EKS-OTG-00324
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-OTG-00324
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
STE/STE20347.64.2E-1042257256
StatusUnreviewed
Ensembl ProteinENSOGAP00000009251
UniProt AccessionH0X2H0;
Protein Name
Protein Synonyms/Alias
Gene NameTNIK
Gene Synonyms/Alias TNIK;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSOGAG00000010333ENSOGAP00000009251ENSOGAT00000010346
OrganismOtolemur garnettii
Functional Description
Protein Length1325
Protein Sequence
(FASTA)
DGERGELHKG RHVKTGQLAA IKVMDVTGDE EEEIKQEINM LKKYSHHRNI ATYYGAFIKK 60
NPPGMDDQLW LVMEFCGAGS VTDLIKNTKG NTLKEEWIAY ICREILRGLS HLHQHKVIHR 120
DIKGQNVLLT ENAEVKLVDF GVSAQLDRTV GRRNTFIGTP YWMAPEVIAC DENPDATYDF 180
KSDLWSLGIT AIEMAEGAPP LCDMHPMRAL FLIPRNPAPR LKSKKWSKKF QSFIESCLVK 240
NHSQRPATEQ LMKHPFIRDQ PNERQVRIQL KDHIDRTKKK RGEKDETEYE YSGSEEEEEE 300
NDSGEPSSIL NLPGESTLRR DFLRLQLANK ERSEALRRQQ LEQQQRENEE HKRQLLAERQ 360
KRIEEQKEQR RRLEEQQRRE KELRKQQERE QRRHYEEQAR REEERRRAEH EQEYIRRQLE 420
EEQRQLEILQ QQLLHEQALL LEYKRKQLEE QRQAERLQRQ LKQERDYLVS LQHQRQEQRP 480
IEKKPLYHYK EGMSPSEKPA WAKEVEERSR LNRQSSPAMP HKVANRVSDP NLPPRSESFS 540
ISGVQPARTP PMLRPVDPQI PHLVAVKPQG PALTASQSVL EQPTKGLSGF QEALAVTSHR 600
AEMPRQNSDP TSENPPLPTR IEKFDRSSWL RQEEDIPPKV PQRTTSISPA LARKNSPGNG 660
SALGPRLGSQ PIRASNPDLR RAEPILDSPL QRTSSGSSSS SSTPSSQPSS QGGSQPGSQA 720
GSSERTRVRA NSKSEGSPVL PHEPAKVKPE ESRDITRPSR PASYKKAIDE DLTALAKELR 780
ELRIEETNRP LKKVTDYSSS SEESESSEEE EEEGESETHD GTVAVSDIPR LIPTGAPGSG 840
EQYSVGMVGT HGLETSHVDA FSSSISREGT LMIRETSGEK KRSGHGDSNG HVNLPDLVQQ 900
SHSPAGTPTE GLGRVSTHPQ EMDTGTEYGL GSSTKASFTP FVDPRVYQTS PTDEDEEDEE 960
SAAAALFTSE LLRQEQAKLN EARKISVVNV NPTNIRPHSD TPEIRKYKKR FNSEILCAAL 1020
WGVNLLVGTE NGLMLLDRSG QGKVYNLINR RRFQQMDVLE GLNVLVTISG KKNKLRVYYL 1080
SWLRNRILHN DPEVEKKQGW VTVGDLEGCV HYKVVKYERI KFLVIALKNA VEIYAWAPKP 1140
YHKFMAFKSF ADLQHKPLLV DLTVEEGQRL KVIFGSHTGF HVIDVDSGNS YDIYIPSHIQ 1200
GNITPHAIVI LPKTDGMEML VCYEDEGVYV STYGRITKDV VLQWGEMPTS VAYIHSNQIM 1260
GWGEKAIEIR SVETGHLDGV FMHKRAQRLK FLCERNDKVF FASVRSGGSS QVFFMTLNRN 1320
SMMNW 1325
Nucleotide Sequence
(FASTA)
GATGGAGAGC GGGGGGAGCT TCATAAAGGT CGTCATGTCA AAACAGGCCA GCTTGCAGCC 60
ATTAAGGTTA TGGATGTCAC AGGGGATGAA GAGGAAGAAA TCAAACAAGA AATTAACATG 120
TTGAAGAAAT ATTCCCATCA CCGGAATATT GCTACATACT ATGGTGCTTT TATCAAAAAG 180
AACCCTCCAG GCATGGATGA TCAGCTGTGG TTGGTGATGG AGTTTTGTGG TGCTGGGTCT 240
