EKS-OTG-00197

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-OTG-00197

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TKL/LISK	483.9	1.1E-145	340	605	266

Status

Unreviewed

Ensembl Protein

ENSOGAP00000011862

UniProt Accession

H0X8N2;

Protein Name

Protein Synonyms/Alias

Gene Name

LIMK1

Gene Synonyms/Alias

LIMK1;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSOGAG00000013239	ENSOGAP00000011862	ENSOGAT00000013242

Organism

Otolemur garnettii

Functional Description

Protein Length

648

Protein Sequence
(FASTA)

MRLTLLCCTW REERMGEEAG SELPVCARCG QRIYDGQYLQ ALSADWHADC FRCCECSASL 60

SHQYYEKDGQ LFCKKDYWAR YGESCHGCSE HITKGLVMVA GELKYHPECF ICLTCGTFIG 120

DGDTYTLVEH SKLYCGHCYY QTVVTPVIEQ ILPDSPGSHL PHTVTLVSIP ASSHGKRGLS 180

VSIDPPHGLP GCGTEHSHTV RVQGVDPGCM SPDVKNSIHV GDRILEINGT PIRNVPLDEI 240

DLLIQETSRL LQLTLEHDPH DTLGQGPGPE ISPLVSPAHT PSGEAGSSAR QKPVLRSHSI 300

DRSPGAGSLG SPASQRKDHG RSESLRVICR PHRIFRPSDL IHGEVLGKGC FGQAIKVTHR 360

ETGEVMVMKE LIRFDEETQR TFLKEVKVMR CLEHPNVLKF IGVLYKDKRL NFITEYIKGG 420

TLRGIIKSMD SQYPWSQRVS FAKDIASGMA YLHSMNIIHR DLNSHNCLVR ENKNVVVADF 480

GLARLMVDEK TQPEDLRSLK KPDRKKRYTV VGNPYWMAPE MINGRSYDEK VDVFSFGIVL 540

CEIIGRVNAD PDYLPRTMDF GLNVRGFLDR YCPPNCPPSF FPITVRCCDL DPEKRPSFVQ 600

LEHWLETLRM HLAGHLPLGP QLEQLERGFW ETYRRGESGL PAHPEVPD 648

Nucleotide Sequence
(FASTA)

