EKS-OTG-00099

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-OTG-00099

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
Atypical/PIKK	406.3	1.1E-121	2123	2447	325

Status

Unreviewed

Ensembl Protein

ENSOGAP00000011846

UniProt Accession

H0X8L7;

Protein Name

Protein Synonyms/Alias

Gene Name

SMG1

Gene Synonyms/Alias

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSOGAG00000013206	ENSOGAP00000011846	ENSOGAT00000013224
ENSOGAG00000013206	ENSOGAP00000017468	ENSOGAT00000030910

Organism

Otolemur garnettii

Functional Description

Protein Length

3661

Protein Sequence
(FASTA)

MSRRAPGSRL SSGGTKYPRS WNDWQPRTDS ASADPDNLKY SSSRDRGGSS SYGLQPSNSA 60

VVSRQRHDDT RVHADIQNDE KGGYSVNGGS GENTYGRKSL GQELRVNNVT SPEFTSVHHG 120

SRALATKDMR KSQERSMSYS DESRLSNLLR RITREDDRDR RLATVKQLKE FIQQPENKLV 180

LVKQLDNILA AVHDVLNESS KLLQELRQEG ACCLGLLCAS LSYEAEKIFK WIFSKFSSSA 240

KDEVKLLYLC ATYKALETVG EKKAFSSVMQ LVMTSLQSIL ENVDTPELLC KCVKCILLVA 300

RCYPHIFSTN FRDTVDILVG WHIDHTQKPS LTQQVSGWLQ SLEPFWVADL AFSTTLLGQF 360

LEDMEAYAED LSHVASGESV DEDIPPPSVS LPKLAALLRV FSTVVRSIGE RFSPIRGPPI 420

TEAYVTDVLY RVMRCVTAAN QVFFSEAVLT AANECVGVLL GSLDPSMTIH CDMVITYGLD 480

QLENCQTCGT DYIISVLNLL TLIVEQINTK LPSSFVEKLF IPSSKLLFLR YHKEKEVVAV 540

AHAVYQAVLS LKNIPVLETA YKLILGEMTC ALNNLLHSLQ LPDACSEIKH EAFKNHVFNV 600

DNAKFVVIFD LSALTTIGNA KNSLIGMWAL SPTVFALLSK NLMIVHNDLA VHFPAIQYAV 660

LYTLYSHCTR HDHFISSSLS SSSPSLFDGA VISTVTTATK KHFSIILNLL GILLKKDNLN 720

QDTRKLLMTW ALEVAVLMKK SETYAPLFSL PSFHKFCKGL LANTLVEDMN ICLQACSSLH 780

ALSSSLPDDL LQRCVDVCRV QLVHSGTRIR QAFGKLLKSI PLDVVLSNNN HTEIQEISLA 840

LRSHMSKAPS NTFHPQDFSD VISFILYGNS HRTGKDNWLE RLFYSCQRLD KRDQSTIPRN 900

LLKTDAVLWQ WAIWEAAQFT VLSKLRTPLG RAQDTFQTIE GIIRSLAAHT LNPDQDVSQW 960

TTADNDEGHS SNQLRLVLLL QYLENLEKLM YNAYEGCANA LTSPPKVIRT FFYTNRQTCQ 1020

DWLTRIRLSI MRVGLLAGQP AVTVRHGFDL LTEMKTTNLS QGNDLEVTIM MVVEALCELH 1080

CPEAIQGIAV WSSSVVGKNL LWINSVAHQA EGRFEKASVE YQEHLCAMTG VDCCISSFDK 1140

SVLTLANAGR NSASPKHSLN GDSRKTVLSK PTDSSPEVIN YLGNKACECY ISIADWAAVQ 1200

DWQNAIHDLK KSTSSTSLNL KADFNYIKSL SSFESGEFVE CTEQLELLPG ENINLLAGGS 1260

KEKIDMKKLL PNMLSPDPRE LQKSIEVQLL RSSVCLATAL NHIEQDQKWQ SITENVVKYL 1320

KQTSRIAIGP LRLSTLTVSQ SLPVLSTLQL YCSSALENTV SNRLSTEDCL IPLFSEALRS 1380

CKQHDVRPWM QALRYTMYQN QLLEKIKEQT VPIRSHLMEL GLTAAKFARK RGNVSLATRL 1440

LAQCSEVQLG KTTTAQDLVQ HFKKLSTQGQ VDEKWGPELD IEKTKLLYTA GQSTHAMEML 1500

SSCAISFCKS AKAEYAVAKS ILTLAKWIQA EWKEISGQLK QVYRAQQQQS VTGLSTLSKN 1560

ILTLIELPSV NTAEEEYPRI ESESTVHIGV GEPDFILGQL YHLSSVQAPE VAKSWAALAS 1620

