EKS-OTG-00317

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-OTG-00317

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
STE/STE20	356.2	1.0E-106	23	287	265

Status

Unreviewed

Ensembl Protein

ENSOGAP00000008647

UniProt Accession

H0X111;

Protein Name

Protein Synonyms/Alias

Gene Name

MINK1

Gene Synonyms/Alias

MINK1;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSOGAG00000009664	ENSOGAP00000008647	ENSOGAT00000009670

Organism

Otolemur garnettii

Functional Description

Protein Length

1333

Protein Sequence
(FASTA)

NPDAVFFLFS LLPSCPQDPA GIFELVEVVG NGTYGQVYKG RHVKTGQLAA IKVMDVTEDE 60

EEEIKQEINM LKKYSHHRNI ATYYGAFIKK SPPGNDDQLW LVMEFCGAGS VTDLVKNTKG 120

NALKEDCIAY ICREILRGLA HLHAHKVIHR DIKGQNVLLT ENAEVKLVDF GVSAQLDRTV 180

GRRNTFIGTP YWMAPEVIAC DENPDATYDY RSDIWSLGIT AIEMAEGAPP LCDMHPMRAL 240

FLIPRNPPPR LKSKKWSKKF IDFIDTCLIK TYLSRPPTEQ LLKFPFIRDQ PTERQVRIQL 300

KDHIDRSRKK RGEKEETEYE YSGSEEEDDS HGEEGEPSSI MNVPGESTLR REFLRLQQEN 360

KSNSEALKQQ QQLQQQQQRD PEAHIKHLLH QRQRRIEEQK EERRRVEEQQ RREREQRKLQ 420

EKEQQRRLED MQALRREEER RQAEREQEYK RKQLEEQRQS ERLQRQLQQE HAYLKSLQQQ 480

QQQQQQQQLQ KQQQQQILPG ERKPLYHYGR GINPADKPAW AREVEERTRM NKQQNSPLAK 540

TKPSSTGPEP SIPQASPGPP GPLSQTPPMQ RPVEPQEGPH KSLVAHRVPL KPYAAPVPRS 600

QSLQDQPTRN LAAFPASHDP DPAIPTPAAT PSARGAVIRQ NSDPTSEGPG PSPNPPAWVR 660

PDNEAPPKVP QRTSSIATAL NTSGAGGSRP AQAVRARPRS NSAWQIYLQR RAERGTPKPP 720

GPPAQPPGPP NASSNPDLRR SDPGWERSDS VLPASHGHLP QAGSLERNRV GASSKLDSSP 780

VLSPGNKAKP DDHRSRPGRP ADFVLLKERT LDEAPRPPKK AMDYSSSSEE VESSEEDEEE 840

GDGEPSEGSR DTPGARSDGD TDSVSTMVVH DIEEIPGTQP PYGGGTMVVQ RTPEEERSLL 900

HADSNGYPNL PDVVQPSHSP TENSKGQSPP SKDGGNDYQS RGLVKAPGKS SFTMFVDLGI 960

YQPGGSGDTI PITALVGGEG TRLDQLQYDV RKGSVVNVNP TNTRAHNETP EIRKYKKRFN 1020

SEILCAALWG VNLLVGTENG LMLLDRSGQG KVYGLIGRRR FQQMDVLEGL NLLITISGKR 1080

NKLRVYYLSW LRNKILHNDP EVEKKQGWTT VGDMEGCGHY RVVKYERIKF LVIALKNSVE 1140

VYAWAPKPYH KFMAFKSFAD LPHRPLLVDL TVEEGQRLKV IYGSSAGFHA VDVDSGNSYD 1200

IYIPVHIQSQ ITPHAIIFLP NTDGMEMLLC YEDEGVYVNT YGRIIKDVVL QWGEMPTSVA 1260

YICSNQIMGW GEKAIEIRSV ETGHLDGVFM HKRAQRLKFL CERNDKVFFA SVRSGGSSQV 1320

YFMTLNRNCI MNW 1333

Nucleotide Sequence
(FASTA)

