EKS-OTG-00265

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-OTG-00265

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TK/Abl	367.5	3.6E-110	215	465	251

Status

Unreviewed

Ensembl Protein

ENSOGAP00000011434

UniProt Accession

H0X7N4;

Protein Name

Protein Synonyms/Alias

Gene Name

ABL2

Gene Synonyms/Alias

ABL2;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSOGAG00000012757	ENSOGAP00000011434	ENSOGAT00000012760

Organism

Otolemur garnettii

Functional Description

Protein Length

1108

Protein Sequence
(FASTA)

EALHRPYGCD VEPQALHEAI RWSSKENLLG ATESDPNLFV ALYDFVASGD NTLSITKGEK 60

LRVLGYNQNG EWSEVRSKNG QGWVPSNYIT PVNSLEKHSW YHGPVSRSAA EYLLSSLING 120

SFLVRESESS PGQLSISLRY EGRVYHYRIN TTADGKVYVT AESRFSTLAE LVHHHSTVAD 180

GLVTTLHYPA PKCNKPTVYG VSPIHDKWEM ERTDITMKHK LGGGQYGEVY VGVWKKYSLT 240

VAVKTLKGDQ VTVQSFTKPL SLFKICKTNS ILQHSGVCTL EPPFYIVTEY MPYGNLLDYL 300

RECNREEVTA VVLLYMATQI SSAMEYLEKK NFIHRDLAAR NCLVGENHVV KVADFGLSRL 360

MTGDTYTAHA GAKFPIKWTA PESLAYNTFS IKSDVWELLF CMIVCVLYLH KSQTQHLNIH 420

LSESIFILLH CLRRTSSIGC YPLSNTGWKW SPADRPSFAE THQAFETMFH DSSISEEVAE 480

ELGRAASSSS VVPYLPRLPI LPSKTRTLKK QLENKENIEG VQDATENSAS SSAPGFIRSA 540

QPSSGSPALP RKQRDKSPSS LLEDAKETCF TRDRKGGFFS SFMKKRNAPT PPKRSSSFRE 600

MENQPHKKYE LTGNFSSVAS LQHVDGFSFT PAQQEANLVP PKCYGGSFAQ RNLCNDDGGG 660

GGGSGTAGGG WSGITGFFTP RLIKKTLGLR AGKPTASDDT SKPFPRSNST SSMSSGLPEQ 720

DRMAMTLPRN CQRSKLQLER TVSTSSQPEE NVDRANDMLP KKSEEGAAPS RERPKAKLLP 780

RGAAALPLRN PSGDPAIAEK DSAGVGVAGV AAASKGKERN GGARLGMAGV PEDGEQPGWS 840

SPAKVAAVLP TTHNHKVPVL ISPTLKHTPA DVQLIGTDSQ GNKFKLLSEH QVASSGDKDR 900

PRRVKPKCAP PPPPVMRLLQ HPSSCSDPTE EPAAPTAGQP PSETQEGGKK AAAGAVPLSG 960

KAGRPVMPPP QVPLPTSSIS PAKMANGTAG TKVALRKTKQ VAEKISADKI SKEALLECAD 1020

LLSNAITEPV PNSQLVDTGH QLLDYCSGYV DCIPQTRNKF AFREAVSKLE LSLQELQVSS 1080

AAAGVPGANP VLNNLLSCVQ EISDVVQR 1108

Nucleotide Sequence
(FASTA)

