EKS-OTG-00309

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-OTG-00309

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TK/Alk	516.7	1.2E-155	434	703	270

Status

Unreviewed

Ensembl Protein

ENSOGAP00000011524

UniProt Accession

H0X7V9;

Protein Name

Protein Synonyms/Alias

Gene Name

LTK

Gene Synonyms/Alias

LTK;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSOGAG00000012850	ENSOGAP00000011524	ENSOGAT00000012860

Organism

Otolemur garnettii

Functional Description

Protein Length

813

Protein Sequence
(FASTA)

MGRLGRLLLW LRAAGAVLCS SSESQTPFPL SSPLPTPSAR DPKVTALPLN PSGTEGSWQF 60

STCGASGPHG PTQAQCNGAY AGSGVVVTVV PAGPLRGVQL WQAPGPGQYL ISAYGAAGGK 120

GAKNHLSRSH GVFVSAIFSL GRGEPLYILV GQQGEDACPG GSPESQLVCL GESPAAEERA 180

AMDGTELVPK SRRWAGGGGG GGATHIFRLR AGELEPLLVA AGGGGRAYLR QQGRGWAQTV 240

PEKLENRSAA PGSDGRGGAA GGDASETDNL WADGEDGVSF IHPSSELYLQ PLAVTESHGE 300

VEIRRYFNCS HCPLRDCQWQ AELQLAECLC PEGMELAVDN VTCMDLPTSP GLLVLMVVTS 360

TLSLLMVCGV LILANQKCQG LWVMKQPGPE LELSKRPTSA IRTAANPYYY QVGLGPAQSW 420

PLPPGLTEVS PANVTLLRAL GHGAFGEVYE GLVIGLPGDS RPLQVAIKTL PEFCSRQDEL 480

DFLMEALIIS KFSHQNIVQC VGLSLQAAPR FILLELMSGG DMKSFLRHSR PHLGQPSTLV 540

MQDLLQLAQD IAQGCHYLEE NHFIHRDIAA RNCLLSCTGP SRVAKIGDFG MARDIYRASY 600

YHKGDRALLP VKWMPPEAFL EGIFTSKTDS WSFGVLLWEI FSLGYMPYPG RTNQEVLDFI 660

VAGGRMDPPR GCPGPVYRIM TQCWQHQPEL RPNFASILEH LQYCTQDPDV LNSPLPVELR 720

PTLEEDGAFG LGNRSLEGPK SPQPQELSPE GMKSWGGSPL GLPSAVKPLK PRGLQPQNLW 780

NPTYGSWAPR GPESEDSGID GRDGSFLYSL SGF 813

Nucleotide Sequence
(FASTA)

