EKS-OTG-00014

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-OTG-00014

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TK/Eph	383.0	4.7E-115	670	914	245

Status

Unreviewed

Ensembl Protein

ENSOGAP00000012132

UniProt Accession

H0X9A8;

Protein Name

Protein Synonyms/Alias

Gene Name

EPHB6

Gene Synonyms/Alias

EPHB6;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSOGAG00000013534	ENSOGAP00000012132	ENSOGAT00000013542

Organism

Otolemur garnettii

Functional Description

Protein Length

1021

Protein Sequence
(FASTA)

MATEGPSRLE SRVVGMVCSL WVLLLVPSAI ALEEVLLDTT GETSEIGWLT YPPGGWDEVS 60

VLDDQRRLTR TFEACHVAGA PPGTGQDNWL QTHFVDRRGA QRVHIRLHFS VRACSSLGVS 120

GGTCRETFTL YYRQAEEPDS PGSVPAWHLK RWTKVDTIAA DESFPSSSSS SSSAASSSAW 180

ALGPHGVGQR AGLQLNVKER SFGPLTQRGF YVAFQDTGAC LALVAVRLFS YTCPAVFRAF 240

ASFPETQASG AGGASLVAAV GTCVAHAEPE EDGVGGQAGS NPPRLHCNGE GKWMVAVGGC 300

RCQPGHQPAR GDKACQACPL GLYKAQPGNG LCSPCPARSH AITPAAPICP CLQGFYRASS 360

DPPEAPCTGP PSAPRELWFE VQGSALMLHW RLPQELGGRG DLLFNVVCKE CGGQREPGSS 420

GGVCRRCRDE VHFDPRQRGL TESRVLVGGL RAHVPYILEV QAVNGVSELS PDPPQAAAIN 480

VSTSHEVPSA VPVVHQVSRA SNSITVSWPQ PDQTNGNILD YQLRYYDQAE DESHSFTLTS 540

ETNTATVTQL SPGHIYGFQV RARTAAGHGP YGGKVYFQTL PQGELSSQLP ERLSLVIGSI 600

LGALAFLLLA AIVVLAVVFQ RKRRGTGYTE QLQQYSSPGL GVKYYIDPST YEDPCQAIRE 660

LAREVDPTYI KIEEVIGTGS FGEVRRGRLQ PRGRREQAVA IQALWAGGAE SLQMTFLGRA 720

AVLGQFQHPN ILRLEGVVTK SRPLMVLTEL MELGPLDSFL RQREGQFSSL QLVAMQRGVA 780

AAMQYLSSFA FVHRALSARS VLVNSHLVCK VARLGHSPQG PGCLLRWAAP EVIAHGKHTT 840

ASDVWSFGIV MWEVMSYGER PYWDMSEQEV LNAIEQEFRL PPPPGCPPGL HLLMLDTWQK 900

DRARRPHFDQ LVAAFDKMIR KPDTLQAGRD LGDRPSQALL NPVALDFPCL DTPQAWLSAI 960

GLECYQDNFS KFGLCTFSDV AQLSLEDLPA LGITLAGHQK KLLHHVQLLQ QHLRQPGSVE 1020

V 1021

Nucleotide Sequence
(FASTA)

