EKS-OTG-00159

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-OTG-00159

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
AGC/NDR	497.9	8.4E-150	708	1013	306

Status

Unreviewed

Ensembl Protein

ENSOGAP00000011201

UniProt Accession

H0X731;

Protein Name

Protein Synonyms/Alias

Gene Name

LATS1

Gene Synonyms/Alias

LATS1;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSOGAG00000012508	ENSOGAP00000011201	ENSOGAT00000012511

Organism

Otolemur garnettii

Functional Description

Protein Length

1133

Protein Sequence
(FASTA)

MKRSEKPEGY RQMRPKTFPA SNYTGSSRQM LQEIRESLRN LSKPSDAAKA EHNMSKMSTE 60

DPRQVRNPPK FGTHHKALQE IRNSLLPFAN ETSSSSQSTS EVNPQMLQDL QAAGFDEDMV 120

IQALQKTNNR SIEAAIEFIS KMSYQDPRWE QMATAAARPI NASMKPDVGS VQQSVNRKQS 180

WKGSKESLVP QRHGPPLGES VAYHSESPNS QTDVGRPLSG SGITAFAQPH PSNGQRVNPP 240

PPPQVRSVTP PPPPRGQTPP PRGTTPPPPS WEPNSQTKRY SGNMEYVISR ISPVPPGAWQ 300

EGYPPPPLNT SPMNPPNQGQ RGINSVPVGR QPIIMQSSSK FNFPPGRSGI QNGNGQTEFM 360

IHQNVVPAGT VNRQPPPPYP LTPTNGQSPS ALQTGGSAAP SSYTNGNVPQ SMMVPNRNSH 420

NMELYNINVP GLPTNWPQSS SAPAQSSPSS GHEIPTWQSN IPVRSNSFNN PLGSRTNHSA 480

NSQPSATTVT AITPAPIQQP VKSMRVLKPE LQTALAPTHP SWIPQPTQTV QPSPFPEGTN 540

SNVTVIPPVA EAPNYQGPPP PYPKHLLHQN PSVAPYESVN KSSKEDQPSL AKDDEGEKNY 600

ENVDSGDKEK KQITTSPITV RKNKKDEERR ESRIQSYSPQ AFKFFMEQHV ENVLKSHQQR 660

LHRKKQLENE MMRVGLSQDA QDQMRKMLCQ KESNYIRLKR AKMDKSMFVK IKTLGIGAFG 720

EVCLARKVDT KALYATKTLR KKDVLLRNQV AHVKAERDIL AEADNEWVVR LYYSFQDKDN 780

LYFVMDYIPG GDMMSLLIRM GIFPENLARF YIAELTCAVE SVHKMGFIHR DIKPDNILID 840

RDGHIKLTDF GLCTGFRWTH DSKYYQSGKH PSDYHSKCQN EMSEKSNCRC GDRLKPLERR 900

AARQHQRCLA HSLVGTPNYI APEVLLRTGY TQLCDWWSVG VILFEMLVGQ PPFLAKTPLE 960

TQMKVINWQT SLHIPPQAKL SPEASDLIIK LCRGPEDRLG KNGADEIKAH PFFKTIDFSS 1020

DLRRQSASYI PKITHPTDTS NFDPVDPDKL WSDDNEEENV NDTLNGWYKN GKHPEHAFYE 1080

FTFRRFFDDN GYPYNYPKPI EYEYINSQGS EQQSDEDDQH PGSEIKNRDL VYV 1133

Nucleotide Sequence
(FASTA)

