EKS-OTG-00405
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-OTG-00405
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TK/PDGFR600.01.5E-180584919336
StatusUnreviewed
Ensembl ProteinENSOGAP00000008546
UniProt AccessionH0X0T0;
Protein Name
Protein Synonyms/Alias
Gene NameKIT
Gene Synonyms/Alias KIT;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSOGAG00000009550ENSOGAP00000008546ENSOGAT00000009556
OrganismOtolemur garnettii
Functional Description
Protein Length971
Protein Sequence
(FASTA)
LMVSSLKWDC HFLPCCLEIH AGSSQPSVSP GELSPPFIHP TKSELIVNVG TELRLLCTDP 60
GFVKWTFEIL NQMRENKLNE WIMEKAEATN TGRYTCTNEH GLSSSIYVFV RDPAKLFLVD 120
RFLYGKEDTD VLVRCPLTDP EVANYSLTGC QGKPLPKDLR FVPDPKAGIT IRSVKRAYHR 180
LCLHCSADQE GKPVLSDKFT LKVRPAFKAV PVVSVSKTRA LLREGEEFTV TCTIKDVSSS 240
VDSVWIGDSG QTKAQVKQNS WHHGDFNYER QETLTVSSAR VNDSGVFTCY ANNTFGSANV 300
TTTLEVVDKG FIHTFPLTNT TVFVNDGENV DLIVEYEAYP KPEQQQWTYM NRTFADKWEH 360
YPKSQNESNI RYVSELHLTR LKGTEGGTYT FLVSNSDVNA SIAFNVYVTT KPEILTYDRL 420
MNGMLQCVAA GFPEPTIDWY FCPGTEQRCS APVLPVGVQI QNSSGPPFGR LVVQSSIDSS 480
AFKHNGTVEC KASNDVGKTS AYFNFAFKEQ IHSHTLFTPL LIGFVVVAGM MCVIVMILTY 540
KYLQKPMYEV QWKVVEEING NNYVYIDPTQ LPYDHKWEFP RNRLSFGKTL GAGAFGKVVE 600
ATAYGLIKSD SAMTVAVKML KPSAHLTERE ALMSELKVLS YLGNHMNIVN LLGACTIGGP 660
TLVITEYCCY GDLLNFLRRK RDSFICSKQE DHAEAALYKN LLHSKGSTCS DSTNEYMDMK 720
PGVSYVVPTK SDKRRSARIG SYIERDVTSA IIEDDELALD LEDLLSFSYQ VAKGMAFLAS 780
KNCIHRDLAA RNILLTHGRI TKICDFGLAR DIKNDSNYVV KGNARLPVKW MAPESIFNCV 840
YTFESDVWSY GIFLWELFSL GSSPYPGMPV DSKFYKMIKE GFRMLSPEHA PAEMYDIMKT 900
CWDADPLKRP TFKQIVQLIE KQISDSTSHI YSNLANCNPN PENPVVDHSV RINSVGSTAS 960
SSQPLLVHED V 971
Nucleotide Sequence
(FASTA)
CTTATGGTCT CATCCTTAAA ATGGGATTGT CATTTTCTGC CTTGTTGTTT GGAGATTCAT 60
GCAGGCTCTT CTCAACCATC TGTGAGTCCA GGAGAACTGT CTCCACCATT CATCCATCCA 120
ACAAAATCAG AGTTAATAGT CAACGTTGGC ACCGAGCTCC GGCTGCTATG CACCGATCCC 180
GGCTTTGTCA AATGGACTTT TGAGATCCTG AATCAGATGC GTGAGAATAA GCTCAATGAA 240
TGGATCATGG AAAAAGCAGA GGCCACCAAC ACGGGCAGAT ACACGTGCAC CAACGAACAC 300
GGCTTAAGCA GTTCCATTTA TGTGTTTGTT AGAGACCCCG CCAAGCTTTT CCTTGTCGAC 360
CGGTTCTTGT ATGGGAAAGA AGACACTGAT GTGCTGGTCC GCTGTCCTCT GACAGACCCC 420
GAGGTGGCCA ACTACTCTCT CACGGGGTGC CAGGGGAAAC CTCTTCCTAA GGACCTGAGG 480
