EKS-OTG-00376

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-OTG-00376

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TK/Src	420.5	2.0E-126	243	496	254

Status

Unreviewed

Ensembl Protein

ENSOGAP00000008195

UniProt Accession

H0WZZ0;

Protein Name

Protein Synonyms/Alias

Gene Name

FRK

Gene Synonyms/Alias

FRK;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSOGAG00000009140	ENSOGAP00000008195	ENSOGAT00000009143

Organism

Otolemur garnettii

Functional Description

Protein Length

514

Protein Sequence
(FASTA)

MGNVFLRLWA YLEPCVPCSS READKPMVIA NPGARSSPEA PGAQEPEPER SPRRYFVALF 60

DYQARTAEDL SFRVGDKLQV LDASHEGWWF ARHLEKRADG SSQQLQGYIP SNYVAEDRSL 120

QAEPWFFGAI KRTDAEKQLL YSENQTGAFL VRESESQKGD FSLSVLHEGV VKHYRIRRLD 180

EGGFFLTPRR NFSTLNKFVR YYSTTSDGLC VKLGKPCLKR QVPTPFDLSY KTADQWEIDR 240

SSVQLLKRLG SGQFGEVWEG LWNNTTPVAV KTLKPGSMDP NDFLREAQIM KSLRHPKLIQ 300

LYAVCTLEDP IYIITELMRH GSLQEYLQND AGSKIHLVQQ VDIAAQVASG MAYLESQNYI 360

HRDLAARNVL VGEHNIYKIA DFGLARVFKV GNEDIYESKH EIKLPVKWTA PEAIRSNKFS 420

IKSDVWSFGI LLYEIITYGK MPYSGMTGAQ VIQMLSQNYR LPQPSNCPQQ FYSIMLECWN 480

AEPKERPTFE TLHWKLEDYF ETDSSYSDAD NFVR 514

Nucleotide Sequence
(FASTA)

