EKS-OTG-00172

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-OTG-00172

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
AGC/PKG	494.8	4.4E-149	453	711	259

Status

Unreviewed

Ensembl Protein

ENSOGAP00000010075

UniProt Accession

H0X4F3;

Protein Name

cGMP-dependent protein kinase

Protein Synonyms/Alias

Gene Name

PRKG2

Gene Synonyms/Alias

PRKG2;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSOGAG00000011251	ENSOGAP00000010075	ENSOGAT00000011256

Organism

Otolemur garnettii

Functional Description

Protein Length

762

Protein Sequence
(FASTA)

MGNGSVKPKH SKHPDGHSGN FTNEALRSKV IELERELRRK DAEIQEREYH LKELREQLSK 60

QTVAIAELTE ELQNKCVQLN KLQDVVLMQG GSPPQASPEK VPLGVQRKTS GLVSLHSRRG 120

AKAGVSAEPT TRTYDLNKPP EFSFEKARVR KDSSEKKLIT DALNKNQFLK RLDPQQIKDM 180

VECMYGRNYQ QGSYIIKQGE PGNHIFVLAE GRLEVFQGEK LLSSIPMWTT FGELAILYNC 240

TRTASVKAIT NVKTWALDRE VFQNIMRRTA QARDEQYRNF LRSVSLLKNL PEDKLTKIID 300

CLEVEYYDKG DYIIREGEEG STFFILAKGK VKVTQSTEGH DQPQLIKTLQ KGEYFGEKAL 360

ISDDVRSANI IAEENDVACL VIDRETFNQT VGTFEELQKY LEGYVANLNR DDEKRHAKRS 420

MSNWKLSKAL SLEMIQLKEK VARFSSSSPF QNLEIIATLG VGGFGRVELV KVKNENVAFA 480

MKCIRKKHIV DTKQQEHVYS EKRILEELCS PFIVKLYRTF KDNKYVYMLL EACLGGELWS 540

ILRDRGSFDE PTSKFCVACV TEAFDYLHRL GIIYRDLKPE NLILDSEGYL KLVDFGFAKK 600

IGSGQKTWTF CGTPEYVAPE VILNKGHDFS VDFWSLGILV YELLTGNPPF SGIDQMMTYN 660

LILKGIEKMD FPKKITRRPE DLIRRLCRQN PTERLGNLKN GIHDIKKHRW LNGFNWEGLK 720

ARSLPSPLRR ELSGPIDHSY FDKYPPEKGV PPDELSGWDR DF 762

Nucleotide Sequence
(FASTA)