WAYRWGRKVV DNASQGEGVR LLPREKSEVQ NLLPDTITEE EKERIYGILG QAVCRPAGIQ 1680

ARKTDEDITL QITESEDNEE DDMVDVIWRQ LISSCPWLSE LDESATEGVI KVWRKVVDRI 1740

FSLYKLSCSA YFTFLKLNAG QIPLDEDDPR LHLSHRVEQS TDDVIVMATL RLLRLLVKHA 1800

GELRQYLEHG LETTPTAPWR GIIPQLFSRL NHPEVYVRQS ICNLLCRVAQ DSPHLILYPA 1860

IVGTISLSSE SQASGNKFSS AIPTLLGNIQ GEELLVSECE GGSPPASQDS NKDEPKSGLN 1920

EDQAMMQDCY SKIVDKLSSA NPTMVLQVQM LVAELRRVTV LWDELWLGVL LQQHMYVLRR 1980

IQQLEDEVKR VQNNNTLRKE EKVAIMREKH TALMKPIVFA LEHVRSITAA PAETPHEKWF 2040

QDNYGDAIEN ALEKLKTPSN PAKPGSSWIP FKEIMLSLQQ RAQKRASYIL RLEEISPWLA 2100

AMTNTEIALP GEVSARDTVT IHSVGGTITI LPTKTKPKKL LFLGSDGKNY PYLFKGLEDL 2160

HLDERIMQFL SIVNTMFATI NRQESPRFHA RHYSVTPLGT RSGLIQWVDG ATPLFGLYKR 2220

WQQREAALQA QKAQDSYQTP QNPGMVPRPS ELYYSKIGPA LKAVGLSLDV SRRDWPLHVM 2280

KAVLEELMEA TPPNLLAKEL WSSCTTPDEW WRVTQSYARS TAVMSMVGYI IGLGDRHLDN 2340

VLIDMTTGEV VHIDYNVCFE KGKSLRVPEK VPFRMTQNIE TALGVTGVEG VFRLSCEQVL 2400

HIMRRGRETL LTLLEAFVYD PLVDWTAGGE AGFAGAVYGG GGQQAESKQS KREMEREITR 2460

SLFSSRVAEI KVNWFKNRDE MLVVLPKLDS SLDEYLSLQE QLTDVEKLQG KLLEEIEFLE 2520

GAEGVDHPSH TLQHRYSEHT QLQTQQRAVQ EAIQVKLNEF EQWITHYQAA FNNLEATQLA 2580

SLLQEISTQM DLGPPSYVPA TAFLQNAGQA HLISQCEQLE GEVGALLQQR RSVLRGCLEQ 2640

LHHYATVALQ YPKAIFQKHR IEQWKTWMEE LICNTTVERC QELYRKYEMQ YAPQPPPTVC 2700

QFITATEMTL QRYAADINSR LIRQVERLKQ EAVTVPVCED QLKEIERCIK VFLHENGEEG 2760

SLSLASVIIS ALCTLTRRNL MMEGAASSAG EQLVDLTSRD GAWFLEELCS MSGNVTCLVQ 2820

LLKQCHLVPQ DLDIPNPVEA SEAVHLANGV YTSLQELNSN FRQIIFPEAL RCLMKGEFTL 2880

ESMLHELDNL IEQTTDGIPL QTLVESLQAY LRNAAMGLEE ETHAHYIDIK EVLHAQYGEL 2940

IQPRNGSVDE TPKMSAGQML LVAFDGMFAQ VETAFGLLVE KLNKMEIPIA WRKIDIIREA 3000

RSTQVNFFDD DNHRQVLEEI FFLKRLQTIK EFFRLCGTFS KTLSGSSSLE DQNSVNGPVQ 3060

IVNVKTLFRN SCFSEDQMAK PIKAFTADFV RQLLIGLPNQ ALGLTLCSFI SALGVDIIAQ 3120

VEAKDFGAES KVSVDDLCKK AVEHNIQVGK FSQLVMNRAT VLASSYDTAW KKHDLVRRLE 3180

TSISSCKTSL QRVQLHIAMF QWQHEDLLIN RPQAMSVTPP PRSAILTSMK KKLHTLSQIE 3240

TSIATVQEKL AALEASIEQR LKWAGGANPA LAPVLQDFEA TIAERRNLVL KESQRASQVT 3300

FLCSNIIHFE SLRTRTAEAL NLDAALFELI KRCQQMCSFA SQFNSSVSEL ELRLLQRVDT 3360

GLEHPIGSSE WLLSAHKQLT QDMSTQRAIQ TEKEQQIETV CETIQNLVDN IKTVLTGHNR 3420

QLGDVKHLLK AMAKDEEAAL ADGEDVPYEN SVRQFLGEYK SWQDNIQTVL FTLVQAMGQV 3480

RSQEHVEMLQ EITPTLKELK TQSQSIYNNL VSFASPLVTD ATNECSSPTS SATYQPSFAA 3540

AVRSNTGQKT QPDVMSQNAK KLIQKNLATS ADTPPSTVPG TGKSVACSPK KAVRDPKTGK 3600

AVQERNSYAV SVWKRVKAKL EGRDVDPNRR MSVAEQVDYV IKEATNLDNL AQLYEGWTAW 3660

V 3661

Nucleotide Sequence
(FASTA)

