EKS-OTG-00152
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-OTG-00152
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TK/FGFR558.61.8E-168482758277
StatusUnreviewed
Ensembl ProteinENSOGAP00000010920
UniProt AccessionH0X6E4;
Protein NameFibroblast growth factor receptor
Protein Synonyms/Alias
Gene NameFGFR2
Gene Synonyms/Alias FGFR2;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSOGAG00000012206ENSOGAP00000010920ENSOGAT00000012210
OrganismOtolemur garnettii
Functional Description
Protein Length822
Protein Sequence
(FASTA)
MVSWGHFICL VVVTMATLSL ARPSFNLVED TTLEPEEPPT KYQISQPEVY VAAPGESLEL 60
RCQLKDASMI SWTKDGVHMG PSNRTVLIGE YLQIKGATPR DSGLYACTAA RTVDSDTWYF 120
MVNVTDAISS GDDEDDTDGP EDFVSENSNN KRAPYWTNTE KMEKRLHAVP AANTVKFRCP 180
AGGNPTPTMR WLKNGKEFKQ EHRIGGYKVR NQHWSLIMES VVPSDKGNYT CVVENGYGSI 240
NHTYHLDVVE RSPHRPILQA GLPANASTVV GGDVEFVCKV YSDAQPHIQW IKHVEKNGSK 300
YGPDGLPYLK VLKHSGINSS NAEVLALFNV TEADAGEYIC KVSNYIGQAN QSAWLTVLPK 360
QQAPVREKEI TASPDYLEIA IYCIGVFLIT CMVVTVVLCR MKTTTKKPDF SSQPAVHKLT 420
KRIPLRRQVT VSAESSSSMN SNTPLVRITT RLSSTADTPM LAGVSEYELP EDPKWEFPRD 480
KLTLGKPLGE GCFGQVVMAE AVGIDKDKPK EAVTVAVKML KDDATEKDLS DLVSEMEMMK 540
MIGKHKNIIN LLGACTQDGP LYVIVEYASK GNLREYLRAR RPPGMEYSYD INRVPEEQMT 600
FKDLVSCTYQ LARGMEYLAS QKCIHRDLAA RNVLVTENNV MKIADFGLAR DINNIDYYKK 660
TTNGRLPVKW MAPEALFDRV YTHQSDVWSF GVLMWEIFTL GGSPYPGIPV EELFKLLKEG 720
HRMDKPANCT NELYMMMRDC WHAVPSQRPT FKQLVEDLDR ILTLTTNEEY LDLSQPLEQY 780
SPSSPDTRSS CSSGDDSVFS PDPMPYEPCL PQYPHRNGSV KT 822
Nucleotide Sequence
(FASTA)
ATGGTCAGCT GGGGGCACTT CATCTGCCTG GTCGTGGTCA CCATGGCAAC CTTGTCCCTG 60
GCCCGGCCCT CATTCAATTT AGTTGAGGAT ACCACATTAG AGCCGGAAGA GCCACCAACC 120
AAATACCAAA TCTCTCAACC AGAAGTTTAC GTGGCCGCAC CCGGGGAGTC GCTCGAGTTG 180
CGCTGCCAGT TGAAAGATGC CTCCATGATC AGTTGGACTA AGGATGGGGT ACACATGGGG 240
CCCAGCAATA GGACAGTGCT TATTGGGGAA TACTTGCAGA TAAAAGGCGC CACACCTAGA 300
GACTCCGGCC TCTATGCTTG TACTGCTGCT AGGACTGTAG ACAGTGACAC TTGGTACTTC 360
ATGGTGAATG TCACAGATGC CATCTCATCT GGAGATGATG AGGACGACAC AGATGGCCCT 420
GAGGATTTTG TCAGTGAGAA CAGTAACAAC AAGAGAGCCC CGTACTGGAC GAACACGGAG 480
AAGATGGAGA AGCGGCTCCA CGCGGTTCCT GCGGCCAACA CCGTCAAGTT CCGCTGCCCG 540
GCTGGGGGGA ACCCAACACC AACCATGAGG TGGCTGAAAA ACGGAAAGGA ATTTAAGCAG 600
GAGCATCGCA TCGGCGGCTA CAAGGTACGA AACCAGCATT GGAGCCTCAT TATGGAGAGT 660
GTGGTCCCGT CTGACAAAGG CAATTATACC TGCGTGGTGG AGAATGGATA CGGGTCCATC 720
AATCACACCT ACCACCTGGA TGTCGTCGAG CGATCGCCAC ACCGGCCCAT CCTCCAAGCT 780
GGACTGCCGG CAAACGCCTC CACGGTGGTT GGAGGGGACG TGGAGTTTGT CTGCAAAGTT 840
TACAGTGACG CCCAGCCCCA CATCCAGTGG ATCAAGCATG TGGAAAAGAA CGGCAGTAAA 900