ATGGGCCGCT TGGGCCGGCT GCTGCTGTGG CTTAGAGCCG CGGGCGCCGT TCTCTGCTCC 60

AGCTCAGAGT CCCAGACGCC TTTTCCATTA TCCTCGCCTC TGCCAACTCC CAGCGCCCGG 120

GACCCGAAAG TCACCGCCCT CCCCTTAAAT CCCTCAGGCA CCGAGGGATC TTGGCAGTTC 180

TCTACCTGTG GGGCCAGTGG CCCGCACGGG CCCACACAAG CACAATGTAA TGGGGCGTAC 240

GCGGGGAGCG GCGTGGTGGT GACTGTGGTG CCCGCCGGGC CGTTGAGAGG CGTGCAGCTG 300

TGGCAGGCGC CAGGCCCGGG CCAGTACCTG ATCTCAGCCT ACGGAGCTGC GGGCGGCAAA 360

GGCGCCAAAA ACCACCTGTC GCGGTCGCAC GGCGTTTTCG TCTCGGCAAT CTTCTCCCTG 420

GGTCGTGGGG AGCCGCTTTA CATCCTCGTA GGGCAGCAGG GAGAGGACGC CTGTCCTGGA 480

GGTAGCCCGG AGAGCCAACT CGTCTGCCTC GGAGAATCTC CAGCCGCTGA AGAGCGCGCA 540

GCGATGGATG GGACCGAATT GGTCCCAAAG TCGCGGCGAT GGGCAGGAGG TGGCGGGGGG 600

GGGGGCGCCA CCCACATCTT CCGGCTGCGC GCCGGCGAGC TGGAGCCACT GCTGGTGGCG 660

GCCGGAGGCG GCGGTCGGGC CTACCTGAGG CAGCAGGGCC GAGGCTGGGC TCAGACGGTC 720

CCTGAGAAAC TGGAGAACCG CTCAGCGGCG CCCGGGAGCG ACGGGAGAGG CGGAGCGGCC 780

GGGGGTGACG CCTCAGAGAC TGACAACCTC TGGGCTGATG GGGAAGATGG GGTATCCTTC 840

ATACACCCCA GCAGCGAACT CTACCTGCAG CCTCTGGCAG TTACAGAAAG CCATGGAGAG 900

GTAGAGATCC GAAGGTACTT CAACTGTAGT CATTGCCCTT TGAGAGATTG CCAGTGGCAG 960

GCTGAGCTCC AGTTGGCTGA ATGCCTGTGC CCGGAGGGCA TGGAGCTAGC TGTGGATAAC 1020

GTCACCTGCA TGGACCTGCC CACCTCCCCA GGCCTTCTGG TTCTAATGGT GGTGACCTCA 1080

ACATTGAGCC TCCTTATGGT GTGTGGGGTC CTGATTCTGG CAAACCAGAA GTGTCAGGGT 1140

CTGTGGGTAA TGAAGCAGCC AGGCCCTGAG CTTGAACTGA GCAAGCGACC AACCTCTGCC 1200

ATCAGGACAG CTGCCAACCC CTATTACTAC CAGGTGGGGC TTGGCCCAGC TCAGTCCTGG 1260

CCTCTGCCCC CAGGGCTTAC AGAGGTTTCC CCAGCCAATG TCACTTTGCT GAGAGCTCTG 1320

GGTCACGGTG CCTTTGGGGA GGTGTATGAG GGACTGGTAA TTGGCCTTCC TGGGGATTCC 1380

AGACCACTGC AGGTGGCTAT TAAGACTCTG CCAGAATTCT GTTCTCGTCA AGACGAGTTG 1440

GACTTCCTGA TGGAGGCACT CATCATCAGC AAGTTTAGCC ATCAGAACAT CGTGCAGTGT 1500

GTGGGGCTCA GCCTCCAGGC TGCCCCCCGC TTCATTCTGC TGGAGCTGAT GTCTGGAGGG 1560

GACATGAAGA GTTTCCTGAG GCATAGCCGG CCACACCTGG GCCAGCCGTC AACTCTAGTC 1620

ATGCAGGACC TGCTGCAGCT GGCCCAGGAC ATAGCCCAGG GCTGCCACTA CCTGGAGGAA 1680

AATCATTTCA TCCACAGGGA CATCGCTGCC CGGAATTGCC TGCTGAGCTG CACTGGGCCC 1740

AGCCGAGTGG CCAAGATTGG GGACTTTGGA ATGGCAAGAG ATATCTACCG GGCCAGTTAT 1800

TACCATAAGG GGGACCGGGC CTTGCTCCCA GTCAAGTGGA TGCCCCCAGA AGCCTTCCTG 1860

GAGGGCATCT TCACATCCAA GACAGACTCC TGGTCTTTTG GGGTGCTGCT CTGGGAGATC 1920

TTCTCACTGG GCTACATGCC CTACCCTGGG CGCACCAACC AGGAGGTGCT GGATTTCATT 1980

GTTGCAGGGG GCCGGATGGA TCCTCCTAGG GGCTGTCCAG GGCCAGTGTA CCGCATCATG 2040

ACCCAGTGTT GGCAGCACCA GCCTGAACTC CGGCCCAACT TTGCCAGCAT TTTGGAGCAT 2100

CTTCAATACT GCACTCAGGA CCCCGATGTG CTGAATTCAC CCCTGCCAGT GGAGCTGAGG 2160

CCCACCCTGG AAGAGGATGG GGCTTTTGGG CTGGGGAACA GATCTTTGGA GGGCCCCAAA 2220

TCCCCACAGC CCCAGGAGCT GAGTCCAGAG GGCATGAAAA GCTGGGGAGG GAGCCCTCTT 2280

GGGCTGCCCT CTGCAGTCAA GCCCCTCAAA CCCAGAGGAC TCCAACCTCA GAACCTTTGG 2340