ATGAAGAGGA GTGAAAAGCC AGAAGGATAT AGACAAATGA GGCCTAAGAC CTTTCCTGCC 60

AGTAACTACA CTGGCAGCAG CCGGCAAATG CTGCAAGAAA TTCGGGAATC CCTTAGGAAT 120

TTATCCAAAC CATCCGATGC TGCTAAGGCT GAGCATAACA TGAGCAAAAT GTCAACTGAA 180

GATCCTCGAC AAGTCAGAAA TCCACCCAAA TTTGGGACAC ATCATAAAGC CTTGCAGGAG 240

ATTCGAAACT CCTTACTACC ATTTGCAAAT GAAACAAGTT CTTCTTCCCA GAGTACCTCA 300

GAAGTCAATC CACAAATGCT TCAAGACTTG CAGGCTGCTG GATTTGATGA GGACATGGTT 360

ATACAAGCTC TTCAGAAAAC TAATAACAGA AGTATAGAAG CAGCAATTGA ATTCATTAGT 420

AAAATGAGTT ATCAAGATCC TCGATGGGAA CAGATGGCTA CAGCAGCTGC CAGACCTATT 480

AATGCCAGCA TGAAGCCAGA TGTAGGGAGT GTACAACAAT CAGTTAACCG CAAACAAAGC 540

TGGAAAGGTT CTAAAGAATC CTTAGTTCCT CAGAGACATG GCCCACCACT AGGAGAAAGC 600

GTGGCCTATC ATTCTGAAAG TCCCAACTCG CAAACAGACG TAGGAAGACC TTTGTCTGGA 660

TCTGGTATAA CGGCATTTGC TCAGCCTCAT CCTAGCAATG GACAGAGAGT AAACCCACCA 720

CCACCACCTC AAGTAAGGAG TGTCACTCCT CCACCACCTC CAAGGGGCCA GACTCCCCCT 780

CCAAGAGGCA CAACTCCACC TCCCCCTTCA TGGGAACCAA ACTCTCAAAC AAAACGCTAT 840

TCTGGGAATA TGGAATATGT AATCTCCCGA ATCTCTCCTG TTCCACCTGG GGCATGGCAG 900

GAAGGCTATC CTCCACCACC TCTTAACACT TCACCCATGA ATCCTCCTAA TCAAGGACAG 960

AGAGGAATCA ATTCTGTTCC TGTTGGCAGA CAACCAATCA TCATGCAGAG TTCTAGCAAG 1020

TTTAACTTTC CACCAGGGAG ATCTGGAATT CAGAATGGTA ATGGTCAAAC TGAGTTTATG 1080

ATACATCAAA ATGTTGTCCC TGCTGGCACT GTGAATCGGC AGCCACCCCC ACCATATCCT 1140

CTGACCCCAA CTAATGGACA AAGCCCTTCT GCTCTACAAA CAGGGGGATC TGCTGCTCCT 1200

TCATCATATA CAAATGGAAA TGTTCCTCAG TCTATGATGG TGCCAAACAG AAATAGTCAT 1260

AACATGGAAC TGTATAACAT TAATGTACCT GGACTGCCAA CAAATTGGCC ACAGTCATCT 1320

TCTGCTCCAG CCCAGTCATC CCCGAGCAGT GGGCATGAAA TCCCTACATG GCAATCTAAC 1380

ATACCAGTGA GGTCAAATTC TTTTAATAAC CCGTTAGGAA GTAGAACAAA TCACTCTGCT 1440

AATTCTCAGC CTTCAGCTAC AACTGTCACT GCAATCACAC CAGCTCCTAT TCAACAACCT 1500

GTGAAAAGCA TGCGTGTTTT AAAACCAGAG CTACAGACTG CGTTGGCACC TACCCACCCT 1560

TCTTGGATAC CACAACCAAC TCAAACTGTT CAACCCAGTC CTTTTCCTGA GGGTACCAAT 1620

TCAAATGTGA CTGTCATACC ACCTGTTGCT GAAGCTCCAA ACTATCAAGG TCCACCACCA 1680

CCTTATCCAA AACATCTCCT ACACCAGAAC CCGTCTGTTG CACCATATGA ATCAGTAAAT 1740

AAATCTAGCA AAGAGGATCA GCCTAGCTTG GCCAAAGATG ATGAGGGTGA AAAAAATTAT 1800

GAAAATGTTG ACAGTGGGGA CAAAGAAAAG AAACAGATTA CAACTTCACC TATCACTGTG 1860

AGGAAAAACA AGAAAGATGA AGAGCGAAGA GAATCCCGTA TTCAAAGTTA TTCCCCTCAG 1920