ATGGCTACTG AGGGGCCTTC CCGGCTGGAG AGCAGAGTGG TGGGCATGGT GTGCAGCTTG 60

TGGGTCCTAC TCCTGGTACC CTCAGCTATA GCCCTGGAAG AGGTACTGTT GGACACCACA 120

GGAGAGACAT CTGAGATTGG CTGGCTCACC TACCCACCGG GTGGGTGGGA TGAGGTGAGT 180

GTGCTGGACG ACCAGCGTCG CCTGACACGG ACCTTCGAGG CCTGCCACGT GGCAGGGGCG 240

CCTCCAGGCA CTGGGCAGGA CAATTGGCTG CAGACACACT TTGTGGACCG GCGAGGGGCG 300

CAGAGGGTGC ACATCCGGCT CCACTTCTCC GTGCGGGCAT GCTCTAGCCT GGGCGTGAGC 360

GGGGGCACCT GCCGGGAGAC CTTCACCCTC TACTACCGCC AGGCCGAGGA GCCTGACAGC 420

CCCGGCAGCG TTCCGGCCTG GCACCTCAAA CGCTGGACCA AGGTGGACAC AATTGCAGCT 480

GATGAGAGCT TCCCCTCCTC GTCCTCCTCT TCGTCCTCTG CTGCCTCCTC CTCTGCGTGG 540

GCTCTGGGGC CCCACGGGGT GGGGCAGCGT GCTGGGCTGC AGCTGAACGT CAAAGAGAGG 600

AGCTTTGGGC CTCTCACCCA GCGCGGCTTC TACGTGGCCT TCCAGGACAC AGGGGCCTGC 660

CTGGCCCTTG TCGCTGTCCG GCTCTTCTCT TACACCTGCC CCGCGGTGTT CCGAGCCTTC 720

GCCTCCTTTC CAGAGACGCA GGCCAGTGGG GCCGGGGGTG CCTCCCTGGT GGCAGCAGTG 780

GGCACCTGTG TGGCTCACGC AGAGCCAGAG GAGGATGGAG TGGGGGGCCA GGCGGGGAGC 840

AACCCCCCTA GGCTGCACTG CAATGGGGAG GGCAAGTGGA TGGTAGCCGT CGGGGGCTGC 900

CGCTGCCAGC CCGGACACCA GCCTGCACGA GGGGACAAGG CCTGCCAAGC CTGTCCCCTG 960

GGGCTCTATA AGGCCCAGCC TGGAAATGGC CTCTGCTCAC CATGCCCTGC CCGAAGCCAC 1020

GCCATCACCC CTGCAGCCCC CATTTGCCCC TGCCTGCAGG GCTTCTACCG GGCCAGCTCT 1080

GACCCACCAG AGGCCCCCTG CACTGGCCCT CCTTCGGCTC CCCGGGAGCT GTGGTTCGAG 1140

GTGCAAGGCT CCGCACTCAT GCTACACTGG CGCCTGCCTC AGGAGCTCGG GGGGCGAGGG 1200

GACCTGCTCT TCAATGTCGT GTGCAAAGAA TGTGGAGGCC AGCGGGAGCC TGGCAGCAGC 1260

GGTGGAGTGT GTCGCCGCTG CAGGGATGAG GTCCATTTCG ACCCCCGCCA GAGGGGCCTG 1320

ACTGAGAGCC GGGTGTTAGT AGGGGGGCTC CGAGCACACG TGCCCTACAT CCTAGAGGTG 1380

CAGGCCGTCA ATGGGGTGTC TGAGCTCAGC CCAGACCCTC CCCAGGCTGC AGCCATCAAT 1440

GTCAGCACCA GCCATGAAGT TCCCTCTGCA GTGCCTGTGG TACACCAGGT GAGCCGGGCA 1500

TCCAACAGCA TCACGGTGTC CTGGCCGCAG CCTGACCAGA CCAACGGCAA CATCCTGGAC 1560

TATCAGCTCC GCTACTATGA CCAGGCAGAA GACGAGTCCC ACTCCTTCAC CCTGACCAGT 1620

GAGACCAACA CTGCCACTGT GACACAGCTG AGTCCTGGCC ACATCTACGG CTTCCAGGTG 1680

CGGGCAAGGA CAGCTGCTGG CCATGGCCCA TATGGGGGCA AAGTCTACTT CCAGACACTG 1740

CCTCAAGGTG AACTGTCCTC TCAGCTTCCA GAGAGACTCT CCTTGGTGAT TGGTTCCATC 1800

CTGGGGGCCT TGGCCTTCCT CCTGCTGGCG GCCATCGTGG TGCTGGCTGT GGTCTTCCAG 1860

CGGAAGCGCC GCGGGACGGG CTACACAGAG CAACTTCAGC AGTACAGCAG CCCAGGGCTT 1920

GGGGTGAAGT ATTACATCGA CCCCTCCACT TATGAGGACC CCTGCCAGGC CATCCGGGAA 1980

CTTGCCCGGG AGGTTGATCC TACCTATATC AAGATTGAGG AGGTCATTGG GACAGGCTCT 2040

TTTGGAGAAG TGCGCAGAGG CCGCCTACAG CCCCGGGGCC GAAGGGAGCA GGCTGTGGCC 2100

ATCCAGGCCC TGTGGGCTGG GGGTGCTGAG AGCCTGCAGA TGACCTTCCT TGGCCGGGCC 2160

GCAGTGCTGG GCCAGTTCCA GCACCCCAAC ATCCTGCGGC TGGAGGGTGT GGTCACCAAG 2220

AGCCGACCCC TCATGGTGCT GACAGAGCTC ATGGAGCTCG GGCCCCTCGA CAGCTTTCTC 2280

AGGCAGCGGG AGGGCCAGTT CAGCAGCCTG CAGCTGGTGG CCATGCAGCG GGGAGTGGCT 2340

GCCGCTATGC AGTACCTGTC CAGCTTTGCC TTCGTGCACC GTGCCCTCTC TGCCCGCAGT 2400

GTGCTGGTGA ACAGCCACCT GGTGTGCAAG GTGGCTCGTC TGGGTCACAG TCCTCAGGGC 2460

CCAGGTTGTT TGCTGCGCTG GGCGGCACCC GAGGTCATTG CACATGGAAA GCATACAACA 2520

GCCAGTGATG TCTGGAGCTT TGGGATAGTT ATGTGGGAAG TGATGAGTTA TGGAGAACGA 2580

CCCTACTGGG ACATGAGCGA GCAGGAGGTA TTAAATGCAA TAGAGCAGGA GTTCCGGTTG 2640

CCCCCACCTC CAGGCTGTCC TCCTGGACTC CATCTCCTTA TGTTGGACAC TTGGCAGAAG 2700

GACCGTGCCC GGCGGCCTCA CTTTGACCAG CTGGTGGCTG CATTTGACAA GATGATTCGA 2760

AAGCCAGATA CCCTACAGGC TGGCAGGGAC CTTGGGGACA GGCCGTCCCA GGCCCTTCTG 2820

