EKS-OTG-00161

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-OTG-00161

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
AGC/RSK	364.3	3.9E-109	67	328	262

Status

Unreviewed

Ensembl Protein

ENSOGAP00000009540

UniProt Accession

H0X362;

Protein Name

Protein Synonyms/Alias

Gene Name

RPS6KB2

Gene Synonyms/Alias

RPS6KB2;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSOGAG00000010658	ENSOGAP00000009540	ENSOGAT00000010664

Organism

Otolemur garnettii

Functional Description

Protein Length

480

Protein Sequence
(FASTA)

MAAVFDLDLE TEEGSEGEGE PEFSPADVCP LAELKAAGLE PVGRYEEVEL TETNVNLGPE 60

RIGPHCFELL RVLGKGGYGK VFQVRKVQGT NLGKIYAMKV LRKAKIVRNA KDTAHTRAER 120

NILESVKHPF IVELAYAFQT GGKLYLILEC LSGGELFTHL EREGIFLEDT ACFYLAEITL 180

ALGHLHSQGI IYRDLKPENI MLSSQGHIKL TDFGLCKESI HEGAVTHTFC GTIEYMAPEI 240

LMRSGHNRAV DWWSLGALMY DMLTGSPPFT AENRKKTMDK IIKGKLALPP YLTPDARDLV 300

KKFLKRNPSQ RIGGGPGDAA DVQKHPFFRH LNWDDLLARR VDPPFRPCLQ SEEDVSQFDT 360

RFTRQTPVDS PDDMALSESA NQAFVGFTYV APSVLESIKE GFSFQPKLRS PRRLNSSPRT 420

PVSPLKFSPF EAFRPSLSEP TEPPLPPLLP PPPPSSTAPL LIRPPSGTKK SKKGRGRPGR 480

Nucleotide Sequence
(FASTA)

