EKS-OTG-00304
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-OTG-00304
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TK/EGFR496.02.1E-149683940258
StatusUnreviewed
Ensembl ProteinENSOGAP00000008154
UniProt AccessionH0WZV6;
Protein Name
Protein Synonyms/Alias
Gene NameEGFR
Gene Synonyms/Alias EGFR;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSOGAG00000009092ENSOGAP00000008154ENSOGAT00000009099
OrganismOtolemur garnettii
Functional Description
Protein Length1178
Protein Sequence
(FASTA)
VCQGTSNKLT QLGTFEDHFL SLRRMFNNCE VVLGNLEITY VQKNYDLSFL KTIQEVAGYV 60
LIALNTVERI PLENLQIIRG NMYYENSYAL AVLSNYGTNK SGLRELPMRS LQEVLQGAVR 120
FSNNPVLCNV DSIQWRDIIS SDFLSNMSMD FQSHLGSCQT CDPSCPNGSC WGAGKENCQK 180
LTKVICAQQC SGRCRGRSPS DCCHNQCAAG CTGPRESDCL VCRKFRDEAT CKDTCPPLML 240
YNPTTYQMDV NSEGKYSFGA TCVKKCPRNY VVTDHGSCVR ACGSDSYEVE EDGIRKCKKC 300
EGPCRKVCNG IGIGEFKDTL SINATNIKHF RNCTSISGDL HILPVAFRGD SFTRTPPLDP 360
KELDILKTVK EITGFLLIQA WPENKTDLHA FENLEIIRGR TKQHGQFSLA VVGLNITSLG 420
LRSLKEISDG DVIISGNKNL CYANTINWKK LFGTSSQKAR IINNRVENNC KAMNHICSSL 480
CSSEGCWGPE PRDCVACQNV SRGRECVGRC HVLEGEPREF VENSECIQCH PECLPQALNI 540
TCTGRGPDHC IQCAHYVDGP HCVRTCPAGV MGENSTLVWK YADASHVCHL CHPNCTYGCT 600
GPGLEGCDGG GLKIPSIATG IVGGLLLVVV VALGVGLFLR RRHIVRKRTL RRLLQERELV 660
EPLTPSGEAP NQALLRILKE TEFKKIKVLG SGAFGTVYKG LWIPEGEKVK IPVAIKELRE 720
ATSPKANKEI LDEAYVMASV DNPHVCRLLG ICLTSTVQLI TQLMPFGCLL DYVREHKDNI 780
GSQHLLNWCV QISKGMNYLE DRRLVHRDLA ARNVLVKTPQ HVKITDFGLA KLLGAEEKEY 840
HAEGGKVPIK WMALESILHR IYTHQSDVWS YGVTVWELMT FGSKPYDGIP ASEISSILEK 900
GERLPQPPIC TIDVYMIMVK CWMIDADSRP KFRELIIEFS KMARDPQRYL VIQGDERMHL 960
PSPTDSNFYR ALMDEEDMED VVDADEYLIP QQGFFHSPST SRTPLLSSLS AASNNSTVAC 1020
VDRNGVLSCP IKEESFLQRY SSDPTGALTE DSVDDAFLPV PEYMNQPVPK RPVGSVQSPV 1080
YHIQPLSPAP GRDPHYQNPH SSAVGNPEYL NTAQPSCVSS TLDSPVHWAR KGNHQISLDN 1140
PEYHQDCFPQ PNGLVRAPAA ENVEYLRAAP PSSEFIGA 1178
Nucleotide Sequence
(FASTA)
GTTTGCCAAG GCACAAGTAA TAAGCTCACT CAGTTGGGCA CTTTTGAAGA CCATTTTCTG 60
AGCCTTCGGA GGATGTTCAA TAACTGTGAA GTGGTCCTGG GGAATTTGGA AATCACCTAT 120
GTGCAAAAGA ATTATGACCT TTCCTTCTTA AAGACCATCC AGGAAGTTGC TGGTTACGTC 180
CTCATTGCCC TCAACACAGT GGAGAGGATT CCTTTGGAAA ACCTTCAGAT CATCAGAGGA 240
AATATGTACT ATGAGAACTC ATATGCCCTG GCAGTCTTAT CCAACTATGG CACAAACAAA 300
TCCGGACTGA GGGAGCTGCC CATGAGGAGC TTGCAGGAGG TCCTGCAGGG CGCGGTGCGT 360
