EKS-OTG-00012

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-OTG-00012

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TK/Eph	424.7	9.2E-128	626	880	255

Status

Unreviewed

Ensembl Protein

ENSOGAP00000012182

UniProt Accession

H0X9F1;

Protein Name

Protein Synonyms/Alias

Gene Name

EPHA1

Gene Synonyms/Alias

EPHA1;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSOGAG00000013593	ENSOGAP00000012182	ENSOGAT00000013600

Organism

Otolemur garnettii

Functional Description

Protein Length

977

Protein Sequence
(FASTA)

MERRWPLGLG LLLLCASLPP GARAIEVTLM DTSMAQGELG WLPDPPEDGW SEVQQMLNGT 60

PLYMYQDCPV QEGGDTDHWL RSNWIYRGEE ASRVHVELQF TVRDCKSFPG GAGPLGCKET 120

FNLLYMESDQ DVGIQLRRPL FQKVTTVAAD QSFTIRDLAS GSMKLNVERC SLGRLTRRGL 180

YLAFHNPGAC VALVSVRVFY QRCPEALHNL AHFPDTLPGP AGLVEVAGTC LPHALTSPGP 240

SGAPRMHCSP DGEWLVPVGR CQCESGYEEG SDGKGCIACP SGSYRTDMDT PHCLKCPQHS 300

TTESEGATIC ICESGHYRAP GEGPQVACTR PPSEPRNLSF SASGTQLSLN WGPPADVGGR 360

QDVRYSVLCS QCQGLAQDGG PCQPCGKSVR FSPGDRGLTA PAVRVEGLEP YANYTFKVEA 420

MNGVSGLGGS SRASASLSIS MGHAGPPESL SGLSLRLVKK EPRQLELTWA GSRPRSPGGN 480

LSYELHVLNQ DEERHEMVLE PRVLLTELQP DTTYIVRVRM LTPLGPGPFS PDHEFRTSPP 540

VSRGLTGGEI VAIIFGLLLG AALLLGILVF RSRRAQRQRH QRQRDRADVD REDKLWLKPY 600

VDLQAYEDPA QGALEFTQEL DPAWLMVDTV IGEGEFGEVY RGTLRLPSQD YKTVAIKTLK 660

DTSPDGHWWN FLREATIMGQ FNHPHILHLE GVVTKRKPIM IITDFMENGA LDAFLRERED 720

QLVPGQLVAM LQGIASGMNY LSDHNYVHRD LAARNILVSQ NLCCKVSDFG LTRLLDDFDG 780

TYETQGGKIP IRWTAPEAIA HRIFTTASDV WSFGIVMWEV LSFGDKPYGE MSNQEVMKSI 840

EDGYRLPPPV DCPAPLYELM KNCWAYDRAR RLPFHKLQAH LEQLLANPHS LRTIANFDPR 900

VTLRLPSLSG SDGIPYRSVS EWLESIRMKR YILHFRSAGL DTMECVLELT AEDLTQMGIT 960

LPGHQKRILC SIQGFKD 977

Nucleotide Sequence
(FASTA)

