EKS-OTG-00155

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-OTG-00155

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TK/FGFR	525.1	3.0E-158	635	911	277

Status

Unreviewed

Ensembl Protein

ENSOGAP00000010241

UniProt Accession

H0X4T5;

Protein Name

Protein Synonyms/Alias

Gene Name

FGFR4

Gene Synonyms/Alias

FGFR4;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSOGAG00000011435	ENSOGAP00000010241	ENSOGAT00000011441

Organism

Otolemur garnettii

Functional Description

Protein Length

969

Protein Sequence
(FASTA)

CVCECSYVCV CVCVCVCVCW AVACTLSTVA LRVASVAYRC MYISRSNGLS SMCLEHAVCV 60

KEAASDGTAR LTDLCPPTEP CLAPSLEQQE QELTVARGQP VRLCCGRAER GGHWYKEGSR 120

LAPAGRVRGW RGRLEIASFL PEDAGHYLCL ARGSMFVLHN LTLVTNGKKP PAMMMRTPKP 180

IMGIFTSSKV SSSRTLVPTA HLVTEKKRPL WQQVIILGAL ISPLAPYWTH PQRMEKKLHA 240

VPAGNTVKFR CPAAGNPMPT IHWLKDGQDF HGENRIGGIR LRHRHWSLVM ESVVPSDRGT 300

YTCLVENPLG SIRYSYLLDV LERSPHRPIL QAGLPANTTA VVGSDVELLC KVYSDAQPHI 360

QWLKHIVING SSFGADGFPY VQVLKTADIN SSEVEVLYLR NVSAEDAGEY TCLAGNSIGL 420

SYQSAWLTVL PGELLRGPGG TVRSYLVQQW TRTCLVDSLP WPLGLGCSVD LCLILCVPLC 480

LSITYSGLCI SATGVCVPMC VGSSENLRLT SQFICVCVRT EEDLTWTAVA PEARYTDIIL 540

YASGSLALAV FLLLAGLYQG QALHSRHPRQ PATVQKLSRF PLARQFSLES GSSGKSSSSL 600

VRGVRLSSSG PPLLAGLVSL DLPLDPLWEF PRDRLVLGKP LGEGCFGQVV RAEAFGMDPA 660

RPDQANTVAV KMLKDNSSDK DLADLVSEME VMKLIGRHKN IINLLGVCTQ EGPLYVIVEC 720

AAKGNLREFL RARRPPGPDL SPDGPQSSEG PLSFPALVSC AYQVARGMQY LESRKCIHRD 780

LAARNVLVTE DNVMKIADFG LARGIHHIDY YKKTSNGRLP VKWMAPEALF DRVYTHQSDV 840

WSFGILLWEI FTLGGSPYPG IPVEELFSLL REGHRMDRPP HCPPELYGLM RECWHAAPSQ 900

RPTFKQLVEA LDKVLLAVSE EYLDLRLTFG PCSPSGGDAS STCSSSDSVF SHDPLPLGPS 960

SFPYSGVQT 969

Nucleotide Sequence
(FASTA)