TTCAGCAACA ACCCGGTCCT CTGCAACGTG GACTCCATCC AGTGGCGGGA CATCATCAGC 420
AGCGACTTCC TGAGCAACAT GTCCATGGAC TTTCAGAGCC ACCTGGGCAG CTGCCAGACA 480
TGTGATCCGA GCTGTCCCAA TGGGAGCTGC TGGGGTGCAG GGAAGGAGAA CTGCCAGAAA 540
TTGACCAAAG TCATCTGTGC CCAGCAGTGC TCTGGGCGCT GTCGCGGCAG GTCCCCCAGC 600
GACTGCTGCC ACAACCAGTG TGCCGCGGGC TGCACGGGGC CCCGGGAGAG CGACTGCCTG 660
GTCTGCCGCA AGTTCCGAGA TGAAGCCACC TGTAAGGACA CCTGCCCACC ACTAATGCTG 720
TACAACCCTA CCACCTACCA GATGGATGTG AACTCTGAAG GCAAATACAG CTTTGGGGCC 780
ACGTGTGTGA AGAAGTGCCC CCGTAACTAC GTGGTAACAG ATCATGGCTC CTGTGTCCGC 840
GCCTGTGGCT CTGACAGCTA TGAGGTGGAG GAGGATGGCA TCCGCAAATG CAAAAAATGC 900
GAGGGGCCTT GTCGCAAAGT TTGCAATGGA ATAGGAATCG GTGAATTTAA GGACACACTT 960
TCCATAAATG CTACAAACAT AAAACACTTC AGAAATTGCA CCTCCATCAG CGGGGACCTC 1020
CACATCCTGC CAGTGGCTTT TAGGGGGGAC TCCTTTACCC GGACCCCTCC ACTGGATCCA 1080
AAGGAACTGG ACATTCTGAA AACTGTGAAG GAAATCACAG GGTTTTTACT GATTCAGGCT 1140
TGGCCTGAAA ACAAGACAGA CCTCCATGCC TTCGAGAACC TGGAAATCAT CCGTGGCAGG 1200
ACCAAGCAAC ATGGTCAATT TTCTCTTGCG GTTGTTGGCC TGAACATAAC ATCCTTGGGT 1260
TTACGCTCCC TCAAGGAGAT AAGTGATGGA GATGTGATAA TTTCAGGAAA CAAGAACTTG 1320
TGCTATGCAA ATACAATAAA CTGGAAAAAA CTCTTTGGGA CCTCTAGTCA GAAAGCCAGA 1380
ATCATCAACA ACAGAGTTGA GAACAACTGC AAGGCCATGA ACCACATCTG CAGTTCCCTG 1440
TGCTCATCAG AGGGCTGCTG GGGCCCAGAG CCGAGAGACT GTGTGGCCTG CCAGAACGTC 1500
AGCCGCGGCC GGGAGTGTGT GGGCAGGTGC CACGTGCTGG AGGGTGAGCC AAGGGAGTTT 1560
GTGGAGAATT CCGAGTGTAT TCAGTGCCAT CCGGAGTGCC TGCCCCAGGC CCTGAACATC 1620
ACCTGCACGG GACGGGGACC AGACCACTGC ATCCAGTGTG CTCACTACGT CGACGGCCCT 1680
CACTGTGTCA GGACCTGCCC TGCGGGAGTC ATGGGGGAGA ACAGCACCCT GGTCTGGAAG 1740
TATGCCGACG CCAGCCACGT GTGCCACCTG TGCCATCCAA ACTGCACCTA TGGATGTACC 1800
GGGCCAGGTC TTGAAGGCTG TGATGGTGGC GGGCTCAAGA TCCCATCCAT CGCCACTGGG 1860
ATTGTGGGTG GCCTCCTCCT GGTGGTGGTG GTGGCCCTGG GCGTTGGCCT GTTCTTGCGA 1920
AGGCGCCACA TAGTCCGGAA GCGCACGCTG CGCCGGCTGC TGCAGGAGAG AGAGCTCGTG 1980
GAGCCCCTCA CACCCAGTGG GGAAGCCCCT AACCAGGCAC TTCTGCGGAT CTTAAAGGAA 2040
ACCGAATTTA AGAAGATTAA GGTTCTGGGC TCTGGCGCAT TTGGCACCGT GTACAAGGGA 2100
CTCTGGATCC CAGAAGGAGA AAAAGTTAAA ATCCCCGTGG CTATCAAGGA ATTGCGAGAA 2160
GCAACATCCC CAAAAGCCAA CAAGGAAATT CTCGACGAGG CCTATGTGAT GGCCAGTGTG 2220
GACAACCCCC ACGTGTGCCG CCTGCTAGGC ATCTGCCTGA CGTCCACCGT GCAGCTCATC 2280
ACGCAGCTGA TGCCCTTTGG CTGCCTCCTC GACTACGTCC GGGAGCACAA GGACAATATC 2340
GGCTCCCAGC ACCTGCTCAA CTGGTGTGTG CAGATCTCAA AGGGCATGAA CTACCTGGAG 2400
