EKS-OTG-00403
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-OTG-00403
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TK/PDGFR609.32.3E-183595954360
StatusUnreviewed
Ensembl ProteinENSOGAP00000011236
UniProt AccessionH0X762;
Protein NameTyrosine-protein kinase receptor
Protein Synonyms/Alias
Gene NamePDGFRA
Gene Synonyms/Alias PDGFRA;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSOGAG00000012544ENSOGAP00000011236ENSOGAT00000012548
OrganismOtolemur garnettii
Functional Description
Protein Length1095
Protein Sequence
(FASTA)
MGTSHGAFLV VGCLLTGPGL ILCQLSFPSI LPNENEKVVQ LNSSFSLRCF GESEVSWQYP 60
MSEEENPSVE VRTEENNSGF FVKVLEVANA SAAHTGLYTC YYNHTQTEEG EPEGRHVYIY 120
VPATDPDVAF VPLGMTDYLV IVEDDDSAII PCRTTDPETP VTLHNSEGVV PASYDSRQGF 180
NGTFTVGPYV CEATVNGKKF QTIPFNVYAL KATSELDLEM KALKTVYKAG ETIEVTCAVF 240
NNEVVDLKWT YPGEMKGKGI TRLDEIKMPS IKLVYTLSVP KATVKDSGDY ECAARQATKE 300
VKEMKRVTIS VHEKGFIEIK PTFSHLEAVN LHEVKHFVVD VQAYPPPRIS WLKDNLTLIE 360
NLTEITTDVE KIQEIRYRSK LKLIRAKEED SGHYTIVVQN EDDTKSYTFE LLTQVPASIL 420
DLVDDHHGST GGQTVRCTAE GTPLPDIEWL ICKDIKKCNN ETSWTVLATN VSNMVTELHA 480
QDRSTVEGRV TFAKVEETIA VRCLAKNLLG AENRELKLVA PTLRSELTVA AAVLVLLVIV 540
IISLIVLVVI WKQKPRYEIR WRVIESISPD GHEYIYVDPM QLPYDSRWEF PRDGLVLGRV 600
LGSGAFGKVV EGTAYGLSRS QPVMKVAVKM LKPTATARSS EKQALMSELK IMTHLGPHLN 660
IVNLLGACTK SGPIYIITEY CFYGDLVNYL HKNRDSFLSH HPEKPKKDLD IFGLNPADES 720
TRSYVILSFE NNGDYMDMKQ ADTTQYVPML ERKEVPKYSD IQRSLYDRPA SYKKKSMLDS 780
EVKNLLSDDN SEGLTLLDLL SFTYQVARGM EFLASKNCVH RDLAARNVLL AQGKIVKICD 840
FGLARDIMHD SNYVSKGSTF LPVKWMAPES IFDNLYTTLS DVWSYGILLW EIFSLGGTPY 900
PGMMVDSTFY NKIKSGYRMA KPDHATSEVY EIMVKCWNSE PEKRPSFYHL SEIVENLLPG 960
QYKKSYEKIH LDFLKSDHPA VARMRVDSDN AYIGVTYKNE EDKLKDWEGG LDEQRLSADS 1020
GYIIPLPDID PAPEEEDLGK RNRHRSSSQT SEESAIETGS SSSTFIKRAD ETIEDIDMMD 1080
DIGIDSSDLV EDSFL 1095
Nucleotide Sequence
(FASTA)
ATGGGGACTT CCCACGGGGC CTTCCTGGTC GTAGGCTGTC TCCTCACAGG GCCGGGCCTA 60
ATCCTCTGCC AGCTTTCATT CCCTTCGATC CTCCCAAACG AGAACGAGAA GGTCGTGCAG 120
CTGAATTCAT CCTTTTCTCT GAGATGCTTT GGGGAGAGTG AAGTGAGCTG GCAGTACCCC 180
ATGTCTGAAG AAGAGAACCC CAGTGTGGAG GTCAGAACTG AGGAGAACAA CAGCGGCTTC 240
TTTGTGAAGG TGCTGGAGGT GGCCAACGCC TCGGCCGCGC ACACGGGGCT GTACACCTGC 300
TATTACAACC ACACTCAGAC AGAGGAGGGC GAGCCTGAAG GCCGGCACGT GTACATCTAC 360
GTGCCAGCCA CAGACCCAGA TGTAGCCTTC GTACCTCTGG GAATGACCGA CTATTTAGTC 420
ATCGTGGAGG ATGATGACTC CGCCATCATT CCTTGTCGCA CGACTGATCC TGAGACTCCC 480