GAAGCCTTGC ATCGCCCCTA TGGTTGTGAT GTTGAACCCC AGGCACTGCA TGAAGCTATC 60

AGGTGGAGCT CCAAGGAGAA CTTGCTTGGA GCCACTGAGA GTGACCCTAA TCTCTTTGTT 120

GCACTTTATG ATTTTGTAGC CAGTGGTGAT AACACACTCA GCATCACTAA AGGTGAAAAG 180

CTACGAGTCC TTGGTTACAA CCAGAATGGC GAGTGGAGTG AAGTTCGCTC TAAGAATGGA 240

CAGGGTTGGG TGCCAAGCAA CTACATTACT CCAGTGAACA GCCTGGAAAA ACATTCCTGG 300

TACCATGGAC CTGTGTCACG TAGTGCAGCA GAGTATCTGC TCAGCAGTCT AATCAATGGT 360

AGTTTCCTGG TGCGAGAAAG TGAGAGCAGC CCTGGGCAGC TGTCCATCTC ACTCAGGTAT 420

GAGGGACGTG TGTATCACTA CAGGATCAAT ACCACCGCAG ATGGCAAGGT ATATGTGACT 480

GCTGAGAGTC GCTTTAGCAC CTTGGCAGAG CTTGTTCACC ATCACTCCAC AGTGGCTGAT 540

GGGCTGGTGA CCACATTACA CTACCCAGCA CCCAAGTGTA ACAAGCCTAC GGTCTATGGC 600

GTGTCCCCCA TCCACGACAA GTGGGAAATG GAACGAACAG ATATTACCAT GAAGCACAAA 660

CTTGGGGGCG GTCAATATGG AGAGGTTTAC GTTGGCGTCT GGAAGAAATA CAGCCTTACA 720

GTTGCTGTGA AAACACTGAA GGGAGACCAA GTCACAGTGC AATCTTTCAC TAAGCCCCTT 780

TCCCTTTTTA AAATATGTAA AACTAACTCT ATTCTTCAAC ACTCAGGTGT GTGTACTTTG 840

GAGCCACCAT TTTACATTGT GACTGAATAT ATGCCATATG GGAATTTGCT TGATTATCTC 900

CGAGAATGTA ACCGAGAAGA GGTGACTGCA GTTGTACTGC TCTACATGGC CACTCAGATC 960

TCTTCTGCAA TGGAGTATTT AGAGAAGAAG AATTTCATCC ATAGAGATCT TGCAGCTCGG 1020

AACTGCCTAG TAGGAGAAAA CCACGTGGTA AAAGTGGCTG ACTTTGGCTT AAGTAGATTG 1080

ATGACTGGAG ACACCTACAC TGCTCATGCT GGAGCCAAAT TTCCTATTAA GTGGACAGCA 1140

CCAGAGAGTC TTGCCTATAA TACCTTCTCA ATTAAATCTG ATGTCTGGGA GCTTCTCTTT 1200

TGTATGATAG TCTGTGTCCT TTATCTTCAT AAATCTCAAA CTCAGCATTT GAACATTCAC 1260

CTAAGTGAAT CTATTTTTAT TTTACTCCAC TGCCTTAGAA GGACAAGTAG CATTGGCTGC 1320

TATCCTTTGT CAAATACAGG CTGGAAGTGG AGCCCTGCTG ACAGGCCCTC TTTTGCAGAA 1380

ACACACCAAG CTTTTGAAAC CATGTTCCAT GATTCCAGCA TTTCTGAAGA GGTAGCTGAG 1440

GAGCTTGGGA GAGCCGCCTC ATCATCATCT GTTGTTCCGT ACCTTCCCCG ATTACCTATA 1500

CTTCCTTCCA AGACTCGGAC ACTGAAGAAA CAGCTGGAGA ACAAGGAGAA CATTGAAGGA 1560

GTACAAGATG CCACAGAAAA CTCTGCTTCC AGTTCAGCAC CAGGGTTCAT AAGAAGTGCA 1620

CAGCCCTCTA GTGGGTCTCC AGCACTGCCT CGAAAACAAA GAGACAAGTC ACCCAGCAGC 1680

CTCTTGGAAG ATGCCAAAGA GACATGCTTC ACTAGGGATA GGAAAGGAGG CTTCTTCAGC 1740

TCCTTCATGA AAAAGAGAAA TGCTCCCACA CCCCCCAAAC GCAGCAGCTC CTTCCGAGAA 1800

ATGGAGAATC AGCCCCACAA GAAATATGAA CTCACGGGTA ACTTCTCATC TGTTGCTTCT 1860

CTACAGCATG TTGACGGGTT CTCTTTCACT CCTGCCCAGC AAGAGGCGAA TCTGGTGCCA 1920

CCCAAGTGCT ATGGGGGGAG CTTTGCACAG AGGAATCTCT GTAATGACGA CGGTGGTGGG 1980

GGTGGGGGCA GTGGCACTGC TGGGGGTGGG TGGTCTGGCA TCACAGGCTT CTTTACGCCA 2040

CGCTTAATCA AAAAGACACT GGGCTTACGA GCAGGTAAAC CCACAGCCAG TGATGACACT 2100

TCCAAGCCTT TCCCAAGGTC AAACTCTACA TCTTCCATGT CCTCAGGGCT TCCAGAGCAG 2160

GATAGGATGG CAATGACTCT TCCCAGGAAC TGCCAGAGGT CCAAACTCCA GCTGGAAAGG 2220

ACAGTATCCA CCTCTTCTCA GCCAGAAGAG AATGTGGACA GGGCCAATGA CATGCTTCCA 2280

AAAAAATCAG AGGAAGGTGC TGCTCCCTCC AGGGAAAGAC CAAAAGCTAA ACTATTGCCC 2340

AGAGGAGCTG CAGCTCTTCC TCTCAGAAAC CCCTCTGGGG ATCCAGCCAT TGCTGAGAAG 2400

GACTCTGCAG GGGTGGGAGT GGCTGGAGTA GCAGCTGCCT CCAAGGGCAA GGAGAGGAAT 2460

GGTGGGGCAC GACTTGGGAT GGCTGGTGTC CCAGAGGATG GAGAGCAACC AGGTTGGTCT 2520

TCTCCAGCCA AGGTCGCAGC AGTCCTCCCA ACCACTCATA ACCACAAAGT GCCAGTCCTT 2580

ATCTCACCCA CTCTGAAACA TACTCCGGCT GACGTGCAGC TCATTGGCAC AGACTCTCAG 2640

GGGAACAAAT TCAAGCTTTT ATCTGAGCAT CAGGTCGCAT CCTCTGGAGA CAAGGACCGA 2700