TGTGTGTGTG AGTGTTCATA TGTCTGTGTG TGTGTGTGTG TGTGTGTGTG TGTGTGTTGG 60

GCAGTGGCAT GTACACTAAG TACTGTGGCC CTGCGTGTGG CATCTGTAGC ATATAGATGT 120

ATGTATATAT CAAGGAGCAA TGGCTTGTCT AGCATGTGCC TTGAGCATGC TGTCTGTGTG 180

AAGGAAGCTG CCTCAGATGG CACTGCAAGG CTCACTGACC TCTGCCCTCC CACAGAGCCC 240

TGCCTAGCTC CCAGCCTGGA ACAGCAAGAG CAGGAACTGA CCGTGGCCCG TGGGCAGCCT 300

GTGCGGCTGT GCTGTGGGAG GGCTGAGCGT GGTGGACACT GGTACAAGGA GGGCAGTCGC 360

TTGGCACCTG CCGGCCGGGT ACGGGGCTGG AGGGGCCGCC TAGAGATTGC CAGCTTCCTA 420

CCTGAGGATG CTGGCCACTA TCTCTGCCTG GCACGAGGCT CCATGTTTGT CTTGCACAAT 480

CTTACCTTGG TTACAAATGG TAAGAAACCT CCAGCAATGA TGATGAGGAC TCCAAAGCCC 540

ATAATGGGCA TATTTACCTC CAGCAAGGTC AGTTCCTCAA GAACTCTTGT CCCCACTGCT 600

CATCTGGTCA CTGAGAAGAA GAGACCTTTG TGGCAGCAGG TGATCATCCT AGGGGCTCTA 660

ATTTCCCCTC TAGCACCATA TTGGACACAC CCCCAGCGCA TGGAGAAGAA ACTACATGCA 720

GTGCCCGCTG GGAACACTGT TAAGTTCCGC TGTCCAGCTG CAGGCAATCC CATGCCCACC 780

ATTCACTGGC TCAAAGATGG ACAGGATTTT CATGGAGAAA ATCGCATTGG AGGCATTCGG 840

CTGCGCCACC GGCACTGGAG CCTGGTGATG GAAAGCGTTG TGCCATCGGA TCGTGGCACA 900

TACACCTGCC TTGTGGAGAA CCCTTTGGGC AGTATCCGCT ACAGCTATCT GCTAGATGTG 960

CTGGAGCGGT CCCCGCACCG GCCCATCCTG CAAGCAGGGC TTCCAGCCAA TACCACAGCT 1020

GTGGTGGGCA GTGATGTGGA GCTGCTATGC AAGGTGTACA GTGATGCCCA GCCCCACATC 1080

CAGTGGCTCA AGCACATCGT CATCAACGGC AGCAGCTTTG GCGCTGATGG CTTCCCCTAC 1140

GTGCAAGTCC TGAAGACTGC AGATATCAAT AGCTCAGAGG TAGAAGTCCT GTACTTACGG 1200

AACGTGTCAG CCGAGGATGC AGGCGAGTAC ACCTGCTTGG CAGGCAATTC CATCGGCCTC 1260

TCCTACCAGT CAGCTTGGCT CACGGTGCTG CCAGGTGAGC TCTTGAGGGG ACCAGGAGGG 1320

ACTGTGAGAT CCTATTTGGT CCAGCAGTGG ACTAGAACCT GTTTGGTAGA TAGTCTCCCT 1380

TGGCCTTTGG GCTTGGGATG TAGTGTAGAT TTGTGTTTGA TTTTGTGTGT CCCTCTGTGC 1440

CTGTCCATAA CATACTCTGG GCTATGCATA TCTGCCACTG GTGTGTGTGT CCCTATGTGT 1500

GTTGGAAGCT CTGAGAATCT GAGACTAACC AGTCAGTTTA TCTGTGTTTG TGTGAGGACA 1560

GAGGAGGACC TTACATGGAC AGCAGTGGCG CCTGAGGCCA GGTACACGGA TATCATCTTG 1620

TATGCATCGG GCTCCCTGGC TTTGGCTGTG TTCCTGCTGC TGGCTGGGCT GTATCAAGGG 1680

CAGGCACTCC ACAGCCGGCA TCCCCGTCAA CCTGCCACCG TGCAGAAGTT GTCCCGCTTC 1740

CCTCTGGCCC GGCAGTTCTC CCTGGAATCA GGCTCCTCGG GTAAGTCAAG CTCCTCCCTG 1800

GTGCGAGGCG TCCGTCTCTC CTCCAGCGGT CCCCCCTTGC TGGCTGGCCT TGTGAGTCTA 1860

GATCTACCTC TCGACCCACT GTGGGAGTTC CCCCGGGACA GGTTGGTTCT TGGGAAGCCC 1920

CTAGGCGAGG GCTGCTTTGG GCAGGTTGTG CGTGCAGAGG CCTTCGGCAT GGACCCTGCC 1980

CGACCTGACC AAGCCAACAC TGTGGCTGTC AAGATGCTCA AGGACAATTC CTCCGACAAG 2040

GACTTGGCGG ACCTCGTCTC TGAGATGGAG GTGATGAAGC TGATTGGCCG ACACAAGAAT 2100

ATCATCAACT TGCTGGGTGT CTGCACCCAA GAAGGGCCCC TGTACGTGAT TGTGGAGTGT 2160

GCTGCCAAGG GAAACCTGCG GGAGTTCCTG AGGGCCCGGC GCCCTCCAGG CCCTGATCTC 2220

AGCCCTGATG GACCTCAGAG CAGCGAAGGG CCACTCTCCT TCCCAGCCCT AGTCTCTTGT 2280

GCCTACCAGG TGGCCCGAGG CATGCAGTAT TTGGAGTCAC GGAAGTGCAT CCACCGGGAC 2340

CTGGCTGCCC GCAATGTGCT GGTGACTGAG GACAATGTGA TGAAGATTGC TGACTTTGGG 2400

CTGGCCCGAG GCATCCACCA CATTGACTAC TATAAGAAAA CTAGCAATGG ACGCCTGCCT 2460

GTCAAGTGGA TGGCACCTGA GGCCTTATTT GACCGAGTGT ATACACACCA GAGTGACGTG 2520

TGGTCTTTTG GGATCCTGTT GTGGGAGATC TTCACCCTTG GGGGATCCCC GTATCCTGGC 2580

ATCCCTGTGG AAGAGCTATT CTCACTGCTA CGGGAAGGAC ATCGGATGGA CCGGCCCCCA 2640