AATCCCACCT ATGGCTCCTG GGCCCCACGA GGCCCTGAGA GTGAGGACTC AGGTATTGAT 2400

GGTAGGGATG GCTCCTTTCT CTACTCCTTA TCAGGCTTCT AA 2442

Domain Profile

S: 1     ielvralGkGafGevyeglvsglpgdasklavavktlpesaseqdeldflkealiiskfn  60

         ++l+ralG+GafGevyeglv+glpgd+ +l+va+ktlpe +s+qdeldfl+ealiiskf+

Q: 434   VTLLRALGHGAFGEVYEGLVIGLPGDSRPLQVAIKTLPEFCSRQDELDFLMEALIISKFS  493

         689*********************************************************

S: 61    henivrliGvsleklprlillellaGGdlksflresrpkpeqlsslamkdllkvaldvak  120

         h+niv+++G+sl+++pr+illel++GGd+ksflr+srp+  q+s+l+m+dll++a+d+a+

Q: 494   HQNIVQCVGLSLQAAPRFILLELMSGGDMKSFLRHSRPHLGQPSTLVMQDLLQLAQDIAQ  553

         ************************************************************

S: 121   GckyleenkfihrdiaarnillsskGpsrvakiadfGmardiyraeyyrkggrallpvkw  180

         Gc+yleen+fihrdiaarn+lls++Gpsrvaki+dfGmardiyra+yy kg+rallpvkw

Q: 554   GCHYLEENHFIHRDIAARNCLLSCTGPSRVAKIGDFGMARDIYRASYYHKGDRALLPVKW  613

         ************************************************************

S: 181   mppeafleGiftsktdvwsfGvllwevfslGvvpypgksnqevlelvveGgrldspkeip  240

         mppeafleGiftsktd+wsfGvllwe+fslG++pypg++nqevl+++v Ggr+d+p+++p

Q: 614   MPPEAFLEGIFTSKTDSWSFGVLLWEIFSLGYMPYPGRTNQEVLDFIVAGGRMDPPRGCP  673

         ************************************************************

S: 241   gsvyrimtdcwkhepedrpkfvsilerlqa  270

         g+vyrimt+cw+h+pe rp+f+sile+lq+

Q: 674   GPVYRIMTQCWQHQPELRPNFASILEHLQY  703

         ****************************97

Domain Sequence
(FASTA)

VTLLRALGHG AFGEVYEGLV IGLPGDSRPL QVAIKTLPEF CSRQDELDFL MEALIISKFS 60

HQNIVQCVGL SLQAAPRFIL LELMSGGDMK SFLRHSRPHL GQPSTLVMQD LLQLAQDIAQ 120

GCHYLEENHF IHRDIAARNC LLSCTGPSRV AKIGDFGMAR DIYRASYYHK GDRALLPVKW 180

MPPEAFLEGI FTSKTDSWSF GVLLWEIFSL GYMPYPGRTN QEVLDFIVAG GRMDPPRGCP 240

GPVYRIMTQC WQHQPELRPN FASILEHLQY 270

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Transferase; Tyrosine-protein kinase.

Sequence Source

Ensembl

Orthology

Ortholog group

Callithrix jacchus"; ?>Cavia porcellus"; ?>Equus caballus"; ?>Felis catus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Loxodonta africana"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Nomascus leucogenys"; ?>Oryctolagus cuniculus"; ?>Pan troglodytes"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004713	; F:protein tyrosine kinase activity
GO:0007165	; P:signal transduction

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR026984	; LTK.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR008266	; Tyr_kinase_AS.
IPR020635	; Tyr_kinase_cat_dom.

Pfam

PF07714

; Pkinase_Tyr; 1.

SMARTs

SM00219

; TyrKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00109	; PROTEIN_KINASE_TYR; 1.

Prints

PR00109

; TYRKINASE.

Created Date

20-Feb-2013