EKS-OTG-00213

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-OTG-00213

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CMGC/CDKL	514.2	6.8E-155	4	287	284

Status

Unreviewed

Ensembl Protein

ENSOGAP00000010561

UniProt Accession

H0X5J6;

Protein Name

Protein Synonyms/Alias

Gene Name

CDKL2

Gene Synonyms/Alias

CDKL2;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSOGAG00000011801	ENSOGAP00000010561	ENSOGAT00000011806

Organism

Otolemur garnettii

Functional Description

Protein Length

569

Protein Sequence
(FASTA)

MEKYENLGLV GEGSYGMVMK CRNKDSGRIV AIKKFLESDD DKMVKKIAMR EIKLLKQLRH 60

ENLVNLLEVC KKKKRWYLVF EFVDHTVLDD LELFSNGLDY QVVRKYLFQI INGIGFCHSH 120

NIIHRDIKPE NILVSQSGVV KLCDFGFART LAAPGEVYTD YVATRWYRAP ELLVGDVKYG 180

KAVDVWAIGC LVTEMLMGEP LFPGDSDIDQ LYHIMMCLGN LIPRHQELFY KNPVFAGVRL 240

PEIKETVPLE KRYPKLPEVV IDLAKKCLHT DPDKRPFCAE LLHHDFFQLD GFAERFSQEL 300

QLKVQKDAKN ISLSKKSQNR KKEKEKDDSL SEERKTLVVQ DTNADPKIKD YKVFKMKGPK 360

IDGEKVEKGN RASNASCLHD NGTSYVKTVP STSLRDCSNV TAGHTRHPGT AIPPLTHNLS 420

AVVPTINSAM GTIPAVQSYR VDEKTKKYCI PFVKPNKHSP SGIYNVNVNT SVSTEKNLFQ 480

ANKKRREYSK TDVRLPELNY NHLPELRALE GITRNSRLVK KENKILSESR IPSLAAIDLH 540

TPGLSSHQVS GTPLSDGSEP DLPRMEHQH 569

Nucleotide Sequence
(FASTA)

