EKS-OTG-00245

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-OTG-00245

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CAMK/CAMKL	387.6	2.2E-116	43	294	252

Status

Unreviewed

Ensembl Protein

ENSOGAP00000010785

UniProt Accession

H0X630;

Protein Name

Protein Synonyms/Alias

Gene Name

MARK1

Gene Synonyms/Alias

MARK1;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSOGAG00000012054	ENSOGAP00000010785	ENSOGAT00000012057

Organism

Otolemur garnettii

Functional Description

Protein Length

782

Protein Sequence
(FASTA)

HTSVDGYTEP HIQPTKSSSR QNIPRCRNSI TSATDEQPHI GNYRLQKTIG KGNFAKVKLA 60

RHVLTGREVA VKIIDKTQLN PTSLQKLFRE VRIMKILNHP NIVKLFEVIE TEKTLYLVME 120

YASGGEVFDY LVAHGRMKEK EARAKFRQIV SAVQYCHQKC IVHRDLKAEN LLLDADMNIK 180

IADFGFSNEF TVGNKLDTFC GSPPYAAPEL FQGKKYDGPE VDVWSLGVIL YTLVSGSLPF 240

DGQNLKELRE RVLRGKYRIP FYMSTDCENL LKKLLVLNPI KRGSLEQIMK DRWMNVGHEE 300

EELKPYSEPD PDFNDTKRID IMVTMGFARD EINDALINQK YDEVMATYIL LGRKPPEFEG 360

GESLSSGNLC QRSRPSSDLN NSTLQSPAHL KVQRSISANQ KQRRFSDHEM TAGPSIPPAV 420

SYTKRPQANS VESEQKEEWD KDVARKLGST TVGSKSEMTA SPLVGPERKK SSTIPSNNMY 480

PGGSMARRNT YVCERTTDRY MALQNGKDNS LTEMSVSSIS SASSSVASAV PSARPRHQKS 540

MSTSGHPIKV TLPTIKDSSE AYRPGSTTQR VPAASPSAHS ISAATPDRTR FPRGSSSRST 600

FHGEQLRERR SAAYNGPPAS PSHETGAFAH ARRGTSTGII SKITSKFVRR DPSEGEASGR 660

TDTSRSTSGE PKERDKEEGK DSKPRSLRFT WSMKTTSSMD PNDMMREIRK VLDANNCDYE 720

QKERFLLFCV HGDARQDSLV QWEMEVCKLP RLSLNGVRFK RISGTSIAFK NIASKIANEL 780

KL 782

Nucleotide Sequence
(FASTA)