GTCACTGACC TGATCAAGAA CACAAAAGGC AACACGTTGA AGGAGGAGTG GATCGCGTAC 300
ATCTGCCGAG AGATCCTGCG GGGGCTGAGC CACCTGCACC AGCATAAAGT GATTCATCGA 360
GACATCAAGG GGCAGAACGT CCTGCTGACG GAGAATGCGG AGGTTAAACT GGTGGACTTC 420
GGGGTCAGTG CCCAGCTAGA CCGGACGGTG GGCAGGAGGA ACACCTTCAT CGGAACCCCC 480
TACTGGATGG CCCCAGAAGT AATTGCCTGT GATGAAAACC CAGATGCCAC GTATGATTTC 540
AAGAGTGATT TGTGGTCCTT GGGAATCACC GCGATCGAGA TGGCAGAAGG TGCTCCCCCT 600
CTCTGTGACA TGCACCCCAT GAGAGCCCTC TTCCTCATCC CCCGGAACCC AGCCCCTCGG 660
CTGAAGTCCA AGAAGTGGTC AAAAAAATTC CAGTCATTTA TTGAGAGCTG TTTGGTAAAG 720
AACCACAGCC AGCGGCCGGC CACAGAGCAG CTGATGAAGC ACCCGTTCAT CCGGGACCAG 780
CCCAATGAGC GACAGGTCCG CATCCAGCTC AAGGACCACA TCGACCGGAC CAAGAAGAAG 840
CGAGGAGAGA AAGACGAGAC AGAGTATGAA TACAGCGGGA GTGAGGAGGA AGAGGAGGAG 900
AATGACTCGG GCGAGCCCAG CTCCATCCTG AACCTGCCTG GTGAGTCCAC ACTGCGCCGG 960
GACTTCCTGC GGCTGCAGTT GGCCAACAAG GAGCGGTCTG AGGCTCTGCG GCGGCAACAG 1020
CTGGAACAGC AGCAGCGGGA GAATGAGGAG CACAAGCGGC AGCTGCTGGC TGAGCGCCAG 1080
AAGCGCATCG AGGAGCAGAA GGAACAGCGG CGGAGGTTGG AGGAGCAACA AAGGCGGGAG 1140
AAGGAGCTGC GGAAGCAGCA GGAGCGCGAG CAGCGCAGGC ACTACGAGGA GCAGGCCCGG 1200
CGGGAGGAGG AGCGGAGGCG GGCGGAGCAC GAGCAGGAAT ACATCAGGCG ACAGTTAGAG 1260
GAGGAGCAGA GGCAGCTAGA GATTCTGCAG CAGCAGCTCC TGCACGAGCA GGCTCTACTT 1320
CTGGAATATA AACGCAAACA GCTGGAAGAG CAAAGACAAG CAGAGAGACT GCAGAGACAG 1380
CTGAAGCAGG AGAGAGACTA CTTGGTTTCC CTTCAGCACC AGCGGCAGGA GCAGAGACCC 1440
ATTGAGAAAA AGCCACTGTA CCATTACAAA GAGGGGATGA GTCCCAGTGA GAAGCCTGCA 1500
TGGGCCAAGG AGGTTGAAGA GCGGTCAAGG CTCAACCGGC AGAGCTCTCC GGCCATGCCT 1560
CACAAAGTTG CCAACAGGGT CTCTGACCCC AACCTGCCCC CCAGGTCAGA GTCCTTCAGC 1620
ATCAGTGGAG TTCAGCCTGC TCGGACACCC CCCATGCTCA GACCGGTGGA CCCCCAGATC 1680
CCACATCTGG TAGCTGTGAA GCCCCAGGGC CCAGCCCTAA CTGCCTCCCA GTCGGTGCTC 1740
GAGCAGCCCA CCAAGGGCCT CTCCGGCTTC CAGGAGGCTC TGGCTGTGAC CTCTCACCGT 1800
GCTGAGATGC CTCGCCAGAA CTCAGACCCC ACCTCCGAAA ACCCTCCTCT CCCGACTCGC 1860
ATTGAAAAGT TTGACCGAAG TTCTTGGTTA CGGCAGGAAG AAGACATCCC ACCAAAGGTG 1920
CCTCAAAGAA CAACTTCTAT ATCGCCAGCG TTAGCTAGAA AGAATTCTCC TGGGAACGGC 1980
AGTGCTCTGG GACCCAGGCT AGGATCTCAG CCCATCAGAG CAAGCAACCC TGACCTCCGG 2040
AGGGCCGAGC CCATCCTGGA CAGCCCCCTG CAGAGGACCA GCAGTGGCAG CTCCTCCAGC 2100
TCCAGCACCC CCAGCTCCCA GCCCAGCTCC CAGGGAGGCT CCCAGCCCGG ATCACAAGCA 2160
GGGTCCAGCG AACGTACCAG AGTCCGAGCC AACAGCAAGT CGGAGGGATC CCCTGTGCTC 2220
CCCCACGAGC CTGCTAAGGT GAAGCCAGAA GAATCCAGGG ACATCACCCG GCCCAGCCGA 2280