ATGAGCCGCA GAGCCCCGGG GTCTCGGCTG AGCAGCGGCG GCACCAAGTA CCCGCGGAGC 60

TGGAATGACT GGCAACCCAG AACTGATAGT GCATCAGCCG ACCCAGATAA TTTAAAATAC 120

TCTTCATCCA GAGATAGGGG TGGTTCTTCC TCTTATGGAT TGCAACCTTC AAATTCTGCT 180

GTGGTGTCTC GGCAAAGGCA CGATGATACC AGAGTCCATG CTGACATACA GAATGACGAA 240

AAGGGTGGCT ACAGTGTCAA TGGAGGATCT GGGGAAAATA CTTATGGTCG GAAGTCGTTG 300

GGGCAAGAGC TGAGGGTTAA CAATGTGACC AGCCCTGAGT TCACCAGTGT TCACCATGGC 360

AGTCGTGCAT TAGCCACTAA AGACATGAGG AAATCACAGG AGCGATCGAT GTCTTATTCT 420

GATGAGTCTC GACTGTCGAA TCTTCTTCGG AGGATCACCC GAGAAGACGA CAGAGACAGA 480

AGACTGGCTA CTGTAAAGCA ACTGAAAGAA TTTATTCAGC AACCAGAAAA TAAGCTGGTA 540

TTAGTTAAAC AGTTGGATAA TATCTTGGCT GCTGTACACG ATGTCCTTAA TGAAAGTAGC 600

AAATTGCTTC AGGAGTTGAG ACAGGAAGGA GCTTGCTGTC TTGGCCTTCT TTGTGCTTCT 660

CTGAGCTATG AGGCTGAGAA GATCTTCAAG TGGATTTTTA GCAAATTTAG CTCATCTGCA 720

AAAGATGAAG TTAAACTCCT CTACTTATGT GCCACCTACA AAGCACTAGA GACTGTAGGA 780

GAAAAGAAAG CCTTTTCATC TGTAATGCAG CTTGTAATGA CCAGCCTACA GTCCATTCTT 840

GAAAATGTGG ATACACCAGA ATTACTTTGC AAATGTGTTA AGTGCATTCT TTTGGTGGCT 900

CGATGTTACC CTCATATTTT CAGCACTAAT TTTAGGGATA CTGTTGATAT ATTGGTTGGA 960

TGGCATATTG ATCATACCCA GAAACCTTCC CTCACACAGC AGGTGTCTGG GTGGTTACAG 1020

AGTTTGGAGC CATTTTGGGT AGCTGATCTT GCATTTTCTA CTACTCTTCT TGGTCAGTTT 1080

CTAGAAGATA TGGAGGCATA TGCTGAGGAC CTCAGCCATG TGGCCTCTGG GGAATCAGTG 1140

GATGAAGACA TCCCTCCTCC ATCAGTGTCA TTACCAAAGC TGGCAGCACT TCTCCGGGTG 1200

TTTAGCACTG TGGTGAGGAG CATTGGGGAA CGTTTCAGCC CAATTAGAGG TCCTCCAATT 1260

ACTGAAGCAT ATGTAACAGA TGTTCTGTAC AGAGTAATGA GATGTGTGAC GGCTGCAAAC 1320

CAAGTGTTTT TTTCTGAGGC TGTGTTGACA GCTGCTAATG AGTGTGTTGG TGTTTTGCTC 1380

GGCAGCTTGG ATCCTAGCAT GACTATACAT TGTGACATGG TCATTACATA TGGATTAGAC 1440

CAATTGGAGA ATTGCCAGAC TTGTGGTACC GATTATATCA TCTCAGTCTT GAATTTACTC 1500

ACATTGATTG TTGAGCAGAT AAATACAAAA CTGCCATCAT CCTTTGTAGA AAAACTGTTT 1560

ATACCATCAT CTAAACTACT ATTTTTGCGT TATCATAAAG AAAAAGAGGT TGTTGCTGTA 1620

GCCCATGCTG TTTATCAAGC AGTGCTAAGC CTGAAGAATA TTCCTGTTTT GGAGACTGCC 1680

TATAAATTAA TTTTGGGAGA GATGACTTGT GCCCTAAACA ACTTGCTACA TAGCCTACAA 1740

CTTCCTGATG CCTGTTCTGA AATAAAACAT GAGGCTTTTA AGAATCATGT ATTCAATGTA 1800

GATAATGCAA AATTTGTAGT TATATTTGAC CTCAGTGCCC TGACTACAAT CGGAAATGCC 1860

AAAAACTCAT TAATTGGAAT GTGGGCACTG TCTCCAACCG TCTTTGCACT TCTGAGTAAG 1920

AATCTGATGA TTGTGCACAA TGACCTGGCT GTTCACTTCC CTGCCATTCA ATATGCTGTG 1980

CTGTACACAT TGTATTCTCA TTGTACCAGG CATGACCACT TTATATCTAG TAGTCTTAGC 2040

TCTTCTTCTC CTTCTTTGTT TGATGGAGCT GTGATCAGTA CTGTAACTAC AGCTACAAAG 2100

AAACATTTCT CAATAATACT AAATCTTCTG GGAATATTGC TGAAGAAGGA TAACCTTAAC 2160

CAGGATACGA GGAAACTGTT AATGACTTGG GCTTTGGAAG TGGCTGTTTT AATGAAGAAG 2220

