EKS-OTG-00238

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-OTG-00238

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CAMK/MAPKAPK	432.5	5.2E-130	62	323	262

Status

Unreviewed

Ensembl Protein

ENSOGAP00000010126

UniProt Accession

H0X4J4;

Protein Name

Protein Synonyms/Alias

Gene Name

MAPKAPK2

Gene Synonyms/Alias

MAPKAPK2;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSOGAG00000011306	ENSOGAP00000010126	ENSOGAT00000011310

Organism

Otolemur garnettii

Functional Description

Protein Length

398

Protein Sequence
(FASTA)

MLSNSQGQTP PVLFPNPPPQ PPAPAQPHPP AQPPPQPPQQ FPQFHVKSSL QIKKNAIIDD 60

YKVTSQVLGL GINGKVLQIF NKRTQEKFAL KMLQDCPKAR REVELHWRAS QCPHIVRIVD 120

VYENLYAGRK CLLIVMECLD GGELFSRIQD RGDQAFTERE ASEIMKSIGE AIQYLHSINI 180

AHRDVKPENL LYTSRRPNAI LKLTDFGFAK ETTSHNSLTT PCYTPYYVAP EVLGPEKYDK 240

SCDMWSLGVI MYILLCGYPP FYSNHGLAIS PGMKTRIRMG QYEFPNPEWS EVSEEVKMLI 300

RNLLKTEPTQ RMTITEFMNH PWIMQSTKVP QTPLHTSRVL KEDKERWEDV KEEMTSALAT 360

MRVDYEQIKI KKIEDASNPL LLKRRKKARA LEAAALAH 398

Nucleotide Sequence
(FASTA)

ATGCTGTCCA ACTCCCAAGG CCAGACCCCG CCGGTGCTGT TCCCAAACCC GCCGCCGCAG 60

CCCCCCGCTC CCGCCCAGCC TCATCCCCCG GCCCAGCCCC CGCCGCAGCC CCCGCAGCAG 120

TTCCCCCAGT TCCATGTGAA GTCGAGCCTG CAGATCAAGA AGAACGCCAT CATCGACGAC 180

TACAAGGTCA CCAGCCAGGT CCTGGGACTG GGCATCAACG GGAAAGTTTT GCAGATCTTC 240

AACAAGAGGA CCCAGGAGAA ATTCGCCCTA AAAATGCTTC AGGACTGCCC CAAGGCCCGC 300

AGGGAGGTGG AGCTGCACTG GCGGGCCTCC CAGTGCCCGC ACATTGTGCG CATCGTGGAT 360

GTCTACGAGA ACCTGTATGC GGGGAGGAAG TGCCTGCTCA TCGTCATGGA GTGTTTGGAT 420

GGTGGAGAAC TCTTTAGTCG AATCCAGGAC CGAGGAGACC AAGCATTCAC AGAAAGAGAG 480

GCATCAGAGA TCATGAAGAG CATTGGTGAG GCCATCCAGT ATTTGCACTC AATCAACATT 540

GCCCATCGGG ATGTCAAGCC TGAGAATCTC TTATACACCT CCAGAAGACC CAATGCCATT 600

CTGAAACTCA CCGATTTCGG CTTTGCCAAG GAAACCACCA GCCACAACTC TTTGACCACT 660

CCTTGTTATA CGCCATACTA TGTGGCTCCG GAAGTTCTGG GCCCAGAGAA GTATGACAAG 720

TCCTGTGACA TGTGGTCCTT GGGTGTCATC ATGTATATCC TGCTGTGTGG GTATCCCCCC 780

TTCTATTCCA ACCATGGCCT TGCCATCTCT CCGGGCATGA AGACTCGTAT TCGAATGGGC 840

CAGTATGAAT TTCCCAATCC AGAATGGTCA GAAGTATCAG AGGAAGTGAA GATGCTCATC 900

CGGAACCTGC TGAAAACAGA GCCCACTCAG AGAATGACCA TCACAGAGTT CATGAACCAC 960

CCCTGGATCA TGCAATCGAC AAAGGTCCCT CAAACCCCAC TGCACACCAG CCGAGTCTTG 1020

AAGGAGGATA AGGAGCGGTG GGAGGATGTC AAGGAGGAGA TGACCAGTGC CTTGGCCACC 1080

ATGCGCGTTG ACTACGAGCA AATCAAGATA AAAAAGATTG AAGATGCATC CAACCCTCTG 1140

CTTCTGAAGA GGCGGAAGAA AGCTCGGGCC CTAGAGGCTG CAGCCCTTGC CCACTGA 1197

Domain Profile

S: 1     klteevlGeGisgkvlecvkkktgekyalkilkdrkkvrrevelhvqasghknivelidv  60

         k+t++vlG Gi+gkvl++++k+t+ek+alk+l+d++k+rrevelh++as++++iv+++dv

Q: 62    KVTSQVLGLGINGKVLQIFNKRTQEKFALKMLQDCPKARREVELHWRASQCPHIVRIVDV  121

         5799********************************************************

S: 61    fensfedekrlllvlekleGGellsriqer..kaftekeasevvkdiasalkflhsknia  118

         +en ++++k+ll+v+e+l+GGel+sriq+r  +afte+ease++k+i++a+++lhs nia

Q: 122   YENLYAGRKCLLIVMECLDGGELFSRIQDRgdQAFTEREASEIMKSIGEAIQYLHSINIA  181

         *******************************9****************************

S: 119   hrDlkpenlLyeskeknapvklcDfglaketeeeeelktpcltaeyvaPevleaekeeal  178

         hrD+kpenlLy+s++ na++kl+Dfg+aket+++++l+tpc+t++yvaPevl++ek

Q: 182   HRDVKPENLLYTSRRPNAILKLTDFGFAKETTSHNSLTTPCYTPYYVAPEVLGPEK----  237

         ********************************************************....

S: 179   lydksCDlWslGvilyillcGypPfyskkgraiskklkeriqegkyefPeeeWsevseea  238

          ydksCD+WslGvi+yillcGypPfys++g ais+++k+ri++g+yefP++eWsevsee+

Q: 238   -YDKSCDMWSLGVIMYILLCGYPPFYSNHGLAISPGMKTRIRMGQYEFPNPEWSEVSEEV  296

         .***********************************************************

S: 239   kdlirklLkrdpkerltieevlnhpwv  265

         k+lir+lLk++p++r+ti+e++nhpw+

Q: 297   KMLIRNLLKTEPTQRMTITEFMNHPWI  323

         **************************8

Domain Sequence
(FASTA)

KVTSQVLGLG INGKVLQIFN KRTQEKFALK MLQDCPKARR EVELHWRASQ CPHIVRIVDV 60

YENLYAGRKC LLIVMECLDG GELFSRIQDR GDQAFTEREA SEIMKSIGEA IQYLHSINIA 120

HRDVKPENLL YTSRRPNAIL KLTDFGFAKE TTSHNSLTTP CYTPYYVAPE VLGPEKYDKS 180

CDMWSLGVIM YILLCGYPPF YSNHGLAISP GMKTRIRMGQ YEFPNPEWSE VSEEVKMLIR 240

NLLKTEPTQR MTITEFMNHP WI 262

Keyword

ATP-binding; Complete proteome; Nucleotide-binding; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Microcebus murinus"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Procavia capensis"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Takifugu rubripes"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069

; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013