GTCACCTTAC ATAACAGCGA GGGGGTGGTA CCTGCTTCCT ATGACAGCAG ACAGGGCTTT 540
AACGGGACCT TCACTGTCGG GCCCTATGTC TGTGAGGCCA CCGTCAACGG AAAGAAGTTC 600
CAGACCATCC CGTTTAATGT TTATGCCTTG AAAGCAACAT CAGAACTGGA TCTAGAAATG 660
AAAGCTCTCA AAACTGTGTA CAAGGCAGGA GAAACCATCG AGGTCACCTG TGCTGTCTTT 720
AACAATGAAG TGGTTGACCT GAAGTGGACG TACCCCGGAG AAATGAAAGG CAAAGGCATC 780
ACCAGGCTGG ATGAAATCAA AATGCCGTCC ATTAAATTGG TGTACACGTT GAGCGTCCCC 840
AAGGCCACAG TGAAAGACAG CGGTGATTAC GAATGTGCTG CTCGCCAGGC TACCAAGGAG 900
GTGAAAGAAA TGAAGAGAGT CACCATTTCT GTTCACGAGA AAGGGTTCAT TGAAATCAAA 960
CCCACCTTCA GCCACTTGGA GGCCGTCAAC CTGCATGAAG TGAAGCACTT CGTGGTGGAC 1020
GTGCAGGCCT ACCCGCCTCC CAGGATATCC TGGCTGAAGG ACAACCTGAC TCTGATTGAG 1080
AATCTCACGG AGATCACCAC CGATGTGGAA AAGATTCAGG AAATAAGGTA TCGAAGTAAG 1140
TTGAAGCTGA TCCGTGCTAA GGAAGAAGAC AGTGGCCATT ATACCATTGT GGTTCAAAAT 1200
GAAGATGACA CGAAGAGCTA TACGTTCGAA CTGTTAACTC AAGTGCCCGC GTCCATCCTG 1260
GACCTGGTTG ATGACCACCA CGGCTCCACG GGGGGACAGA CCGTGAGGTG CACGGCTGAA 1320
GGCACACCCC TTCCTGATAT CGAGTGGCTG ATTTGCAAGG ATATTAAGAA GTGTAACAAT 1380
GAAACTTCAT GGACGGTCTT GGCCACCAAC GTCTCCAACA TGGTCACAGA GCTCCATGCA 1440
CAGGACAGGA GCACAGTAGA GGGCCGAGTG ACATTCGCCA AGGTGGAAGA GACCATTGCA 1500
GTTCGATGCC TGGCCAAGAA CCTCCTGGGG GCTGAGAACC GAGAACTGAA GCTGGTGGCG 1560
CCCACCTTGC GTTCTGAACT CACGGTGGCA GCCGCGGTTC TGGTGCTGTT GGTGATTGTG 1620
ATCATTTCAC TCATTGTCCT GGTCGTCATC TGGAAGCAGA AACCGAGGTA TGAAATTCGC 1680
TGGAGGGTCA TCGAGTCAAT CAGCCCTGAT GGACATGAAT ATATTTATGT GGACCCAATG 1740
CAACTGCCTT ACGACTCGAG ATGGGAGTTT CCAAGAGATG GACTCGTGCT TGGTCGCGTC 1800
TTGGGATCTG GAGCATTTGG GAAAGTGGTG GAGGGAACAG CCTACGGATT AAGCCGGTCT 1860
CAGCCCGTCA TGAAGGTAGC GGTGAAGATG CTGAAACCAA CAGCCACGGC CAGATCCAGT 1920
GAGAAACAAG CTCTCATGTC TGAACTGAAG ATAATGACTC ACCTGGGGCC GCATTTAAAC 1980
ATCGTGAACT TGCTGGGAGC CTGCACCAAG TCAGGCCCCA TTTACATCAT CACAGAGTAC 2040
TGCTTCTACG GGGATCTGGT CAACTATCTG CACAAGAATC GGGACAGCTT CCTGAGCCAC 2100
CACCCGGAGA AGCCCAAGAA GGACCTGGAC ATCTTTGGGC TGAACCCCGC TGATGAAAGC 2160
ACACGGAGCT ATGTTATTTT ATCTTTTGAA AACAATGGTG ACTACATGGA CATGAAGCAG 2220
GCCGACACCA CACAATACGT CCCTATGCTG GAAAGGAAAG AGGTCCCTAA ATATTCAGAC 2280
ATCCAGAGGT CACTGTATGA TCGTCCAGCC TCATACAAGA AGAAATCAAT GTTAGACTCA 2340
GAAGTGAAAA ACCTCCTTTC AGACGATAAC TCAGAAGGCC TCACTTTGTT GGATTTGTTG 2400
AGCTTCACCT ATCAAGTTGC CCGAGGAATG GAGTTTTTGG CTTCAAAAAA TTGTGTCCAC 2460
CGTGACCTGG CTGCTCGGAA TGTCCTCCTG GCACAAGGGA AAATCGTGAA GATCTGTGAT 2520