TCTGAAACAT ATGCACCCTT ATTTTCTCTT CCATCTTTCC ATAAATTTTG CAAAGGCCTA 2280

TTAGCCAACA CTCTTGTTGA AGATATGAAT ATCTGTCTGC AAGCCTGCAG TAGTCTTCAT 2340

GCTCTGTCCT CTTCCTTGCC AGATGATCTT TTACAGAGGT GTGTTGATGT TTGCCGTGTT 2400

CAGCTAGTCC ATAGTGGAAC TCGTATCCGA CAAGCATTTG GAAAGCTACT GAAGTCTATT 2460

CCTTTAGATG TTGTCCTAAG CAATAATAAT CACACAGAAA TTCAAGAAAT TTCTTTAGCA 2520

TTAAGAAGTC ATATGAGTAA AGCGCCAAGT AACACATTCC ACCCACAAGA TTTCTCTGAT 2580

GTTATTAGCT TTATTTTGTA TGGGAATTCT CACAGAACAG GGAAGGACAA TTGGTTAGAA 2640

AGATTGTTCT ATAGCTGCCA GAGACTGGAT AAGCGTGACC AATCAACAAT TCCTCGCAAT 2700

CTTCTAAAGA CAGATGCTGT CCTCTGGCAG TGGGCTATTT GGGAAGCAGC GCAATTTACT 2760

GTCCTTTCTA AATTGAGAAC CCCACTGGGC AGAGCTCAAG ACACCTTCCA GACAATTGAA 2820

GGTATCATTA GGAGTCTTGC AGCTCACACA TTAAACCCTG ATCAAGATGT TAGTCAGTGG 2880

ACAACTGCAG ACAATGATGA AGGACACAGC AGCAACCAAC TTAGACTTGT TCTTCTTCTA 2940

CAGTATCTGG AAAATTTAGA GAAACTAATG TATAATGCAT ATGAAGGATG TGCTAATGCC 3000

TTAACATCAC CTCCCAAGGT CATCAGGACT TTTTTCTATA CCAATCGCCA AACTTGTCAA 3060

GACTGGCTGA CCCGGATCAG ACTCTCCATT ATGAGGGTTG GCTTGTTAGC AGGCCAGCCT 3120

GCAGTGACCG TGAGACATGG CTTTGACTTA CTTACAGAGA TGAAGACAAC TAACCTATCT 3180

CAGGGAAATG ATTTGGAAGT AACCATTATG ATGGTGGTGG AAGCATTGTG TGAACTTCAT 3240

TGTCCTGAAG CTATACAGGG AATTGCTGTT TGGTCATCTT CTGTTGTTGG AAAAAATCTT 3300

CTCTGGATTA ACTCAGTGGC CCATCAGGCT GAAGGGAGGT TTGAAAAGGC CTCTGTGGAG 3360

TACCAGGAGC ACCTGTGTGC CATGACAGGT GTTGATTGCT GCATCTCCAG CTTTGACAAG 3420

TCTGTGCTTA CGTTGGCCAA TGCTGGGCGT AACAGTGCCA GTCCCAAGCA TTCTCTGAAT 3480

GGTGATTCCA GGAAAACTGT GCTGTCCAAA CCAACTGATT CTTCTCCTGA GGTTATAAAT 3540

TACTTAGGAA ATAAAGCATG TGAGTGCTAC ATCTCAATTG CCGATTGGGC TGCTGTACAG 3600

GACTGGCAGA ATGCTATCCA TGACTTGAAA AAGAGTACCA GTTCTACTTC TCTCAACCTA 3660

AAAGCCGATT TCAACTATAT AAAATCACTA AGCAGTTTTG AGTCTGGGGA ATTTGTTGAA 3720

TGTACTGAGC AGTTAGAATT ATTACCAGGA GAAAATATCA ATCTACTTGC TGGAGGATCA 3780

AAAGAAAAAA TAGATATGAA AAAACTGCTT CCTAACATGT TAAGTCCAGA TCCAAGGGAA 3840

CTTCAGAAAT CCATTGAAGT TCAGTTATTG AGAAGTTCTG TTTGTTTGGC AACTGCTTTA 3900

AACCACATAG AACAAGATCA GAAGTGGCAA TCTATAACTG AAAACGTGGT AAAATACTTG 3960

AAGCAGACAT CCCGCATAGC GATTGGACCA CTGAGACTTT CTACTTTAAC AGTTTCGCAG 4020

TCCTTACCTG TTCTAAGCAC CTTACAGCTG TATTGCTCAT CTGCCTTGGA GAACACAGTT 4080

TCTAACAGAC TTTCAACAGA GGACTGTCTA ATTCCACTCT TCAGTGAAGC TTTACGTTCA 4140

TGTAAACAGC ACGATGTGAG GCCATGGATG CAGGCATTAA GATATACTAT GTACCAAAAT 4200

CAGTTGTTGG AGAAAATTAA AGAACAAACA GTCCCAATTA GGAGCCATCT TATGGAATTA 4260

GGTTTAACAG CAGCAAAATT TGCTAGAAAA CGGGGAAATG TGTCACTTGC AACAAGACTA 4320

CTGGCACAGT GCAGTGAAGT TCAGCTGGGA AAGACCACCA CTGCACAGGA TTTAGTCCAG 4380