AATCCTGATG CCGTATTCTT TCTTTTCTCC CTCCTACCCT CTTGCCCCCA GGACCCTGCT 60

GGAATCTTTG AGCTGGTGGA AGTGGTCGGC AATGGAACCT ATGGGCAGGT GTACAAGGGT 120

CGGCATGTCA AGACCGGGCA GCTGGCTGCC ATCAAGGTCA TGGATGTCAC AGAGGATGAG 180

GAGGAAGAGA TCAAGCAGGA GATCAACATG TTGAAAAAGT ATTCTCACCA TCGAAACATT 240

GCCACCTACT ATGGAGCCTT CATCAAGAAG AGCCCCCCTG GAAATGACGA TCAGCTCTGG 300

CTGGTGATGG AGTTCTGTGG TGCTGGTTCA GTGACCGACC TGGTAAAGAA CACAAAGGGT 360

AACGCTCTGA AAGAGGACTG CATTGCCTAC ATCTGCAGGG AGATTCTCAG GGGTCTGGCC 420

CATCTCCATG CCCACAAGGT GATCCATCGA GACATTAAGG GGCAGAATGT GCTGCTGACA 480

GAGAATGCTG AGGTCAAGCT AGTGGATTTT GGGGTGAGTG CTCAGCTGGA CCGCACGGTG 540

GGCAGGCGGA ACACTTTCAT TGGGACTCCC TACTGGATGG CCCCAGAAGT CATCGCCTGT 600

GATGAGAACC CTGACGCCAC TTACGATTAC AGGAGTGACA TTTGGTCTCT GGGAATCACA 660

GCCATTGAGA TGGCAGAGGG AGCCCCCCCT CTGTGTGACA TGCACCCCAT GCGAGCCCTC 720

TTCCTCATCC CTCGGAACCC TCCACCCAGG CTCAAGTCCA AGAAATGGTC TAAGAAGTTC 780

ATTGACTTCA TCGACACATG TCTCATCAAG ACTTACTTGA GCCGCCCGCC TACAGAACAG 840

TTACTGAAGT TTCCCTTCAT CCGAGACCAG CCCACGGAGC GGCAGGTCCG CATCCAGCTC 900

AAGGACCACA TCGACCGGTC CCGGAAGAAA CGGGGTGAGA AAGAGGAGAC AGAATACGAG 960

TACAGCGGCA GTGAGGAAGA AGATGACAGC CATGGAGAGG AAGGAGAGCC AAGCTCCATC 1020

ATGAATGTGC CTGGTGAGTC AACACTACGC CGGGAGTTTC TCCGGCTTCA GCAGGAGAAT 1080

AAGAGCAACT CAGAGGCTTT AAAGCAGCAG CAGCAGCTGC AGCAACAGCA ACAGCGAGAC 1140

CCCGAGGCAC ACATCAAGCA CCTGTTACAT CAGCGGCAGC GACGCATAGA AGAACAAAAG 1200

GAGGAGCGGC GGCGCGTTGA GGAGCAACAG CGGCGGGAGC GGGAGCAGCG AAAGCTGCAG 1260

GAGAAGGAGC AGCAGCGGCG GCTAGAGGAC ATGCAGGCGC TGCGGCGGGA GGAGGAGCGG 1320

CGGCAGGCGG AGCGAGAGCA GGAATACAAG CGGAAGCAGC TGGAGGAGCA GCGGCAGTCA 1380

GAACGTCTCC AGAGGCAACT GCAGCAGGAG CACGCCTACC TCAAGTCCCT ACAGCAGCAG 1440

CAACAGCAGC AGCAGCAGCA GCAGCTTCAG AAACAGCAGC AGCAGCAGAT CCTGCCTGGG 1500

GAAAGGAAGC CCCTGTATCA TTATGGTCGG GGCATTAATC CCGCTGACAA GCCAGCGTGG 1560

GCTCGAGAGG TAGAAGAGAG AACAAGGATG AATAAGCAGC AGAACTCTCC CTTGGCCAAG 1620

ACCAAGCCAA GCAGCACAGG GCCTGAGCCC TCCATCCCCC AGGCCTCCCC TGGACCCCCA 1680

GGACCTCTTT CCCAAACTCC TCCTATGCAG AGGCCAGTGG AGCCCCAGGA GGGACCACAC 1740

AAGAGCCTGG TAGCACACCG GGTCCCACTG AAGCCATATG CAGCACCTGT ACCCCGATCC 1800

CAGTCCCTGC AGGACCAGCC CACCCGAAAC CTGGCTGCCT TCCCAGCCTC TCACGACCCT 1860

GATCCTGCCA TCCCCACACC TGCTGCCACT CCCAGTGCCC GGGGAGCTGT CATCCGCCAG 1920

AATTCAGACC CCACTTCTGA AGGGCCTGGC CCCAGCCCAA ACCCCCCAGC CTGGGTCCGG 1980

