EKS-OTG-00445

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-OTG-00445

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
AGC/DMPK	470.4	1.6E-141	76	338	263

Status

Unreviewed

Ensembl Protein

ENSOGAP00000010872

UniProt Accession

H0X6A1;

Protein Name

Protein Synonyms/Alias

Gene Name

ROCK1

Gene Synonyms/Alias

ROCK1;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSOGAG00000012135	ENSOGAP00000010872	ENSOGAT00000012154

Organism

Otolemur garnettii

Functional Description

Protein Length

1365

Protein Sequence
(FASTA)

MSTGDSFETR FEKIDNLLRD PKSEVNSDCL LDGLDALVYD LDFPALRKNK NIDNFLSRYK 60

DTINKIRDLR MKAEDYEVVK VIGRGAFGEV QLVRHKSTRK VYAMKLLSKF EMIKRSDSAF 120

FWEERDIMAF ANSPWVVQLF YAFQDDRYLY MVMEYMPGGD LVNLMSNYDV PEKWARFYTA 180

EVVLALDAIH SMGFIHRDVK PDNMLLDKSG HLKLADFGTC MKMNKEGMVR CDTAVGTPDY 240

ISPEVLKSQG GDGYYGRECD WWSVGVFLYE MLVGDTPFYA DSLVGTYSKI MNHKNSLTFP 300

DDNDISKEAK NLICAFLTDR EVRLGRNGVE EIKRHLFFKN DQWAWETLRD TVAPVVPDLS 360

SDIDTSNFDD LEEDKGDEET FPIPKAFVGN QLPFVGFTYY SNRRYLSSAN PNDNRTSSNV 420

DKSLQESLQK TIYKLEEQLH NEMQLKDEME QKCRTSNIKL DTIMKELDEE GSQRRNLEST 480

VSQIEKEKMV LQHRINEYQR KAEQENEKRR NVENEVSTLK DQLEDLKKVS QNSQLANEKL 540

AQLQKQLEEA NDLLRTESDT AVRLRKSHTE MSKSISQLES LNRELQERNR ILETSKSQTD 600

KDYYQLQAVL EAERRDRGHD SEMIGDLQAR ITSLQEEVKH LKHSLTEKEN KGSVYTRILT 660

LISQEKNNLE IDLNYKLKSL QQRLEQEVNE HKVTKARLTD KHQSIEEAKS VAMCEMEKKL 720

KEERETREKA ENRVVQIEKQ CSMLDVDLKQ SQQKLEHLAE NKERMEDEVK NLTLQLEQES 780

NKRLLLQNEL KTQAFEADNL KVLQKQMKQE INTLLEAKRL LEFELAQLTK QYRGNEGQMR 840

ELQDQLEAEQ YFSTLYKTQV KELKEEIEEK NRENLKKIQE LQNEKSLFLS QIKVFERNLK 900

LFKCYRNSLQ GQHSETLSKN KNKNYFVSKG YTVVNLLEET NSMLTKDIEL LRKENEELTE 960

KMKRAEEDYK LKKEEEIGNL KAAYEKNINT ERTLKTQAVN KLAEIMNRKD FKIDRKKANT 1020

QDLRKKEKEN RKLQLELNQE REKFNQMVVK HQKELNEMQA QLVEECTHRN ELQMQLASKE 1080

SDIEQLRAKL LDLSDSTSVA SFPSADETDG NLPVDSACIP YLFIFYSYQS RIEGWLSVPN 1140

RGNIKRYGWK KQYVVVSSKK ILFYNDEQDK EQSNPSMVLD IDKLFHVRPV TQGDVYRAET 1200

EEIPKIFQIL YANEGECRKD VEMEPVQQAE KTNFQNHKGH EFIPTLYHFP ANCEACAKPL 1260

WHVFKPPPAL ECRRCHVKCH RDHLDKKEDL ISPCKVSYDV TSARDMLLLA CSQDEQKKWV 1320

THLVKKIPKN PPSGFVRASP RTLSTRSTAN QSFRKVVKNT SGKTR 1365

Nucleotide Sequence
(FASTA)