TACGGGCCAG ACGGGCTGCC CTACCTCAAG GTTCTCAAGC ACTCGGGGAT AAATAGTTCC 960
AATGCAGAAG TGCTGGCTCT GTTCAATGTG ACTGAGGCGG ATGCTGGGGA GTATATATGT 1020
AAGGTCTCCA ATTATATAGG GCAGGCCAAC CAGTCTGCCT GGCTCACTGT CCTGCCCAAA 1080
CAGCAAGCTC CCGTAAGAGA AAAGGAGATC ACAGCTTCCC CAGACTACCT GGAGATAGCC 1140
ATTTACTGCA TAGGGGTCTT CTTAATCACC TGTATGGTGG TCACAGTCGT CTTGTGCCGA 1200
ATGAAGACCA CGACAAAGAA GCCAGACTTC AGCAGCCAGC CAGCTGTGCA CAAGCTGACC 1260
AAGCGCATCC CCCTGCGGAG ACAGGTAACA GTCTCTGCTG AGTCCAGCTC CTCCATGAAT 1320
TCCAACACCC CACTGGTGAG GATAACCACG CGCCTCTCCT CCACAGCGGA CACCCCCATG 1380
CTGGCCGGGG TCTCTGAGTA TGAACTGCCA GAGGACCCAA AATGGGAGTT TCCAAGGGAC 1440
AAGCTGACGC TGGGCAAACC CCTGGGGGAA GGCTGCTTTG GGCAAGTGGT CATGGCAGAA 1500
GCGGTGGGAA TCGATAAAGA TAAGCCCAAG GAGGCGGTCA CCGTGGCCGT GAAGATGCTG 1560
AAAGATGATG CCACAGAGAA GGACCTTTCT GATCTGGTAT CAGAGATGGA GATGATGAAG 1620
ATGATTGGGA AACACAAAAA TATCATAAAT CTTCTTGGAG CCTGTACTCA GGATGGGCCT 1680
CTGTACGTTA TAGTTGAGTA TGCCTCGAAA GGCAACCTCC GTGAATACCT CCGCGCCCGG 1740
AGGCCACCCG GGATGGAGTA CTCCTATGAC ATCAACCGCG TTCCCGAGGA GCAGATGACC 1800
TTCAAGGACT TGGTGTCATG CACCTACCAG CTGGCCAGAG GCATGGAGTA TTTGGCTTCC 1860
CAAAAGTGTA TCCATCGAGA TTTAGCAGCC AGGAATGTTT TGGTAACAGA AAACAATGTG 1920
ATGAAAATAG CAGACTTTGG ACTGGCCAGA GATATCAACA ATATAGACTA TTACAAAAAG 1980
ACTACAAATG GGCGACTTCC AGTCAAATGG ATGGCTCCAG AAGCGCTTTT TGATAGAGTA 2040
TACACGCACC AGAGCGATGT CTGGTCCTTT GGGGTGTTAA TGTGGGAGAT CTTCACATTA 2100
GGGGGCTCAC CCTACCCAGG GATTCCTGTG GAGGAACTGT TTAAGCTGCT GAAGGAGGGA 2160
CACAGGATGG ATAAGCCGGC GAACTGCACC AATGAACTGT ATATGATGAT GAGGGACTGT 2220
TGGCATGCAG TCCCCTCCCA GAGACCGACG TTCAAGCAGC TGGTGGAGGA CTTAGACCGG 2280
ATTCTCACTC TCACAACCAA TGAGGAATAC TTGGACCTCA GTCAGCCTCT CGAACAGTAT 2340
TCTCCTAGTT CCCCTGACAC AAGGAGTTCT TGTTCTTCAG GAGATGACTC TGTTTTCTCT 2400
CCAGACCCCA TGCCTTACGA ACCATGCCTT CCTCAGTACC CACACAGAAA TGGCAGTGTT 2460
AAGACATGA 2469
Domain Profile
S: 1     lvlgkllGeGafGqvvkaeaigldkdkekkevtvavkmlkedatdkdladlvsemevlkl  60
         l+lgk+lGeG+fGqvv+aea+g+dkdk+k++vtvavkmlk+dat+kdl+dlvseme++k+
Q: 482   LTLGKPLGEGCFGQVVMAEAVGIDKDKPKEAVTVAVKMLKDDATEKDLSDLVSEMEMMKM  541
         79**********************************************************
S: 61    iGkhkniinllGactqeGplyviveyaakGnlreflrarrpkgeeaskdkskaseeqlte  120
         iGkhkniinllGactq+Gplyviveya+kGnlre+lrarrp+g+e+s+d ++++eeq+t+
Q: 542   IGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLRARRPPGMEYSYDINRVPEEQMTF  601
         ************************************************************
S: 121   kdlvsfayqvarGmeylaskkcihrdlaarnvlvtednvlkiadfGlardvheidyykkt  180