CCAGACAACG AGGCCCCACC CAAGGTGCCT CAGAGGACCT CATCTATCGC CACTGCCCTT 2040

AACACCAGTG GGGCCGGAGG GTCCCGGCCA GCCCAGGCTG TCCGAGCAAG ACCTCGCAGC 2100

AACTCCGCCT GGCAAATCTA TCTGCAAAGG CGGGCAGAGC GGGGCACCCC CAAGCCTCCA 2160

GGGCCCCCTG CTCAGCCCCC TGGCCCGCCC AACGCCTCTA GTAACCCCGA CCTCAGGAGG 2220

AGCGACCCTG GCTGGGAGCG CTCAGACAGT GTCCTCCCGG CCTCTCATGG GCACCTTCCT 2280

CAGGCTGGCT CACTGGAGCG AAACCGTGTG GGAGCCTCCT CCAAACTGGA TAGCTCCCCA 2340

GTGCTCTCCC CTGGGAACAA AGCCAAGCCT GATGACCACC GCTCACGGCC AGGCCGGCCC 2400

GCAGATTTCG TGTTACTGAA AGAGCGGACC CTGGATGAAG CCCCTCGGCC TCCTAAGAAG 2460

GCCATGGACT ACTCGTCATC CAGTGAGGAA GTGGAAAGCA GTGAAGAGGA TGAGGAGGAA 2520

GGTGATGGCG AGCCATCAGA GGGGAGCAGA GACACCCCAG GGGCCCGCAG TGATGGAGAC 2580

ACAGACAGCG TCAGCACCAT GGTGGTCCAT GATATTGAGG AGATCCCTGG GACCCAGCCC 2640

CCATACGGGG GCGGCACCAT GGTGGTCCAG CGTACCCCTG AAGAGGAGCG GAGCTTGCTG 2700

CATGCTGACA GCAATGGTTA CCCAAACCTG CCTGATGTGG TCCAGCCCAG CCACTCACCC 2760

ACTGAAAACA GCAAAGGTCA AAGCCCACCT TCAAAGGATG GAGGAAATGA TTACCAATCT 2820

CGTGGGCTAG TAAAAGCCCC TGGCAAGAGT TCGTTCACGA TGTTTGTGGA TCTAGGGATC 2880

TACCAGCCTG GAGGCAGTGG GGACACCATC CCCATCACAG CCCTAGTGGG TGGAGAGGGC 2940

ACTCGTCTTG ATCAGCTACA GTACGACGTG AGGAAGGGCT CTGTGGTCAA TGTGAACCCC 3000

ACCAACACCC GGGCCCACAA TGAAACTCCT GAGATTCGCA AGTACAAGAA ACGATTCAAT 3060

TCTGAGATCC TCTGTGCAGC CCTTTGGGGG GTCAACCTGC TGGTGGGCAC GGAGAATGGG 3120

CTGATGCTGC TAGACCGAAG CGGGCAGGGA AAGGTATATG GACTCATTGG GCGGCGACGC 3180

TTCCAGCAAA TGGATGTGCT GGAGGGGCTC AACCTGCTCA TCACCATCTC AGGGAAAAGG 3240

AACAAACTGC GGGTGTATTA CCTGTCTTGG CTCCGAAACA AGATTCTGCA CAATGACCCA 3300

GAAGTGGAGA AGAAGCAGGG CTGGACGACC GTGGGGGACA TGGAGGGCTG TGGGCACTAC 3360

CGAGTTGTGA AATATGAGCG TATTAAGTTC CTGGTCATTG CCCTGAAGAA CTCTGTGGAG 3420

GTATATGCCT GGGCCCCCAA ACCCTACCAC AAATTCATGG CCTTCAAGTC CTTCGCTGAC 3480

CTTCCTCACC GCCCTCTGCT GGTTGACCTG ACCGTAGAGG AGGGACAGCG TCTCAAGGTC 3540

ATTTATGGCT CCAGTGCTGG CTTCCACGCT GTAGATGTCG ACTCGGGGAA TAGCTATGAC 3600

ATCTATATCC CTGTGCATAT CCAGAGCCAG ATCACGCCTC ATGCCATCAT CTTCCTCCCC 3660

AACACTGACG GCATGGAGAT GCTGCTATGC TATGAAGATG AGGGAGTCTA TGTCAACACA 3720

TATGGGCGGA TCATCAAAGA TGTGGTGCTG CAGTGGGGAG AGATGCCCAC CTCTGTGGCC 3780

TACATTTGCT CCAACCAGAT TATGGGCTGG GGTGAGAAAG CCATTGAGAT CCGCTCTGTG 3840

GAGACAGGCC ATCTGGATGG GGTCTTCATG CACAAACGAG CCCAGAGGCT CAAGTTCCTG 3900

TGTGAGCGGA ATGACAAGGT CTTTTTTGCC TCAGTCCGCT CCGGGGGCAG CAGCCAAGTT 3960