GCATTTAAAT TCTTTATGGA GCAACACGTA GAAAACGTAC TCAAATCTCA TCAACAACGT 1980

CTACATCGTA AAAAACAATT AGAGAATGAA ATGATGCGGG TTGGATTATC TCAAGATGCC 2040

CAGGATCAAA TGAGAAAGAT GCTTTGCCAA AAAGAATCTA ATTACATCCG TCTTAAAAGG 2100

GCTAAAATGG ACAAGTCTAT GTTTGTGAAG ATAAAGACAC TAGGAATAGG AGCATTTGGT 2160

GAAGTTTGTC TAGCAAGAAA AGTAGATACT AAGGCTTTGT ATGCAACAAA AACTCTCCGA 2220

AAGAAAGATG TTCTGCTTCG AAATCAAGTC GCCCATGTTA AAGCTGAAAG AGATATCCTG 2280

GCTGAAGCTG ACAATGAATG GGTAGTTCGT CTGTATTATT CATTCCAAGA TAAGGACAAT 2340

TTATACTTTG TAATGGACTA CATTCCTGGG GGTGATATGA TGAGCCTATT AATCAGAATG 2400

GGCATTTTTC CAGAAAATCT GGCACGATTC TATATAGCAG AACTTACCTG TGCAGTCGAA 2460

AGTGTTCATA AAATGGGTTT TATTCATAGA GATATTAAAC CTGATAACAT TTTGATTGAT 2520

CGTGATGGTC ATATTAAATT GACTGACTTC GGCCTCTGCA CTGGCTTCAG ATGGACGCAT 2580

GATTCTAAGT ACTATCAAAG TGGTAAACAT CCCAGTGATT ATCACAGCAA GTGTCAAAAT 2640

GAAATGTCAG AGAAATCAAA CTGTAGATGT GGAGATAGAC TGAAACCACT AGAGCGGAGA 2700

GCTGCACGTC AGCACCAACG ATGTCTAGCA CATTCTTTGG TTGGAACTCC CAATTATATT 2760

GCACCTGAAG TGTTGCTACG AACAGGATAC ACACAGTTGT GTGATTGGTG GAGTGTCGGT 2820

GTTATTCTTT TTGAAATGTT GGTGGGACAG CCTCCTTTCC TGGCAAAAAC ACCATTAGAA 2880

ACACAGATGA AGGTTATCAA CTGGCAAACA TCTCTTCACA TTCCACCACA AGCTAAACTG 2940

AGTCCTGAAG CTTCTGATCT TATTATCAAA CTTTGCCGAG GACCAGAAGA TCGCTTAGGC 3000

AAGAATGGTG CTGATGAAAT AAAAGCTCAT CCATTTTTTA AAACAATCGA TTTCTCTAGT 3060

GACCTGAGAC GTCAGTCTGC TTCATACATT CCTAAAATCA CACACCCAAC AGATACATCT 3120

AATTTTGATC CTGTTGATCC TGATAAGTTA TGGAGTGATG ATAATGAGGA AGAAAATGTA 3180

AATGACACTC TCAACGGATG GTATAAAAAT GGAAAGCATC CTGAACATGC TTTCTATGAA 3240

TTTACCTTTC GGAGATTTTT TGATGACAAC GGCTACCCAT ATAATTACCC AAAGCCTATT 3300

GAATATGAAT ACATTAATTC ACAAGGCTCC GAGCAACAAT CAGATGAAGA TGATCAACAC 3360

CCAGGCTCAG AGATCAAAAA TCGAGATCTA GTATATGTGT AA 3402

Domain Profile

S: 1     feklkvigkGafGevrlvrkkdtkevyalkilrkkdllkknqvahvkaerdilaeadsew  60

         f k+k++g+GafGev+l+rk dtk++ya+k+lrkkd+l +nqvahvkaerdilaead+ew

Q: 708   FVKIKTLGIGAFGEVCLARKVDTKALYATKTLRKKDVLLRNQVAHVKAERDILAEADNEW  767

         889*********************************************************

S: 61    vvklyysfqdkenlylvmeylPGGdlmtllikkeilkeelarfyiaelvlavesvhklGf  120

         vv+lyysfqdk+nly+vm+y+PGGd+m+lli+++i++e+larfyiael++avesvhk+Gf

