EKS-OTG-00198

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-OTG-00198

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TKL/LISK	474.7	7.3E-143	365	634	270

Status

Unreviewed

Ensembl Protein

ENSOGAP00000011887

UniProt Accession

H0X8Q4;

Protein Name

Protein Synonyms/Alias

Gene Name

LIMK2

Gene Synonyms/Alias

LIMK2;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSOGAG00000013267	ENSOGAP00000011887	ENSOGAT00000013269

Organism

Otolemur garnettii

Functional Description

Protein Length

672

Protein Sequence
(FASTA)

SSSCSGGRGE REQTACSRRS REPWAPGLSW WPSSASLRHS QTGLQLSLFV WCGKKMGSYL 60

SVPAYFTSKD PFRCSECQDS LTNWYYEKDG KLYCHKDYWG KFGEFCHGCS LLMTGPVMVA 120

GEFKYHPECF ACMSCKVIIE DGDAYALVQH ATLYCGKCHN EVVLAPMFER LSTESAQDQL 180

PYSVTLISMP ATTESTRGFT MSVESACSNY ATTVQVKEVN RMHISPNNRN AIHPGDRILE 240

INGTPVRTLR VEEVEDAINQ TSQTLQLLIE HDPVSQHLDQ LRLDAQLSPH MQNAGHSHTL 300

STLDTKENLE GTLRRRSLRR SNSISKSPGP SSPKEPLLLS RDISRSESLR CSSSYSQQIF 360

RPCDLIHGEV LGKGFFGQAI KVTHKATGKV MVMKELIRCD EETQKTFLTE VKVMRSLDHP 420

NVLKFIGVLY KDKKLNLLTE YIEGGTLKDF LRSVDPFPWQ QKVRFAKGIA SGMAYLHSMC 480

IIHRDLNSHN CLIKLDKTVV VADFGLSRLI VEERKRPPLE KATTKKRTLR KNDRKKRYTV 540

VGNPYWMAPE MLNGKSYDET VDVFSFGIVL CEIIGQVYAD PDCLPRTLDF GLNVKLFWEK 600

FVPTDCPPAF FPLATICCKL EPESRPAFSK LEDSFEALSL YLGELAIPLP AELEELDHTV 660

SMQYGLTRDS PP 672

Nucleotide Sequence
(FASTA)

