EKS-OTG-00004
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-OTG-00004
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TK/Eph513.38.3E-155597856260
StatusUnreviewed
Ensembl ProteinENSOGAP00000011839
UniProt AccessionH0X8L0;
Protein Name
Protein Synonyms/Alias
Gene NameEPHB1
Gene Synonyms/Alias EPHB1;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSOGAG00000013210ENSOGAP00000011839ENSOGAT00000013215
OrganismOtolemur garnettii
Functional Description
Protein Length962
Protein Sequence
(FASTA)
MDTRTATAEL GWTANPASGW EEVSGYDENL NTIRTYQVCN VFEPNQNNWL LTTFINRRGA 60
HRIYTEMRFT VRDCSSLPNV PGSCKETFNL YYYETDSVIA TKKSAFWSEA PYLKVDTIAA 120
DESFSQVDFG GRLMKVNTEV RSFGPLTRNG FYLAFQDYGA CMSLLSVRVF FKKCPSIVQN 180
FAVFPETMTG AESTSLVIAR GTCIPNAEEV DVPIKLYCNG DGEWMVPIGR CTCKPGYEPE 240
NSVACKACPA GMFKASQEAE GCSHCPSNSR SPSEASPICT CRTGYYRADF DPPEVACTSV 300
PSGPRNVISI VNETSIILEW HPPRETGGRD DVTYNIICKK CRADRRSCSR CDDNVEFVPR 360
QLGLTEGRVS ISSLWAHTPY TFDIQAINGV SSKSPFPPQH VSVNITTNQA APSTVPIMHQ 420
VSATMRSITL SWPQPEQPNG IILDYEIRYY EKEHNEFNSS MARSQTNTAR IDGLRPGMVY 480
VVQVRARTVA GYGKFSGKMC FQTLTDDDYK SELREQLPLI AGSAAAGVVF VVSLVAISIV 540
CSRKRAYSKE AVYSDKLQHY STGRGSPGMK IYIDPFTYED PNEAVREFAK EIDVSFVKIE 600
EVIGAGEFGE VYKGRLKLPG KREISVAIKT LKAGYSEKQR RDFLSEASIM GQFDHPNIIR 660
LEGVVTKSRP VMIVTEFMEN GALDSFLRQN DGQFTVIQLV GMLRGIAAGM KYLAEMNYVH 720
RDLAARNILV NSNLVCKVSD FGLSRYLQDD TSDPTYTSSL GGKIPVRWTA PEAIAYRKFT 780
SASDVWSYGI VMWEVMSFGE RPYWDMSNQD VINAIEQDYR LPPPMDCPAA LHQLMLDCWQ 840
KDRNSRPRFA EIVNTLDKMI RNPASLKTMA TITAVPSQPL LDRSIPDFTA FTTVDDWLSA 900
IKMVQYRDSF LTAGFTSLQL VTQMTSEDLL RIGITLAGHQ KKILNSIHSM RVQMSQSPTA 960
MA 962
Nucleotide Sequence
(FASTA)
ATGGACACCA GGACGGCTAC TGCAGAGCTG GGCTGGACAG CCAATCCTGC ATCAGGGTGG 60
GAAGAAGTCA GTGGCTACGA TGAAAACCTA AACACCATCC GCACCTACCA GGTGTGCAAT 120
GTCTTCGAGC CCAATCAAAA CAACTGGCTG CTCACCACCT TCATCAACCG GCGGGGAGCC 180
CATCGCATCT ACACAGAGAT GCGCTTCACT GTGAGAGACT GCAGCAGCCT TCCCAATGTC 240
CCAGGTTCCT GCAAGGAGAC CTTCAACTTG TATTATTATG AGACTGACTC TGTCATTGCC 300
ACCAAGAAGT CGGCCTTCTG GTCTGAGGCC CCCTACCTCA AAGTAGACAC CATTGCTGCA 360
GATGAGAGCT TCTCCCAAGT GGACTTTGGA GGAAGGCTGA TGAAGGTCAA CACGGAAGTC 420
