EKS-OTG-00303

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-OTG-00303

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TK/EGFR	496.0	2.1E-149	720	977	258

Status

Unreviewed

Ensembl Protein

ENSOGAP00000009662

UniProt Accession

H0X3G4;

Protein Name

Protein Synonyms/Alias

Gene Name

ERBB2

Gene Synonyms/Alias

ERBB2;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSOGAG00000010792	ENSOGAP00000009662	ENSOGAT00000010798

Organism

Otolemur garnettii

Functional Description

Protein Length

1256

Protein Sequence
(FASTA)

MELAAWCRWG LVLALLPPAA AGTQVCTGTD MKLRLPASPE THLDMLRHLY QGCQVVQGNL 60

ELTYLPANAS LSFLQDIQEV QGYVLIAHNR VRQIPLQRLR IVRGTQLFED SYALAVLDNG 120

DLLDNATPAT GASPEGLREL QLRSLTEILK GGVLIQRNPQ LCHQDTVLWE DIFHKNNQLA 180

AMQIDSTRSR ACNPCSPACK ASHCWGESFE DCQTLTRTVC ASGCARCKGR LPTDCCHEQC 240

AAGCTGPKHS DCLACLHFNH SGICELHCPA LVTYNTDTFE SMPNPEGRYT FGASCVTACP 300

YNYLSTDVGS CTLVCPLHNQ EVTAEDGTQR CEKCSKPCAR VCYGLGMEHL REVRAVTSAN 360

IQEFAGCKKI FGSLAFLLES FDGDPASNIA PLQPEQLRVF ESLEEITGYL YISAWPDSLP 420

DLSVFQNLQV IRGRVLHDGA YSLTLQGLGI SWLGLRSLRE LGSGLVLIHR NARLCFVHTV 480

PWDQLFRNPH QALLHTANRP ENECVGENLG CYSLCAHGHC WGPGPTQCVN CSQFLRGQEC 540

VEECRVLQGL PREYVDGRHC LPCHPECQPQ NGSVTCFGSE ADQCVACAHY KDSPYCVARC 600

PSGVKPDLSY MPIWKFPDEE GTCQLCPINC THSCVDLDDK GCPAEQRASP LPYIIPAVVG 660

TLLVVLLGLV AGILIKRRQQ KIRKYTMRRL LQETELVEPL TPSGAMPNQA QMRILKETEL 720

RKVKVLGSGA FGTVYKGIWI PDGENVKIPV AIKVLRENTS PKANKEILDE AYVMAGVGSP 780

YVSRLLGICL TSTVQLVTQL MPYGCLLDHV REHRGRLGSQ DLLNWCVQIA KGMSYLEDVR 840

LVHRDLAARN VLVKSPNHVK ITDFGLARLL DIDETEYHAD GGKVPIKWMA LESILRRRFT 900

HQSDVWSYGV TVWELMTFGA KPYDGIPARE IPDLLEKGER LPQPPICTID VYMIMVKCWM 960

IDSECRPRFR ELVAEFSRMA RDPQRFVVIQ NEDLGPASPL DSTFYRSLLE DDDMGDLVDA 1020

EEYLVPQQGF FCPDPAPGAG GTAHHRHRSS STRSGGGGDL TLGLEPSEGE PPRSPLAPSE 1080

GAGSDVFDGD LGMGAAKGLQ SLPLHDPSPL QRYSEDPTLP LPPETDGYVA PLTCSSQPEY 1140

VNQPDVRQQP PLSLEGPMPP ARPAGATLER PKTLSPGKNG VVKDVFAFGG AVENPEYLAP 1200

RGGAAPQPHP PPPFSPAFDN LYYWDQDPSV RGSPPSTFEG TPTAENPEYL GLDVPV 1256

Nucleotide Sequence
(FASTA)

