EKS-OTG-00083

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-OTG-00083

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TK/Musk	595.3	1.8E-179	582	862	281

Status

Unreviewed

Ensembl Protein

ENSOGAP00000011386

UniProt Accession

H0X7J8;

Protein Name

Protein Synonyms/Alias

Gene Name

MUSK

Gene Synonyms/Alias

MUSK;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSOGAG00000012704	ENSOGAP00000011386	ENSOGAT00000012709

Organism

Otolemur garnettii

Functional Description

Protein Length

876

Protein Sequence
(FASTA)

MRELVNIPLV QILTLVAFSR TEKLPKAPVI TTPLETVDAL VEEVATFMCA VESYPQPEIS 60

WTRNKILIKL FDTRYSIREN GQLLSILSVE DSDDGIYCCI ANNGVGGAAE SCGALQVKMK 120

PKITRPPINV KITEGLKAVL PCTTMGNPKP SVSWIKGDSP LRKNKRVQTL EKTSFTLHNG 180

QSQQTLNRLL LGKNSIVKNY GLLFNLDVEK ESEPEQDAKV FARILRAPES HNVTFGSFVT 240

LRCTATGIPV PTITWIENGN AVSSGSIQES VKDRVIDSRL QLFVTKPGLY TCIATNKHGE 300

KFSTAKAAAT ISISGWRKPQ KDNKGYCAQY RGEVCHAVLA RDALVFFNTS YVDPEEAQEL 360

LVHTAWNELS AVSPLCRPAA EALLCRHIFQ ECNPGAAPTP TPLCREYCLA VKELFCAKEW 420

RAMEEKTHRG LYRPGMHLLS LPECSKLPSM HWDPRACSRL PYLDYKKENL TTFPPMTSSK 480

PSVDIPNLPS SSSSSFSVSP TYSMTVIISI MSSFAIFVLL TITTLYCCRR RKQWKNKKRK 540

GMCVTLPVPN ESIVLLKNPM YQRMPLLLNP KLLSLEYPRN NIEYVRDIGE GAFGRVFQAR 600

APGLLPYEPF TMVAVKMLKE EASADMQADF QREAALMAEF DNPNIVKLLG VCAVGKPMCL 660

LFEYMAYGDL NEFLRSMSPH TACTVSNGDL SPGAPACSPG PPALSCAEQL GIARQVAAGM 720

AYLSERKFVH RDLATRNCLV GENMVVKIAD FGLSRNMYSA DYYKANENDA IPIRWMPPES 780

IFYNRYTTES DVWAYGVVLW EIFSYGLQPY YGMAHEEVIY YVRDGHILSC PDNCPLELYN 840

LMRLCWSRLP ADRPSFASIH RILDRMCQRA GGAVSV 876

Nucleotide Sequence
(FASTA)