CATTTTAAAA AACTATCAAC TCAAGGTCAA GTGGATGAAA AATGGGGGCC TGAACTTGAT 4440

ATTGAAAAAA CCAAATTGCT GTATACGGCA GGCCAGTCAA CACACGCAAT GGAAATGTTG 4500

AGTTCTTGTG CCATATCTTT CTGCAAGTCT GCAAAAGCTG AATATGCAGT TGCTAAGTCA 4560

ATTCTGACAT TGGCTAAATG GATCCAGGCA GAGTGGAAAG AGATTTCAGG ACAGCTGAAA 4620

CAGGTTTACA GAGCTCAGCA ACAGCAGAGT GTCACAGGGC TTTCTACTTT GTCTAAAAAC 4680

ATACTCACCT TAATAGAACT GCCATCTGTT AATACAGCGG AAGAAGAGTA CCCTCGGATT 4740

GAGAGTGAAT CCACAGTGCA TATTGGAGTT GGAGAACCTG ACTTCATTTT GGGACAGTTG 4800

TACCACCTGT CTTCAGTACA GGCACCTGAA GTAGCCAAAT CTTGGGCAGC GTTGGCTAGT 4860

TGGGCGTATA GGTGGGGCAG AAAAGTAGTT GACAATGCCA GTCAGGGAGA AGGTGTTCGT 4920

CTGCTGCCTA GAGAAAAATC TGAAGTTCAG AATCTGCTTC CAGACACTAT AACTGAAGAA 4980

GAGAAAGAGA GAATATATGG TATTCTTGGA CAGGCTGTAT GTCGGCCAGC AGGAATTCAG 5040

GCAAGGAAAA CAGATGAAGA TATAACACTT CAGATAACAG AGAGTGAAGA CAATGAAGAA 5100

GATGACATGG TCGATGTTAT CTGGCGTCAG TTAATATCAA GCTGCCCATG GCTCTCAGAA 5160

CTTGATGAAA GTGCAACTGA AGGAGTTATT AAAGTGTGGA GGAAAGTTGT AGATAGAATC 5220

TTCAGCCTGT ACAAACTCTC TTGCAGTGCA TATTTTACTT TTCTTAAACT CAATGCTGGT 5280

CAAATTCCTT TAGATGAGGA CGACCCTAGG TTACATTTAA GTCACAGAGT GGAGCAGAGT 5340

ACTGATGACG TGATTGTGAT GGCCACGTTG CGACTGCTCA GATTGCTCGT GAAACATGCA 5400

GGCGAGCTTC GGCAGTATCT GGAACATGGC TTGGAGACAA CACCTACTGC TCCATGGAGA 5460

GGAATTATTC CGCAGCTTTT CTCACGCTTA AACCATCCTG AAGTGTATGT GCGCCAAAGT 5520

ATTTGTAACC TTCTGTGCCG TGTGGCTCAA GATTCCCCAC ATCTCATATT GTATCCTGCA 5580

ATAGTGGGTA CCATATCACT TAGTAGTGAA TCCCAGGCTT CAGGAAATAA GTTTTCTTCT 5640

GCAATTCCAA CTTTACTTGG CAATATTCAA GGAGAAGAAT TGCTGGTTTC TGAATGTGAG 5700

GGTGGAAGTC CTCCTGCTTC TCAGGATAGC AATAAGGATG AACCTAAAAG TGGATTAAAT 5760

GAAGACCAAG CCATGATGCA GGATTGTTAT AGCAAAATTG TAGATAAACT CTCTTCAGCA 5820

AACCCAACTA TGGTGCTGCA GGTTCAGATG CTCGTGGCTG AGCTGCGCAG GGTCACTGTG 5880

CTTTGGGATG AGCTCTGGCT GGGAGTTTTG TTACAGCAAC ACATGTATGT CCTGAGACGA 5940

ATTCAGCAGC TTGAAGATGA GGTGAAGAGA GTCCAGAACA ACAATACCTT ACGCAAGGAA 6000

GAGAAAGTTG CCATCATGCG GGAGAAGCAT ACAGCTCTTA TGAAGCCCAT TGTATTTGCT 6060

TTGGAGCATG TGAGGAGCAT CACAGCGGCC CCTGCAGAAA CGCCTCATGA AAAATGGTTT 6120

CAGGATAACT ATGGTGATGC AATTGAAAAT GCTCTGGAAA AACTGAAGAC CCCATCAAAC 6180

CCAGCAAAGC CTGGAAGCAG CTGGATTCCA TTTAAAGAGA TAATGTTGAG TTTGCAACAG 6240

AGAGCACAGA AACGTGCCAG TTACATCTTA CGTCTTGAAG AAATCAGTCC GTGGTTGGCT 6300

GCCATGACTA ACACTGAAAT TGCTCTTCCC GGGGAAGTCT CAGCCAGAGA CACTGTCACC 6360

ATCCACAGTG TGGGTGGAAC CATCACAATC TTACCCACTA AAACCAAGCC AAAGAAACTT 6420

CTCTTTCTGG GATCAGATGG AAAGAACTAT CCTTACCTGT TTAAAGGACT AGAGGATTTA 6480

CATTTGGATG AGAGAATAAT GCAGTTCCTA TCTATTGTGA ATACCATGTT TGCTACAATT 6540

AACCGCCAGG AGTCACCCCG TTTCCACGCT CGACACTATT CTGTAACACC ACTAGGAACC 6600