TACTTCATGA CTCTGAACCG TAACTGCATC ATGAACTGGT GA 4002

Domain Profile

S: 1     yelleeigkGalgkvylarekktgelvaikkinlekqekleelqkeisvlkklkh.pniv  59

         +el+e++g+G++g+vy++r++ktg+l+aik++++++ +++ee+++ei++lkk++h +ni

Q: 23    FELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDVTE-DEEEEIKQEINMLKKYSHhRNIA  81

         899********************************8.999*************998****

S: 60    eylesflk......eeelwlvmeylagGslsdlvkeelkselkEeqiayilrevlkaLey  113

         +y+++f+k      +++lwlvme++ +Gs++dlvk+++ + lkE+ iayi+re+l++L++

Q: 82    TYYGAFIKksppgnDDQLWLVMEFCGAGSVTDLVKNTKGNALKEDCIAYICREILRGLAH  141

         *************99*********************************************

S: 114   lHskkviHrdikakniLlteegeVkLsdfgvaaqlektrkkrktvvgtpywmAPEviaqe  173

         lH++kviHrdik++n+Llte++eVkL+dfgv+aql++t+ +r+t++gtpywmAPEvia++

Q: 142   LHAHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFIGTPYWMAPEVIACD  201

         ************************************************************

S: 174   ...ekgYdekaDiwslGItaielaegepPfkdleplkallkilkneppklkskkkfskef  230

            + +Yd+++DiwslGItaie+aeg+pP++d++p++al++i++n+pp+lksk k+sk+f

Q: 202   enpDATYDYRSDIWSLGITAIEMAEGAPPLCDMHPMRALFLIPRNPPPRLKSK-KWSKKF  260

         999999********************************************888.******

S: 231   kefvekclqknpekRpsasellkhkFl  257

          +f+++cl k + +Rp +++llk +F+

Q: 261   IDFIDTCLIKTYLSRPPTEQLLKFPFI  287

         *************************97

Domain Sequence
(FASTA)

FELVEVVGNG TYGQVYKGRH VKTGQLAAIK VMDVTEDEEE EIKQEINMLK KYSHHRNIAT 60

YYGAFIKKSP PGNDDQLWLV MEFCGAGSVT DLVKNTKGNA LKEDCIAYIC REILRGLAHL 120

HAHKVIHRDI KGQNVLLTEN AEVKLVDFGV SAQLDRTVGR RNTFIGTPYW MAPEVIACDE 180

NPDATYDYRS DIWSLGITAI EMAEGAPPLC DMHPMRALFL IPRNPPPRLK SKKWSKKFID 240

FIDTCLIKTY LSRPPTEQLL KFPFI 265

Keyword

ATP-binding; Complete proteome; Nucleotide-binding; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Dipodomys ordii"; ?>Equus caballus"; ?>Felis catus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Pan troglodytes"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity
GO:0005083	; F:small GTPase regulator activity

KEGG

InterPros

IPR001180	; Citron.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00780	; CNH; 1.
PF00069	; Pkinase; 1.

SMARTs

SM00036	; CNH; 1.
SM00220	; S_TKc; 1.

Prosites

PS50219	; CNH; 1.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013