ATGGGAAATG GTTCAGTGAA ACCCAAACAT TCCAAGCATC CAGATGGCCA CTCTGGGAAC 60

TTCACCAATG AGGCCCTGCG GAGCAAGGTG ATAGAGCTGG AGAGAGAGCT GAGGAGGAAG 120

GATGCTGAGA TCCAGGAGCG CGAGTACCAT CTGAAGGAGC TGCGGGAGCA GCTGTCCAAG 180

CAGACCGTGG CCATCGCTGA GCTCACGGAG GAGCTCCAGA ACAAGTGCGT CCAGCTGAAC 240

AAGCTGCAGG ATGTGGTGCT CATGCAGGGC GGGAGCCCGC CGCAGGCCTC TCCAGAGAAA 300

GTGCCTCTGG GGGTCCAACG GAAGACTTCG GGGTTGGTGT CTCTCCACAG CAGGAGGGGA 360

GCAAAGGCTG GGGTGTCTGC TGAGCCAACC ACCCGCACCT ATGACCTCAA CAAACCCCCT 420

GAATTTTCCT TTGAGAAAGC AAGAGTCCGA AAGGACTCCA GTGAGAAGAA GCTCATTACG 480

GATGCCCTCA ATAAAAACCA GTTTCTGAAG AGACTGGATC CGCAGCAGAT CAAAGACATG 540

GTGGAATGCA TGTATGGGCG AAACTACCAG CAAGGGAGTT ACATCATTAA GCAGGGAGAG 600

CCGGGAAATC ATATCTTTGT GCTGGCAGAG GGTCGACTAG AGGTGTTCCA AGGGGAGAAA 660

TTGCTATCAT CCATCCCTAT GTGGACCACG TTTGGAGAAC TAGCTATTTT ATACAACTGT 720

ACAAGGACTG CCTCCGTGAA AGCCATTACC AATGTTAAAA CGTGGGCCCT AGATCGAGAG 780

GTGTTCCAGA ATATAATGAG GAGAACAGCC CAAGCTAGAG ATGAACAGTA CAGAAATTTC 840

CTGCGAAGTG TATCCTTGCT GAAGAATTTA CCTGAAGATA AGTTAACCAA GATCATCGAC 900

TGCTTGGAAG TGGAGTACTA TGACAAAGGA GATTACATCA TTAGAGAGGG TGAGGAAGGA 960

AGTACCTTTT TCATTTTGGC CAAAGGAAAG GTTAAAGTTA CACAGAGTAC AGAGGGCCAC 1020

GACCAACCAC AACTGATAAA AACCCTGCAG AAAGGTGAAT ATTTTGGAGA AAAAGCTCTT 1080

ATCAGCGATG ATGTCAGGTC AGCTAACATT ATTGCTGAAG AAAATGATGT CGCATGCCTG 1140

GTTATAGACC GAGAGACATT CAACCAAACT GTCGGGACAT TCGAAGAACT CCAAAAATAC 1200

CTGGAAGGGT ATGTGGCGAA CCTGAACCGT GATGATGAAA AAAGACATGC GAAGCGTTCC 1260

ATGTCTAACT GGAAGCTGTC CAAAGCACTC TCTCTGGAAA TGATTCAGCT GAAGGAGAAG 1320

GTGGCCAGAT TTTCCTCATC ATCCCCATTC CAGAACCTTG AGATTATTGC AACACTGGGC 1380

GTTGGTGGGT TCGGAAGAGT TGAGCTTGTT AAAGTGAAAA ATGAGAATGT TGCTTTTGCT 1440

ATGAAGTGTA TAAGGAAGAA GCACATAGTT GACACCAAGC AACAGGAACA TGTCTACTCA 1500

GAAAAGAGGA TCCTGGAGGA GTTGTGCTCC CCATTCATCG TGAAATTATA TCGTACTTTC 1560

AAGGACAATA AATACGTATA TATGCTCCTA GAGGCCTGCC TGGGGGGAGA GCTGTGGAGT 1620

ATTCTAAGGG ACAGGGGCAG CTTTGATGAA CCCACCTCCA AGTTCTGTGT TGCTTGTGTG 1680

ACGGAAGCCT TTGATTACCT GCATCGACTG GGGATCATCT ACAGAGATCT CAAGCCAGAA 1740

AACTTAATTT TAGATTCCGA GGGTTACCTT AAGTTGGTTG ACTTTGGATT TGCTAAGAAA 1800

ATAGGATCTG GGCAGAAGAC ATGGACATTC TGTGGGACCC CAGAGTACGT AGCCCCTGAA 1860

GTCATTCTCA ACAAAGGACA CGACTTCAGT GTGGATTTCT GGTCGCTGGG AATTCTAGTG 1920

TATGAGCTGC TAACGGGCAA CCCACCCTTT TCTGGGATTG ATCAAATGAT GACCTACAAT 1980

TTAATTCTCA AAGGAATTGA AAAAATGGAT TTTCCTAAAA AGATAACAAG GCGGCCTGAA 2040

GATTTGATTC GGAGGCTTTG CAGGCAAAAC CCAACAGAAA GGCTGGGAAA TTTGAAGAAT 2100

GGAATCCATG ACATTAAGAA ACACAGGTGG TTAAATGGTT TTAATTGGGA GGGACTGAAA 2160

GCACGGAGCC TTCCATCACC TTTACGAAGA GAGCTCAGTG GACCCATAGA TCACAGCTAC 2220