Q: 768   VVRLYYSFQDKDNLYFVMDYIPGGDMMSLLIRMGIFPENLARFYIAELTCAVESVHKMGF  827

         ************************************************************

S: 121   ihrdlkPdnllidakGhikltdfGlctGlkkthrseyykelekakeddlease.......  173

         ihrd+kPdn+lid++GhikltdfGlctG+++th+s+yy++ ++  + + + ++

Q: 828   IHRDIKPDNILIDRDGHIKLTDFGLCTGFRWTHDSKYYQSGKHPSDYHSKCQNemseksn  887

         ***************************************999987766655556777889

S: 174   .....elkvlerrkkkknrrllayslvGtpdyiapevlekkgynklcdwWslGvilyeml  228

              +lk+lerr++++++r+la+slvGtp+yiapevl+++gy++lcdwWs+Gvil+eml

Q: 888   crcgdRLKPLERRAARQHQRCLAHSLVGTPNYIAPEVLLRTGYTQLCDWWSVGVILFEML  947

         ****99******************************************************

S: 229   vGypPflaetpqetykkvinwketlkfpeevelseeakdlierliadaekrlgkkGvdei  288

         vG+pPfla+tp et++kvinw+++l++p++++ls+ea+dli +l+  +e+rlgk+G+dei

Q: 948   VGQPPFLAKTPLETQMKVINWQTSLHIPPQAKLSPEASDLIIKLCRGPEDRLGKNGADEI  1007

         ************************************************************

S: 289   kkhpff  294

         k+hpff

Q: 1008  KAHPFF  1013

         *****9

Domain Sequence
(FASTA)

FVKIKTLGIG AFGEVCLARK VDTKALYATK TLRKKDVLLR NQVAHVKAER DILAEADNEW 60

VVRLYYSFQD KDNLYFVMDY IPGGDMMSLL IRMGIFPENL ARFYIAELTC AVESVHKMGF 120

IHRDIKPDNI LIDRDGHIKL TDFGLCTGFR WTHDSKYYQS GKHPSDYHSK CQNEMSEKSN 180

CRCGDRLKPL ERRAARQHQR CLAHSLVGTP NYIAPEVLLR TGYTQLCDWW SVGVILFEML 240

VGQPPFLAKT PLETQMKVIN WQTSLHIPPQ AKLSPEASDL IIKLCRGPED RLGKNGADEI 300

KAHPFF 306

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Erinaceus europaeus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tarsius syrichta"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity

KEGG

InterPros

IPR000961	; AGC-kinase_C.
IPR011009	; Kinase-like_dom.
IPR017892	; Pkinase_C.
IPR000719	; Prot_kinase_cat_dom.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.
IPR009060	; UBA-like.
IPR000449	; UBA/transl_elong_EF1B_N.
IPR015940	; UBA/transl_elong_EF1B_N_euk.

Pfam

PF00069	; Pkinase; 2.
PF00433	; Pkinase_C; 1.
PF00627	; UBA; 1.

SMARTs

SM00133	; S_TK_X; 1.
SM00220	; S_TKc; 1.

Prosites

PS51285	; AGC_KINASE_CTER; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.
PS50030	; UBA; 1.

Prints

Created Date

20-Feb-2013