ATGGAAAAAT ATGAGAACCT GGGATTGGTT GGAGAAGGAA GTTATGGAAT GGTGATGAAG 60

TGTAGGAATA AAGATAGTGG AAGAATTGTG GCCATCAAGA AGTTCTTAGA AAGTGATGAT 120

GACAAAATGG TTAAAAAAAT TGCAATGCGG GAAATCAAGT TACTAAAGCA ACTGAGGCAT 180

GAAAATTTGG TGAATCTGTT GGAAGTGTGT AAGAAAAAGA AACGATGGTA CCTAGTCTTT 240

GAGTTTGTTG ACCACACAGT TCTTGATGAC TTGGAGCTCT TTTCAAATGG ACTAGACTAC 300

CAAGTAGTTC GAAAGTATTT GTTTCAAATT ATTAATGGAA TTGGATTCTG TCACAGTCAC 360

AATATCATAC ACAGAGACAT AAAGCCAGAG AATATATTAG TCTCCCAGTC GGGTGTTGTC 420

AAGTTATGTG ATTTTGGATT TGCACGCACA TTGGCGGCAC CTGGGGAGGT TTATACTGAC 480

TATGTGGCGA CCCGATGGTA CCGAGCCCCC GAGCTGCTGG TTGGTGATGT CAAGTATGGC 540

AAGGCTGTGG ACGTGTGGGC CATTGGTTGT CTGGTCACTG AAATGCTCAT GGGAGAACCC 600

CTATTTCCTG GAGATTCTGA CATTGATCAG CTGTATCATA TTATGATGTG TTTAGGTAAT 660

CTCATTCCAA GACATCAGGA GCTGTTTTAT AAAAATCCTG TGTTTGCTGG AGTAAGGCTG 720

CCTGAAATCA AGGAAACAGT CCCTCTTGAA AAGCGCTACC CTAAACTCCC TGAAGTGGTC 780

ATAGACCTAG CGAAGAAATG CTTACATACT GACCCAGACA AAAGACCCTT CTGTGCTGAG 840

CTCCTGCACC ATGACTTTTT TCAATTGGAT GGATTTGCTG AGAGGTTTTC TCAGGAACTA 900

CAGTTAAAAG TACAGAAAGA TGCCAAAAAT ATTTCTTTAT CTAAAAAATC CCAAAATAGA 960

AAGAAGGAAA AAGAGAAGGA CGATTCCTTA AGTGAAGAAA GAAAAACACT TGTAGTTCAG 1020

GATACCAATG CTGATCCCAA AATTAAGGAT TATAAAGTTT TTAAAATGAA AGGGCCAAAA 1080

ATTGATGGAG AAAAAGTTGA AAAAGGCAAT AGAGCTTCAA ATGCCAGCTG TCTCCATGAC 1140

AACGGGACAA GCTATGTCAA AACAGTGCCT TCAACAAGCC TCAGAGACTG CAGCAACGTC 1200

ACCGCGGGTC ACACACGGCA CCCGGGCACG GCGATCCCCC CACTCACACA CAATCTTTCT 1260

GCAGTTGTTC CCACTATTAA TTCTGCAATG GGGACTATAC CAGCAGTTCA AAGTTACAGG 1320

GTGGATGAGA AAACAAAGAA GTATTGTATT CCATTTGTTA AACCAAATAA ACATTCCCCA 1380

TCAGGCATTT ATAATGTTAA TGTGAACACA TCAGTCTCCA CTGAAAAGAA CCTTTTCCAG 1440

GCAAATAAGA AAAGAAGGGA ATACTCCAAG ACAGATGTCC GTCTGCCCGA ACTGAACTAC 1500

AATCATCTCC CTGAGCTCAG AGCCTTGGAA GGCATAACTC GAAATTCCAG GCTAGTAAAG 1560

AAAGAGAACA AAATTCTTTC AGAATCTCGA ATTCCTTCTC TGGCTGCTAT TGACTTGCAC 1620

ACCCCCGGTC TCTCATCACA TCAGGTCTCA GGCACACCCC TATCGGATGG TTCAGAGCCT 1680

GACTTGCCTC GAATGGAACA CCAGCACTGA 1710

Domain Profile

S: 1     yeklgkvGeGsyGvvlkcrnkdtgqivaikkfleseddkevkkialreikllkqlkhenl  60

         ye+lg vGeGsyG+v+kcrnkd+g+ivaikkfles+ddk+vkkia+reikllkql+henl

Q: 4     YENLGLVGEGSYGMVMKCRNKDSGRIVAIKKFLESDDDKMVKKIAMREIKLLKQLRHENL  63

         9***********************************************************

S: 61    vnllevfrrkkklylvfeyvdktvldelerypnGveeelvkkilyqilkaiefchknnii  120

         vnllev+++kk++ylvfe+vd+tvld+le ++nG+++++v+k+l+qi+++i fch++nii

Q: 64    VNLLEVCKKKKRWYLVFEFVDHTVLDDLELFSNGLDYQVVRKYLFQIINGIGFCHSHNII  123

         ************************************************************

S: 121   hrdikpenilisksgvvklcdfGfarllaapgdvytdyvatrwyrapellvgdtkyGksv  180

         hrdikpenil+s+sgvvklcdfGfar+laapg+vytdyvatrwyrapellvgd+kyGk+v

Q: 124   HRDIKPENILVSQSGVVKLCDFGFARTLAAPGEVYTDYVATRWYRAPELLVGDVKYGKAV  183

         ************************************************************

S: 181   dvwaiGcllaelltGeplfpgksdvdqlykirktlGeliprhqkifsknevfaGvklpev  240

         dvwaiGcl++e+l+Geplfpg+sd+dqly+i+++lG+liprhq++f+kn+vfaGv+lpe+

Q: 184   DVWAIGCLVTEMLMGEPLFPGDSDIDQLYHIMMCLGNLIPRHQELFYKNPVFAGVRLPEI  243

         ************************************************************

S: 241   edleslekkypklnevlldllkkclkldpaerlsceellkheyf  284

         +++ +lek+ypkl ev++dl+kkcl+ dp++r +c+ell+h++f

Q: 244   KETVPLEKRYPKLPEVVIDLAKKCLHTDPDKRPFCAELLHHDFF  287

         ******************************************98

Domain Sequence
(FASTA)

YENLGLVGEG SYGMVMKCRN KDSGRIVAIK KFLESDDDKM VKKIAMREIK LLKQLRHENL 60

VNLLEVCKKK KRWYLVFEFV DHTVLDDLEL FSNGLDYQVV RKYLFQIING IGFCHSHNII 120

HRDIKPENIL VSQSGVVKLC DFGFARTLAA PGEVYTDYVA TRWYRAPELL VGDVKYGKAV 180

DVWAIGCLVT EMLMGEPLFP GDSDIDQLYH IMMCLGNLIP RHQELFYKNP VFAGVRLPEI 240

KETVPLEKRY PKLPEVVIDL AKKCLHTDPD KRPFCAELLH HDFF 284

Keyword

ATP-binding; Complete proteome; Nucleotide-binding; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Choloepus hoffmanni"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069

; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013