ATGTCGACTG GGGACAGTTT TGAGACTCGA TTTGAAAAAA TCGACAACCT GCTGCGGGAT 60

CCCAAGTCGG AAGTGAATTC GGATTGTTTG CTGGATGGAT TGGATGCTTT GGTATATGAT 120

TTGGATTTTC CTGCCTTAAG AAAAAACAAA AACATTGACA ACTTTTTAAG CAGATATAAA 180

GATACAATAA ATAAAATTAG AGATTTACGA ATGAAAGCTG AAGATTATGA AGTAGTCAAG 240

GTGATTGGTA GAGGTGCATT TGGAGAAGTT CAATTGGTAA GGCATAAATC TACCAGGAAG 300

GTATATGCTA TGAAGCTTCT TAGCAAATTT GAAATGATTA AGAGATCTGA TTCTGCTTTT 360

TTCTGGGAAG AAAGAGACAT CATGGCTTTT GCTAACAGTC CCTGGGTTGT TCAGCTTTTC 420

TATGCATTCC AAGATGATCG TTATCTCTAC ATGGTGATGG AATACATGCC TGGTGGAGAT 480

CTTGTAAACT TAATGAGCAA CTATGATGTA CCTGAAAAAT GGGCACGTTT CTATACTGCA 540

GAAGTAGTTC TTGCATTGGA TGCAATTCAT TCCATGGGTT TTATCCATAG AGATGTGAAG 600

CCTGATAACA TGCTGCTGGA TAAATCTGGA CATTTGAAGT TAGCAGATTT TGGTACTTGT 660

ATGAAGATGA ATAAGGAAGG TATGGTACGA TGTGATACAG CAGTTGGAAC ACCTGATTAT 720

ATTTCCCCAG AGGTATTAAA ATCCCAAGGT GGTGATGGTT ATTATGGAAG AGAATGTGAC 780

TGGTGGTCTG TTGGGGTATT TTTATATGAG ATGCTTGTAG GTGATACACC TTTTTATGCA 840

GATTCTCTGG TTGGGACTTA TAGTAAGATT ATGAACCATA AAAATTCACT TACCTTCCCT 900

GATGACAATG ACATATCAAA AGAAGCAAAA AATCTTATTT GTGCCTTCCT TACTGACAGA 960

GAAGTGAGAT TAGGGCGAAA TGGTGTAGAA GAAATCAAAC GACATCTCTT CTTCAAAAAT 1020

GATCAGTGGG CTTGGGAAAC CCTTCGAGAC ACTGTAGCAC CAGTCGTACC TGATTTAAGT 1080

AGTGACATTG ATACTAGTAA TTTTGATGAC CTGGAAGAAG ATAAAGGAGA TGAAGAAACA 1140

TTCCCTATTC CTAAAGCTTT TGTTGGCAAT CAGCTACCTT TTGTAGGATT TACATATTAT 1200

AGCAATCGTA GATATTTATC TTCAGCAAAT CCTAATGATA ACAGAACTAG CTCCAATGTG 1260

GATAAAAGCT TGCAGGAAAG TTTGCAAAAA ACAATCTATA AGCTGGAAGA ACAGCTACAT 1320

AATGAAATGC AATTAAAAGA TGAAATGGAG CAGAAGTGCA GAACTTCAAA TATAAAACTA 1380

GACACAATAA TGAAAGAATT GGATGAAGAG GGAAGTCAAA GAAGAAATCT AGAATCTACA 1440

GTGTCCCAAA TAGAGAAAGA AAAAATGGTG CTACAGCATA GAATTAATGA ATACCAAAGA 1500

AAAGCTGAGC AGGAAAATGA AAAGAGGAGA AATGTAGAAA ATGAAGTTTC TACATTAAAG 1560

GATCAATTGG AAGACTTAAA GAAAGTAAGT CAGAATTCAC AGCTTGCTAA TGAGAAGCTG 1620

GCACAATTAC AAAAACAGCT AGAAGAAGCC AATGACTTAC TTAGGACAGA ATCGGACACA 1680

GCAGTAAGAT TAAGGAAGAG TCACACAGAG ATGAGCAAGT CAATTAGTCA GCTAGAGTCC 1740

CTGAACAGAG AATTGCAAGA GAGAAATAGA ATTTTAGAGA CTTCAAAATC ACAAACGGAC 1800

AAGGATTATT ACCAGCTACA GGCTGTATTG GAAGCTGAAC GAAGAGACAG GGGTCATGAT 1860

TCTGAGATGA TTGGAGACCT GCAAGCTCGA ATTACATCTT TGCAAGAGGA GGTGAAGCAT 1920

CTCAAACATA GCCTTACAGA AAAGGAAAAC AAGGGCTCAG TATATACGAG GATTCTTACT 1980

CTCATTTCAC AGGAAAAGAA TAATTTAGAG ATAGATTTAA ACTATAAACT TAAATCATTA 2040

CAACAGCGGT TAGAACAAGA GGTAAATGAA CACAAGGTAA CCAAAGCTCG TTTAACTGAC 2100

AAACATCAGT CTATTGAAGA GGCAAAGTCT GTTGCAATGT GTGAGATGGA AAAAAAGCTG 2160

AAAGAAGAGA GAGAAACTCG AGAGAAGGCT GAAAATAGGG TTGTTCAGAT TGAGAAACAA 2220