TTTGTTCCCG ACCCCAAGGC TGGCATCACA ATCAGAAGCG TGAAGCGTGC CTACCACCGG 540
CTCTGCCTAC ACTGTTCTGC TGACCAGGAG GGCAAGCCAG TGCTGTCGGA CAAATTCACT 600
CTGAAAGTGC GGCCAGCCTT CAAAGCTGTA CCAGTTGTGT CTGTGTCCAA AACAAGAGCC 660
CTTCTTCGAG AAGGGGAAGA ATTCACAGTG ACATGCACGA TAAAAGACGT GTCCAGTTCT 720
GTGGACTCCG TGTGGATAGG GGACAGTGGT CAGACTAAAG CACAGGTAAA ACAGAATAGC 780
TGGCATCACG GTGACTTCAA TTACGAGCGT CAGGAGACGC TGACTGTCAG CTCAGCCAGA 840
GTTAACGATT CTGGAGTGTT CACGTGTTAT GCCAATAATA CTTTTGGATC GGCAAATGTC 900
ACAACAACCT TGGAAGTAGT AGATAAAGGA TTCATTCATA CCTTCCCCCT GACAAACACC 960
ACGGTATTTG TAAATGATGG AGAAAATGTG GATTTGATTG TGGAATACGA GGCGTACCCC 1020
AAACCTGAAC AACAGCAGTG GACATACATG AACAGGACCT TTGCTGACAA GTGGGAGCAT 1080
TACCCCAAGT CTCAGAATGA AAGTAATATC AGATATGTCA GTGAACTTCA CTTAACCAGA 1140
TTAAAAGGGA CCGAAGGAGG CACTTACACA TTTCTAGTGT CCAATTCTGA CGTCAATGCT 1200
TCCATAGCAT TTAATGTTTA CGTGACCACA AAACCAGAAA TCCTGACTTA TGACAGGCTT 1260
ATGAATGGCA TGCTCCAGTG TGTGGCTGCC GGGTTCCCTG AGCCCACCAT AGATTGGTAC 1320
TTTTGTCCAG GAACTGAGCA GAGATGTTCA GCTCCTGTAC TGCCAGTGGG TGTGCAGATC 1380
CAGAACTCCT CCGGGCCACC CTTCGGCAGA CTGGTGGTTC AGAGCTCCAT AGATTCTAGT 1440
GCCTTCAAGC ACAATGGCAC AGTTGAGTGT AAGGCCTCCA ACGATGTGGG CAAGACTTCT 1500
GCCTATTTTA ACTTTGCATT TAAAGAGCAA ATCCACTCCC ACACCCTGTT CACTCCTCTG 1560
CTGATCGGCT TTGTGGTTGT AGCTGGGATG ATGTGTGTTA TTGTGATGAT CCTCACCTAC 1620
AAATATTTAC AGAAGCCAAT GTATGAAGTA CAGTGGAAGG TTGTTGAGGA GATAAATGGA 1680
AACAATTATG TTTACATAGA CCCGACACAA CTTCCTTATG ATCACAAGTG GGAGTTTCCC 1740
AGGAACAGGC TGAGTTTTGG GAAAACCTTG GGCGCTGGTG CCTTCGGGAA AGTTGTTGAG 1800
GCGACTGCCT ACGGCTTAAT TAAGTCCGAC TCGGCTATGA CCGTGGCTGT GAAGATGCTC 1860
AAACCAAGTG CCCATTTAAC GGAACGAGAA GCCCTGATGT CTGAGCTCAA AGTCCTTAGC 1920
TACCTGGGTA ATCATATGAA CATTGTGAAC CTTCTCGGCG CCTGCACCAT TGGAGGGCCC 1980
ACCTTGGTCA TTACGGAATA TTGTTGCTAT GGTGATCTTT TGAATTTTTT GAGACGAAAA 2040
CGTGATTCAT TTATTTGCTC AAAGCAGGAA GATCACGCAG AAGCAGCACT TTATAAGAAC 2100
CTTCTCCATT CAAAGGGGTC GACCTGCAGT GACAGCACTA ATGAATACAT GGACATGAAA 2160
CCTGGAGTGT CTTATGTTGT CCCAACCAAG TCAGACAAAC GGAGATCTGC ACGAATAGGC 2220
TCCTACATAG AGAGAGACGT GACCTCTGCC ATCATAGAGG ATGATGAGTT GGCCCTGGAC 2280
CTGGAGGACC TGCTGAGCTT TTCTTACCAG GTGGCAAAGG GCATGGCTTT CCTCGCCTCC 2340
AAAAACTGTA TTCACAGAGA CTTGGCAGCC AGAAATATCC TCCTTACCCA TGGTCGAATC 2400