ATGGAGCGGC GCTGGCCCCT GGGGCTCGGG CTGCTGCTGC TCTGCGCCTC GCTGCCCCCG 60

GGGGCGCGAG CCATAGAAGT CACTCTGATG GACACAAGCA TGGCACAGGG AGAGTTGGGC 120

TGGCTGCCGG ATCCCCCGGA GGATGGGTGG AGTGAGGTGC AGCAGATGCT GAATGGGACA 180

CCCCTGTACA TGTACCAGGA CTGCCCGGTA CAAGAAGGCG GAGACACTGA CCACTGGCTT 240

CGCTCCAACT GGATCTACCG GGGGGAGGAG GCATCTCGTG TCCATGTGGA GCTGCAGTTT 300

ACTGTGCGGG ACTGCAAGAG CTTCCCTGGG GGAGCTGGGC CTCTTGGCTG CAAGGAGACC 360

TTCAACCTTC TGTACATGGA GAGTGACCAG GATGTGGGCA TTCAGCTCCG ACGGCCCTTG 420

TTCCAGAAGG TCACCACGGT GGCTGCAGAT CAGAGCTTCA CCATTCGAGA CCTTGCCTCT 480

GGATCCATGA AGCTGAACGT GGAGCGCTGC TCCCTGGGCC GCCTGACCCG CCGTGGCCTC 540

TACCTCGCTT TCCACAACCC AGGTGCCTGT GTGGCCCTGG TGTCTGTCCG GGTCTTCTAT 600

CAGCGCTGCC CTGAGGCCCT GCACAACTTG GCCCATTTCC CTGACACTCT CCCTGGACCT 660

GCAGGGTTGG TGGAAGTGGC AGGGACCTGC TTGCCACACG CACTGACCAG CCCCGGGCCC 720

TCCGGTGCAC CCCGCATGCA CTGCAGCCCT GATGGCGAGT GGCTGGTGCC AGTGGGACGG 780

TGCCAATGCG AGTCTGGCTA TGAAGAAGGC AGTGACGGCA AGGGCTGTAT TGCCTGCCCC 840

AGCGGTTCCT ACCGGACTGA CATGGACACA CCCCATTGTC TCAAGTGCCC CCAACACAGC 900

ACCACAGAGT CTGAGGGTGC CACCATCTGC ATCTGTGAGA GTGGTCATTA CAGAGCTCCT 960

GGGGAGGGCC CCCAGGTGGC ATGCACACGT CCCCCCTCAG AGCCTCGAAA CCTGAGCTTC 1020

TCTGCCTCAG GGACTCAGCT CTCATTGAAC TGGGGGCCGC CAGCAGATGT GGGAGGACGC 1080

CAAGATGTCC GATACAGCGT GCTGTGTTCC CAGTGTCAGG GCCTTGCACA GGATGGGGGG 1140

CCCTGCCAGC CCTGTGGCAA GAGTGTGCGC TTCTCTCCAG GGGACAGGGG GCTCACTGCA 1200

CCTGCTGTGC GAGTTGAAGG CCTAGAACCC TATGCCAACT ACACCTTCAA GGTCGAGGCC 1260

ATGAATGGAG TGTCGGGGCT GGGTGGCTCC AGCCGTGCCA GTGCTTCCCT CAGCATCAGC 1320

ATGGGACATG CAGGACCCCC AGAGTCACTG TCAGGCTTGT CTCTGAGGCT GGTGAAGAAA 1380

GAACCGAGAC AGCTGGAGCT GACCTGGGCA GGATCCCGGC CACGTAGTCC TGGGGGTAAC 1440

CTGAGCTACG AGTTGCACGT GCTGAACCAG GATGAAGAAA GGCATGAGAT GGTTCTGGAA 1500

CCCAGGGTTT TACTGACAGA ACTGCAACCA GATACCACAT ACATCGTCAG AGTGCGAATG 1560

CTGACACCTC TAGGCCCTGG CCCTTTCTCC CCTGACCATG AGTTTCGAAC CAGTCCACCA 1620

GTTTCCAGGG GGCTAACAGG AGGAGAGATC GTGGCCATCA TCTTTGGGCT GTTGCTTGGG 1680

GCAGCTCTGC TGCTCGGGAT CCTGGTCTTC CGGTCAAGGA GAGCACAGCG GCAGCGGCAT 1740

CAGAGGCAGC GTGATCGTGC TGACGTGGAT AGGGAGGACA AGCTGTGGCT GAAGCCCTAC 1800

GTGGACCTGC AGGCATATGA GGACCCTGCC CAGGGAGCAC TGGAGTTCAC CCAGGAGCTC 1860

GACCCAGCCT GGCTGATGGT GGACACTGTC ATAGGGGAAG GCGAGTTTGG GGAAGTGTAT 1920

CGTGGGACCC TGAGGCTGCC CAGCCAAGAC TACAAGACTG TGGCCATTAA GACCTTGAAA 1980

GACACATCCC CAGATGGCCA CTGGTGGAAT TTCCTTCGAG AGGCAACCAT CATGGGCCAG 2040

TTCAACCACC CACACATTCT GCATTTGGAA GGCGTTGTCA CAAAGAGGAA GCCCATCATG 2100

ATTATCACAG ACTTTATGGA GAATGGAGCC CTGGACGCTT TCCTCAGGGA GCGGGAAGAC 2160

CAGCTGGTTC CTGGGCAGCT GGTGGCCATG CTGCAGGGCA TAGCGTCAGG CATGAACTAC 2220

CTCAGTGACC ACAATTATGT CCACCGGGAC CTGGCTGCCA GGAACATCTT GGTGAGTCAG 2280

AACCTGTGCT GCAAGGTTTC TGACTTTGGC CTGACCCGCC TCTTGGATGA CTTTGATGGC 2340

ACCTACGAAA CCCAGGGAGG AAAGATACCC ATCCGCTGGA CAGCACCTGA AGCCATTGCC 2400

CATCGGATCT TCACCACAGC CAGCGATGTA TGGAGCTTTG GGATTGTGAT GTGGGAGGTG 2460

CTGAGCTTTG GGGACAAGCC CTATGGGGAA ATGAGCAATC AGGAGGTCAT GAAGAGCATT 2520

GAGGATGGGT ACCGACTGCC CCCTCCCGTG GACTGCCCTG CTCCCCTATA TGAACTCATG 2580

AAGAACTGCT GGGCATATGA CCGTGCCCGG AGGCTCCCCT TCCACAAGCT GCAGGCACAT 2640

CTGGAGCAAT TGCTTGCCAA CCCCCACTCC CTGCGGACCA TTGCCAACTT CGACCCCAGG 2700

GTGACCCTCC GTCTGCCCAG CCTGAGTGGC TCAGATGGGA TCCCGTATCG AAGTGTATCT 2760