CCCCGACGGG TAAAACCAAA GTGTGCCCCG CCCCCACCAC CAGTGATGAG ACTACTGCAG 2760

CATCCGTCCT CATGTTCAGA CCCTACGGAA GAGCCTGCTG CCCCAACTGC AGGACAGCCC 2820

CCATCAGAAA CACAGGAAGG AGGGAAAAAG GCAGCTGCAG GGGCAGTGCC TCTCAGTGGG 2880

AAAGCTGGGA GGCCAGTGAT GCCTCCACCT CAAGTGCCTC TGCCCACATC TTCCATCTCG 2940

CCAGCCAAAA TGGCCAATGG CACAGCAGGT ACTAAAGTGG CTCTCAGAAA AACCAAACAG 3000

GTGGCTGAGA AAATCTCAGC AGACAAAATC AGTAAAGAGG CCCTGTTGGA ATGTGCTGAC 3060

CTACTGTCCA ATGCAATCAC GGAACCTGTG CCCAATAGCC AGTTGGTAGA CACTGGACAC 3120

CAGCTCCTCG ACTACTGCTC AGGCTATGTG GACTGCATCC CTCAAACTCG CAACAAATTT 3180

GCCTTCCGAG AGGCTGTGAG CAAACTGGAA CTCAGCCTGC AGGAGCTACA GGTGTCTTCA 3240

GCAGCTGCTG GTGTGCCAGG GGCAAACCCT GTCCTTAATA ACTTATTGTC ATGTGTACAA 3300

GAAATCAGTG ATGTGGTGCA GAGGTAG 3327

Domain Profile

S: 1     iimkhklgggqygevyegvwkkysltvavktlkedtmeveeflkeaavmkelkhpnlvql  60

         i+mkhklgggqygevy+gvwkkysltvavktlk d ++v+ f k  +++k  k + ++q

Q: 215   ITMKHKLGGGQYGEVYVGVWKKYSLTVAVKTLKGDQVTVQSFTKPLSLFKICKTNSILQH  274

         89**********************************************************

S: 61    lgvctreppfyiitefmsygnlldylreadreeveavvllymatqissameylekknfih  120

          gvct eppfyi+te+m+ygnlldylre++reev+avvllymatqissameylekknfih

Q: 275   SGVCTLEPPFYIVTEYMPYGNLLDYLRECNREEVTAVVLLYMATQISSAMEYLEKKNFIH  334

         ************************************************************

S: 121   rdlaarnclvgenklvkvadfglsrlmkedtytahagakfpikwtapeslaynkfsiksd  180

         rdlaarnclvgen++vkvadfglsrlm++dtytahagakfpikwtapeslayn+fsiksd

Q: 335   RDLAARNCLVGENHVVKVADFGLSRLMTGDTYTAHAGAKFPIKWTAPESLAYNTFSIKSD  394

         ************************************************************

S: 181   vwafgvllweiaty...gmspypgidlsqvyellekgyrmerpegcppkvyelmracwkw  237

         vw +   +     y     + + +i+ls+   +l +  r     gc    y l  + wkw

Q: 395   VWELLFCMIVCVLYlhkSQTQHLNIHLSESIFILLHCLRRTSSIGC----YPLSNTGWKW  450

         **8655555444442224567889*****99999999********9....7799******

S: 238   spsdrpsfaeihqal  252

         sp+drpsfae+hqa+

Q: 451   SPADRPSFAETHQAF  465

         ************986

Domain Sequence
(FASTA)

ITMKHKLGGG QYGEVYVGVW KKYSLTVAVK TLKGDQVTVQ SFTKPLSLFK ICKTNSILQH 60

SGVCTLEPPF YIVTEYMPYG NLLDYLRECN REEVTAVVLL YMATQISSAM EYLEKKNFIH 120

RDLAARNCLV GENHVVKVAD FGLSRLMTGD TYTAHAGAKF PIKWTAPESL AYNTFSIKSD 180

VWELLFCMIV CVLYLHKSQT QHLNIHLSES IFILLHCLRR TSSIGCYPLS NTGWKWSPAD 240

RPSFAETHQA F 251

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; SH3 domain; Transferase; Tyrosine-protein kinase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gorilla gorilla"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004715	; F:non-membrane spanning protein tyrosine kinase activity

KEGG

InterPros

IPR015015	; F-actin_binding.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR000980	; SH2.
IPR001452	; SH3_domain.
IPR008266	; Tyr_kinase_AS.

Pfam

PF08919	; F_actin_bind; 1.
PF07714	; Pkinase_Tyr; 1.
PF00017	; SH2; 1.
PF00018	; SH3_1; 1.

SMARTs

SM00808	; FABD; 1.
SM00252	; SH2; 1.
SM00326	; SH3; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00109	; PROTEIN_KINASE_TYR; 1.
PS50001	; SH2; 1.
PS50002	; SH3; 1.

Prints

PR00401	; SH2DOMAIN.
PR00109	; TYRKINASE.

Created Date

20-Feb-2013