TCCTCCAGCT GCTCCGGAGG GAGAGGTGAG CGTGAGCAGA CAGCCTGCAG CCGGAGGTCC 60

CGGGAGCCCT GGGCCCCGGG CCTGTCATGG TGGCCATCTT CAGCCAGTTT GAGGCACTCC 120

CAGACGGGTT TGCAGCTGAG CCTGTTTGTC TGGTGTGGGA AGAAGATGGG GAGTTACTTA 180

TCAGTCCCAG CTTACTTCAC CTCCAAAGAC CCATTTCGGT GTTCAGAATG CCAGGATTCC 240

CTCACCAACT GGTACTACGA GAAGGATGGG AAGCTCTACT GCCACAAGGA CTACTGGGGG 300

AAATTTGGGG AATTTTGCCA CGGGTGCTCC TTGCTGATGA CAGGGCCTGT TATGGTGGCC 360

GGGGAGTTCA AGTACCACCC AGAATGCTTT GCCTGTATGA GCTGCAAGGT GATCATTGAG 420

GATGGGGATG CTTATGCCCT GGTACAGCAC GCTACCCTCT ACTGTGGGAA GTGCCACAAC 480

GAGGTGGTAC TGGCACCCAT GTTTGAGAGG CTATCCACGG AGTCTGCTCA GGACCAGCTG 540

CCCTACTCTG TCACACTCAT CTCTATGCCA GCCACCACTG AAAGCACTCG GGGCTTCACT 600

ATGTCTGTGG AGAGTGCCTG CTCCAACTAC GCCACCACTG TCCAAGTAAA AGAGGTCAAC 660

AGGATGCACA TCAGTCCCAA CAACCGCAAC GCCATCCACC CTGGGGACCG CATCCTAGAG 720

ATCAATGGGA CCCCCGTCCG TACACTCCGA GTGGAGGAGG TAGAGGATGC CATTAACCAG 780

ACGAGCCAGA CGCTTCAGCT GTTGATTGAA CATGACCCTG TCTCTCAGCA TCTGGACCAG 840

CTGCGGCTGG ATGCCCAGCT ATCTCCCCAC ATGCAGAATG CTGGACACTC CCATACCCTC 900

AGCACCCTGG ACACCAAGGA GAATCTGGAG GGGACACTGA GGAGACGCTC CCTGAGGCGC 960

AGTAACAGCA TCTCCAAGTC CCCTGGCCCC AGCTCCCCAA AGGAGCCCCT GCTGCTCAGC 1020

CGTGACATCA GCCGCTCAGA ATCCCTTCGT TGTTCCAGCA GCTACTCACA GCAGATCTTC 1080

CGGCCCTGTG ACCTGATCCA TGGAGAGGTC CTTGGGAAGG GCTTCTTTGG GCAGGCCATC 1140

AAGGTGACAC ATAAAGCAAC AGGCAAAGTG ATGGTCATGA AGGAGTTAAT TCGATGTGAT 1200

GAGGAGACCC AGAAGACTTT TCTAACAGAG GTGAAAGTGA TGCGCAGCCT GGACCATCCC 1260

AATGTGCTCA AGTTCATTGG CGTACTATAC AAGGACAAGA AGCTGAACTT GCTGACAGAG 1320

TACATTGAGG GGGGCACGCT GAAGGACTTT CTGCGCAGTG TGGACCCATT CCCCTGGCAG 1380

CAGAAGGTCA GATTTGCCAA AGGCATCGCT TCTGGAATGG CCTATTTACA CTCCATGTGC 1440

ATTATCCACC GGGATCTGAA CTCACACAAC TGCCTCATTA AGTTGGACAA GACTGTGGTG 1500

GTGGCAGACT TTGGGCTATC ACGGCTCATA GTGGAAGAGA GGAAAAGGCC GCCACTGGAA 1560

AAGGCCACCA CCAAGAAACG TACCTTGCGT AAGAATGACC GCAAGAAGCG CTACACAGTG 1620

GTGGGAAACC CCTACTGGAT GGCCCCTGAG ATGCTGAATG GAAAGAGCTA CGATGAGACA 1680

GTGGATGTCT TCTCTTTTGG GATCGTTCTC TGTGAGATCA TTGGGCAGGT GTATGCAGAT 1740

CCTGATTGCC TACCCCGAAC ACTGGACTTT GGCCTCAACG TGAAGCTTTT CTGGGAGAAG 1800

TTTGTCCCCA CAGACTGCCC CCCAGCTTTC TTCCCCCTGG CCACCATCTG CTGCAAACTG 1860

GAGCCTGAGA GCAGACCGGC ATTCTCAAAA CTGGAGGACT CCTTTGAGGC CCTCTCCCTG 1920

TACCTGGGGG AGCTGGCCAT CCCACTGCCT GCAGAGCTGG AGGAGTTGGA CCACACTGTG 1980

AGCATGCAGT ATGGCCTCAC CCGGGACTCA CCTCCCTAG 2019

Domain Profile

S: 1     livgeklGkGffsevfkvthrasGevmvlkeliradeenrknllkevkllrklehpnvlk  60

         li+ge+lGkGff++++kvth+a+G+vmv+kelir+dee++k++l+evk++r+l+hpnvlk

Q: 365   LIHGEVLGKGFFGQAIKVTHKATGKVMVMKELIRCDEETQKTFLTEVKVMRSLDHPNVLK  424

         689*********************************************************

S: 61    fiGvlvkdkklhllteyiegGtlkellkskeslpwtqrvrlakdiasGlsylhskgiihr  120

         fiGvl+kdkkl+llteyiegGtlk++l+s +++pw+q+vr+ak+iasG++ylhs++iihr

Q: 425   FIGVLYKDKKLNLLTEYIEGGTLKDFLRSVDPFPWQQKVRFAKGIASGMAYLHSMCIIHR  484

         ************************************************************

S: 121   dlnsknclvredksvvvadfGlarlvveerkks......eklrslkkkdrkkrltvvGsP  174

         dlns+ncl++ dk+vvvadfGl+rl+veerk++      +k+r+l+k+drkkr+tvvG+P

Q: 485   DLNSHNCLIKLDKTVVVADFGLSRLIVEERKRPplekatTKKRTLRKNDRKKRYTVVGNP  544

         ********************************99999999********************

S: 175   ywmaPevlkgksydekvdvfsfGivlceiiarveadPdylPrtedfgldvkafreklvae  234

         ywmaPe+l+gksyde+vdvfsfGivlceii++v+adPd+lPrt dfgl+vk f+ek+v++

Q: 545   YWMAPEMLNGKSYDETVDVFSFGIVLCEIIGQVYADPDCLPRTLDFGLNVKLFWEKFVPT  604

         ************************************************************

S: 235   dcPeaflklavvccdldpesrpsfeelekk  264

         dcP+af++la +cc+l+pesrp+f++le++

Q: 605   DCPPAFFPLATICCKLEPESRPAFSKLEDS  634

         ***************************986

Domain Sequence
(FASTA)

LIHGEVLGKG FFGQAIKVTH KATGKVMVMK ELIRCDEETQ KTFLTEVKVM RSLDHPNVLK 60

FIGVLYKDKK LNLLTEYIEG GTLKDFLRSV DPFPWQQKVR FAKGIASGMA YLHSMCIIHR 120

DLNSHNCLIK LDKTVVVADF GLSRLIVEER KRPPLEKATT KKRTLRKNDR KKRYTVVGNP 180

YWMAPEMLNG KSYDETVDVF SFGIVLCEII GQVYADPDCL PRTLDFGLNV KLFWEKFVPT 240

DCPPAFFPLA TICCKLEPES RPAFSKLEDS 270

Keyword

Complete proteome; LIM domain; Metal-binding; Reference proteome; Zinc.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Choloepus hoffmanni"; ?>Ciona intestinalis"; ?>Danio rerio"; ?>Echinops telfairi"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Procavia capensis"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004672	; F:protein kinase activity
GO:0008270	; F:zinc ion binding

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR001478	; PDZ.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR001781	; Znf_LIM.

Pfam

PF00412	; LIM; 2.
PF00595	; PDZ; 1.
PF07714	; Pkinase_Tyr; 1.

SMARTs

SM00132	; LIM; 2.
SM00228	; PDZ; 1.

Prosites

PS00478	; LIM_DOMAIN_1; 1.
PS50023	; LIM_DOMAIN_2; 1.
PS50106	; PDZ; 1.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.

Prints

Created Date

20-Feb-2013