CCAGCTAGCT ATAAGAAAGC GATAGATGAG GATCTGACGG CATTAGCCAA AGAATTACGA 2340
GAACTCCGGA TTGAGGAAAC GAATCGCCCC CTGAAGAAGG TGACCGACTA CTCCTCTTCC 2400
AGTGAGGAGT CCGAGAGCAG TGAGGAAGAG GAAGAGGAGG GGGAGAGTGA GACCCATGAC 2460
GGGACCGTGG CAGTCAGCGA CATCCCCAGG CTGATACCAA CAGGAGCTCC GGGCAGCGGC 2520
GAGCAGTACA GTGTGGGCAT GGTCGGCACG CATGGGCTGG AGACCTCACA CGTGGACGCC 2580
TTCAGCAGCA GCATTTCAAG AGAAGGGACC TTGATGATTA GGGAGACATC TGGAGAGAAG 2640
AAGCGCTCAG GCCATGGTGA CAGCAATGGC CATGTCAACC TCCCAGACCT GGTGCAGCAG 2700
AGCCACTCCC CAGCAGGGAC CCCGACCGAG GGCCTGGGGC GCGTCTCTAC CCACCCCCAG 2760
GAGATGGACA CTGGGACAGA ATACGGCCTG GGGAGCAGCA CCAAAGCCTC TTTCACCCCC 2820
TTCGTGGACC CCAGAGTGTA CCAGACGTCT CCCACTGACG AAGACGAAGA GGATGAGGAG 2880
TCGGCGGCTG CAGCTCTGTT CACTAGCGAA CTTCTTAGGC AAGAGCAGGC CAAACTCAAC 2940
GAAGCCAGGA AGATTTCGGT GGTGAACGTG AACCCGACCA ACATCCGGCC GCACAGCGAC 3000
ACCCCTGAGA TCAGGAAGTA CAAGAAGCGG TTCAACTCGG AGATTCTGTG CGCAGCCCTG 3060
TGGGGTGTGA ACCTCCTGGT GGGAACCGAG AATGGCCTCA TGCTGTTGGA CCGCAGTGGG 3120
CAAGGCAAAG TCTATAATCT GATCAACCGG AGGCGATTCC AGCAGATGGA TGTGCTAGAG 3180
GGGCTGAACG TGCTGGTGAC AATTTCAGGA AAGAAGAATA AGCTGCGGGT GTACTACCTC 3240
TCATGGCTGA GGAACCGGAT CCTGCACAAC GACCCCGAGG TGGAGAAGAA GCAGGGCTGG 3300
GTCACCGTGG GGGACCTGGA AGGCTGCGTC CACTACAAAG TTGTTAAATA TGAAAGGATC 3360
AAGTTCTTGG TGATTGCCTT GAAGAACGCT GTGGAGATCT ATGCCTGGGC TCCTAAACCA 3420
TATCATAAGT TTATGGCATT TAAGTCCTTT GCAGACCTCC AGCACAAGCC TCTGCTGGTC 3480
GACCTCACCG TGGAAGAGGG GCAGAGACTG AAGGTCATTT TCGGCTCACA CACTGGTTTC 3540
CATGTGATCG ATGTTGATTC AGGAAACTCC TACGACATCT ATATACCATC TCATATTCAG 3600
GGCAACATCA CCCCTCATGC CATCGTCATC CTCCCTAAAA CGGACGGCAT GGAGATGCTG 3660
GTGTGCTATG AGGACGAGGG TGTGTACGTG AGCACCTACG GCCGGATCAC CAAGGACGTG 3720
GTGCTCCAGT GGGGAGAAAT GCCCACGTCT GTGGCCTACA TTCATTCCAA TCAGATAATG 3780
GGCTGGGGCG AGAAAGCTAT TGAGATCCGG TCAGTGGAAA CAGGACATTT GGATGGAGTA 3840
TTTATGCATA AGCGAGCTCA AAGGTTAAAG TTTCTATGTG AAAGAAATGA TAAGGTGTTT 3900
TTTGCATCCG TGCGATCTGG AGGAAGTAGC CAAGTGTTTT TCATGACCCT CAACAGAAAT 3960
TCCATGATGA ACTGGTAA 3978
Domain Profile
S: 10    Galgkvylarekktgelvaikkinlekqekleelqkeisvlkklkh.pniveylesflk.  67
         G+ g+ +++r++ktg+l+aik+++++  +++ee+++ei++lkk++h +ni +y+++f+k 
Q: 2     GERGELHKGRHVKTGQLAAIKVMDVTG-DEEEEIKQEINMLKKYSHhRNIATYYGAFIKk  60
         8899**********************8.999*************998*************
S: 68    .....eeelwlvmeylagGslsdlvkeelkselkEeqiayilrevlkaLeylHskkviHr  122
