EKS-OTG-00474

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-OTG-00474

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CMGC/MAPK	397.3	3.4E-119	1	276	276

Status

Unreviewed

Ensembl Protein

ENSOGAP00000008157

UniProt Accession

H0WZV9;

Protein Name

Protein Synonyms/Alias

Gene Name

MAPK1

Gene Synonyms/Alias

MAPK1;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSOGAG00000009099	ENSOGAP00000008157	ENSOGAT00000009102

Organism

Otolemur garnettii

Functional Description

Protein Length

323

Protein Sequence
(FASTA)

SAYDNVNKVR VAIKKISPFE HQTYCQRTLR EIKILLRFRH ENIIGINDII RAPTIEQMKD 60

DRERYIVQDL METDLYKLLK TQHLSNDHIC YFLYQILRGL KYIHSANVLH RDLKPSNLLL 120

NTTCDLKICD FGLARVADPD HDHTGFLTEY VATRWYRAPE IMLNSKGYTK SIDIWSVGCI 180

LAEMLSNRPI FPGKHYLDQL NHILGILGSP SQEDLNCIIN LKARNYLLSL PHKNKVPWNR 240

LFPNADSKAL DLLDKMLTFN PHKRIEVEQA LAHPYLEQYY DPSDEPIAEA PFKFDMELDD 300

LPKEKLKELI FEETARFQPG YRS 323

Nucleotide Sequence
(FASTA)

TCTGCTTATG ATAATGTCAA CAAAGTTCGT GTAGCTATCA AGAAAATCAG TCCTTTTGAG 60

CACCAGACCT ACTGCCAGAG AACCCTGAGA GAGATAAAAA TCTTACTGCG CTTCAGACAT 120

GAGAACATCA TTGGAATCAA TGATATTATT CGAGCACCAA CCATCGAGCA AATGAAAGAT 180

GATAGGGAAA GATACATAGT ACAGGACCTC ATGGAAACAG ATCTTTACAA GCTCTTGAAG 240

ACACAACACC TCAGCAATGA CCATATCTGC TATTTTCTTT ACCAGATCCT CAGAGGGTTA 300

AAATATATCC ATTCAGCTAA TGTTTTGCAT CGTGACCTCA AGCCTTCCAA CCTGCTGCTC 360

AACACCACCT GTGATCTCAA GATCTGTGAC TTTGGCCTGG CCCGTGTTGC AGATCCAGAC 420

CATGATCACA CAGGGTTCCT GACAGAGTAT GTAGCCACGC GTTGGTACAG GGCTCCGGAA 480

ATTATGTTGA ATTCCAAGGG CTATACCAAG TCCATCGATA TTTGGTCTGT AGGCTGCATT 540

CTGGCAGAAA TGCTCTCCAA CAGGCCCATC TTTCCAGGGA AGCATTACCT CGACCAGTTG 600

AACCACATCC TGGGTATTCT TGGATCCCCA TCACAGGAAG ACCTGAATTG TATAATAAAT 660

TTAAAAGCTA GAAACTATTT GCTTTCTCTT CCACACAAAA ATAAGGTGCC ATGGAACAGG 720

CTGTTCCCAA ATGCTGACTC CAAAGCTCTG GACTTACTGG ACAAAATGCT GACATTTAAC 780

CCTCACAAGA GGATCGAAGT AGAACAGGCT CTGGCCCACC CTTATCTGGA GCAGTATTAC 840

GATCCAAGTG ATGAGCCCAT TGCTGAAGCA CCATTCAAGT TTGACATGGA ATTGGATGAC 900

TTGCCTAAGG AAAAGCTCAA AGAGCTCATT TTTGAAGAAA CCGCTAGATT CCAGCCAGGA 960

TACAGATCTT AA 972

Domain Profile

S: 17    savdkrteervaikklsrpfqketsakrtlRElkllkelkheNiiklldvftpee..ele  74

         sa+d+ ++ rvaikk+s pf+++t ++rtlRE+k+l +++heNii + d++++ +  +++

Q: 1     SAYDNVNKVRVAIKKIS-PFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTieQMK  59

         5899999*********9.*********************************998755788

S: 75    elkdvYlvtelmetdLkkviksqklsdehiklllyqilrglkylHsanviHrDlKPsNll  134

         + ++ Y+v++lmetdL+k++k+q+ls++hi ++lyqilrglky+Hsanv+HrDlKPsNll

Q: 60    DDRERYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLL  119

         8999********************************************************

S: 135   vnedcelkildFGlarsadkekekk..lteyvatrwYraPeillslkeytkavDiWsvGC  192

         +n++c+lki+dFGlar+ad++++++  lteyvatrwYraPei+l++k ytk++DiWsvGC

Q: 120   LNTTCDLKICDFGLARVADPDHDHTgfLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGC  179

         *********************999999*********************************

S: 193   IlaElltgkplfpgkdeidqlekilevlgtpseeflkkieseearnyikslpkkkkkdfe  252

         IlaE+l+++p+fpgk+++dql++il +lg+ps+e+l++i + +arny+ slp+k+k +++

Q: 180   ILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWN  239

         ************************************************************

S: 253   elfpkaseealdLleklLvldpdkRisveeaLehpYl  289

         +lfp+a+++aldLl+k+L+++p+kRi+ve+aL+hpYl

Q: 240   RLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYL  276

         ************************************7

Domain Sequence
(FASTA)

SAYDNVNKVR VAIKKISPFE HQTYCQRTLR EIKILLRFRH ENIIGINDII RAPTIEQMKD 60

DRERYIVQDL METDLYKLLK TQHLSNDHIC YFLYQILRGL KYIHSANVLH RDLKPSNLLL 120

NTTCDLKICD FGLARVADPD HDHTGFLTEY VATRWYRAPE IMLNSKGYTK SIDIWSVGCI 180

LAEMLSNRPI FPGKHYLDQL NHILGILGSP SQEDLNCIIN LKARNYLLSL PHKNKVPWNR 240

LFPNADSKAL DLLDKMLTFN PHKRIEVEQA LAHPYL 276

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Dasypus novemcinctus"; ?>Dipodomys ordii"; ?>Drosophila melanogaster"; ?>Echinops telfairi"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Macropus eugenii"; ?>Meleagris gallopavo"; ?>Microcebus murinus"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tarsius syrichta"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>Schizosaccharomyces pombe"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004707	; F:MAP kinase activity
GO:0000165	; P:MAPK cascade

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR003527	; MAP_kinase_CS.
IPR008349	; MAPK_ERK1/2.
IPR000719	; Prot_kinase_cat_dom.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069

; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS01351	; MAPK; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

PR01770

; ERK1ERK2MAPK.

Created Date

20-Feb-2013