AACCCTGTGG CCCTGGACTT TCCCTGCCTG GACACTCCCC AGGCCTGGCT CTCGGCCATT 2880

GGACTGGAGT GCTACCAGGA CAACTTCTCC AAATTTGGCC TCTGCACCTT CAGCGACGTG 2940

GCTCAGCTCA GCCTGGAAGA CCTGCCTGCT CTGGGTATCA CCCTGGCTGG CCACCAGAAG 3000

AAGCTGCTGC ACCATGTCCA GCTCCTTCAG CAGCACCTGC GGCAGCCAGG CTCAGTGGAG 3060

GTCTGA 3066

Domain Profile

S: 1     vkiekviGaGefGevcsGrlklpgkreiavaiktlkagstekqrrdflseasilGqfdhp  60

         +kie+viG+G+fGev++Grl+ +g+re+avai++l+ag +e+ +++fl +a++lGqf+hp

Q: 670   IKIEEVIGTGSFGEVRRGRLQPRGRREQAVAIQALWAGGAESLQMTFLGRAAVLGQFQHP  729

         79**********************************************************

S: 61    niirleGvvtkskpvmivteymengaldsflrkkdgqftviqlvgmlrGiasgmkylsdm  120

         ni+rleGvvtks+p+m++te me g ldsflr+++gqf+++qlv+m+rG+a++m+yls++

Q: 730   NILRLEGVVTKSRPLMVLTELMELGPLDSFLRQREGQFSSLQLVAMQRGVAAAMQYLSSF  789

         ************************************************************

S: 121   gyvhrdlaarnilvnsnlvckvsdfGlsrvleddseaayttsggkipirwtapeaiayrk  180

         ++vhr l+ar++lvns+lvckv+++G+s++            g  + +rw+ape+ia++k

Q: 790   AFVHRALSARSVLVNSHLVCKVARLGHSPQ------------GPGCLLRWAAPEVIAHGK  837

         ****************************98............8999**************

S: 181   ftsasdvwsyGivlwevlsyGerpywdmsnqdvikaieegyrlpppmdcpaalyqlmldc  240

         +t+asdvws+Giv+wev+syGerpywdms+q+v++aie+++rlppp +cp +l+ lmld+

Q: 838   HTTASDVWSFGIVMWEVMSYGERPYWDMSEQEVLNAIEQEFRLPPPPGCPPGLHLLMLDT  897

         ************************************************************

S: 241   wqkdraerpkfeqivsi  257

         wqkdra+rp+f+q+v++

Q: 898   WQKDRARRPHFDQLVAA  914

         **************986

Domain Sequence
(FASTA)

IKIEEVIGTG SFGEVRRGRL QPRGRREQAV AIQALWAGGA ESLQMTFLGR AAVLGQFQHP 60

NILRLEGVVT KSRPLMVLTE LMELGPLDSF LRQREGQFSS LQLVAMQRGV AAAMQYLSSF 120

AFVHRALSAR SVLVNSHLVC KVARLGHSPQ GPGCLLRWAA PEVIAHGKHT TASDVWSFGI 180

VMWEVMSYGE RPYWDMSEQE VLNAIEQEFR LPPPPGCPPG LHLLMLDTWQ KDRARRPHFD 240

QLVAA 245

Keyword

ATP-binding; Complete proteome; Membrane; Nucleotide-binding; Receptor; Reference proteome; Transmembrane; Transmembrane helix.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Equus caballus"; ?>Felis catus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Macaca mulatta"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Nomascus leucogenys"; ?>Oryctolagus cuniculus"; ?>Pan troglodytes"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>

Gene Ontology

GO:0005887	; C:integral to plasma membrane
GO:0005524	; F:ATP binding
GO:0005003	; F:ephrin receptor activity

KEGG

InterPros

IPR001090	; Ephrin_rcpt_lig-bd_dom.
IPR003961	; Fibronectin_type3.
IPR008979	; Galactose-bd-like.
IPR013783	; Ig-like_fold.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR001660	; SAM.
IPR013761	; SAM/pointed.
IPR011510	; SAM_2.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR016257	; Tyr_kinase_ephrin_rcpt.
IPR001426	; Tyr_kinase_rcpt_V_CS.

Pfam

PF01404	; Ephrin_lbd; 1.
PF00041	; fn3; 2.
PF07714	; Pkinase_Tyr; 1.
PF07647	; SAM_2; 1.

SMARTs

SM00615	; EPH_lbd; 1.
SM00060	; FN3; 2.
SM00454	; SAM; 1.

Prosites

PS51550	; EPH_LBD; 1.
PS50853	; FN3; 2.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00790	; RECEPTOR_TYR_KIN_V_1; 1.
PS00791	; RECEPTOR_TYR_KIN_V_2; 1.
PS50105	; SAM_DOMAIN; 1.

Prints

PR00109

; TYRKINASE.

Created Date

20-Feb-2013