              +++lwlvme++ +Gs++dl+k+++ ++lkEe+iayi+re+l++L++lH++kviHr
Q: 61    nppgmDDQLWLVMEFCGAGSVTDLIKNTKGNTLKEEWIAYICREILRGLSHLHQHKVIHR  120
         ************************************************************
S: 123   dikakniLlteegeVkLsdfgvaaqlektrkkrktvvgtpywmAPEviaqe...ekgYde  179
         dik++n+Llte++eVkL+dfgv+aql++t+ +r+t++gtpywmAPEvia++   + +Yd 
Q: 121   DIKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFIGTPYWMAPEVIACDenpDATYDF  180
         ***************************************************999999***
S: 180   kaDiwslGItaielaegepPfkdleplkallkilkneppklkskkkfskefkefvekclq  239
         k+D+wslGItaie+aeg+pP++d++p++al++i++n++p+lksk k+sk+f++f+e+cl 
Q: 181   KSDLWSLGITAIEMAEGAPPLCDMHPMRALFLIPRNPAPRLKSK-KWSKKFQSFIESCLV  239
         *****************************************888.***************
S: 240   knpekRpsasellkhkFl  257
         kn ++Rp++++l+kh+F+
Q: 240   KNHSQRPATEQLMKHPFI  257
         *****************7
Domain Sequence
(FASTA)
GERGELHKGR HVKTGQLAAI KVMDVTGDEE EEIKQEINML KKYSHHRNIA TYYGAFIKKN 60
PPGMDDQLWL VMEFCGAGSV TDLIKNTKGN TLKEEWIAYI CREILRGLSH LHQHKVIHRD 120
IKGQNVLLTE NAEVKLVDFG VSAQLDRTVG RRNTFIGTPY WMAPEVIACD ENPDATYDFK 180
SDLWSLGITA IEMAEGAPPL CDMHPMRALF LIPRNPAPRL KSKKWSKKFQ SFIESCLVKN 240
HSQRPATEQL MKHPFI 256
KeywordComplete proteome; Reference proteome.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>
EKS-AIM-00288
EKS-ANC-00307
EKS-BOT-00325
EKS-CAJ-00314
EKS-CAF-00329
EKS-CAP-00343
EKS-DAR-00667
EKS-EQC-00300
EKS-FEC-00295
EKS-GAG-00270
EKS-GAA-00382
EKS-GOG-00305
EKS-HOS-00315
EKS-ICT-00307
EKS-LAC-00328
EKS-LOA-00329
EKS-MAM-00312
EKS-MOD-00303
EKS-MUM-00340
EKS-MUP-00305
EKS-MYL-00320
EKS-NOL-00284
EKS-ORN-00400
EKS-ORC-00291
EKS-ORL-00382
EKS-PAT-00292
EKS-PES-00274
EKS-PEM-00170
EKS-POA-00300
EKS-RAN-00324
EKS-SUS-00290
EKS-TAG-00323
EKS-TAR-00403
EKS-XET-00385
EKS-XIM-00416
Gene Ontology
GO:0005524; F:ATP binding
GO:0004674; F:protein serine/threonine kinase activity
GO:0005083; F:small GTPase regulator activity
KEGG
InterPros
IPR001180; Citron.
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR002290; Ser/Thr_dual-sp_kinase_dom.
IPR008271; Ser/Thr_kinase_AS.
Pfam
PF00780; CNH; 1.
PF00069; Pkinase; 1.
SMARTs
SM00036; CNH; 1.
SM00220; S_TKc; 1.
Prosites
PS50219; CNH; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00108; PROTEIN_KINASE_ST; 1.
Prints
Created Date20-Feb-2013