ACAAAGATTT GTGATTTTGG TCTAGCCAGA GACATCAAGA ATGATTCTAA TTATGTGGTG 2460
AAAGGAAATG CTCGTCTGCC TGTCAAGTGG ATGGCACCCG AGAGCATTTT CAACTGTGTG 2520
TACACATTTG AAAGTGATGT CTGGTCCTAT GGGATTTTTC TGTGGGAGCT GTTTTCTTTA 2580
GGAAGCAGCC CTTACCCTGG GATGCCCGTC GACTCTAAGT TCTACAAGAT GATTAAGGAA 2640
GGCTTCCGAA TGCTCAGCCC CGAGCACGCA CCTGCTGAAA TGTATGACAT CATGAAGACT 2700
TGCTGGGACG CCGATCCTCT AAAAAGGCCA ACATTCAAGC AGATCGTTCA GCTGATAGAG 2760
AAGCAGATTT CAGACAGCAC CAGTCATATT TACTCCAACT TAGCAAACTG CAACCCCAAC 2820
CCTGAGAACC CCGTGGTGGA CCATTCCGTG AGGATCAACT CCGTTGGCAG CACTGCTTCC 2880
TCCTCCCAGC CCCTGCTCGT GCATGAAGAC GTCTGA 2916
Domain Profile
S: 1     lelGkvlGsGafGkvveatayGlsksdavlkvavkmlkstarssekealmselkilshlG  60
         l++Gk+lG+GafGkvveatayGl+ksd++++vavkmlk++a+ +e+ealmselk+ls+lG
Q: 584   LSFGKTLGAGAFGKVVEATAYGLIKSDSAMTVAVKMLKPSAHLTEREALMSELKVLSYLG  643
         79**********************************************************
S: 61    ehenivnllGactkgGpiyviteyccyGdllnylrrkresflkkslekkkekeeeldska  120
         +h+nivnllGact gGp++viteyccyGdlln+lrrkr+sf+   ++k+++++e++ +k+
Q: 644   NHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFI---CSKQEDHAEAALYKN  700
         ******************************************...99999*********9
S: 121   lladkslrsksslssesseeyvdlkkdvsdvssskadklasekkksalerevkaaleeed  180
         l     l+sk s++s+s++ey+d+k++vs+v ++k+dk++s+++ s++er+v++a++e+d
Q: 701   L-----LHSKGSTCSDSTNEYMDMKPGVSYVVPTKSDKRRSARIGSYIERDVTSAIIEDD  755
         9.....9*****************************************************
S: 181   sevleledllsfsyqvakGmeflaskncvhrdlaarnvllteGkvvkicdfGlardimkd  240
         + +l+ledllsfsyqvakGm+flasknc+hrdlaarn+llt+G+++kicdfGlardi++d
Q: 756   ELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARDIKND  815
         ************************************************************
S: 241   snyvvkGnarlpvkwmapesifdslytvksdvwsyGillweifslGstpypgllvdskfy  300
         snyvvkGnarlpvkwmapesif+++yt++sdvwsyGi+lwe+fslGs+pypg++vdskfy
Q: 816   SNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFY  875
         ************************************************************
S: 301   klikeGyrmaqpayateeiyeimqkcweaepekrpsfkqlvell  344
         k+ikeG+rm +p++a++e+y+im++cw+a+p krp+fkq+v+l+
Q: 876   KMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLI  919