AGGAGCTTTG GGCCTCTTAC TCGGAATGGT TTTTACCTCG CTTTCCAAGA TTATGGAGCC 480
TGCATGTCTC TCCTTTCTGT CCGTGTCTTC TTCAAAAAAT GTCCCAGCAT TGTGCAAAAT 540
TTTGCAGTGT TTCCAGAGAC CATGACAGGG GCAGAGAGCA CATCTCTGGT GATTGCTCGA 600
GGCACATGCA TTCCCAATGC AGAGGAAGTG GATGTGCCTA TTAAACTCTA CTGCAACGGG 660
GATGGGGAAT GGATGGTACC CATTGGACGA TGCACCTGCA AACCTGGCTA TGAGCCTGAG 720
AACAGCGTGG CCTGCAAGGC CTGTCCTGCA GGGATGTTCA AGGCCAGCCA GGAAGCTGAA 780
GGCTGCTCCC ACTGCCCCTC CAACAGCCGC TCCCCTTCAG AGGCATCTCC TATTTGTACC 840
TGCCGGACTG GCTATTACCG TGCGGATTTT GACCCCCCAG AAGTGGCCTG CACTAGTGTT 900
CCATCTGGTC CCCGAAATGT CATCTCCATT GTCAACGAGA CGTCCATCAT TCTGGAGTGG 960
CACCCTCCAA GGGAGACAGG TGGCCGGGAT GATGTGACCT ACAACATCAT CTGCAAAAAG 1020
TGCCGGGCGG ACCGCCGGAG CTGCTCCCGC TGTGACGACA ACGTGGAGTT CGTGCCCAGG 1080
CAGCTGGGCC TGACCGAGGG CCGGGTCTCC ATCAGCAGCC TGTGGGCCCA CACCCCCTAC 1140
ACCTTTGATA TCCAGGCCAT CAATGGAGTC TCCAGCAAGA GTCCCTTTCC CCCACAGCAC 1200
GTGTCTGTCA ACATCACCAC AAATCAAGCT GCCCCCTCCA CTGTTCCCAT CATGCACCAG 1260
GTCAGCGCCA CCATGAGGAG CATCACCTTG TCATGGCCAC AGCCAGAGCA GCCCAATGGC 1320
ATCATCCTGG ACTATGAGAT TCGGTACTAT GAGAAGGAAC ACAATGAGTT TAACTCCTCC 1380
ATGGCCAGGA GCCAGACCAA CACGGCACGG ATCGATGGGC TGCGGCCTGG CATGGTGTAT 1440
GTGGTGCAGG TGCGCGCCCG CACTGTGGCA GGCTATGGCA AGTTCAGCGG CAAGATGTGC 1500
TTCCAAACTC TGACGGATGA TGATTACAAG TCAGAGCTGA GGGAGCAGCT GCCCCTGATT 1560
GCTGGCTCAG CAGCGGCTGG AGTTGTGTTT GTCGTGTCCT TGGTGGCCAT CTCCATCGTC 1620
TGTAGCAGGA AACGGGCTTA TAGCAAGGAG GCCGTGTACA GCGATAAGCT TCAGCATTAC 1680
AGCACAGGCC GAGGCTCCCC AGGGATGAAG ATCTACATTG ACCCCTTCAC TTATGAGGAC 1740
CCCAATGAAG CTGTCCGGGA GTTTGCCAAG GAGATTGATG TATCTTTTGT GAAAATTGAA 1800
GAGGTCATCG GAGCAGGAGA GTTTGGAGAA GTGTACAAGG GACGTTTGAA ACTGCCAGGC 1860
AAGAGGGAGA TCTCAGTGGC CATCAAGACG CTGAAGGCAG GCTACTCGGA GAAGCAGCGC 1920
CGGGACTTCC TGAGCGAGGC AAGCATCATG GGCCAGTTCG ACCACCCCAA CATCATCCGC 1980
CTGGAGGGCG TGGTCACCAA GAGCCGGCCC GTTATGATCG TCACTGAGTT CATGGAGAAT 2040
GGGGCTCTGG ATTCTTTCCT CAGGCAGAAT GACGGGCAGT TCACAGTGAT CCAGCTGGTG 2100
GGTATGCTCA GGGGCATTGC CGCTGGCATG AAGTACCTGG CCGAGATGAA CTACGTGCAC 2160
CGGGACCTGG CTGCTAGGAA CATTCTGGTC AACAGTAACC TGGTGTGCAA GGTGTCTGAC 2220
TTTGGCCTGT CCCGCTACCT CCAGGATGAC ACCTCAGACC CCACTTACAC CAGCTCCTTG 2280
