EKS-OTG-00283

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-OTG-00283

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TKL/STKR	453.4	2.9E-136	188	475	288

Status

Unreviewed

Ensembl Protein

ENSOGAP00000010440

UniProt Accession

H0X5A0;

Protein Name

Protein Synonyms/Alias

Gene Name

ACVR1

Gene Synonyms/Alias

ACVR1;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSOGAG00000011662	ENSOGAP00000010440	ENSOGAT00000011667

Organism

Otolemur garnettii

Functional Description

Protein Length

489

Protein Sequence
(FASTA)

MEDEKPKVTP KLYMCVCEGL SCGSEDHCEG QQCFSSLSIN DGFHVYQKGC FQVYEQGKMT 60

CKTPPSPGQA VECCQGDWCN RNITAQLPTK GKSFPGTQNF HLEVGLIILS VVFAVCLLAC 120

LLGVALRKFK RRNQERLNPR DVEYGTIEGL ITTNVGDSTL ADLLDHSCTS GSGSGLPFLV 180

QRTVARQITL LECVGKGRYG EVWRGSWQGE NVAVKIFSSR DEKSWFRETE LYNTVMLRHE 240

NILGFIASDM TSRHSSTQLW LITHYHEMGS LYDYLQLTTL DTVSCLRIVL SIASGLAHLH 300

IEIFGTQGKP AIAHRDLKSK NILVKKNGQC CIADLGLAVM HSQSTNQLDV GNNPRVGTKR 360

YMAPEVLDET IQVDCFDSYK RVDIWAFGLV LWEVARRMVS NGIVEDYKPP FYDVVPNDPS 420

FEDMRKVVCV DQQRPNIPNR WFSDPTLTSL AKLMKECWYQ NPSARLTALR IKKTLTKIDN 480

SLDKLKTDC 489

Nucleotide Sequence
(FASTA)