ATGAGAGAGC TCGTCAACAT TCCACTGGTA CAGATCCTTA CTCTGGTTGC CTTCAGCAGG 60

ACCGAGAAAC TTCCAAAAGC TCCTGTCATC ACCACTCCTC TTGAAACAGT GGATGCCTTA 120

GTTGAAGAGG TGGCTACTTT TATGTGTGCA GTGGAATCCT ATCCCCAGCC TGAGATTTCC 180

TGGACGAGAA ATAAAATTCT TATCAAGCTC TTTGACACCC GATACAGCAT TCGGGAGAAT 240

GGGCAGCTCC TCAGCATCCT GAGCGTGGAG GACAGCGACG ATGGCATTTA CTGCTGCATA 300

GCCAACAATG GCGTGGGAGG GGCTGCCGAG AGCTGCGGAG CTCTGCAAGT GAAGATGAAA 360

CCTAAAATAA CTCGTCCTCC CATAAATGTA AAAATCACAG AGGGATTAAA AGCAGTTCTA 420

CCATGTACTA CAATGGGCAA CCCCAAGCCG TCAGTGTCTT GGATCAAAGG GGACAGCCCC 480

CTTAGGAAGA ATAAGAGAGT CCAGACTCTT GAGAAAACGT CATTTACCCT TCACAATGGA 540

CAATCGCAAC AAACTCTTAA TAGACTGCTA TTGGGGAAAA ACAGTATTGT CAAAAATTAT 600

GGATTACTAT TTAACTTGGA TGTTGAAAAA GAAAGTGAAC CTGAGCAAGA TGCTAAAGTT 660

TTTGCCAGAA TCCTGAGGGC TCCTGAATCC CACAATGTCA CCTTTGGCTC CTTTGTGACC 720

CTGCGCTGTA CAGCAACAGG CATCCCTGTC CCCACCATCA CCTGGATTGA AAACGGAAAT 780

GCTGTTTCTT CTGGGTCCAT TCAAGAGAGT GTGAAAGACC GAGTGATTGA CTCAAGACTG 840

CAGCTATTTG TTACCAAGCC AGGACTCTAC ACATGCATAG CTACTAATAA GCATGGAGAG 900

AAATTCAGTA CTGCAAAGGC TGCAGCCACC ATCAGCATAT CAGGGTGGAG GAAACCACAG 960

AAAGATAACA AAGGCTACTG TGCCCAGTAC AGAGGGGAGG TGTGTCATGC AGTCCTGGCC 1020

AGAGATGCTC TTGTTTTTTT CAACACCTCC TACGTGGACC CTGAGGAGGC CCAAGAGCTA 1080

CTGGTGCACA CTGCCTGGAA TGAGCTGAGC GCGGTGAGCC CGCTCTGCCG GCCGGCTGCT 1140

GAGGCTCTGC TGTGCAGACA CATCTTCCAG GAGTGCAACC CCGGGGCAGC ACCTACCCCT 1200

ACCCCCCTGT GCAGAGAGTA CTGCTTGGCA GTAAAGGAGC TGTTCTGTGC AAAAGAATGG 1260

CGGGCTATGG AAGAAAAGAC CCATCGAGGA CTCTACAGAC CTGGGATGCA TCTCCTGTCC 1320

CTGCCAGAAT GCAGCAAGCT TCCCAGCATG CACTGGGACC CCCGGGCCTG TAGCAGACTG 1380

CCATATTTAG ATTACAAAAA AGAAAACCTA ACAACATTCC CACCAATGAC GTCCTCGAAG 1440

CCGAGTGTGG ACATTCCAAA TTTGCCTTCC TCCTCCTCAT CTTCCTTCTC TGTCTCACCT 1500

ACGTACTCCA TGACTGTAAT AATCTCCATC ATGTCCAGCT TTGCAATATT TGTGCTTCTT 1560

ACCATAACTA CACTTTATTG CTGCCGAAGA AGAAAACAGT GGAAAAATAA GAAAAGAAAA 1620

GGAATGTGCG TAACCCTGCC GGTCCCTAAT GAATCCATAG TGCTACTTAA AAATCCCATG 1680

TACCAGAGGA TGCCACTCCT TCTGAATCCT AAGCTGCTCA GCCTAGAGTA TCCAAGGAAT 1740

AACATTGAAT ATGTGAGAGA TATTGGAGAG GGAGCATTTG GAAGGGTATT TCAAGCAAGG 1800

GCTCCAGGCT TACTTCCCTA CGAACCTTTC ACTATGGTGG CAGTAAAGAT GCTGAAAGAA 1860

GAAGCTTCGG CAGATATGCA AGCAGACTTT CAGAGGGAGG CGGCCCTCAT GGCAGAATTT 1920

GACAACCCCA ACATTGTGAA ACTCCTAGGC GTGTGCGCAG TCGGGAAGCC CATGTGCCTG 1980

CTCTTCGAAT ACATGGCCTA CGGGGACCTC AACGAGTTCC TGCGCAGCAT GTCGCCTCAC 2040

ACCGCGTGCA CCGTCAGCAA CGGTGACTTG TCCCCGGGGG CCCCGGCGTG CAGCCCCGGG 2100

CCCCCGGCCC TGTCCTGCGC CGAGCAGCTG GGCATCGCCC GGCAGGTGGC CGCCGGCATG 2160

GCATACCTCT CGGAGCGCAA GTTCGTCCAC CGGGACTTAG CCACCAGGAA CTGCCTGGTG 2220

GGGGAGAACA TGGTGGTAAA AATCGCGGAC TTCGGCCTCT CCAGGAACAT GTACTCGGCG 2280

GATTACTACA AAGCGAACGA AAACGACGCG ATCCCCATCC GCTGGATGCC GCCCGAGTCC 2340

ATCTTCTACA ACCGCTACAC CACCGAGTCG GACGTGTGGG CCTACGGCGT GGTGCTCTGG 2400

GAGATCTTCT CCTACGGCCT GCAGCCCTAC TACGGCATGG CCCACGAGGA GGTCATCTAC 2460