GAATGGCTGG AGTCCATCCG CATGAAGCGC TATATCCTGC ACTTCCGCTC AGCCGGGCTG 2820

GACACCATGG AGTGTGTGCT GGAGCTGACA GCCGAGGACC TGACACAGAT GGGAATCACA 2880

CTGCCTGGGC ACCAGAAACG CATTCTTTGC AGTATACAGG GATTTAAGGA CTGA 2934

Domain Profile

S: 2     kiekviGaGefGevcsGrlklpgkreiavaiktlkagstekqrrdflseasilGqfdhpn  61

         ++++viG+GefGev++G+l+lp++   +vaiktlk++s + ++++fl+ea+i+Gqf+hp+

Q: 626   MVDTVIGEGEFGEVYRGTLRLPSQDYKTVAIKTLKDTSPDGHWWNFLREATIMGQFNHPH  685

         6899********************************************************

S: 62    iirleGvvtkskpvmivteymengaldsflrkkdgqftviqlvgmlrGiasgmkylsdmg  121

         i++leGvvtk+kp+mi+t++mengald+flr++++q++  qlv+ml+Giasgm+ylsd++

Q: 686   ILHLEGVVTKRKPIMIITDFMENGALDAFLREREDQLVPGQLVAMLQGIASGMNYLSDHN  745

         ************************************************************

S: 122   yvhrdlaarnilvnsnlvckvsdfGlsrvleddseaayttsggkipirwtapeaiayrkf  181

         yvhrdlaarnilv++nl+ckvsdfGl+r l dd + +y+t+ggkipirwtapeaia+r f

Q: 746   YVHRDLAARNILVSQNLCCKVSDFGLTRLL-DDFDGTYETQGGKIPIRWTAPEAIAHRIF  804

         ****************************98.7889*************************

S: 182   tsasdvwsyGivlwevlsyGerpywdmsnqdvikaieegyrlpppmdcpaalyqlmldcw  241

         t+asdvws+Giv+wevls+G++py +msnq+v+k+ie+gyrlppp+dcpa ly+lm++cw

Q: 805   TTASDVWSFGIVMWEVLSFGDKPYGEMSNQEVMKSIEDGYRLPPPVDCPAPLYELMKNCW  864

         ************************************************************

S: 242   qkdraerpkfeqivsi  257

           dra+r  f++++++

Q: 865   AYDRARRLPFHKLQAH  880

         **********999876

Domain Sequence
(FASTA)

MVDTVIGEGE FGEVYRGTLR LPSQDYKTVA IKTLKDTSPD GHWWNFLREA TIMGQFNHPH 60

ILHLEGVVTK RKPIMIITDF MENGALDAFL REREDQLVPG QLVAMLQGIA SGMNYLSDHN 120

YVHRDLAARN ILVSQNLCCK VSDFGLTRLL DDFDGTYETQ GGKIPIRWTA PEAIAHRIFT 180

TASDVWSFGI VMWEVLSFGD KPYGEMSNQE VMKSIEDGYR LPPPVDCPAP LYELMKNCWA 240

YDRARRLPFH KLQAH 255

Keyword

ATP-binding; Complete proteome; Kinase; Membrane; Nucleotide-binding; Receptor; Reference proteome; Transferase; Transmembrane; Transmembrane helix; Tyrosine-protein kinase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oryctolagus cuniculus"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>

Gene Ontology

GO:0005887	; C:integral to plasma membrane
GO:0005524	; F:ATP binding
GO:0005003	; F:ephrin receptor activity

KEGG

InterPros

IPR001090	; Ephrin_rcpt_lig-bd_dom.
IPR003961	; Fibronectin_type3.
IPR008979	; Galactose-bd-like.
IPR009030	; Growth_fac_rcpt.
IPR013783	; Ig-like_fold.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR001660	; SAM.
IPR013761	; SAM/pointed.
IPR021129	; SAM_type1.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR011641	; Tyr-kin_ephrin_A/B_rcpt-like.
IPR008266	; Tyr_kinase_AS.
IPR020635	; Tyr_kinase_cat_dom.
IPR016257	; Tyr_kinase_ephrin_rcpt.
IPR001426	; Tyr_kinase_rcpt_V_CS.

Pfam

PF01404	; Ephrin_lbd; 1.
PF00041	; fn3; 2.
PF07699	; GCC2_GCC3; 1.
PF07714	; Pkinase_Tyr; 1.
PF00536	; SAM_1; 1.

SMARTs

SM00615	; EPH_lbd; 1.
SM00060	; FN3; 2.
SM00454	; SAM; 1.
SM00219	; TyrKc; 1.

Prosites

PS51550	; EPH_LBD; 1.
PS50853	; FN3; 2.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00109	; PROTEIN_KINASE_TYR; 1.
PS00790	; RECEPTOR_TYR_KIN_V_1; 1.
PS00791	; RECEPTOR_TYR_KIN_V_2; 1.
PS50105	; SAM_DOMAIN; 1.

Prints

PR00109

; TYRKINASE.

Created Date

20-Feb-2013