ATGGAAGATG AGAAACCCAA GGTCACCCCC AAACTTTACA TGTGTGTATG CGAAGGCCTC 60

TCCTGCGGTA GCGAGGACCA CTGTGAAGGC CAGCAGTGCT TTTCCTCGCT AAGCATCAAT 120

GATGGCTTCC ATGTCTACCA GAAAGGCTGC TTCCAGGTCT ATGAGCAGGG GAAGATGACT 180

TGTAAGACCC CACCATCCCC TGGCCAAGCT GTGGAGTGCT GCCAAGGGGA CTGGTGTAAC 240

AGGAACATCA CAGCCCAGCT GCCCACTAAA GGGAAGTCCT TCCCTGGAAC ACAGAATTTC 300

CACTTGGAGG TTGGCCTCAT TATTCTCTCT GTAGTGTTTG CAGTATGCCT TCTAGCCTGC 360

CTTCTGGGAG TGGCTCTCCG AAAATTTAAA AGGCGCAACC AAGAACGCCT CAATCCCCGA 420

GATGTTGAGT ACGGCACCAT CGAAGGGCTC ATCACCACCA ATGTTGGAGA CAGCACTTTA 480

GCTGATTTAT TGGATCATTC GTGTACATCA GGAAGTGGCT CTGGTCTTCC CTTTCTGGTA 540

CAGAGAACAG TGGCTCGCCA GATTACACTC TTGGAGTGTG TCGGTAAAGG CAGGTACGGT 600

GAGGTGTGGA GAGGCAGCTG GCAAGGAGAA AATGTTGCCG TGAAGATCTT CTCCTCCCGG 660

GATGAGAAGT CGTGGTTCAG GGAAACAGAA TTGTACAACA CTGTGATGCT GAGGCACGAA 720

AATATTTTAG GTTTCATTGC TTCAGACATG ACATCAAGGC ACTCCAGTAC CCAGTTATGG 780

TTAATCACAC ATTACCATGA AATGGGATCG TTGTATGACT ATCTTCAGCT TACTACTCTG 840

GATACAGTTA GCTGCCTTCG AATAGTGCTG TCCATAGCTA GTGGGCTTGC TCATTTGCAC 900

ATAGAGATAT TTGGGACCCA AGGGAAACCA GCCATTGCCC ATCGAGATTT AAAGAGCAAA 960

AATATCCTGG TTAAGAAGAA TGGACAGTGC TGCATAGCAG ATTTGGGCCT GGCAGTCATG 1020

CACTCCCAGA GCACCAATCA ACTTGACGTG GGGAACAACC CCCGCGTGGG CACCAAGCGC 1080

TACATGGCCC CAGAAGTTCT AGATGAAACT ATCCAGGTGG ATTGTTTTGA TTCTTACAAG 1140

AGGGTCGATA TTTGGGCCTT TGGACTTGTA TTGTGGGAAG TGGCCCGGCG GATGGTGAGC 1200

AATGGTATAG TGGAGGATTA CAAGCCACCA TTCTACGATG TGGTTCCCAA TGACCCAAGT 1260

TTTGAAGACA TGAGGAAAGT AGTCTGTGTG GATCAGCAGA GGCCAAACAT ACCCAACAGA 1320

TGGTTCTCAG ATCCGACATT AACCTCTCTG GCCAAGCTCA TGAAAGAATG CTGGTATCAG 1380

AACCCATCGG CAAGACTCAC AGCTCTGCGC ATCAAAAAGA CTTTGACCAA AATTGATAAT 1440

TCCCTAGACA AATTGAAAAC TGACTGTTGA 1470

Domain Profile

S: 1     lklleligkGrygeVwkaklrgeevAvKifstedeaswkrEkeiyqtvllrhenilqfia  60

         ++lle++gkGrygeVw+++++ge+vAvKifs++de+sw+rE+e+y+tv+lrhenil+fia

Q: 188   ITLLECVGKGRYGEVWRGSWQGENVAVKIFSSRDEKSWFRETELYNTVMLRHENILGFIA  247

         789*********************************************************

S: 61    adkkeedsltelllvteyhekgsLsdyLkretldveellrlalslasGlahLHeeivgtk  120

         +d+++++s+t+l+l+t+yhe+gsL+dyL+ +tld+ ++lr++ls+asGlahLH ei+gt+

Q: 248   SDMTSRHSSTQLWLITHYHEMGSLYDYLQLTTLDTVSCLRIVLSIASGLAHLHIEIFGTQ  307

         ************************************************************

S: 121   gkkKpaiaHRDlkskNilvkkdltcciaDlGLalkleeekeeldlaansqvGtkRYmaPE  180

         g  KpaiaHRDlkskNilvkk+++cciaDlGLa+++++++++ld+ +n +vGtkRYmaPE

Q: 308   G--KPAIAHRDLKSKNILVKKNGQCCIADLGLAVMHSQSTNQLDVGNNPRVGTKRYMAPE  365

         *..*********************************************************

S: 181   vleealnlkdfeafkraDvYslgLvlWEvasRceevdeeveeyklpfeevvgsdPsleem  240

         vl+e++++++f+++kr+D++++gLvlWEva+R+ + +++ve+yk+pf++vv++dPs+e+m

Q: 366   VLDETIQVDCFDSYKRVDIWAFGLVLWEVARRMVS-NGIVEDYKPPFYDVVPNDPSFEDM  424

         **********************************9.************************

S: 241   kevvvekklrPkipeawkkkealkelsklleecWdadpeaRltalrvkkrl  291

         ++vv+++++rP+ip++w ++++l++l+kl++ecW+++p+aRltalr+kk+l

Q: 425   RKVVCVDQQRPNIPNRWFSDPTLTSLAKLMKECWYQNPSARLTALRIKKTL  475

         *************************************************97

Domain Sequence
(FASTA)

ITLLECVGKG RYGEVWRGSW QGENVAVKIF SSRDEKSWFR ETELYNTVML RHENILGFIA 60

SDMTSRHSST QLWLITHYHE MGSLYDYLQL TTLDTVSCLR IVLSIASGLA HLHIEIFGTQ 120

GKPAIAHRDL KSKNILVKKN GQCCIADLGL AVMHSQSTNQ LDVGNNPRVG TKRYMAPEVL 180

DETIQVDCFD SYKRVDIWAF GLVLWEVARR MVSNGIVEDY KPPFYDVVPN DPSFEDMRKV 240

VCVDQQRPNI PNRWFSDPTL TSLAKLMKEC WYQNPSARLT ALRIKKTL 288

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Microcebus murinus"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0016020	; C:membrane
GO:0005524	; F:ATP binding
GO:0004702	; F:receptor signaling protein serine/threonine kinase activity
GO:0005024	; F:transforming growth factor beta-activated receptor activity
GO:0023014	; P:signal transduction by phosphorylation

KEGG

InterPros

IPR000333	; Activin_II/TGFBeta-II_recpt.
IPR000472	; Activin_rcpt.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR008271	; Ser/Thr_kinase_AS.
IPR003605	; TGF_beta_rcpt_GS.

Pfam

PF01064	; Activin_recp; 1.
PF00069	; Pkinase; 1.
PF08515	; TGF_beta_GS; 1.

SMARTs

SM00467

; GS; 1.

Prosites

PS51256	; GS; 1.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

PR00653

; ACTIVIN2R.

Created Date

20-Feb-2013