GGTGGAAAGA TCCCTGTGAG ATGGACGGCT CCAGAGGCCA TTGCCTACCG CAAGTTCACT 2340
TCAGCCAGCG ACGTCTGGAG CTACGGGATT GTCATGTGGG AAGTCATGTC ATTTGGAGAG 2400
AGACCCTACT GGGATATGTC CAACCAAGAT GTAATCAATG CCATTGAGCA GGACTACCGG 2460
CTACCTCCAC CCATGGACTG CCCAGCTGCT CTACACCAGC TCATGCTGGA CTGTTGGCAG 2520
AAAGACCGAA ACAGCCGGCC CCGCTTTGCA GAGATTGTCA ACACCCTGGA CAAGATGATC 2580
CGGAACCCAG CAAGTCTCAA GACTATGGCA ACCATCACCG CCGTGCCTTC CCAACCCCTG 2640
CTCGACCGCT CCATCCCCGA CTTCACAGCC TTTACCACCG TGGATGACTG GCTCAGTGCC 2700
ATCAAAATGG TTCAGTACAG GGACAGCTTC CTCACCGCTG GCTTTACCTC CCTCCAGCTG 2760
GTCACCCAGA TGACATCAGA AGACCTCCTG AGAATAGGGA TCACCTTGGC AGGCCATCAG 2820
AAGAAGATCC TGAACAGTAT TCATTCTATG AGAGTCCAGA TGAGTCAGTC ACCAACGGCA 2880
ATGGCATGA 2889
Domain Profile
S: 1     vkiekviGaGefGevcsGrlklpgkreiavaiktlkagstekqrrdflseasilGqfdhp  60
         vkie+viGaGefGev++Grlklpgkrei+vaiktlkag++ekqrrdflseasi+Gqfdhp
Q: 597   VKIEEVIGAGEFGEVYKGRLKLPGKREISVAIKTLKAGYSEKQRRDFLSEASIMGQFDHP  656
         79**********************************************************
S: 61    niirleGvvtkskpvmivteymengaldsflrkkdgqftviqlvgmlrGiasgmkylsdm  120
         niirleGvvtks+pvmivte+mengaldsflr++dgqftviqlvgmlrGia+gmkyl++m
Q: 657   NIIRLEGVVTKSRPVMIVTEFMENGALDSFLRQNDGQFTVIQLVGMLRGIAAGMKYLAEM  716
         ************************************************************
S: 121   gyvhrdlaarnilvnsnlvckvsdfGlsrvledds.eaaytts.ggkipirwtapeaiay  178
         +yvhrdlaarnilvnsnlvckvsdfGlsr l+dd+ +++yt+s ggkip+rwtapeaiay
Q: 717   NYVHRDLAARNILVNSNLVCKVSDFGLSRYLQDDTsDPTYTSSlGGKIPVRWTAPEAIAY  776
         *******************************99999*****999****************
S: 179   rkftsasdvwsyGivlwevlsyGerpywdmsnqdvikaieegyrlpppmdcpaalyqlml  238
         rkftsasdvwsyGiv+wev+s+Gerpywdmsnqdvi+aie++yrlpppmdcpaal+qlml
Q: 777   RKFTSASDVWSYGIVMWEVMSFGERPYWDMSNQDVINAIEQDYRLPPPMDCPAALHQLML  836
         ************************************************************
S: 239   dcwqkdraerpkfeqivsil  258
         dcwqkdr++rp+f++iv++l
Q: 837   DCWQKDRNSRPRFAEIVNTL  856
         *****************975
Domain Sequence
(FASTA)
VKIEEVIGAG EFGEVYKGRL KLPGKREISV AIKTLKAGYS EKQRRDFLSE ASIMGQFDHP 60
