EKS-OTG-00247

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-OTG-00247

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CAMK/CAMKL	382.4	8.2E-115	59	310	252

Status

Unreviewed

Ensembl Protein

ENSOGAP00000010099

UniProt Accession

H0X4H1;

Protein Name

Protein Synonyms/Alias

Gene Name

MARK4

Gene Synonyms/Alias

MARK4;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSOGAG00000011279	ENSOGAP00000010099	ENSOGAT00000011283

Organism

Otolemur garnettii

Functional Description

Protein Length

752

Protein Sequence
(FASTA)

MSSRTALAPG NDRNSDTHGT LGSGRSSDKG PSWSSRSLGA RCRNSIASCP EEQPHVGNYR 60

LLRTIGKGNF AKVKLARHIL TGREVAIKII DKTQLNPSSL QKLFREVRIM KGLNHPNIVK 120

LFEVIETEKT LYLVMEYASA GEVFDYLVSH GRMKEKEARA KFRQIVSAVH YCHQKNIVHR 180

DLKAENLLLD AEANIKIADF GFSNEFTLGS KLDTFCGSPP YAAPELFQGK KYDGPEVDIW 240

SLGVILYTLV SGSLPFDGHN LKELRERVLR GKYRVPFYMS TDCESILRRF LVLNPAKRCT 300

LEQIMKDKWI NIGYEGEELK PYTEPEEDFG DTKRIEVMVG MGYTREEIKE ALTSQKYNEV 360

TATYLLLGRK TEEGGDRGTP GLALARVRAP SDTTNGTSSS KGTSHSKGQR SSSSTYHRQR 420

RHSDFCGPSP APLHPKRSPT STGETELKEE RLPGRKASCS AAGSGSRGLP PSSPMVSSAH 480

NPNKAEIPER RKDSTSTPNN LPPSMMARRN TYVCTERPGA ERPSLLPNGK ENSSGTPRVP 540

PASPSSHSLA PPSGERSRLA RGSTIRSTFH GGQVRDRRAG GGGGGGVQNG PPASPTLAHE 600

ATPLPAGRPR PTTNLFTKLT SKLTRRVADE SERIGGPEVT SCHLPWDQTE TAPRLLRFPW 660

SVKLTSSRPP EALMAALRQA TAAARCRCRQ PQPFLLACLH GGAGGPEPLS HFEVEVCQLP 720

RPGLRGVLFR RVAGTALAFR TLVTRISNDL EL 752

Nucleotide Sequence
(FASTA)