GACCGGCGCC TGGTGCACCG AGACCTGGCA GCCAGGAATG TGCTGGTGAA GACGCCACAG 2460
CACGTCAAGA TCACGGATTT TGGGCTGGCC AAACTGCTCG GTGCTGAAGA GAAAGAGTAC 2520
CATGCAGAGG GTGGCAAAGT GCCCATCAAA TGGATGGCAC TGGAATCAAT TTTACACCGA 2580
ATTTATACCC ATCAAAGCGA TGTCTGGAGC TATGGAGTCA CTGTTTGGGA ACTGATGACC 2640
TTTGGCTCCA AACCCTATGA CGGAATCCCT GCCAGTGAGA TCTCTTCCAT CCTGGAGAAG 2700
GGAGAGCGCC TGCCCCAGCC GCCCATCTGC ACCATTGATG TCTACATGAT CATGGTCAAG 2760
TGCTGGATGA TAGATGCAGA TAGTCGCCCA AAGTTCCGCG AGTTGATCAT TGAATTCTCC 2820
AAAATGGCCC GAGACCCTCA GCGCTATCTA GTCATCCAGG GAGACGAACG CATGCATCTG 2880
CCAAGCCCCA CGGACTCCAA TTTCTACCGT GCCCTGATGG ATGAAGAGGA CATGGAGGAT 2940
GTCGTGGACG CCGACGAGTA CCTTATCCCA CAGCAGGGTT TCTTCCACAG CCCATCCACG 3000
TCCCGGACAC CCCTTCTGAG CTCGCTGAGT GCAGCCAGCA ACAATTCCAC TGTGGCCTGC 3060
GTGGACCGGA ATGGGGTATT GAGCTGTCCC ATCAAGGAGG AGAGCTTCCT GCAACGGTAT 3120
AGTTCAGACC CCACCGGTGC CTTGACCGAG GACAGTGTGG ATGATGCCTT CCTCCCAGTG 3180
CCTGAGTACA TGAACCAGCC TGTCCCCAAG AGGCCTGTTG GCTCTGTGCA GAGCCCGGTG 3240
TATCACATTC AGCCTCTGAG TCCAGCCCCT GGGAGGGACC CCCACTACCA GAACCCCCAC 3300
AGCAGTGCCG TGGGCAACCC TGAGTATCTC AACACGGCCC AGCCTTCTTG TGTCAGCAGC 3360
ACTCTCGACA GCCCTGTCCA TTGGGCCCGG AAGGGCAACC ACCAGATCAG CCTGGATAAC 3420
CCTGAGTACC ACCAGGACTG CTTCCCCCAA CCGAATGGCC TGGTCCGGGC TCCTGCAGCT 3480
GAGAATGTGG AGTACCTGAG GGCAGCACCC CCAAGCAGTG AGTTCATTGG AGCATGA 3537
Domain Profile
S: 1     lkklkvlGsGafGtvykGiwipegenvkipvaikvleektgkkankelldealvlasldh  60
         +kk+kvlGsGafGtvykG+wipege+vkipvaik+l+e+t++kanke+ldea+v+as+d+
Q: 683   FKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDN  742
         59**********************************************************
S: 61    anlvrllglclsstlqlvtqllplGclldyvrehkdklGsqellnwcvqiakGmsyleek  120
         ++++rllg+cl+st+ql+tql+p+Gclldyvrehkd++Gsq+llnwcvqi+kGm+yle++
Q: 743   PHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQHLLNWCVQISKGMNYLEDR  802
         ************************************************************
S: 121   rlvhrdlaarnvlvkspnhvkitdfGlaklleadekelkaeggkvpikwlalesilkrky  180
         rlvhrdlaarnvlvk+p+hvkitdfGlakll a+eke++aeggkvpikw+alesil+r+y
Q: 803   RLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIY  862
         ************************************************************
S: 181   thqsdvwsyGvtvwelltfGakpydgipakeipdllekGerlaqppictidvymvlvkcw  240