TGTTCCATGT TAGATGTTGA TCTGAAACAA TCTCAGCAGA AGCTAGAGCA TTTGGCTGAA 2280

AATAAAGAAA GGATGGAGGA TGAAGTTAAG AATCTAACCC TGCAACTGGA GCAGGAATCA 2340

AATAAGCGAC TGTTGTTACA AAATGAATTG AAGACTCAAG CATTTGAGGC GGACAATTTA 2400

AAGGTTTTAC AAAAGCAGAT GAAACAGGAA ATAAATACTT TATTGGAAGC AAAGAGGTTG 2460

TTAGAATTTG AGTTAGCTCA GCTTACAAAA CAATATAGAG GAAATGAAGG ACAAATGCGG 2520

GAACTACAAG ATCAGCTTGA AGCCGAGCAG TATTTCTCGA CACTTTATAA AACCCAGGTA 2580

AAAGAACTTA AAGAAGAAAT TGAAGAAAAA AACAGAGAAA ATTTAAAGAA AATACAGGAA 2640

CTGCAAAATG AAAAATCATT ATTTCTAAGT CAGATAAAGG TTTTTGAAAG AAATTTAAAA 2700

CTATTTAAAT GTTATAGAAA CTCCCTTCAA GGGCAACATA GTGAGACGCT TTCAAAAAAC 2760

AAAAACAAAA ACTACTTCGT GTCCAAGGGA TATACAGTAG TAAACCTTCT TGAAGAAACG 2820

AACAGCATGC TAACCAAAGA CATTGAATTA TTAAGAAAAG AAAATGAAGA GCTAACTGAG 2880

AAAATGAAGA GGGCAGAGGA AGACTATAAG TTGAAGAAGG AGGAGGAGAT CGGTAATCTT 2940

AAAGCTGCCT ATGAAAAGAA TATCAATACT GAACGAACTC TTAAAACCCA GGCTGTTAAC 3000

AAGCTGGCAG AAATAATGAA CCGAAAAGAT TTTAAAATTG ATAGAAAGAA AGCTAATACA 3060

CAAGATTTGA GAAAGAAAGA AAAGGAAAAT CGAAAGCTAC AACTGGAACT CAACCAAGAA 3120

AGAGAAAAAT TCAACCAGAT GGTAGTGAAA CATCAGAAGG AACTGAATGA GATGCAAGCG 3180

CAATTGGTAG AAGAATGTAC GCATAGGAAT GAGCTTCAGA TGCAGTTGGC TAGCAAAGAG 3240

AGTGATATCG AGCAATTGCG TGCTAAACTT TTGGACCTTT CGGATTCTAC AAGTGTTGCT 3300

AGTTTTCCTA GTGCTGATGA AACTGATGGA AACCTTCCAG TTGATTCTGC CTGCATTCCT 3360

TATTTATTTA TCTTCTATTC TTATCAATCA AGAATTGAAG GTTGGCTTTC TGTACCAAAT 3420

AGAGGAAATA TCAAACGATA TGGCTGGAAA AAACAGTATG TTGTAGTTAG CAGCAAAAAA 3480

ATTTTGTTCT ACAATGATGA ACAAGACAAG GAACAATCCA ATCCATCTAT GGTATTGGAC 3540

ATAGATAAAT TGTTTCATGT TCGACCTGTA ACCCAAGGAG ATGTGTATAG AGCTGAAACT 3600

GAAGAAATTC CTAAAATATT CCAGATACTA TATGCAAATG AAGGTGAATG TAGAAAAGAT 3660

GTAGAGATGG AACCAGTACA ACAAGCAGAG AAAACCAATT TCCAAAATCA CAAAGGCCAT 3720

GAGTTCATTC CTACCCTCTA CCACTTTCCT GCCAATTGTG AGGCCTGTGC CAAACCTCTC 3780

TGGCATGTTT TTAAGCCACC CCCAGCCCTA GAGTGTCGAA GATGCCATGT TAAGTGCCAC 3840

AGAGATCACT TAGATAAAAA AGAAGATTTA ATTTCTCCAT GTAAAGTAAG TTATGATGTA 3900

ACATCAGCAA GAGATATGCT GCTGTTAGCA TGTTCTCAGG ATGAACAAAA AAAATGGGTA 3960

ACACATTTAG TAAAGAAAAT CCCTAAGAAT CCACCATCTG GTTTTGTTCG TGCCTCCCCT 4020

CGAACTCTTT CTACAAGATC CACAGCAAAT CAGTCTTTCC GAAAAGTGGT CAAAAATACA 4080

TCTGGAAAAA CTAGGTAA 4098

Domain Profile

S: 1     feilkviGrGafgevavvrekatekvyamkilkklellkraesaffreerdvlvkadsew  60

         +e++kviGrGafgev++vr+k+t+kvyamk+l+k+e++kr++saff+eerd++++a+s+w

Q: 76    YEVVKVIGRGAFGEVQLVRHKSTRKVYAMKLLSKFEMIKRSDSAFFWEERDIMAFANSPW  135

         89**********************************************************