ATGGAGCTGG CGGCCTGGTG CCGCTGGGGG CTGGTCCTCG CCCTCCTGCC CCCCGCAGCC 60

GCGGGCACCC AAGTGTGCAC CGGCACAGAC ATGAAGCTGC GACTCCCAGC CAGTCCTGAG 120

ACCCACCTGG ACATGCTCCG CCACCTCTAC CAGGGCTGTC AGGTGGTGCA GGGTAACCTG 180

GAACTCACCT ACCTGCCCGC CAATGCCAGC CTCTCCTTTC TGCAGGACAT CCAGGAGGTG 240

CAGGGCTATG TGCTCATTGC TCACAACCGA GTGAGGCAGA TCCCGCTGCA GAGGCTGAGG 300

ATTGTGCGAG GCACCCAGCT CTTTGAGGAC AGCTATGCCC TGGCCGTGCT TGACAATGGA 360

GACCTGCTGG ACAATGCCAC CCCTGCCACA GGGGCCTCCC CAGAAGGGCT GCGAGAGCTA 420

CAGCTAAGAA GCCTCACAGA GATCCTGAAA GGAGGGGTCT TGATCCAGCG GAACCCCCAG 480

CTCTGCCACC AGGACACGGT TTTATGGGAG GACATCTTCC ACAAGAATAA CCAGCTGGCT 540

GCCATGCAGA TAGACAGCAC CCGTTCGAGG GCCTGCAACC CCTGTTCTCC AGCTTGTAAA 600

GCCTCCCACT GCTGGGGAGA AAGTTTTGAG GACTGTCAGA CCTTGACACG CACCGTTTGT 660

GCCAGTGGCT GTGCCCGCTG CAAGGGCCGG CTGCCCACTG ACTGCTGCCA TGAGCAGTGT 720

GCTGCCGGCT GCACGGGCCC CAAGCACTCT GACTGCCTGG CCTGCCTCCA CTTCAACCAC 780

AGTGGCATCT GTGAGCTGCA TTGCCCAGCC CTGGTCACCT ATAACACAGA CACCTTCGAG 840

TCCATGCCCA ACCCTGAGGG CCGTTATACA TTTGGTGCCA GCTGTGTGAC TGCCTGTCCC 900

TACAATTACC TGTCTACGGA TGTAGGATCC TGCACCCTGG TCTGCCCTCT GCACAACCAA 960

GAGGTGACAG CCGAGGATGG AACACAGCGT TGTGAGAAGT GCAGCAAGCC CTGTGCCCGA 1020

GTGTGCTATG GTCTGGGCAT GGAGCACCTG CGGGAGGTGA GGGCTGTCAC CAGCGCCAAC 1080

ATCCAGGAGT TTGCTGGCTG CAAGAAGATC TTTGGGAGCC TAGCATTTCT GCTGGAGAGT 1140

TTTGATGGGG ACCCAGCCTC CAACATTGCC CCCCTCCAGC CAGAGCAGCT CCGAGTGTTT 1200

GAGAGTCTGG AGGAGATCAC AGGTTACCTA TACATCTCAG CATGGCCAGA CAGTCTGCCT 1260

GACCTCAGTG TTTTCCAGAA CCTTCAAGTA ATCCGGGGAC GAGTTCTCCA TGATGGTGCC 1320

TACTCACTGA CCCTGCAAGG GCTGGGCATC AGCTGGCTGG GGCTGCGCTC GCTACGGGAG 1380

CTGGGCAGCG GGCTGGTTCT CATCCACCGA AACGCCCGCC TTTGCTTCGT CCACACGGTG 1440

CCCTGGGACC AGCTTTTCCG GAACCCGCAC CAGGCTCTGC TCCACACAGC CAACCGGCCA 1500

GAGAACGAGT GTGTAGGTGA GAACCTAGGC TGCTACTCAC TATGTGCCCA TGGGCACTGC 1560

TGGGGTCCAG GACCCACCCA GTGTGTCAAC TGCAGCCAGT TCCTTCGGGG CCAGGAGTGC 1620

GTGGAGGAAT GCCGAGTACT GCAGGGGCTT CCCAGGGAGT ATGTGGATGG CAGGCACTGT 1680

CTACCATGCC ATCCCGAGTG TCAGCCCCAG AATGGCTCAG TGACCTGCTT TGGATCGGAG 1740

GCTGACCAGT GTGTGGCCTG TGCCCACTAC AAGGACTCTC CCTACTGTGT GGCTCGCTGC 1800

CCCAGCGGTG TGAAACCTGA CCTCTCCTAT ATGCCCATCT GGAAGTTTCC AGATGAGGAG 1860

GGCACATGCC AGCTGTGCCC CATCAACTGC ACACACTCCT GCGTGGACCT GGATGACAAG 1920

GGCTGCCCCG CTGAGCAGAG AGCCAGCCCT CTGCCGTACA TCATCCCTGC CGTGGTGGGC 1980

ACTCTGCTGG TCGTGCTCTT GGGGCTGGTC GCTGGGATCC TAATTAAGCG AAGGCAGCAG 2040