         thqsdvwsyGvtvwel+tfG+kpydgipa+ei+++lekGerl+qppictidvym++vkcw
Q: 863   THQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCW  922
         ************************************************************
S: 241   midaesrpkfkelaeefs  258
         mida+srpkf+el+ efs
Q: 923   MIDADSRPKFRELIIEFS  940
         ****************96
Domain Sequence
(FASTA)
FKKIKVLGSG AFGTVYKGLW IPEGEKVKIP VAIKELREAT SPKANKEILD EAYVMASVDN 60
PHVCRLLGIC LTSTVQLITQ LMPFGCLLDY VREHKDNIGS QHLLNWCVQI SKGMNYLEDR 120
RLVHRDLAAR NVLVKTPQHV KITDFGLAKL LGAEEKEYHA EGGKVPIKWM ALESILHRIY 180
THQSDVWSYG VTVWELMTFG SKPYDGIPAS EISSILEKGE RLPQPPICTI DVYMIMVKCW 240
MIDADSRPKF RELIIEFS 258
KeywordATP-binding; Complete proteome; Kinase; Nucleotide-binding; Phosphoprotein; Reference proteome; Transferase; Tyrosine-protein kinase.
Sequence SourceEnsembl
Orthology
Ortholog group
Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Equus caballus"; ?>Felis catus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>
EKS-ANC-00290
EKS-BOT-00297
EKS-CAJ-00304
EKS-CAF-00304
EKS-CAP-00333
EKS-CII-00174
EKS-CIS-00072
EKS-EQC-00289
EKS-FEC-00283
EKS-GAA-00368
EKS-GOG-00295
EKS-HOS-00304
EKS-ICT-00280
EKS-LOA-00308
EKS-MAM-00301
EKS-MEG-00239
EKS-MOD-00292
EKS-MUM-00329
EKS-MUP-00295
EKS-NOL-00274
EKS-ORN-00386
EKS-ORA-00262
EKS-ORC-00280
EKS-ORL-00359
EKS-PAT-00283
EKS-PES-00265
EKS-PEM-00164
EKS-POA-00289
EKS-RAN-00314
EKS-SAH-00279
EKS-TAG-00314
EKS-TAR-00390
EKS-TEN-00385
EKS-XET-00371
EKS-XIM-00378
Gene Ontology
GO:0016021; C:integral to membrane
GO:0005524; F:ATP binding
GO:0004716; F:receptor signaling protein tyrosine kinase activity
GO:0004714; F:transmembrane receptor protein tyrosine kinase activity
GO:0023014; P:signal transduction by phosphorylation
GO:0007169; P:transmembrane receptor protein tyrosine kinase signaling pathway
KEGG
InterPros
IPR000494; EGF_rcpt_L.
IPR006211; Furin-like_Cys-rich_dom.
IPR006212; Furin_repeat.
IPR009030; Growth_fac_rcpt.
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
IPR008266; Tyr_kinase_AS.
IPR020635; Tyr_kinase_cat_dom.
IPR016245; Tyr_kinase_EGF/ERB/XmrK_rcpt.
Pfam
PF00757; Furin-like; 1.
PF07714; Pkinase_Tyr; 1.
PF01030; Recep_L_domain; 2.
SMARTs
SM00261; FU; 4.
SM00219; TyrKc; 1.
Prosites
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00109; PROTEIN_KINASE_TYR; 1.
Prints
PR00109; TYRKINASE.
Created Date20-Feb-2013