ATGGCGGCAG TGTTTGATCT GGACCTGGAG ACCGAGGAAG GCAGCGAGGG TGAAGGCGAG 60

CCAGAGTTCA GCCCTGCGGA CGTGTGTCCC CTTGCCGAGT TGAAGGCTGC TGGCTTGGAG 120

CCTGTAGGAC GTTATGAGGA GGTGGAGCTG ACTGAGACCA ACGTGAACCT GGGCCCTGAG 180

CGCATCGGGC CCCATTGCTT TGAGTTGCTG CGTGTACTGG GCAAGGGAGG CTATGGAAAG 240

GTGTTCCAGG TGCGAAAGGT GCAAGGTACC AACTTGGGCA AAATATATGC CATGAAAGTT 300

TTAAGGAAGG CCAAAATTGT GCGCAATGCC AAGGACACAG CACACACACG GGCTGAACGG 360

AACATTCTAG AGTCAGTGAA GCACCCCTTC ATTGTGGAAC TGGCCTATGC CTTTCAGACT 420

GGTGGCAAAC TCTACCTCAT CCTTGAGTGC CTTAGTGGTG GTGAACTCTT CACGCATCTG 480

GAGCGAGAGG GCATTTTTCT AGAAGACACA GCCTGCTTCT ACCTGGCTGA GATCACACTG 540

GCCCTGGGCC ATCTCCACTC TCAAGGCATC ATCTACCGAG ACCTCAAGCC CGAGAATATC 600

ATGCTCAGCA GCCAGGGCCA CATCAAACTG ACGGACTTTG GACTCTGCAA GGAGTCAATC 660

CATGAAGGCG CTGTCACTCA CACCTTCTGT GGCACCATTG AATACATGGC CCCAGAGATC 720

CTGATGCGCA GTGGCCACAA CCGGGCTGTG GACTGGTGGA GCCTGGGTGC CCTGATGTAC 780

GACATGCTCA CTGGATCGCC ACCCTTCACT GCAGAGAACC GGAAGAAAAC CATGGATAAA 840

ATAATCAAAG GGAAGCTGGC ACTGCCCCCC TACCTCACCC CAGATGCCCG GGACCTTGTC 900

AAAAAGTTTC TGAAGCGGAA TCCCAGCCAA CGGATTGGGG GTGGTCCAGG GGATGCTGCT 960

GATGTGCAGA AACACCCCTT CTTCCGGCAC CTGAATTGGG ATGATCTTCT GGCCCGCCGT 1020

GTGGACCCCC CTTTCAGGCC CTGTCTGCAG TCAGAGGAGG ACGTGAGCCA GTTTGATACC 1080

CGCTTCACAC GGCAGACACC AGTGGACAGT CCGGATGACA TGGCCCTCAG TGAGAGTGCC 1140

AACCAGGCCT TTGTGGGCTT CACATATGTG GCGCCCTCTG TCCTGGAGAG CATTAAGGAG 1200

GGCTTCTCCT TCCAGCCTAA GCTGCGCTCC CCAAGGCGCC TCAACAGCAG CCCCCGGACT 1260

CCCGTAAGCC CCCTCAAGTT CTCTCCATTT GAGGCCTTCC GACCCAGCCT GTCAGAACCC 1320

ACAGAGCCAC CTCTTCCTCC ACTGCTGCCA CCACCGCCAC CCTCAAGCAC TGCCCCCCTC 1380

CTTATCCGTC CCCCCTCAGG GACCAAGAAA TCCAAGAAGG GTCGCGGCCG CCCTGGACGC 1440

TAG 1443

Domain Profile

S: 1     fellkvlgkGaygkvflvrkvekkdtgklyavKvlkkaelvk..kkkertkeereiLeev  58

         fell+vlgkG+ygkvf+vrkv++++ gk+ya+Kvl+ka++v+  k++++t++er+iLe+v

Q: 67    FELLRVLGKGGYGKVFQVRKVQGTNLGKIYAMKVLRKAKIVRnaKDTAHTRAERNILESV  126

         89***************************************999****************

S: 59    ehpfivklheafqdekklylvlellkGgeLlerlkkkklfseeeasfilaelvlaleylH  118

         +hpfiv+l +afq+  klyl+le+l+GgeL+++l+++++f e++a+f+lae++lal +lH

Q: 127   KHPFIVELAYAFQTGGKLYLILECLSGGELFTHLEREGIFLEDTACFYLAEITLALGHLH  186

         ************************************************************

S: 119   skgvvyrDLkpeNilldeeghvkltDfglakekiaeneekaysfcgTleyvaPevlkrkg  178

         s+g++yrDLkpeNi+l+++gh+kltDfgl+ke+i +++  +++fcgT+ey+aPe+l+r+g

Q: 187   SQGIIYRDLKPENIMLSSQGHIKLTDFGLCKESI-HEGAVTHTFCGTIEYMAPEILMRSG  245

         *********************************9.9999999******************

S: 179   ydeavDlwslGvllyemLtGktPftgeerketlarilkgkfslklpaweelseeakdlvk  238

         +++avD+wslG+l+y+mLtG++Pft+e+rk+t+++i kgk  l lp +  l+++a+dlvk

Q: 246   HNRAVDWWSLGALMYDMLTGSPPFTAENRKKTMDKIIKGK--LALPPY--LTPDARDLVK  301

         ****************************************..9*****..**********

S: 239   klLkkdpakRlga...taeeikehkfl  262

         k+Lk++p++R+g    +a+++++h+f+

Q: 302   KFLKRNPSQRIGGgpgDAADVQKHPFF  328

         ***********99999*********97

Domain Sequence
(FASTA)

FELLRVLGKG GYGKVFQVRK VQGTNLGKIY AMKVLRKAKI VRNAKDTAHT RAERNILESV 60

KHPFIVELAY AFQTGGKLYL ILECLSGGEL FTHLEREGIF LEDTACFYLA EITLALGHLH 120

SQGIIYRDLK PENIMLSSQG HIKLTDFGLC KESIHEGAVT HTFCGTIEYM APEILMRSGH 180

NRAVDWWSLG ALMYDMLTGS PPFTAENRKK TMDKIIKGKL ALPPYLTPDA RDLVKKFLKR 240

NPSQRIGGGP GDAADVQKHP FF 262

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Dipodomys ordii"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Oryzias latipes"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Tursiops truncatus"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity
GO:0007165	; P:signal transduction

KEGG

InterPros

IPR000961	; AGC-kinase_C.
IPR011009	; Kinase-like_dom.
IPR017892	; Pkinase_C.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR016238	; Ribosomal_S6_kinase.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069	; Pkinase; 1.
PF00433	; Pkinase_C; 1.

SMARTs

SM00133	; S_TK_X; 1.
SM00220	; S_TKc; 1.

Prosites

PS51285	; AGC_KINASE_CTER; 1.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013