AAAATCCGGA AGTACACGAT GCGGAGGCTG TTGCAGGAAA CAGAGCTGGT GGAGCCGCTG 2100

ACACCAAGTG GAGCGATGCC CAACCAGGCT CAGATGCGGA TTCTGAAAGA GACAGAACTA 2160

AGGAAGGTGA AGGTGCTTGG ATCTGGAGCG TTTGGCACAG TCTACAAGGG CATCTGGATC 2220

CCTGATGGGG AGAATGTGAA AATCCCAGTG GCCATCAAAG TGTTGAGGGA AAACACATCC 2280

CCCAAAGCCA ACAAAGAAAT CTTGGACGAA GCATACGTGA TGGCTGGTGT GGGCTCGCCA 2340

TATGTCTCCC GCCTCCTGGG CATCTGCCTG ACATCCACAG TGCAGCTGGT GACACAGCTT 2400

ATGCCCTATG GCTGCCTCCT AGACCATGTT CGGGAACACC GAGGGCGCCT GGGCTCTCAG 2460

GACCTGCTCA ACTGGTGTGT ACAGATCGCC AAGGGGATGA GCTACCTGGA GGATGTGCGG 2520

CTTGTGCACA GGGACCTGGC TGCACGGAAC GTGCTGGTCA AGAGTCCCAA CCATGTCAAG 2580

ATTACAGACT TCGGGCTGGC TCGCCTGCTG GACATTGATG AGACAGAGTA TCATGCTGAT 2640

GGGGGCAAGG TACCCATCAA GTGGATGGCA TTGGAGTCCA TTCTTCGCCG GCGGTTCACC 2700

CACCAGAGTG ATGTGTGGAG CTATGGTGTG ACAGTGTGGG AGCTGATGAC TTTTGGGGCC 2760

AAACCTTACG ATGGGATCCC AGCCCGGGAG ATCCCTGACC TGTTGGAGAA GGGGGAGCGG 2820

CTGCCCCAGC CCCCAATCTG CACCATCGAT GTCTACATGA TCATGGTCAA ATGTTGGATG 2880

ATTGACTCTG AATGTCGGCC AAGGTTTCGG GAGTTGGTGG CCGAATTTTC CCGTATGGCC 2940

AGGGATCCTC AGCGTTTTGT AGTTATACAG AATGAGGACT TGGGCCCAGC CAGCCCCTTG 3000

GATAGCACCT TCTACCGCTC ACTGCTGGAG GATGATGACA TGGGGGACCT GGTGGATGCT 3060

GAAGAGTATC TGGTACCCCA GCAGGGCTTT TTCTGCCCAG ACCCTGCCCC AGGTGCTGGG 3120

GGCACAGCTC ACCACAGGCA TCGCAGCTCA TCCACCAGGA GTGGTGGTGG TGGTGACCTG 3180

ACACTGGGGC TGGAGCCCTC TGAAGGGGAG CCCCCCAGGT CTCCACTGGC CCCCTCAGAA 3240

GGGGCTGGCT CCGATGTGTT TGATGGTGAC CTGGGAATGG GGGCAGCCAA GGGGCTGCAA 3300

AGCCTCCCTC TACATGACCC CAGCCCTCTA CAGCGGTACA GTGAGGATCC TACATTACCC 3360

CTGCCCCCTG AAACTGACGG CTATGTTGCC CCTCTGACCT GCAGCTCCCA GCCTGAATAT 3420

GTGAACCAGC CAGATGTTCG GCAACAGCCT CCCCTGTCCC TGGAAGGCCC CATGCCTCCT 3480

GCCCGACCTG CTGGTGCTAC GTTGGAAAGG CCCAAGACTC TCTCTCCTGG GAAGAATGGG 3540

GTTGTCAAAG ACGTTTTTGC CTTTGGGGGT GCTGTGGAGA ACCCTGAGTA CTTGGCACCC 3600

AGGGGAGGGG CTGCCCCTCA GCCCCACCCT CCTCCTCCCT TCAGTCCAGC CTTTGACAAC 3660

CTCTATTATT GGGACCAGGA CCCATCAGTG CGGGGGTCTC CACCCAGCAC CTTTGAAGGG 3720

ACCCCTACGG CAGAGAACCC TGAGTACCTG GGCCTGGATG TGCCAGTATG A 3771

Domain Profile

S: 1     lkklkvlGsGafGtvykGiwipegenvkipvaikvleektgkkankelldealvlasldh  60

         l+k+kvlGsGafGtvykGiwip+genvkipvaikvl+e+t++kanke+ldea+v+a + +

Q: 720   LRKVKVLGSGAFGTVYKGIWIPDGENVKIPVAIKVLRENTSPKANKEILDEAYVMAGVGS  779

         69**********************************************************

S: 61    anlvrllglclsstlqlvtqllplGclldyvrehkdklGsqellnwcvqiakGmsyleek  120