AGATCAGGAT TAATCCAGTG GGTGGATGGA GCTACACCAT TATTTGGTCT TTACAAACGA 6660

TGGCAACAAC GGGAAGCTGC ATTACAAGCA CAAAAGGCCC AAGATTCCTA CCAAACTCCT 6720

CAGAATCCTG GAATGGTGCC CCGTCCTAGT GAACTGTATT ACAGTAAAAT TGGCCCTGCT 6780

TTGAAAGCAG TTGGGCTTAG CCTGGATGTG TCCCGGCGCG ATTGGCCTCT TCATGTAATG 6840

AAGGCAGTGT TAGAGGAATT AATGGAGGCC ACACCCCCAA ACCTTCTGGC CAAGGAGCTC 6900

TGGTCGTCTT GCACAACACC TGATGAGTGG TGGAGAGTTA CACAGTCTTA CGCAAGATCT 6960

ACTGCTGTCA TGTCTATGGT TGGATACATC ATTGGCCTTG GAGATAGACA TCTGGATAAT 7020

GTTCTCATAG ATATGACGAC TGGAGAAGTT GTTCACATAG ATTACAATGT TTGCTTTGAA 7080

AAAGGTAAAA GCCTCAGAGT TCCTGAGAAA GTACCTTTTC GAATGACGCA AAACATTGAA 7140

ACAGCACTGG GTGTAACTGG TGTAGAAGGT GTTTTTAGGC TTTCCTGTGA GCAGGTTTTA 7200

CACATTATGC GGCGTGGCAG AGAGACTCTG CTGACACTGT TGGAGGCCTT CGTATACGAC 7260

CCTCTGGTGG ACTGGACGGC AGGAGGCGAG GCTGGCTTTG CTGGCGCTGT CTATGGCGGG 7320

GGTGGCCAGC AGGCTGAAAG CAAGCAGAGC AAGAGGGAGA TGGAGCGAGA GATTACCCGC 7380

AGCCTCTTTT CTTCCAGAGT AGCTGAAATT AAGGTGAACT GGTTTAAGAA TAGGGATGAG 7440

ATGCTGGTTG TGCTTCCCAA GCTGGACAGC AGCTTAGACG AATACCTAAG CTTGCAAGAG 7500

CAACTGACAG ATGTGGAAAA ACTACAGGGC AAACTGCTAG AGGAAATAGA ATTTCTGGAA 7560

GGAGCTGAAG GAGTGGATCA TCCTTCTCAT ACTTTGCAAC ACAGGTATTC TGAACACACC 7620

CAACTACAGA CTCAGCAAAG AGCAGTTCAG GAAGCAATCC AGGTGAAGCT GAATGAATTT 7680

GAACAGTGGA TAACACATTA CCAGGCTGCA TTCAATAATT TAGAAGCAAC ACAGCTTGCA 7740

AGCTTACTTC AGGAGATAAG CACACAAATG GACCTTGGGC CCCCAAGTTA TGTGCCAGCG 7800

ACAGCCTTTC TGCAGAATGC TGGCCAGGCC CACTTGATTA GCCAATGTGA GCAGCTGGAG 7860

GGGGAGGTTG GCGCTCTCCT GCAGCAGAGG CGCTCCGTGC TCCGTGGCTG TCTGGAACAG 7920

CTCCATCATT ATGCAACTGT AGCTCTACAG TATCCGAAGG CCATATTTCA GAAACATCGA 7980

ATTGAACAGT GGAAGACCTG GATGGAAGAG CTCATCTGTA ACACTACAGT AGAGCGCTGT 8040

CAAGAGCTCT ATAGGAAATA TGAAATGCAG TATGCTCCCC AACCACCCCC AACAGTGTGT 8100

CAGTTCATCA CTGCCACAGA AATGACCCTG CAGCGGTATG CAGCAGACAT AAACAGTAGA 8160

CTAATTCGAC AAGTGGAACG TTTGAAACAA GAAGCAGTCA CTGTGCCTGT TTGTGAAGAT 8220

CAGCTGAAAG AAATTGAGCG TTGCATTAAA GTTTTCCTTC ATGAGAATGG AGAAGAAGGG 8280

TCTTTGAGTC TAGCAAGTGT TATTATTTCT GCCCTTTGTA CCCTGACAAG GCGTAACCTG 8340

ATGATGGAAG GTGCTGCTTC AAGTGCTGGA GAGCAGCTGG TTGATCTGAC TTCTCGAGAC 8400

GGAGCCTGGT TCTTGGAGGA GCTGTGCAGT ATGAGTGGTA ACGTCACTTG CTTGGTTCAG 8460

TTACTGAAGC AGTGCCACCT GGTGCCACAG GACTTAGACA TCCCCAACCC CGTGGAAGCG 8520

TCAGAGGCAG TTCACTTAGC CAATGGAGTG TACACTTCAC TTCAGGAATT GAATTCAAAT 8580

TTCCGGCAAA TCATATTTCC AGAAGCACTT AGATGTTTAA TGAAGGGGGA ATTCACGTTG 8640

GAAAGTATGC TTCATGAACT GGACAATCTT ATTGAGCAGA CAACTGATGG CATTCCCCTA 8700

CAGACTCTAG TTGAATCTCT TCAAGCCTAT TTAAGAAATG CAGCGATGGG ACTTGAAGAA 8760

GAAACACACG CTCATTACAT TGATATAAAG GAGGTACTAC ATGCTCAATA TGGTGAATTA 8820