ATGGGCAACG TTTTTCTGAG GCTCTGGGCG TACCTGGAGC CCTGCGTCCC CTGCTCATCC 60

CGGGAGGCCG ACAAGCCAAT GGTGATTGCG AATCCAGGGG CCCGAAGCTC CCCCGAAGCT 120

CCTGGGGCGC AGGAGCCGGA GCCGGAGAGA AGTCCCAGGC GCTACTTTGT GGCTCTGTTT 180

GACTACCAGG CTCGGACTGC AGAGGACCTG AGCTTCCGGG TTGGCGACAA ATTGCAAGTC 240

CTGGACGCTT CCCACGAGGG CTGGTGGTTT GCCCGGCACT TGGAAAAAAG GGCAGATGGC 300

TCCAGCCAGC AGCTACAGGG CTATATTCCT TCTAACTATG TGGCTGAGGA CAGGAGCCTA 360

CAGGCAGAGC CGTGGTTCTT TGGAGCAATC AAAAGAACAG ATGCAGAAAA ACAACTATTA 420

TATTCAGAAA ATCAGACGGG TGCCTTTCTA GTCAGAGAGA GTGAGAGCCA GAAAGGAGAC 480

TTCTCTCTTT CAGTTTTACA TGAAGGAGTT GTAAAACACT ACAGAATCAG AAGACTGGAT 540

GAAGGGGGAT TTTTTCTCAC CCCGAGAAGG AACTTTTCAA CACTGAATAA ATTTGTGAGG 600

TACTACAGCA CCACTAGCGA TGGCTTGTGT GTCAAGCTGG GAAAGCCATG CTTAAAGAGA 660

CAGGTCCCAA CGCCTTTTGA TTTGTCTTAT AAAACCGCGG ACCAGTGGGA GATAGACCGC 720

AGCTCCGTGC AGCTTCTGAA GCGACTGGGA TCCGGCCAGT TTGGCGAGGT GTGGGAAGGC 780

CTGTGGAACA ACACCACTCC TGTAGCAGTC AAAACGTTAA AACCAGGTTC AATGGATCCA 840

AATGACTTCC TGAGGGAGGC ACAGATAATG AAGAGCCTAA GACATCCCAA GCTTATCCAG 900

CTTTATGCTG TTTGCACTTT AGAAGATCCA ATTTATATTA TTACAGAGTT GATGAGACAT 960

GGAAGTCTGC AAGAGTATCT CCAAAATGAT GCTGGGTCCA AAATCCACCT GGTTCAACAA 1020

GTAGACATAG CAGCACAGGT TGCCTCTGGA ATGGCCTATC TGGAGTCTCA GAACTATATC 1080

CACAGAGATC TGGCTGCCAG AAATGTCCTC GTTGGTGAAC ATAATATCTA CAAAATAGCG 1140

GATTTTGGAC TTGCAAGAGT TTTTAAGGTA GGTAATGAAG ACATCTATGA ATCTAAACAC 1200

GAAATAAAGC TGCCGGTGAA GTGGACTGCG CCTGAAGCCA TTCGTTCCAA TAAATTCAGC 1260

ATTAAGTCTG ATGTGTGGTC ATTTGGAATC CTTCTTTATG AAATCATTAC CTATGGCAAA 1320

ATGCCTTATA GTGGTATGAC AGGTGCTCAG GTAATCCAAA TGTTGAGTCA AAACTACAGA 1380

CTGCCACAAC CATCTAACTG TCCACAGCAG TTCTACAGCA TCATGCTGGA GTGCTGGAAC 1440

GCGGAGCCCA AGGAACGCCC AACATTTGAG ACACTGCACT GGAAACTTGA GGATTATTTT 1500

GAAACAGACT CTTCATATTC AGATGCAGAT AACTTTGTAA GATGA 1545

Domain Profile

S: 1     lklvkklGeGqfGevwlgkwkgsvkvavktlkegtlspeafleeaqilkklrheklvkly  60

         ++l+k+lG+GqfGevw+g+w+++++vavktlk+g+++p++fl+eaqi+k+lrh+kl++ly

Q: 243   VQLLKRLGSGQFGEVWEGLWNNTTPVAVKTLKPGSMDPNDFLREAQIMKSLRHPKLIQLY  302

         6899********************************************************

S: 61    avvseeePiyivtelmakGslldflkeeegkklklpklvdlaaqvaeGmayleeknlihr  120

         av++ e+Piyi+telm++Gsl+++l+++ g+k++l ++vd+aaqva+Gmayle++n+ihr

Q: 303   AVCTLEDPIYIITELMRHGSLQEYLQNDAGSKIHLVQQVDIAAQVASGMAYLESQNYIHR  362

         ************************************************************

S: 121   dlaarnvlvgeslvvkvadfGlarlie...ddeytakegaklPikWtaPeaiklgkftik  177

         dlaarnvlvge++++k+adfGlar+++   +d+y++k++ klP+kWtaPeai+ +kf+ik

Q: 363   DLAARNVLVGEHNIYKIADFGLARVFKvgnEDIYESKHEIKLPVKWTAPEAIRSNKFSIK  422

         ************************999888******************************

S: 178   sdvWsfGillteivtkGkvPypGmtneevleqvergyrlprpeecpeelyelllecwkkd  237

         sdvWsfGill+ei+t+Gk+Py+Gmt ++v+++++++yrlp+p++cp+++y+++lecw+++

Q: 423   SDVWSFGILLYEIITYGKMPYSGMTGAQVIQMLSQNYRLPQPSNCPQQFYSIMLECWNAE  482

         ************************************************************

S: 238   peerPtfetlqevl  251

         p+erPtfetl+++l

Q: 483   PKERPTFETLHWKL  496

         **********9986

Domain Sequence
(FASTA)

VQLLKRLGSG QFGEVWEGLW NNTTPVAVKT LKPGSMDPND FLREAQIMKS LRHPKLIQLY 60

AVCTLEDPIY IITELMRHGS LQEYLQNDAG SKIHLVQQVD IAAQVASGMA YLESQNYIHR 120

DLAARNVLVG EHNIYKIADF GLARVFKVGN EDIYESKHEI KLPVKWTAPE AIRSNKFSIK 180

SDVWSFGILL YEIITYGKMP YSGMTGAQVI QMLSQNYRLP QPSNCPQQFY SIMLECWNAE 240

PKERPTFETL HWKL 254

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; SH3 domain; Transferase; Tyrosine-protein kinase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Dasypus novemcinctus"; ?>Dipodomys ordii"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Macropus eugenii"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tarsius syrichta"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004713	; F:protein tyrosine kinase activity

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR000980	; SH2.
IPR001452	; SH3_domain.
IPR008266	; Tyr_kinase_AS.
IPR020635	; Tyr_kinase_cat_dom.

Pfam

PF07714	; Pkinase_Tyr; 1.
PF00017	; SH2; 1.
PF00018	; SH3_1; 1.

SMARTs

SM00252	; SH2; 1.
SM00326	; SH3; 1.
SM00219	; TyrKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00109	; PROTEIN_KINASE_TYR; 1.
PS50001	; SH2; 1.
PS50002	; SH3; 1.

Prints

PR00401	; SH2DOMAIN.
PR00452	; SH3DOMAIN.
PR00109	; TYRKINASE.

Created Date

20-Feb-2013