         kdlvs++yq+arGmeylas+kcihrdlaarnvlvte+nv+kiadfGlard+++idyykkt
Q: 602   KDLVSCTYQLARGMEYLASQKCIHRDLAARNVLVTENNVMKIADFGLARDINNIDYYKKT  661
         ************************************************************
S: 181   tnGrlpvkwmapealfdrvytsqsdvwsfGvllweiltlGgspypgiaveelfkllkeGh  240
         tnGrlpvkwmapealfdrvyt+qsdvwsfGvl+wei+tlGgspypgi+veelfkllkeGh
Q: 662   TNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFTLGGSPYPGIPVEELFKLLKEGH  721
         ************************************************************
S: 241   rmekpakctkelyvlmrecwhakaserptfkqlvedl  277
         rm+kpa+ct+ely++mr+cwha++s+rptfkqlvedl
Q: 722   RMDKPANCTNELYMMMRDCWHAVPSQRPTFKQLVEDL  758
         ***********************************97
Domain Sequence
(FASTA)
LTLGKPLGEG CFGQVVMAEA VGIDKDKPKE AVTVAVKMLK DDATEKDLSD LVSEMEMMKM 60
IGKHKNIINL LGACTQDGPL YVIVEYASKG NLREYLRARR PPGMEYSYDI NRVPEEQMTF 120
KDLVSCTYQL ARGMEYLASQ KCIHRDLAAR NVLVTENNVM KIADFGLARD INNIDYYKKT 180
TNGRLPVKWM APEALFDRVY THQSDVWSFG VLMWEIFTLG GSPYPGIPVE ELFKLLKEGH 240
RMDKPANCTN ELYMMMRDCW HAVPSQRPTF KQLVEDL 277
KeywordATP-binding; Complete proteome; Immunoglobulin domain; Kinase; Membrane; Nucleotide-binding; Phosphoprotein; Receptor; Reference proteome; Repeat; Transferase; Transmembrane; Transmembrane helix; Tyrosine-protein kinase.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>
EKS-AIM-00139
EKS-ANC-00140
EKS-BOT-00148
EKS-CAJ-00155
EKS-CAF-00154
EKS-CAP-00147
EKS-DAR-00432
EKS-DRM-00071
EKS-EQC-00145
EKS-FEC-00140
EKS-GAM-00078
EKS-GAG-00125
EKS-GAA-00175
EKS-GOG-00147
EKS-HOS-00152
EKS-ICT-00144
EKS-LAC-00158
EKS-LOA-00149
EKS-MAM-00147
EKS-MOD-00147
EKS-MUM-00151
EKS-MUP-00151
EKS-NOL-00141
EKS-ORN-00182
EKS-ORC-00138
EKS-ORL-00170
EKS-PAT-00137
EKS-PES-00132
EKS-POA-00143
EKS-PTV-00139
EKS-RAN-00145
EKS-SAH-00142
EKS-TAG-00176
EKS-TAR-00191
EKS-TEN-00183
EKS-XET-00137
EKS-XIM-00176
Gene Ontology
GO:0016021; C:integral to membrane
GO:0005524; F:ATP binding
GO:0005007; F:fibroblast growth factor-activated receptor activity
GO:0008284; P:positive regulation of cell proliferation
KEGG
InterPros
IPR007110; Ig-like.
IPR013783; Ig-like_fold.
IPR013098; Ig_I-set.
IPR003598; Ig_sub2.
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
IPR008266; Tyr_kinase_AS.
IPR020635; Tyr_kinase_cat_dom.
IPR016248; Tyr_kinase_fibroblast_GF_rcpt.
Pfam
PF07679; I-set; 3.
PF07714; Pkinase_Tyr; 1.
SMARTs
SM00408; IGc2; 3.
SM00219; TyrKc; 1.
Prosites
PS50835; IG_LIKE; 3.
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00109; PROTEIN_KINASE_TYR; 1.
Prints
PR00109; TYRKINASE.
Created Date20-Feb-2013