ATTCAACCAA GAAATGGTTC AGTTGATGAA ACACCTAAAA TGTCAGCTGG CCAGATGCTT 8880

TTGGTAGCAT TTGATGGCAT GTTTGCCCAA GTTGAAACAG CTTTTGGCTT ATTAGTTGAA 8940

AAGTTAAACA AAATGGAAAT TCCTATAGCT TGGCGAAAGA TTGACATCAT AAGGGAAGCA 9000

AGGAGTACCC AAGTTAATTT TTTTGATGAT GATAACCACC GACAGGTGCT AGAAGAGATT 9060

TTTTTTCTAA AAAGACTACA GACAATTAAG GAGTTCTTCA GGCTCTGTGG CACCTTTTCT 9120

AAAACATTGT CAGGATCAAG TTCACTTGAA GATCAGAATT CTGTGAATGG GCCTGTACAG 9180

ATTGTCAATG TGAAAACCCT TTTTAGAAAC TCTTGTTTCA GTGAAGACCA AATGGCCAAA 9240

CCTATCAAGG CATTCACAGC CGATTTCGTA AGGCAGCTCT TGATAGGACT ACCAAACCAA 9300

GCCCTTGGAC TTACACTGTG CAGTTTTATC AGTGCTCTGG GTGTAGACAT CATTGCTCAA 9360

GTGGAGGCAA AGGACTTTGG TGCCGAAAGC AAAGTTTCTG TTGATGATTT GTGTAAGAAA 9420

GCGGTGGAGC ACAACATTCA GGTTGGGAAG TTCTCTCAGT TGGTTATGAA CAGGGCAACG 9480

GTATTAGCAA GTTCTTATGA CACAGCCTGG AAGAAGCACG ACTTGGTACG AAGGCTGGAA 9540

ACCAGCATTT CTTCTTGTAA GACAAGCCTG CAACGGGTTC AGTTGCATAT TGCCATGTTT 9600

CAGTGGCAAC ATGAAGATCT GCTTATTAAC AGACCACAAG CCATGTCAGT AACACCTCCC 9660

CCTCGGTCTG CTATCCTAAC CAGCATGAAA AAGAAACTAC ATACTCTGAG CCAAATTGAA 9720

ACTTCCATTG CAACAGTTCA GGAGAAACTA GCAGCCCTTG AAGCAAGTAT TGAGCAGCGA 9780

CTCAAGTGGG CAGGTGGTGC TAACCCTGCG TTGGCACCTG TGCTACAAGA TTTTGAAGCA 9840

ACAATAGCTG AAAGAAGAAA TCTTGTCCTT AAAGAGAGCC AAAGAGCAAG TCAGGTCACT 9900

TTTCTCTGCA GCAATATCAT TCATTTTGAA AGCTTACGAA CAAGAACTGC AGAAGCCTTA 9960

AACCTGGACG CTGCATTATT TGAACTAATC AAACGGTGTC AGCAAATGTG TTCATTTGCA 10020

TCACAGTTTA ACAGTTCAGT GTCTGAGTTA GAGCTTCGTT TATTACAGAG AGTGGACACT 10080

GGTCTTGAAC ATCCTATTGG CAGCTCTGAA TGGCTTTTGT CAGCACATAA ACAATTGACC 10140

CAGGATATGT CTACTCAGAG GGCAATTCAA ACAGAGAAAG AGCAACAGAT TGAAACAGTC 10200

TGTGAAACAA TTCAGAATCT GGTTGATAAT ATAAAGACTG TGCTCACTGG TCATAATCGA 10260

CAGCTTGGAG ATGTCAAACA TCTCCTAAAA GCAATGGCTA AGGATGAAGA AGCTGCTTTG 10320

GCAGATGGTG AAGATGTTCC CTATGAGAAC AGTGTTAGAC AGTTTTTGGG TGAATATAAA 10380

TCATGGCAAG ACAACATTCA GACAGTTCTG TTTACATTAG TCCAGGCTAT GGGTCAGGTT 10440

CGAAGTCAAG AACATGTTGA AATGCTCCAG GAAATTACTC CCACCTTGAA AGAACTGAAA 10500

ACACAAAGTC AGAGTATCTA TAATAATTTA GTGAGTTTTG CATCACCCTT AGTCACTGAT 10560

GCAACAAATG AATGTTCGAG TCCAACGTCA TCTGCTACTT ATCAGCCATC CTTTGCTGCA 10620

GCAGTCCGGA GTAACACTGG CCAGAAGACT CAGCCTGACG TCATGTCACA GAATGCTAAA 10680

AAGCTGATTC AGAAAAATCT TGCTACATCA GCAGATACGC CACCAAGCAC AGTTCCAGGA 10740

ACTGGCAAGA GTGTTGCTTG TAGTCCTAAA AAGGCTGTCA GAGACCCTAA AACTGGGAAA 10800

GCTGTGCAAG AGAGAAACTC ATATGCAGTG AGTGTGTGGA AGAGAGTGAA AGCCAAGTTA 10860

GAGGGCCGAG ATGTTGATCC CAACAGGAGG ATGTCAGTTG CTGAACAGGT TGACTATGTC 10920

ATTAAGGAAG CAACTAATCT AGATAACTTG GCTCAGCTGT ATGAAGGTTG GACAGCCTGG 10980

GTATGA 10986