         *****************************************996
Domain Sequence
(FASTA)
LSFGKTLGAG AFGKVVEATA YGLIKSDSAM TVAVKMLKPS AHLTEREALM SELKVLSYLG 60
NHMNIVNLLG ACTIGGPTLV ITEYCCYGDL LNFLRRKRDS FICSKQEDHA EAALYKNLLH 120
SKGSTCSDST NEYMDMKPGV SYVVPTKSDK RRSARIGSYI ERDVTSAIIE DDELALDLED 180
LLSFSYQVAK GMAFLASKNC IHRDLAARNI LLTHGRITKI CDFGLARDIK NDSNYVVKGN 240
ARLPVKWMAP ESIFNCVYTF ESDVWSYGIF LWELFSLGSS PYPGMPVDSK FYKMIKEGFR 300
MLSPEHAPAE MYDIMKTCWD ADPLKRPTFK QIVQLI 336
KeywordATP-binding; Complete proteome; Disulfide bond; Immunoglobulin domain; Kinase; Membrane; Nucleotide-binding; Phosphoprotein; Receptor; Reference proteome; Repeat; Transferase; Transmembrane; Transmembrane helix; Tyrosine-protein kinase.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>
EKS-AIM-00374
EKS-ANC-00389
EKS-BOT-00402
EKS-CAJ-00407
EKS-CAF-00402
EKS-CAP-00432
EKS-DAR-00787
EKS-EQC-00394
EKS-FEC-00386
EKS-GAG-00341
EKS-GAA-00515
EKS-GOG-00394
EKS-HOS-00409
EKS-ICT-00381
EKS-LAC-00419
EKS-LOA-00412
EKS-MAM-00402
EKS-MEG-00335
EKS-MOD-00391
EKS-MUM-00435
EKS-MUP-00399
EKS-MYL-00397
EKS-NOL-00368
EKS-ORN-00514
EKS-ORA-00347
EKS-ORC-00378
EKS-ORL-00472
EKS-PAT-00381
EKS-PES-00357
EKS-POA-00394
EKS-PTV-00114
EKS-RAN-00418
EKS-SAH-00372
EKS-SUS-00353
EKS-TAG-00473
EKS-TAR-00510
EKS-TEN-00511
EKS-XET-00515
EKS-XIM-00506
Gene Ontology
GO:0005887; C:integral to plasma membrane
GO:0005524; F:ATP binding
GO:0005021; F:vascular endothelial growth factor-activated receptor activity
GO:0048010; P:vascular endothelial growth factor receptor signaling pathway
GO:0038084; P:vascular endothelial growth factor signaling pathway
KEGG
InterPros
IPR007110; Ig-like.
IPR013783; Ig-like_fold.
IPR013098; Ig_I-set.
IPR003599; Ig_sub.
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
IPR008266; Tyr_kinase_AS.
IPR020635; Tyr_kinase_cat_dom.
IPR016243; Tyr_kinase_CSF1/PDGF_rcpt.
IPR001824; Tyr_kinase_rcpt_3_CS.
IPR009134; Tyr_kinase_VEGFR_rcpt_N.
Pfam
PF07679; I-set; 1.
PF07714; Pkinase_Tyr; 1.
SMARTs
SM00409; IG; 3.
SM00219; TyrKc; 1.
Prosites
PS50835; IG_LIKE; 1.
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00109; PROTEIN_KINASE_TYR; 1.
PS00240; RECEPTOR_TYR_KIN_III; 1.
Prints
PR01832; VEGFRECEPTOR.
Created Date20-Feb-2013