S: 61    ivqlqyafqdekylylvmeylvGGdlltllskyedklpeelarfylaelvlaldsvhelg  120

         +vql+yafqd++yly+vmey++GGdl++l+s+y+  +pe++arfy+ae+vlald++h++g

Q: 136   VVQLFYAFQDDRYLYMVMEYMPGGDLVNLMSNYD--VPEKWARFYTAEVVLALDAIHSMG  193

         **********************************..9***********************

S: 121   yvhrdikpdnilldksGhikladfGsclklnedgtvkssvavGtpdyispevlkaleegk  180

         ++hrd+kpdn+lldksGh+kladfG+c+k+n++g+v++++avGtpdyispevlk+++ g+

Q: 194   FIHRDVKPDNMLLDKSGHLKLADFGTCMKMNKEGMVRCDTAVGTPDYISPEVLKSQG-GD  252

         ********************************************************9.**

S: 181   geygkecdwwslGvilyellvgetpfyaeslvetyskilnhkeslkfpedekvseeakdl  240

         g+yg+ecdwws+Gv+lye+lvg+tpfya+slv tyski+nhk+sl+fp+d+++s+eak+l

Q: 253   GYYGRECDWWSVGVFLYEMLVGDTPFYADSLVGTYSKIMNHKNSLTFPDDNDISKEAKNL  312

         ************************************************************

S: 241   ikklltsreerlgregiedlkkhpff  266

         i+++lt+re rlgr+g+e++k+h ff

Q: 313   ICAFLTDREVRLGRNGVEEIKRHLFF  338

         *************************9

Domain Sequence
(FASTA)

YEVVKVIGRG AFGEVQLVRH KSTRKVYAMK LLSKFEMIKR SDSAFFWEER DIMAFANSPW 60

VVQLFYAFQD DRYLYMVMEY MPGGDLVNLM SNYDVPEKWA RFYTAEVVLA LDAIHSMGFI 120

HRDVKPDNML LDKSGHLKLA DFGTCMKMNK EGMVRCDTAV GTPDYISPEV LKSQGGDGYY 180

GRECDWWSVG VFLYEMLVGD TPFYADSLVG TYSKIMNHKN SLTFPDDNDI SKEAKNLICA 240

FLTDREVRLG RNGVEEIKRH LFF 263

Keyword

ATP-binding; Complete proteome; Kinase; Metal-binding; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase; Zinc; Zinc-finger.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Oryzias latipes"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005622	; C:intracellular
GO:0005524	; F:ATP binding
GO:0046872	; F:metal ion binding
GO:0005543	; F:phospholipid binding
GO:0004674	; F:protein serine/threonine kinase activity
GO:0000910	; P:cytokinesis
GO:0035556	; P:intracellular signal transduction

KEGG

InterPros

IPR000961	; AGC-kinase_C.
IPR011072	; HR1_rho-bd.
IPR011009	; Kinase-like_dom.
IPR011993	; PH_like_dom.
IPR017892	; Pkinase_C.
IPR001849	; Pleckstrin_homology.
IPR002219	; Prot_Kinase_C-like_PE/DAG-bd.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR020684	; Rho-assoc_coiled-coil_kin.
IPR015008	; Rho-bd.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF02185	; HR1; 1.
PF00169	; PH; 1.
PF00069	; Pkinase; 1.
PF00433	; Pkinase_C; 1.
PF08912	; Rho_Binding; 1.

SMARTs

SM00109	; C1; 1.
SM00233	; PH; 1.
SM00133	; S_TK_X; 1.
SM00220	; S_TKc; 1.

Prosites

PS51285	; AGC_KINASE_CTER; 1.
PS50003	; PH_DOMAIN; 1.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.
PS50081	; ZF_DAG_PE_2; 1.

Prints

Created Date

20-Feb-2013