Domain Profile

S: 3     gfderveilaskqkpkklllrGsdgkeypyLvkgkeDlrqdervlqlfslvNtlLakdke  62

         ++  +++il++k+kpkkll++Gsdgk ypyL+kg+eDl+ der++q++s+vNt++a+ ++

Q: 2123  SVGGTITILPTKTKPKKLLFLGSDGKNYPYLFKGLEDLHLDERIMQFLSIVNTMFATINR  2182

         566789******************************************************

S: 63    tsrrkLkirtykVvplstrsgliewventvsLkellkklvekkavlldqpi..syrykdl  120

         ++ +++++r+y+V+pl+trsgli+wv+++++L+ l+k++++++a+l++q++  sy+++++

Q: 2183  QESPRFHARHYSVTPLGTRSGLIQWVDGATPLFGLYKRWQQREAALQAQKAqdSYQTPQN  2242

         **************************************************999*******

S: 121   stvqar.........kpklkhlkls.........levfkevlenlv...pkdllkkllle  159

         + +++r         +p+lk++ ls         l+v+k+vle+l+   p++ll+k+l++

Q: 2243  PGMVPRpselyyskiGPALKAVGLSldvsrrdwpLHVMKAVLEELMeatPPNLLAKELWS  2302

         ***************999999999999*****************99999***********

S: 160   kfpspeewfelrkaytrslAvislvgyiLgLgdrhlenllidqetgevvhidfgvafeka  219

         ++++p+ew++++++y+rs+Av+s+vgyi+gLgdrhl+n+lid++tgevvhid++v+fek+

Q: 2303  SCTTPDEWWRVTQSYARSTAVMSMVGYIIGLGDRHLDNVLIDMTTGEVVHIDYNVCFEKG  2362

         ************************************************************

S: 220   ktqlkvpekvPFRLTrnivnalgvtgveGvfrasceavlrvlreskeklltiLevflydp  279

         k+ l+vpekvPFR+T+ni++algvtgveGvfr sce+vl+++r+ +e+llt+Le+f+ydp

Q: 2363  KS-LRVPEKVPFRMTQNIETALGVTGVEGVFRLSCEQVLHIMRRGRETLLTLLEAFVYDP  2421

         **.*********************************************************

S: 280   lvdwkk...................k  286

         lvdw+                    +

Q: 2422  LVDWTAggeagfagavyggggqqaeS  2447

         *****988777777666555522222

Domain Sequence
(FASTA)

SVGGTITILP TKTKPKKLLF LGSDGKNYPY LFKGLEDLHL DERIMQFLSI VNTMFATINR 60

QESPRFHARH YSVTPLGTRS GLIQWVDGAT PLFGLYKRWQ QREAALQAQK AQDSYQTPQN 120

PGMVPRPSEL YYSKIGPALK AVGLSLDVSR RDWPLHVMKA VLEELMEATP PNLLAKELWS 180

SCTTPDEWWR VTQSYARSTA VMSMVGYIIG LGDRHLDNVL IDMTTGEVVH IDYNVCFEKG 240

KSLRVPEKVP FRMTQNIETA LGVTGVEGVF RLSCEQVLHI MRRGRETLLT LLEAFVYDPL 300

VDWTAGGEAG FAGAVYGGGG QQAES 325

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0016301	; F:kinase activity
GO:0016773	; F:phosphotransferase activity, alcohol group as acceptor

KEGG

InterPros

IPR011989	; ARM-like.
IPR016024	; ARM-type_fold.
IPR003152	; FATC.
IPR011009	; Kinase-like_dom.
IPR000403	; PI3/4_kinase_cat_dom.
IPR018936	; PI3/4_kinase_CS.
IPR014009	; PIK_FAT.

Pfam

PF02260	; FATC; 1.
PF00454	; PI3_PI4_kinase; 1.

SMARTs

SM00146

; PI3Kc; 1.

Prosites

PS51189	; FAT; 1.
PS51190	; FATC; 1.
PS00916	; PI3_4_KINASE_2; 1.
PS50290	; PI3_4_KINASE_3; 1.

Prints

Created Date

20-Feb-2013