CACTGCCCCC CAGAGCTGTA TGGGCTGATG CGTGAGTGCT GGCATGCTGC ACCCTCTCAG 2700

AGACCCACTT TCAAGCAGCT GGTGGAGGCA CTGGACAAAG TCCTGCTGGC TGTCTCTGAG 2760

GAGTACTTGG ATCTTCGCCT GACCTTTGGA CCCTGCTCCC CCTCTGGTGG GGATGCCAGC 2820

AGTACCTGCT CCTCCAGCGA TTCTGTCTTC AGCCATGACC CCCTGCCACT GGGGCCCAGC 2880

TCATTCCCCT ATTCCGGGGT TCAGACATGA 2910

Domain Profile

S: 1     lvlgkllGeGafGqvvkaeaigldkdkekkevtvavkmlkedatdkdladlvsemevlkl  60

         lvlgk+lGeG+fGqvv+aea+g+d  +++++ tvavkmlk++++dkdladlvsemev+kl

Q: 635   LVLGKPLGEGCFGQVVRAEAFGMDPARPDQANTVAVKMLKDNSSDKDLADLVSEMEVMKL  694

         79**********************************************************

S: 61    iGkhkniinllGactqeGplyviveyaakGnlreflrarrpkgeeaskdkskaseeqlte  120

         iG+hkniinllG+ctqeGplyvive+aakGnlreflrarrp+g + s d +++se  l++

Q: 695   IGRHKNIINLLGVCTQEGPLYVIVECAAKGNLREFLRARRPPGPDLSPDGPQSSEGPLSF  754

         ************************************************************

S: 121   kdlvsfayqvarGmeylaskkcihrdlaarnvlvtednvlkiadfGlardvheidyykkt  180

           lvs+ayqvarGm+yl+s+kcihrdlaarnvlvtednv+kiadfGlar++h+idyykkt

Q: 755   PALVSCAYQVARGMQYLESRKCIHRDLAARNVLVTEDNVMKIADFGLARGIHHIDYYKKT  814

         ************************************************************

S: 181   tnGrlpvkwmapealfdrvytsqsdvwsfGvllweiltlGgspypgiaveelfkllkeGh  240

         +nGrlpvkwmapealfdrvyt+qsdvwsfG+llwei+tlGgspypgi+veelf+ll+eGh

Q: 815   SNGRLPVKWMAPEALFDRVYTHQSDVWSFGILLWEIFTLGGSPYPGIPVEELFSLLREGH  874

         ************************************************************

S: 241   rmekpakctkelyvlmrecwhakaserptfkqlvedl  277

         rm++p +c+ ely lmrecwha++s+rptfkqlve+l

Q: 875   RMDRPPHCPPELYGLMRECWHAAPSQRPTFKQLVEAL  911

         **********************************986

Domain Sequence
(FASTA)

LVLGKPLGEG CFGQVVRAEA FGMDPARPDQ ANTVAVKMLK DNSSDKDLAD LVSEMEVMKL 60

IGRHKNIINL LGVCTQEGPL YVIVECAAKG NLREFLRARR PPGPDLSPDG PQSSEGPLSF 120

PALVSCAYQV ARGMQYLESR KCIHRDLAAR NVLVTEDNVM KIADFGLARG IHHIDYYKKT 180

SNGRLPVKWM APEALFDRVY THQSDVWSFG ILLWEIFTLG GSPYPGIPVE ELFSLLREGH 240

RMDRPPHCPP ELYGLMRECW HAAPSQRPTF KQLVEAL 277

Keyword

ATP-binding; Complete proteome; Immunoglobulin domain; Kinase; Membrane; Nucleotide-binding; Phosphoprotein; Receptor; Reference proteome; Repeat; Transferase; Transmembrane; Transmembrane helix; Tyrosine-protein kinase.

Sequence Source

Ensembl

Orthology

Ortholog group

Gorilla gorilla"; ?>Homo sapiens"; ?>Macaca mulatta"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>

Gene Ontology

GO:0016021	; C:integral to membrane
GO:0005524	; F:ATP binding
GO:0004713	; F:protein tyrosine kinase activity

KEGG

InterPros

IPR007110	; Ig-like.
IPR013783	; Ig-like_fold.
IPR013098	; Ig_I-set.
IPR003598	; Ig_sub2.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR008266	; Tyr_kinase_AS.
IPR020635	; Tyr_kinase_cat_dom.

Pfam

PF07679	; I-set; 2.
PF07714	; Pkinase_Tyr; 1.

SMARTs

SM00408	; IGc2; 3.
SM00219	; TyrKc; 1.

Prosites

PS50835	; IG_LIKE; 2.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00109	; PROTEIN_KINASE_TYR; 1.

Prints

PR00109

; TYRKINASE.

Created Date

20-Feb-2013