ATGAGGTTGA CGCTACTTTG TTGCACCTGG AGGGAAGAAC GTATGGGAGA GGAAGCAGGA 60

AGTGAGTTGC CTGTGTGTGC ACGCTGTGGC CAGAGGATCT ATGATGGCCA GTACCTCCAG 120

GCCCTGAGTG CTGACTGGCA CGCGGACTGT TTCAGGTGTT GTGAATGCAG CGCCTCTCTC 180

TCGCACCAGT ACTATGAGAA AGATGGGCAG CTCTTCTGTA AGAAAGACTA CTGGGCCCGC 240

TATGGCGAGT CCTGCCATGG GTGCTCGGAG CACATCACCA AGGGGCTGGT CATGGTGGCT 300

GGGGAGCTGA AGTACCACCC TGAGTGCTTC ATCTGCCTGA CATGCGGGAC CTTCATCGGT 360

GACGGGGACA CCTACACGCT GGTGGAGCAC TCCAAGCTGT ACTGTGGACA CTGCTACTAC 420

CAGACCGTGG TGACCCCTGT CATCGAGCAG ATCCTGCCTG ACTCCCCTGG CTCCCACCTG 480

CCCCACACAG TCACCCTAGT TTCCATCCCA GCCTCATCTC ATGGCAAGCG TGGCCTCTCA 540

GTCTCCATTG ACCCCCCTCA TGGCCTGCCG GGTTGCGGCA CCGAGCACTC CCACACCGTC 600

CGCGTCCAGG GAGTGGACCC AGGCTGCATG AGCCCTGATG TGAAGAATTC CATCCATGTT 660

GGAGACCGGA TCTTGGAAAT CAATGGCACA CCCATCCGGA ATGTACCCCT GGATGAGATT 720

GATCTGCTGA TCCAGGAGAC CAGTCGCCTG CTGCAGCTGA CTCTTGAGCA TGACCCCCAT 780

GACACACTAG GCCAAGGGCC AGGGCCTGAG ATCAGCCCTC TGGTTTCCCC GGCTCACACC 840

CCCAGCGGGG AGGCTGGTAG CTCTGCTCGG CAGAAGCCTG TCTTGAGGAG CCACAGCATC 900

GACAGGTCCC CGGGAGCTGG CTCGCTAGGC TCTCCTGCCT CCCAGCGCAA GGACCATGGA 960

CGCTCTGAGT CCCTCCGCGT CATCTGCCGG CCACACCGCA TCTTCCGGCC ATCGGACCTC 1020

ATCCATGGGG AGGTGTTGGG CAAGGGCTGC TTTGGCCAGG CCATCAAGGT GACACACCGA 1080

GAGACAGGTG AGGTGATGGT GATGAAGGAG CTGATCAGGT TCGACGAGGA GACCCAAAGG 1140

ACATTCCTCA AGGAGGTGAA GGTCATGCGG TGCCTAGAGC ACCCTAATGT GCTCAAGTTC 1200

ATTGGAGTGC TCTACAAGGA CAAGAGGCTC AACTTCATCA CTGAGTACAT CAAGGGGGGC 1260

ACCCTGCGGG GCATCATCAA GAGTATGGAC AGCCAGTACC CGTGGAGTCA GAGGGTGAGC 1320

TTTGCCAAGG ATATCGCTTC AGGGATGGCC TACCTCCACT CCATGAACAT CATCCACCGA 1380

GACCTCAACT CCCACAACTG CTTAGTCCGA GAGAACAAGA ATGTGGTGGT GGCTGACTTC 1440

GGGCTGGCAC GGCTCATGGT GGATGAGAAG ACTCAGCCCG AGGATCTGCG AAGCCTCAAG 1500

AAGCCAGACC GTAAAAAGCG CTACACCGTG GTAGGCAACC CCTACTGGAT GGCACCTGAG 1560

ATGATCAACG GCCGCAGCTA CGATGAGAAG GTGGATGTAT TTTCCTTTGG AATTGTCCTA 1620

TGTGAGATCA TTGGGCGGGT GAACGCAGAC CCTGACTACC TGCCCCGCAC CATGGACTTC 1680

GGCCTCAATG TGCGAGGCTT TCTGGACCGC TATTGTCCCC CAAACTGCCC CCCGAGCTTC 1740

TTCCCTATTA CTGTGCGCTG CTGTGATCTG GACCCTGAGA AAAGGCCCTC CTTCGTGCAG 1800

CTGGAGCACT GGCTGGAGAC CCTCCGCATG CACTTGGCCG GCCATCTGCC ACTGGGCCCA 1860

CAGCTGGAGC AGCTGGAGAG GGGCTTCTGG GAGACCTACC GGCGTGGCGA GAGTGGACTG 1920

CCTGCCCACC CTGAGGTCCC TGACTGA 1947

Domain Profile

S: 1     livgeklGkGffsevfkvthrasGevmvlkeliradeenrknllkevkllrklehpnvlk  60

         li+ge+lGkG+f++++kvthr++Gevmv+kelir+dee+++++lkevk++r+lehpnvlk

Q: 340   LIHGEVLGKGCFGQAIKVTHRETGEVMVMKELIRFDEETQRTFLKEVKVMRCLEHPNVLK  399

         689*********************************************************

S: 61    fiGvlvkdkklhllteyiegGtlkellkskes.lpwtqrvrlakdiasGlsylhskgiih  119

         fiGvl+kdk+l+++teyi+gGtl+ ++ks++s +pw+qrv++akdiasG++ylhs++iih

Q: 400   FIGVLYKDKRLNFITEYIKGGTLRGIIKSMDSqYPWSQRVSFAKDIASGMAYLHSMNIIH  459

         ******************************999***************************

S: 120   rdlnsknclvredksvvvadfGlarlvveerkkseklrslkkkdrkkrltvvGsPywmaP  179

         rdlns+nclvre+k+vvvadfGlarl+v+e++++e+lrslkk drkkr+tvvG+PywmaP

Q: 460   RDLNSHNCLVRENKNVVVADFGLARLMVDEKTQPEDLRSLKKPDRKKRYTVVGNPYWMAP  519

         ************************************************************

S: 180   evlkgksydekvdvfsfGivlceiiarveadPdylPrtedfgldvkafreklvaedcPea  239

         e+++g+sydekvdvfsfGivlceii+rv+adPdylPrt+dfgl+v+ f +++++ +cP++

Q: 520   EMINGRSYDEKVDVFSFGIVLCEIIGRVNADPDYLPRTMDFGLNVRGFLDRYCPPNCPPS  579

         ************************************************************

S: 240   flklavvccdldpesrpsfeelekkl  265

         f++++v+ccdldpe+rpsf++le++l

Q: 580   FFPITVRCCDLDPEKRPSFVQLEHWL  605

         ***********************997

Domain Sequence
(FASTA)

LIHGEVLGKG CFGQAIKVTH RETGEVMVMK ELIRFDEETQ RTFLKEVKVM RCLEHPNVLK 60

FIGVLYKDKR LNFITEYIKG GTLRGIIKSM DSQYPWSQRV SFAKDIASGM AYLHSMNIIH 120

RDLNSHNCLV RENKNVVVAD FGLARLMVDE KTQPEDLRSL KKPDRKKRYT VVGNPYWMAP 180

EMINGRSYDE KVDVFSFGIV LCEIIGRVNA DPDYLPRTMD FGLNVRGFLD RYCPPNCPPS 240

FFPITVRCCD LDPEKRPSFV QLEHWL 266

Keyword

Complete proteome; LIM domain; Metal-binding; Reference proteome; Zinc.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Dipodomys ordii"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Macropus eugenii"; ?>Meleagris gallopavo"; ?>Microcebus murinus"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004672	; F:protein kinase activity
GO:0008270	; F:zinc ion binding

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR001478	; PDZ.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR001781	; Znf_LIM.

Pfam

PF00412	; LIM; 2.
PF00595	; PDZ; 1.
PF07714	; Pkinase_Tyr; 1.

SMARTs

SM00132	; LIM; 2.
SM00228	; PDZ; 1.

Prosites

PS00478	; LIM_DOMAIN_1; 2.
PS50023	; LIM_DOMAIN_2; 2.
PS50106	; PDZ; 1.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.

Prints

PR00109

; TYRKINASE.

Created Date

20-Feb-2013