TTTGACAAGT ATCCCCCTGA GAAGGGCGTG CCTCCCGATG AACTGTCGGG CTGGGACAGA 2280

GACTTCTGA 2289

Domain Profile

S: 1     lkviatlgvggfgrvelvkvksdeskafalkilkkkhivdtkqqehvlsekrileeaksd  60

         l++iatlgvggfgrvelvkvk+ e+ afa+k+++kkhivdtkqqehv+sekrilee++s+

Q: 453   LEIIATLGVGGFGRVELVKVKN-ENVAFAMKCIRKKHIVDTKQQEHVYSEKRILEELCSP  511

         689******************9.999**********************************

S: 61    fivklyrtfkdekyvyllleaclggelwtilrdrgsfddktakfivacvvealeylhskn  120

         fivklyrtfkd+kyvy+lleaclggelw+ilrdrgsfd+ t+kf+vacv+ea++ylh+ +

Q: 512   FIVKLYRTFKDNKYVYMLLEACLGGELWSILRDRGSFDEPTSKFCVACVTEAFDYLHRLG  571

         ************************************************************

S: 121   iiyrdlkpenllldeegylklvdfgfakklksgkktwtfcgtpeyvapeiilnkghdlsv  180

         iiyrdlkpenl+ld+egylklvdfgfakk++sg+ktwtfcgtpeyvape+ilnkghd+sv

Q: 572   IIYRDLKPENLILDSEGYLKLVDFGFAKKIGSGQKTWTFCGTPEYVAPEVILNKGHDFSV  631

         ************************************************************

S: 181   dywalgilvyelltgkppfsgvdplktynlilkgidklelprkitkeaedlikklcrdnp  240

         d+w+lgilvyelltg+ppfsg+d+++tynlilkgi+k+++p+kit+++edli++lcr+np

Q: 632   DFWSLGILVYELLTGNPPFSGIDQMMTYNLILKGIEKMDFPKKITRRPEDLIRRLCRQNP  691

         ************************************************************

S: 241   aerlgylkggikdikkhkwf  260

         +erlg+lk+gi+dikkh+w+

Q: 692   TERLGNLKNGIHDIKKHRWL  711

         *******************7

Domain Sequence
(FASTA)

LEIIATLGVG GFGRVELVKV KNENVAFAMK CIRKKHIVDT KQQEHVYSEK RILEELCSPF 60

IVKLYRTFKD NKYVYMLLEA CLGGELWSIL RDRGSFDEPT SKFCVACVTE AFDYLHRLGI 120

IYRDLKPENL ILDSEGYLKL VDFGFAKKIG SGQKTWTFCG TPEYVAPEVI LNKGHDFSVD 180

FWSLGILVYE LLTGNPPFSG IDQMMTYNLI LKGIEKMDFP KKITRRPEDL IRRLCRQNPT 240

ERLGNLKNGI HDIKKHRWL 259

Keyword

ATP-binding; cGMP; cGMP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Pan troglodytes"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0030553	; F:cGMP binding
GO:0004692	; F:cGMP-dependent protein kinase activity

KEGG

InterPros

IPR000961	; AGC-kinase_C.
IPR016232	; cGMP-dependent_protein_kinase.
IPR002374	; cGMP_dep_kinase.
IPR018490	; cNMP-bd-like.
IPR018488	; cNMP-bd_CS.
IPR000595	; cNMP-bd_dom.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR014710	; RmlC-like_jellyroll.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00027	; cNMP_binding; 2.
PF00069	; Pkinase; 1.

SMARTs

SM00100	; cNMP; 2.
SM00133	; S_TK_X; 1.
SM00220	; S_TKc; 1.

Prosites

PS51285	; AGC_KINASE_CTER; 1.
PS00888	; CNMP_BINDING_1; 2.
PS00889	; CNMP_BINDING_2; 2.
PS50042	; CNMP_BINDING_3; 2.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

PR00104

; CGMPKINASE.

Created Date

20-Feb-2013