TTTGGCCTGG CCAGAGACAT CATGCATGAT TCAAACTACG TGTCAAAGGG CAGCACCTTT 2580
CTGCCCGTGA AGTGGATGGC TCCGGAAAGC ATCTTTGACA ACCTCTACAC CACCCTGAGC 2640
GACGTCTGGT CTTACGGCAT TCTGCTCTGG GAGATCTTCT CCCTCGGTGG CACGCCTTAC 2700
CCTGGCATGA TGGTGGATTC CACATTCTAC AATAAGATCA AGAGTGGATA CCGGATGGCC 2760
AAACCTGACC ACGCCACCAG CGAAGTCTAT GAGATCATGG TGAAGTGCTG GAACAGTGAG 2820
CCGGAGAAGA GACCCTCCTT CTACCACTTG AGTGAGATTG TGGAGAATCT GCTTCCTGGA 2880
CAATATAAAA AGAGTTATGA AAAAATTCAC CTGGACTTCC TGAAGAGTGA CCATCCCGCC 2940
GTGGCACGCA TGCGTGTAGA TTCGGACAAT GCCTACATTG GTGTCACCTA CAAAAATGAG 3000
GAGGACAAGC TGAAGGACTG GGAGGGCGGC CTCGACGAGC AGAGACTGAG CGCAGACAGC 3060
GGCTACATCA TCCCTCTGCC CGACATTGAC CCCGCCCCAG AGGAGGAGGA CCTGGGCAAG 3120
AGGAACAGAC ACAGGTCCAG CTCACAGACC TCTGAAGAGA GTGCCATTGA GACAGGTTCC 3180
AGCAGCTCCA CCTTCATCAA GAGGGCGGAT GAGACTATCG AGGACATCGA CATGATGGAC 3240
GACATCGGCA TCGACTCCTC GGACCTGGTG GAGGACAGCT TCCTGTGA 3288
Domain Profile
S: 1     lelGkvlGsGafGkvveatayGlsksdavlkvavkmlkst..arssekealmselkilsh  58
         l+lG+vlGsGafGkvve+tayGls+s++v+kvavkmlk+t  arssek+almselki++h
Q: 595   LVLGRVLGSGAFGKVVEGTAYGLSRSQPVMKVAVKMLKPTatARSSEKQALMSELKIMTH  654
         78************************************9622689***************
S: 59    lGehenivnllGactkgGpiyviteyccyGdllnylrrkresflkkslekkkekeeelds  118
         lG+h+nivnllGactk+Gpiy+iteyc+yGdl+nyl+++r+sfl+++ ek   ++++ld+
Q: 655   LGPHLNIVNLLGACTKSGPIYIITEYCFYGDLVNYLHKNRDSFLSHHPEK---PKKDLDI  711
         ***********************************************999...999****
S: 119   kal.ladkslrsksslssesseeyvdlkkd................vsdvssskadklas  161
         ++l +ad+s+rs+++ls+e++++y+d+k++                +sd+++s +d++as
Q: 712   FGLnPADESTRSYVILSFENNGDYMDMKQAdttqyvpmlerkevpkYSDIQRSLYDRPAS  771
         ***9*************************9******************************
S: 162   ekkksalerevkaaleeedsevleledllsfsyqvakGmeflaskncvhrdlaarnvllt  221
         +kkks+l++evk+ l++++se+l+l dllsf+yqva+Gmeflaskncvhrdlaarnvll+
Q: 772   YKKKSMLDSEVKNLLSDDNSEGLTLLDLLSFTYQVARGMEFLASKNCVHRDLAARNVLLA  831
         ************************************************************
S: 222   eGkvvkicdfGlardimkdsnyvvkGnarlpvkwmapesifdslytvksdvwsyGillwe  281
         +Gk+vkicdfGlardim+dsnyv+kG+++lpvkwmapesifd+lyt+ sdvwsyGillwe
Q: 832   QGKIVKICDFGLARDIMHDSNYVSKGSTFLPVKWMAPESIFDNLYTTLSDVWSYGILLWE  891
         ************************************************************
S: 282   ifslGstpypgllvdskfyklikeGyrmaqpayateeiyeimqkcweaepekrpsfkqlv  341
