQAHMED TPKRKGVKVF GSLERGLDKV 540

ITVLTRSKKK GSAKDGPRRL KLHYNVTTTK LVNPDQLLNE IISILPEKHV DFVQKGYTLK 600

CQTQSDFGKV TMQFELEVCQ LQKPDVVGIR RQRLKGDAWV YKRLVEDILA SCKV 654

Nucleotide Sequence
(FASTA)

ATGAAAGATT ATGATGAACT TCTCAAATAC TATGAATTAT ATGAAACTAT TGGGACAGGT 60

GGCTTTGCAA AGGTCAAACT TGCCTGCCAT ATCCTTACTG GAGAAATGGT AGCTATAAAA 120

ATCATGGATA AAAATGCACT AGGGAGTGAT TTGCCCCGGA TCAAAACGGA GATTGATGCC 180

TTGAAGAACC TTAGACATCA GCATATATGT CAACTCTACC ATGTGCTAGA GACAGCTAAC 240

AAAATATTCA TGGTTCTTGA GTACTGCCCT GGAGGAGAGC TGTTTGACTA TATAATTTCC 300

CAGGATCGCC TGTCAGAAGA GGAAACCCGA GTTGTCTTCC GTCAGATAGT ATCTGCGGTT 360

GCTTATGTGC ACAGTCAGGG CTATGCTCAC AGGGACCTCA AACCGGAAAA TTTATTGTTT 420

GATGAATATC ATAAATTAAA GCTGATTGAC TTCGGTTTGT GTGCAAAACC TAAGGGTGAC 480

AAAGATTACC ATCTACAGAC ATGCTGTGGA AGTCTTGCTT ATGCAGCACC TGAATTAATA 540

CAAGGGAAAT CATATCTTGG GTCAGAGGCT GATGTGTGGA GCATGGGTAT ACTCTTATAT 600

GTACTTATGT GTGGATTTCT ACCATTTGAT GATGATAATG TCATGGCTTT ATATAAGAAG 660

ATTATGAAAG GAAAATATGA TGTTCCCAAG TGGCTTTCTC CCAGTAGCAT TCTGCTCCTT 720

CAACAAATGC TGCAGGTGGA CCCAAAGAAA CGGATTTCTT TGAAAAATCT ATTGAACCAT 780

CCCTGGATCA TGCAAGATTA CAACTGTCCT GTTGAGTGGC AAAGCAAAAA TCCTTTTATT 840

CACCTTGATG ACGATTGTGT AACAGAACTT TCTGTACATC ACAGAACCAA CAGGCAGACA 900

ATGGCGGACT TAATTTCATT GTGGCAATAT GATCACCTCA CAGCTACCTA TCTTCTGCTT 960

CTAACCAAGA AGGCTCGAGG AAAACCAGTT CGTTTAAGGC TTCCTTCTTT TTCCTGTGGA 1020

CAAGTCAGTG CTTCCCCATT CATAGATATC AAGTCAAAGA ATCTGAGTCT GGAAGATGTG 1080

ACCACAAGTG ATGAAAGGAA TGTAGCTGGA TTAATAGACT ATGAATGGTG TGAAGATTAT 1140

TTATCAACAG GTCTATCTAC TCCCCAAACA CCACAGGTTG TTGTCATTGT TGTTTACCTA 1200

GCTGGGGCCG GGTTTGAACC TGCCAGCCTC AGTGTTTGTG GCTGGCGCCA TAACCAAGTG 1260

CTATGGTTAT GGTACTGTTA TGGTGCTACG GGTGCCAAGC TTTCTTTTGA TAATCAGCCA 1320

TCATTGTTGT TTGGCGGGCC TGGGCTGGGG ATTCGAACCC GCCACCTTAG TTTTGAGGAC 1380

CCCTGCTCTA ACCTGTTGCT TCCTCTAATG GCTCCAGCTA GAAACAAGTG CCTGAAGGAA 1440

ACCCCAATTA AAACACCAAT ATATTCAACA GGAGCAGACA AGTTAATGGC AGGTGTCATT 1500

AGCCCTGAAA GGCGGTGCCG CTCAGTAGAA CTAGATCTCA ACCAAGCACA TATGGAGGAT 1560

ACTCCAAAGA GAAAAGGAGT CAAAGTGTTT GGGAGCCTTG AAAGGGGACT GGATAAGGTG 1620

ATCACTGTGC TTACCAGGAG CAAAAAGAAG GGCTCCGCTA AAGACGGGCC ACGAAGACTA 1680

AAGCTTCACT ATAATGTGAC TACAACCAAA TTAGTGAATC CAGATCAACT CTTGAATGAA 1740