         ++++rllg+cl+st+qlvtql+p+Gclld+vreh+++lGsq+llnwcvqiakGmsyle+

Q: 780   PYVSRLLGICLTSTVQLVTQLMPYGCLLDHVREHRGRLGSQDLLNWCVQIAKGMSYLEDV  839

         ************************************************************

S: 121   rlvhrdlaarnvlvkspnhvkitdfGlaklleadekelkaeggkvpikwlalesilkrky  180

         rlvhrdlaarnvlvkspnhvkitdfGla+ll+ de+e++a+ggkvpikw+alesil+r++

Q: 840   RLVHRDLAARNVLVKSPNHVKITDFGLARLLDIDETEYHADGGKVPIKWMALESILRRRF  899

         ************************************************************

S: 181   thqsdvwsyGvtvwelltfGakpydgipakeipdllekGerlaqppictidvymvlvkcw  240

         thqsdvwsyGvtvwel+tfGakpydgipa+eipdllekGerl+qppictidvym++vkcw

Q: 900   THQSDVWSYGVTVWELMTFGAKPYDGIPAREIPDLLEKGERLPQPPICTIDVYMIMVKCW  959

         ************************************************************

S: 241   midaesrpkfkelaeefs  258

         mid+e+rp+f+el++efs

Q: 960   MIDSECRPRFRELVAEFS  977

         ****************96

Domain Sequence
(FASTA)

LRKVKVLGSG AFGTVYKGIW IPDGENVKIP VAIKVLRENT SPKANKEILD EAYVMAGVGS 60

PYVSRLLGIC LTSTVQLVTQ LMPYGCLLDH VREHRGRLGS QDLLNWCVQI AKGMSYLEDV 120

RLVHRDLAAR NVLVKSPNHV KITDFGLARL LDIDETEYHA DGGKVPIKWM ALESILRRRF 180

THQSDVWSYG VTVWELMTFG AKPYDGIPAR EIPDLLEKGE RLPQPPICTI DVYMIMVKCW 240

MIDSECRPRF RELVAEFS 258

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Phosphoprotein; Reference proteome; Transferase; Tyrosine-protein kinase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Pan troglodytes"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0016021	; C:integral to membrane
GO:0005524	; F:ATP binding
GO:0004716	; F:receptor signaling protein tyrosine kinase activity
GO:0004714	; F:transmembrane receptor protein tyrosine kinase activity
GO:0023014	; P:signal transduction by phosphorylation
GO:0007169	; P:transmembrane receptor protein tyrosine kinase signaling pathway

KEGG

InterPros

IPR021157	; Cyt_c1_TM_anchor_C.
IPR000494	; EGF_rcpt_L.
IPR006211	; Furin-like_Cys-rich_dom.
IPR006212	; Furin_repeat.
IPR009030	; Growth_fac_rcpt.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR008266	; Tyr_kinase_AS.
IPR020635	; Tyr_kinase_cat_dom.
IPR016245	; Tyr_kinase_EGF/ERB/XmrK_rcpt.

Pfam

PF00757	; Furin-like; 1.
PF07714	; Pkinase_Tyr; 1.
PF01030	; Recep_L_domain; 2.

SMARTs

SM00261	; FU; 3.
SM00219	; TyrKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00109	; PROTEIN_KINASE_TYR; 1.

Prints

PR00109

; TYRKINASE.

Created Date

20-Feb-2013