         ifslG+tpypg++vds+fy++ik+Gyrma+p++at+e+yeim+kcw++epekrpsf++l+
Q: 892   IFSLGGTPYPGMMVDSTFYNKIKSGYRMAKPDHATSEVYEIMVKCWNSEPEKRPSFYHLS  951
         ***********************************************************9
S: 342   ell  344
         e++
Q: 952   EIV  954
         986
Domain Sequence
(FASTA)
LVLGRVLGSG AFGKVVEGTA YGLSRSQPVM KVAVKMLKPT ATARSSEKQA LMSELKIMTH 60
LGPHLNIVNL LGACTKSGPI YIITEYCFYG DLVNYLHKNR DSFLSHHPEK PKKDLDIFGL 120
NPADESTRSY VILSFENNGD YMDMKQADTT QYVPMLERKE VPKYSDIQRS LYDRPASYKK 180
KSMLDSEVKN LLSDDNSEGL TLLDLLSFTY QVARGMEFLA SKNCVHRDLA ARNVLLAQGK 240
IVKICDFGLA RDIMHDSNYV SKGSTFLPVK WMAPESIFDN LYTTLSDVWS YGILLWEIFS 300
LGGTPYPGMM VDSTFYNKIK SGYRMAKPDH ATSEVYEIMV KCWNSEPEKR PSFYHLSEIV 360
KeywordATP-binding; Complete proteome; Disulfide bond; Immunoglobulin domain; Kinase; Membrane; Nucleotide-binding; Phosphoprotein; Receptor; Reference proteome; Repeat; Transferase; Transmembrane; Transmembrane helix; Tyrosine-protein kinase.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>
EKS-AIM-00373
EKS-ANC-00388
EKS-BOT-00401
EKS-CAJ-00405
EKS-CAF-00401
EKS-CAP-00430
EKS-EQC-00393
EKS-FEC-00385
EKS-GAG-00339
EKS-GAA-00490
EKS-GOG-00393
EKS-HOS-00407
EKS-ICT-00380
EKS-LAC-00417
EKS-LOA-00410
EKS-MAM-00400
EKS-MEG-00333
EKS-MOD-00390
EKS-MUM-00433
EKS-MUP-00395
EKS-MYL-00396
EKS-NOL-00366
EKS-OCP-00085
EKS-ORN-00512
EKS-ORA-00350
EKS-ORC-00376
EKS-ORL-00470
EKS-PAT-00380
EKS-PES-00356
EKS-POA-00392
EKS-RAN-00416
EKS-SAH-00370
EKS-TAG-00476
EKS-TAR-00508
EKS-TEN-00509
EKS-TUT-00117
EKS-XET-00512
Gene Ontology
GO:0005887; C:integral to plasma membrane
GO:0005524; F:ATP binding
GO:0005021; F:vascular endothelial growth factor-activated receptor activity
GO:0048010; P:vascular endothelial growth factor receptor signaling pathway
GO:0038084; P:vascular endothelial growth factor signaling pathway
KEGG
InterPros
IPR007110; Ig-like.
IPR013783; Ig-like_fold.
IPR013098; Ig_I-set.
IPR003599; Ig_sub.
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
IPR008266; Tyr_kinase_AS.
IPR020635; Tyr_kinase_cat_dom.
IPR016243; Tyr_kinase_CSF1/PDGF_rcpt.
IPR001824; Tyr_kinase_rcpt_3_CS.
IPR009134; Tyr_kinase_VEGFR_rcpt_N.
Pfam
PF07679; I-set; 2.
PF07714; Pkinase_Tyr; 1.
SMARTs
SM00409; IG; 3.
SM00219; TyrKc; 1.
Prosites
PS50835; IG_LIKE; 2.
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00109; PROTEIN_KINASE_TYR; 1.
PS00240; RECEPTOR_TYR_KIN_III; 1.
Prints
PR01832; VEGFRECEPTOR.
Created Date20-Feb-2013