NIIRLEGVVT KSRPVMIVTE FMENGALDSF LRQNDGQFTV IQLVGMLRGI AAGMKYLAEM 120
NYVHRDLAAR NILVNSNLVC KVSDFGLSRY LQDDTSDPTY TSSLGGKIPV RWTAPEAIAY 180
RKFTSASDVW SYGIVMWEVM SFGERPYWDM SNQDVINAIE QDYRLPPPMD CPAALHQLML 240
DCWQKDRNSR PRFAEIVNTL 260
KeywordATP-binding; Complete proteome; Kinase; Membrane; Nucleotide-binding; Phosphoprotein; Receptor; Reference proteome; Transferase; Transmembrane; Transmembrane helix; Tyrosine-protein kinase.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona savignyi"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Ictidomys tridecemlineatus"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Microcebus murinus"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>
EKS-AIM-00006
EKS-BOT-00012
EKS-CAJ-00006
EKS-CAF-00006
EKS-CAP-00013
EKS-CIS-00003
EKS-DRM-00001
EKS-EQC-00006
EKS-FEC-00003
EKS-GAM-00002
EKS-GAG-00006
EKS-GAA-00007
EKS-GOG-00005
EKS-ICT-00005
EKS-MAM-00005
EKS-MEG-00005
EKS-MIM-00001
EKS-MOD-00007
EKS-MUM-00006
EKS-MUP-00006
EKS-MYL-00006
EKS-NOL-00005
EKS-ORN-00008
EKS-ORC-00006
EKS-ORL-00006
EKS-PAT-00006
EKS-PES-00006
EKS-POA-00004
EKS-RAN-00006
EKS-TAG-00013
EKS-TAR-00007
EKS-XET-00003
EKS-XIM-00006
Gene Ontology
GO:0005887; C:integral to plasma membrane
GO:0005524; F:ATP binding
GO:0005003; F:ephrin receptor activity
KEGG
InterPros
IPR001090; Ephrin_rcpt_lig-bd_dom.
IPR003961; Fibronectin_type3.
IPR008979; Galactose-bd-like.
IPR009030; Growth_fac_rcpt.
IPR013783; Ig-like_fold.
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR001660; SAM.
IPR013761; SAM/pointed.
IPR021129; SAM_type1.
IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
IPR008266; Tyr_kinase_AS.
IPR020635; Tyr_kinase_cat_dom.
IPR016257; Tyr_kinase_ephrin_rcpt.
IPR001426; Tyr_kinase_rcpt_V_CS.
Pfam
PF01404; Ephrin_lbd; 1.
PF00041; fn3; 2.
PF07714; Pkinase_Tyr; 1.
PF00536; SAM_1; 1.
SMARTs
SM00615; EPH_lbd; 1.
SM00060; FN3; 2.
SM00454; SAM; 1.
SM00219; TyrKc; 1.
Prosites
PS51550; EPH_LBD; 1.
PS50853; FN3; 2.
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00109; PROTEIN_KINASE_TYR; 1.
PS00790; RECEPTOR_TYR_KIN_V_1; 1.
PS00791; RECEPTOR_TYR_KIN_V_2; 1.
PS50105; SAM_DOMAIN; 1.
Prints
PR00109; TYRKINASE.
Created Date20-Feb-2013