TACGTGCGCG ACGGCCACAT CCTCTCCTGC CCCGACAACT GCCCCCTGGA GCTGTACAAC 2520

CTCATGCGTC TGTGCTGGAG CAGGCTGCCC GCCGACCGGC CCAGCTTCGC CAGCATCCAC 2580

CGAATCCTGG ACCGCATGTG CCAGAGGGCG GGGGGCGCCG TGAGCGTCTG A 2631

Domain Profile

S: 1     ieyvrdlgegafgrvfqarapgllpyeefllvavkmlkeeasadmqadfereaallaefd  60

         ieyvrd+gegafgrvfqarapgllpye+f++vavkmlkeeasadmqadf+reaal+aefd

Q: 582   IEYVRDIGEGAFGRVFQARAPGLLPYEPFTMVAVKMLKEEASADMQADFQREAALMAEFD  641

         89**********************************************************

S: 61    npnivkllgvcavgkpmcllfeymaygdlneflrslspytvcslshsdlslraqvsspdr  120

         npnivkllgvcavgkpmcllfeymaygdlneflrs+sp+t+c++s+ dls  a + sp++

Q: 642   NPNIVKLLGVCAVGKPMCLLFEYMAYGDLNEFLRSMSPHTACTVSNGDLSPGAPACSPGP  701

         ************************************************************

S: 121   lplseaellciarqvaagmaylserkfvhrdlatrnclvgetmvvkiadfglsrkiysad  180

         + ls+ae+l iarqvaagmaylserkfvhrdlatrnclvge+mvvkiadfglsr++ysad

Q: 702   PALSCAEQLGIARQVAAGMAYLSERKFVHRDLATRNCLVGENMVVKIADFGLSRNMYSAD  761

         ************************************************************

S: 181   yykadendaipirwmplesilynrytlesdvwaygvvlweifsyalqpyyglaheeviky  240

         yyka+endaipirwmp+esi+ynryt+esdvwaygvvlweifsy+lqpyyg+aheevi+y

Q: 762   YYKANENDAIPIRWMPPESIFYNRYTTESDVWAYGVVLWEIFSYGLQPYYGMAHEEVIYY  821

         ************************************************************

S: 241   vrdgnilacpentplelyalmrlcwsklpadrpsfasihri  281

         vrdg il+cp+n+plely+lmrlcws+lpadrpsfasihri

Q: 822   VRDGHILSCPDNCPLELYNLMRLCWSRLPADRPSFASIHRI  862

         ***************************************98

Domain Sequence
(FASTA)

IEYVRDIGEG AFGRVFQARA PGLLPYEPFT MVAVKMLKEE ASADMQADFQ REAALMAEFD 60

NPNIVKLLGV CAVGKPMCLL FEYMAYGDLN EFLRSMSPHT ACTVSNGDLS PGAPACSPGP 120

PALSCAEQLG IARQVAAGMA YLSERKFVHR DLATRNCLVG ENMVVKIADF GLSRNMYSAD 180

YYKANENDAI PIRWMPPESI FYNRYTTESD VWAYGVVLWE IFSYGLQPYY GMAHEEVIYY 240

VRDGHILSCP DNCPLELYNL MRLCWSRLPA DRPSFASIHR I 281

Keyword

ATP-binding; Complete proteome; Disulfide bond; Immunoglobulin domain; Kinase; Membrane; Nucleotide-binding; Phosphoprotein; Receptor; Reference proteome; Repeat; Transferase; Transmembrane; Transmembrane helix; Tyrosine-protein kinase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0016021	; C:integral to membrane
GO:0005524	; F:ATP binding
GO:0004713	; F:protein tyrosine kinase activity

KEGG

InterPros

IPR020067	; Frizzled_dom.
IPR007110	; Ig-like.
IPR013783	; Ig-like_fold.
IPR013098	; Ig_I-set.
IPR003598	; Ig_sub2.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR008266	; Tyr_kinase_AS.
IPR020635	; Tyr_kinase_cat_dom.

Pfam

PF01392	; Fz; 1.
PF07679	; I-set; 2.
PF07714	; Pkinase_Tyr; 1.

SMARTs

SM00408	; IGc2; 2.
SM00219	; TyrKc; 1.

Prosites

PS50038	; FZ; 1.
PS50835	; IG_LIKE; 3.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00109	; PROTEIN_KINASE_TYR; 1.

Prints

PR00109

; TYRKINASE.

Created Date

20-Feb-2013