ATAATATCTA TTCTTCCGGA GAAGCATGTT GACTTTGTAC AGAAGGGTTA TACACTGAAG 1800

TGTCAAACAC AGTCAGATTT TGGCAAAGTG ACAATGCAGT TTGAACTAGA AGTGTGCCAG 1860

CTTCAAAAAC CTGATGTGGT GGGTATCAGG AGGCAGCGGC TTAAGGGCGA TGCCTGGGTT 1920

TACAAGAGAT TGGTCGAAGA CATCCTGGCT AGCTGCAAGG TATAA 1965

Domain Profile

S: 1     ykllktlGegsfgkVklakhketkekvavKiikkkklseeslekikrEieilkklkhpni  60

         y+l +t+G+g f+kVkla+h +t+e+va+Ki++k++l +  l +ik+Ei++lk+l+h++i

Q: 11    YELYETIGTGGFAKVKLACHILTGEMVAIKIMDKNALGS-DLPRIKTEIDALKNLRHQHI  69

         999*******************************88875.589*****************

S: 61    ikllevietkkklylvleyasggeLfdyieekgrlkekearklfkqlvsavkYlhskgiv  120

         ++l++v+et +k+++vley+ ggeLfdyi ++ rl+e+e+r +f+q+vsav Y+hs+g +

Q: 70    CQLYHVLETANKIFMVLEYCPGGELFDYIISQDRLSEEETRVVFRQIVSAVAYVHSQGYA  129

         ************************************************************

S: 121   HrDlKpeNllldkkenikiaDFGlanlfkeg..klletfcGsppYaaPellkgkkYegpk  178

         HrDlKpeNll+d+ +++k++DFGl+++ k +   +l+t+cGs++YaaPel++gk+Y g++

Q: 130   HRDLKPENLLFDEYHKLKLIDFGLCAKPKGDkdYHLQTCCGSLAYAAPELIQGKSYLGSE  189

         **************************665543389*************************

S: 179   vDvWslGvvLyalvtgklPfdeenlkellekilkgkleipkklskelesLlrklLvvdpe  238

         +DvWs+G++Ly+l++g lPfd++n+ +l++ki+kgk+++pk+ls++ + Ll+++L+vdp+

Q: 190   ADVWSMGILLYVLMCGFLPFDDDNVMALYKKIMKGKYDVPKWLSPSSILLLQQMLQVDPK  249

         ************************************************************

S: 239   kRatieeilkhewl  252

         kR++++++l+h+w+

Q: 250   KRISLKNLLNHPWI  263

         *************7

Domain Sequence
(FASTA)

YELYETIGTG GFAKVKLACH ILTGEMVAIK IMDKNALGSD LPRIKTEIDA LKNLRHQHIC 60

QLYHVLETAN KIFMVLEYCP GGELFDYIIS QDRLSEEETR VVFRQIVSAV AYVHSQGYAH 120

RDLKPENLLF DEYHKLKLID FGLCAKPKGD KDYHLQTCCG SLAYAAPELI QGKSYLGSEA 180

DVWSMGILLY VLMCGFLPFD DDNVMALYKK IMKGKYDVPK WLSPSSILLL QQMLQVDPKK 240

RISLKNLLNH PWI 253

Keyword

ATP-binding; Complete proteome; Nucleotide-binding; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tarsius syrichta"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity

KEGG

InterPros

IPR001772	; Kinase-assoc_KA1.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF02149	; KA1; 1.
PF00069	; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS50032	; KA1; 1.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013