CATACATCTG TGGATGGATA TACTGAACCA CACATCCAGC CTACCAAGTC AAGTAGCAGA 60

CAGAACATCC CCCGGTGTAG AAACTCCATT ACGTCAGCCA CAGATGAACA GCCTCACATT 120

GGAAATTACC GTTTACAAAA AACAATAGGG AAGGGAAATT TTGCCAAAGT GAAATTGGCA 180

AGACATGTTC TAACTGGTAG AGAGGTTGCT GTGAAAATAA TAGACAAAAC CCAGCTAAAT 240

CCTACCAGTC TACAAAAGTT ATTTCGAGAA GTACGAATAA TGAAGATATT GAATCATCCT 300

AACATAGTAA AATTGTTTGA AGTTATTGAA ACAGAGAAGA CCCTCTATTT AGTCATGGAA 360

TACGCGAGTG GGGGTGAAGT ATTTGATTAC TTAGTTGCCC ATGGAAGAAT GAAAGAGAAA 420

GAGGCCCGTG CAAAATTTAG GCAGATTGTA TCTGCTGTAC AGTATTGTCA TCAAAAGTGC 480

ATTGTTCACC GTGATCTTAA GGCTGAAAAC CTTCTCCTTG ATGCAGATAT GAATATTAAA 540

ATTGCTGACT TTGGTTTTAG TAATGAATTT ACAGTTGGGA ACAAATTGGA CACATTTTGT 600

GGAAGCCCAC CCTATGCTGC TCCCGAGCTG TTCCAAGGAA AGAAGTACGA TGGGCCTGAA 660

GTGGATGTGT GGAGTCTGGG CGTCATTCTC TACACACTAG TCAGTGGCTC CTTGCCCTTC 720

GATGGCCAGA ATTTAAAGGA ATTGCGGGAA CGGGTCTTAC GAGGGAAGTA CCGTATTCCC 780

TTCTATATGT CCACAGACTG TGAAAATCTT CTGAAGAAAT TATTAGTTCT GAATCCAATA 840

AAGAGAGGCA GCTTGGAACA AATAATGAAA GATCGATGGA TGAATGTTGG TCATGAAGAG 900

GAAGAACTAA AGCCATACTC TGAGCCTGAT CCAGATTTCA ATGACACAAA AAGAATAGAC 960

ATTATGGTCA CCATGGGTTT TGCACGAGAT GAAATAAATG ACGCCTTAAT AAATCAGAAA 1020

TATGATGAAG TTATGGCTAC CTATATTCTT CTAGGTAGAA AACCACCTGA ATTTGAAGGC 1080

GGTGAGTCAT TATCCAGTGG AAACTTGTGT CAGAGATCCC GGCCCAGTAG TGATTTAAAC 1140

AACAGCACTC TTCAGTCCCC TGCTCACCTG AAGGTCCAGC GAAGCATTTC AGCAAATCAG 1200

AAGCAGCGGC GTTTCAGTGA TCATGAAATG ACAGCTGGTC CATCCATTCC TCCTGCCGTA 1260

TCATATACCA AAAGACCTCA GGCTAACAGT GTGGAAAGTG AACAGAAGGA AGAGTGGGAC 1320

AAAGATGTGG CTCGAAAACT TGGCAGCACA ACAGTTGGAT CAAAAAGTGA GATGACTGCA 1380

AGCCCTCTTG TAGGGCCAGA GAGGAAAAAG TCATCAACTA TTCCAAGTAA CAACATGTAT 1440

CCTGGAGGTA GCATGGCAAG AAGGAACACT TATGTCTGTG AAAGGACCAC AGATCGGTAC 1500

ATGGCATTGC AGAATGGAAA AGACAACAGC CTTACGGAGA TGTCTGTGAG CAGCATATCG 1560

TCTGCCAGCT CTTCTGTGGC CTCTGCTGTC CCCTCAGCAC GACCCCGCCA CCAGAAGTCC 1620

ATGTCCACTT CTGGTCATCC TATTAAAGTT ACACTGCCAA CCATTAAGGA CAGCTCTGAA 1680

GCTTATCGAC CTGGCAGTAC AACACAGAGA GTGCCTGCTG CTTCCCCATC TGCTCATAGT 1740

ATTAGTGCTG CCACTCCAGA CAGGACCCGT TTTCCCCGAG GGAGTTCAAG CCGAAGCACT 1800

TTCCATGGTG AACAGCTCCG GGAGCGACGC AGCGCAGCTT ATAATGGGCC ACCTGCTTCA 1860

CCATCCCATG AAACGGGTGC ATTTGCACAC GCCAGAAGGG GAACATCAAC TGGTATAATA 1920

AGCAAAATCA CATCCAAATT TGTTCGCAGG GATCCAAGTG AAGGCGAAGC CAGTGGCAGA 1980

ACCGACACCT CAAGAAGTAC GTCAGGGGAA CCAAAAGAAA GAGACAAGGA AGAGGGTAAA 2040

GATTCCAAAC CGCGTTCTTT GCGGTTCACG TGGAGCATGA AGACCACTAG TTCAATGGAC 2100

CCTAATGACA TGATGAGAGA AATCCGAAAA GTGTTAGATG CAAATAACTG TGATTATGAA 2160

CAAAAAGAGA GGTTTTTACT TTTCTGTGTC CATGGAGATG CTAGACAGGA CAGCCTGGTG 2220

CAGTGGGAGA TGGAAGTCTG CAAGTTGCCA CGGCTGTCAC TTAATGGGGT CCGATTCAAA 2280

CGAATATCTG GAACATCTAT TGCCTTTAAG AACATTGCAT CCAAAATAGC GAATGAGCTT 2340

AAGCTGTAA 2349

Domain Profile

S: 1     ykllktlGegsfgkVklakhketkekvavKiikkkklseeslekikrEieilkklkhpni  60

         y+l+kt+G+g+f+kVkla+h +t+++vavKii+k++l+ +sl+k++rE++i+k+l+hpni

Q: 43    YRLQKTIGKGNFAKVKLARHVLTGREVAVKIIDKTQLNPTSLQKLFREVRIMKILNHPNI  102

         99**********************************************************

S: 61    ikllevietkkklylvleyasggeLfdyieekgrlkekearklfkqlvsavkYlhskgiv  120

         +kl+eviet+k+lylv+eyasgge+fdy++++gr+kekear+ f+q+vsav+Y+h+k iv

Q: 103   VKLFEVIETEKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQYCHQKCIV  162

         ************************************************************

S: 121   HrDlKpeNllldkkenikiaDFGlanlfkegklletfcGsppYaaPellkgkkYegpkvD  180

         HrDlK+eNllld+++nikiaDFG++n+f+ g++l+tfcGsppYaaPel++gkkY+gp+vD

Q: 163   HRDLKAENLLLDADMNIKIADFGFSNEFTVGNKLDTFCGSPPYAAPELFQGKKYDGPEVD  222

         ************************************************************

S: 181   vWslGvvLyalvtgklPfdeenlkellekilkgkleipkklskelesLlrklLvvdpekR  240

         vWslGv+Ly+lv+g+lPfd++nlkel+e++l+gk++ip+++s+++e+Ll+klLv +p kR

Q: 223   VWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLKKLLVLNPIKR  282

         ************************************************************

S: 241   atieeilkhewl  252

          ++e+i+k++w+

Q: 283   GSLEQIMKDRWM  294

         ***********8

Domain Sequence
(FASTA)

YRLQKTIGKG NFAKVKLARH VLTGREVAVK IIDKTQLNPT SLQKLFREVR IMKILNHPNI 60

VKLFEVIETE KTLYLVMEYA SGGEVFDYLV AHGRMKEKEA RAKFRQIVSA VQYCHQKCIV 120

HRDLKAENLL LDADMNIKIA DFGFSNEFTV GNKLDTFCGS PPYAAPELFQ GKKYDGPEVD 180

VWSLGVILYT LVSGSLPFDG QNLKELRERV LRGKYRIPFY MSTDCENLLK KLLVLNPIKR 240

GSLEQIMKDR WM 252

Keyword

ATP-binding; Complete proteome; Nucleotide-binding; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Tetraodon nigroviridis"; ?>Tupaia belangeri"; ?>Tursiops truncatus"; ?>Vicugna pacos"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity

KEGG

InterPros

IPR001772	; Kinase-assoc_KA1.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.
IPR015940	; UBA/transl_elong_EF1B_N_euk.

Pfam

PF02149	; KA1; 1.
PF00069	; Pkinase; 1.

SMARTs

SM00220	; S_TKc; 1.
SM00165	; UBA; 1.

Prosites

PS50032	; KA1; 1.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.
PS50030	; UBA; 1.

Prints

Created Date

20-Feb-2013