ATGTCTTCGC GGACGGCGCT GGCCCCGGGC AACGATCGGA ACTCGGACAC GCATGGCACC 60

TTGGGCAGTG GCCGCTCCTC AGACAAAGGA CCATCCTGGT CCAGCCGCTC CCTGGGTGCC 120

CGCTGCCGGA ATTCCATCGC CTCCTGTCCC GAGGAACAGC CCCACGTGGG CAACTACCGC 180

CTGCTGAGGA CCATCGGGAA GGGCAACTTT GCCAAAGTCA AGCTGGCTCG GCACATCCTC 240

ACTGGTCGGG AGGTGGCCAT CAAGATCATC GACAAAACCC AGCTGAACCC CAGCAGCCTG 300

CAGAAGCTAT TTCGAGAAGT CCGCATCATG AAGGGCTTAA ACCACCCCAA CATCGTAAAA 360

CTCTTCGAGG TGATTGAGAC TGAGAAGACA CTGTACCTGG TGATGGAATA CGCAAGTGCT 420

GGAGAAGTGT TTGACTACCT CGTGTCACAT GGCCGCATGA AGGAGAAAGA AGCTCGAGCC 480

AAGTTCCGAC AGATTGTATC AGCTGTGCAC TATTGTCATC AGAAAAACAT TGTACACAGA 540

GACTTGAAGG CCGAGAACCT CTTGCTGGAC GCAGAGGCCA ACATCAAGAT TGCTGACTTT 600

GGTTTCAGCA ATGAGTTCAC ACTGGGCTCA AAGCTGGACA CGTTCTGTGG GAGTCCCCCA 660

TATGCTGCCC CAGAGCTGTT TCAGGGCAAG AAATACGACG GGCCGGAGGT GGACATCTGG 720

AGCCTCGGCG TCATCCTATA CACCCTCGTC AGCGGCTCCC TGCCCTTTGA TGGGCACAAC 780

CTCAAGGAGC TGCGAGAGCG TGTCCTCAGA GGGAAGTACC GAGTCCCTTT CTACATGTCA 840

ACAGACTGTG AGAGCATCCT GCGGAGGTTT TTGGTGCTGA ACCCAGCTAA GCGCTGTACC 900

CTCGAGCAAA TCATGAAAGA CAAATGGATC AACATTGGCT ATGAGGGTGA GGAGTTGAAG 960

CCATACACAG AACCCGAGGA GGACTTCGGG GACACCAAGC GAATCGAGGT GATGGTGGGT 1020

ATGGGCTACA CACGGGAAGA AATCAAAGAG GCCTTGACCA GCCAGAAGTA CAACGAAGTG 1080

ACCGCTACCT ACCTCCTGCT GGGCAGGAAA ACTGAGGAGG GTGGGGACCG GGGCACCCCA 1140

GGGCTGGCCC TGGCACGGGT GCGGGCGCCC AGCGACACCA CCAATGGAAC AAGCTCCAGC 1200

AAAGGCACCA GCCACAGCAA AGGGCAACGG AGTTCCTCTT CCACCTACCA CCGCCAACGC 1260

AGGCATAGCG ACTTCTGTGG CCCATCCCCA GCACCCCTGC ACCCCAAGCG CAGCCCAACG 1320

AGCACGGGGG AGACGGAGTT GAAAGAGGAG CGACTGCCAG GCCGAAAGGC GAGCTGCAGT 1380

GCTGCAGGGA GTGGAAGTCG AGGGCTGCCC CCCTCCAGCC CCATGGTCAG CAGCGCCCAC 1440

AACCCCAACA AGGCAGAGAT CCCAGAGCGA CGGAAGGACA GCACGAGCAC CCCTAACAAC 1500

CTCCCCCCCA GCATGATGGC CCGCAGGAAC ACCTATGTAT GCACAGAGCG CCCGGGGGCT 1560

GAGCGCCCTT CACTGTTGCC AAATGGCAAA GAAAACAGCT CAGGCACCCC ACGGGTGCCC 1620

CCTGCCTCCC CCTCCAGTCA CAGCCTGGCT CCCCCATCAG GGGAGCGGAG CCGTCTGGCA 1680

CGAGGTTCCA CCATCCGCAG CACCTTCCAT GGTGGCCAGG TCCGGGACCG GCGGGCAGGG 1740

GGTGGGGGTG GTGGGGGTGT GCAGAATGGT CCCCCTGCCT CTCCCACACT GGCCCATGAG 1800

GCCACACCCC TGCCCGCTGG GCGACCACGC CCCACCACCA ACCTCTTCAC CAAGCTGACC 1860

TCCAAACTGA CCCGAAGGGT CGCAGACGAA TCTGAGAGAA TCGGGGGACC TGAGGTCACA 1920

AGTTGCCATC TACCTTGGGA TCAAACGGAA ACCGCCCCCC GGCTGCTCCG ATTCCCCTGG 1980

AGTGTGAAGC TGACCAGCTC GCGCCCTCCC GAGGCCCTGA TGGCAGCTCT GCGCCAGGCC 2040

ACAGCAGCCG CCCGCTGCCG TTGCCGCCAG CCACAGCCGT TCCTGCTGGC CTGCCTGCAC 2100

GGGGGTGCGG GCGGGCCCGA GCCCCTGTCC CACTTCGAAG TGGAGGTCTG CCAGCTGCCC 2160

CGGCCAGGCC TGCGGGGAGT TCTCTTCCGC CGTGTGGCGG GCACCGCCCT GGCCTTCCGC 2220

ACCCTCGTCA CCCGCATCTC CAATGACCTC GAGCTCTGA 2259

Domain Profile

S: 1     ykllktlGegsfgkVklakhketkekvavKiikkkklseeslekikrEieilkklkhpni  60

         y+ll+t+G+g+f+kVkla+h +t+++va+Kii+k++l+ +sl+k++rE++i+k l+hpni

Q: 59    YRLLRTIGKGNFAKVKLARHILTGREVAIKIIDKTQLNPSSLQKLFREVRIMKGLNHPNI  118

         99**********************************************************

S: 61    ikllevietkkklylvleyasggeLfdyieekgrlkekearklfkqlvsavkYlhskgiv  120

         +kl+eviet+k+lylv+eyas ge+fdy++++gr+kekear+ f+q+vsav+Y+h+k+iv

Q: 119   VKLFEVIETEKTLYLVMEYASAGEVFDYLVSHGRMKEKEARAKFRQIVSAVHYCHQKNIV  178

         ************************************************************

S: 121   HrDlKpeNllldkkenikiaDFGlanlfkegklletfcGsppYaaPellkgkkYegpkvD  180

         HrDlK+eNllld++ nikiaDFG++n+f+ g++l+tfcGsppYaaPel++gkkY+gp+vD

Q: 179   HRDLKAENLLLDAEANIKIADFGFSNEFTLGSKLDTFCGSPPYAAPELFQGKKYDGPEVD  238

         ************************************************************

S: 181   vWslGvvLyalvtgklPfdeenlkellekilkgkleipkklskelesLlrklLvvdpekR  240

         +WslGv+Ly+lv+g+lPfd++nlkel+e++l+gk+++p+++s+++es+lr++Lv +p+kR

Q: 239   IWSLGVILYTLVSGSLPFDGHNLKELRERVLRGKYRVPFYMSTDCESILRRFLVLNPAKR  298

         ************************************************************

S: 241   atieeilkhewl  252

         +t+e+i+k++w+

Q: 299   CTLEQIMKDKWI  310

         ***********7

Domain Sequence
(FASTA)

YRLLRTIGKG NFAKVKLARH ILTGREVAIK IIDKTQLNPS SLQKLFREVR IMKGLNHPNI 60

VKLFEVIETE KTLYLVMEYA SAGEVFDYLV SHGRMKEKEA RAKFRQIVSA VHYCHQKNIV 120

HRDLKAENLL LDAEANIKIA DFGFSNEFTL GSKLDTFCGS PPYAAPELFQ GKKYDGPEVD 180

IWSLGVILYT LVSGSLPFDG HNLKELRERV LRGKYRVPFY MSTDCESILR RFLVLNPAKR 240

CTLEQIMKDK WI 252

Keyword

ATP-binding; Complete proteome; Nucleotide-binding; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Macropus eugenii"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Oryzias latipes"; ?>Pan troglodytes"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Takifugu rubripes"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity

KEGG

InterPros

IPR001772	; Kinase-assoc_KA1.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.
IPR000449	; UBA/transl_elong_EF1B_N.
IPR015940	; UBA/transl_elong_EF1B_N_euk.

Pfam

PF02149	; KA1; 1.
PF00069	; Pkinase; 1.
PF00627	; UBA; 1.

SMARTs

SM00220	; S_TKc; 1.
SM00165	; UBA; 1.

Prosites

PS50032	; KA1; 1.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.
PS50030	; UBA; 1.

Prints

Created Date

20-Feb-2013