EKS-OTG-00175
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-OTG-00175
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
AGC/PKC478.84.5E-144349607259
StatusUnreviewed
Ensembl ProteinENSOGAP00000012206
UniProt AccessionH0X9H1;
Protein NameProtein kinase C
Protein Synonyms/Alias
Gene NamePRKCA
Gene Synonyms/Alias PRKCA;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSOGAG00000013623ENSOGAP00000012206ENSOGAT00000013626
OrganismOtolemur garnettii
Functional Description
Protein Length691
Protein Sequence
(FASTA)
MADVFPANDS TTSQDVANRF ARKGALRQKN VHEVKDHKFI ARFFKQPTFC SHCTDFIWGF 60
GKQGFQCQVC CFVVHKRCHE FVTFSCPGAD KGPDTDDPRS KHKFKIHTYG SPTFCDHCGS 120
LLYGLIHQGM KCDTCDMNVH KQCVINVPSL CGMDHTEKRG RIYLKAEVTD EKLHVTVRDA 180
KNLIPMDPNG LSDPYVKLKL IPDPKNESKQ KTKTIRSTLN PQWNESFTFK LKPSDKDRRL 240
SVEIWDWDRT TRNDFMGSLS FGVSELMKMP ASGWYKLLNQ EEGEYYNVPI PEGDEEGNME 300
LRQKFESSQS PLEEFKKAKL GPAGNKVISP SEDRKQPSNN LDRVKLSDFN FLMVLGKGSF 360
GKVMLADRKG TEELYAIKIL KKDVVIQDDD VECTMVEKRV LALLDKPPFL TQLHSCFQTV 420
DRLYFVMEYV NGGDLMYHIQ QVGKFKEPQA VFYAAEISIG LFFLHKRGII YRDLKLDNVM 480
LDSEGHIKIA DFGMCKEHMM DGVTTRTFCG TPDYIAPEII AYQPYGKSVD WWAYGVLLYE 540
MLAGQPPFDG EDEDELFQSI MEHNVSYPKS LSKEAVSICK GLMTKHPAKR LGCGPEGERD 600
VREHAFFRRI DWEKLENREI QPPFKPKVCG KGAENFDKFF TRGQPVLTPP DQLVIANIDQ 660
SDFEGFSYVN PQFVHPILQS APTSTLPLTL C 691
Nucleotide Sequence
(FASTA)
ATGGCTGACG TTTTCCCGGC CAACGACTCC ACGACGTCTC AGGACGTGGC CAACCGCTTC 60
GCCCGCAAAG GGGCGCTGAG GCAGAAGAAC GTGCACGAGG TGAAGGACCA CAAATTCATC 120
GCCCGCTTCT TCAAGCAGCC CACCTTCTGC AGCCACTGCA CCGACTTCAT CTGGGGGTTT 180
GGGAAACAAG GCTTCCAGTG CCAAGTTTGC TGTTTTGTGG TTCACAAGAG GTGCCATGAA 240
TTTGTTACGT TTTCCTGCCC GGGTGCGGAT AAGGGCCCTG ACACTGATGA CCCCAGGAGC 300
AAGCACAAGT TCAAAATCCA CACTTACGGG AGCCCCACCT TCTGCGATCA CTGCGGCTCG 360
CTGCTGTACG GACTTATCCA TCAAGGGATG AAATGTGACA CCTGCGACAT GAATGTTCAC 420
AAGCAGTGCG TGATCAATGT CCCCAGCCTC TGCGGAATGG ACCACACAGA GAAGAGGGGG 480
CGGATCTACC TGAAGGCCGA GGTCACCGAC GAGAAGCTTC ACGTCACGGT ACGAGATGCA 540
AAAAATTTAA TCCCTATGGA TCCAAACGGG CTTTCAGATC CTTATGTGAA GCTGAAACTT 600
ATTCCCGATC CCAAGAACGA AAGCAAACAG AAAACCAAAA CCATCCGCTC TACACTAAAC 660
CCCCAGTGGA ATGAGTCCTT TACCTTCAAA TTAAAACCTT CAGACAAAGA CCGGCGACTG 720
TCTGTAGAAA TCTGGGACTG GGACCGAACA ACAAGAAATG ACTTCATGGG ATCCCTCTCC 780
TTTGGTGTTT CAGAGCTAAT GAAGATGCCG GCCAGTGGAT GGTACAAGCT GCTTAACCAG 840
GAAGAAGGGG AGTACTACAA TGTACCCATT CCCGAAGGAG ACGAGGAAGG AAACATGGAG 900
CTCAGGCAGA AATTCGAGAG TAGCCAATCA CCTTTAGAGG AGTTCAAGAA AGCCAAGCTC 960
GGCCCTGCTG GTAATAAAGT AATCAGTCCT TCGGAGGACA GGAAGCAACC TTCTAACAAC 1020
CTTGACCGAG TGAAACTCAG TGACTTCAAT TTCCTCATGG TGCTGGGGAA GGGGAGTTTC 1080
GGGAAGGTGA TGCTTGCCGA CAGGAAGGGG ACGGAAGAGC TGTATGCGAT CAAAATCCTG 1140
AAGAAGGACG TGGTGATTCA GGACGACGAT GTGGAGTGCA CCATGGTGGA AAAGCGCGTC 1200
CTGGCCTTGC TGGACAAGCC CCCGTTCCTG ACGCAGCTGC ACTCCTGCTT CCAAACGGTG 1260
GATCGGCTGT ACTTTGTCAT GGAATACGTC AACGGCGGGG ACCTCATGTA CCACATTCAG 1320
CAAGTAGGAA AATTTAAGGA GCCACAAGCA GTATTCTATG CGGCAGAGAT TTCCATTGGA 1380
TTGTTCTTTC TGCATAAAAG AGGGATAATT TATAGGGATC TGAAGTTAGA CAATGTCATG 1440
TTGGATTCGG AAGGACATAT CAAAATCGCG GACTTTGGGA TGTGCAAGGA ACACATGATG 1500
GATGGAGTCA CAACCAGGAC CTTCTGCGGG ACTCCAGATT ACATCGCCCC GGAGATAATC 1560
GCCTATCAGC CGTATGGGAA ATCCGTGGAC TGGTGGGCCT ATGGTGTCCT GCTGTACGAG 1620
ATGCTCGCCG GGCAGCCTCC GTTTGATGGT GAAGATGAAG ACGAACTATT TCAGTCTATC 1680
ATGGAGCACA ACGTCTCCTA CCCCAAATCC TTGTCCAAGG AGGCCGTTTC CATCTGCAAA 1740
GGACTGATGA CCAAACACCC TGCCAAGCGG CTGGGCTGCG GGCCTGAGGG AGAAAGGGAC 1800
GTCAGAGAAC ACGCCTTCTT CCGGAGGATC GACTGGGAGA AACTGGAGAA CAGGGAGATC 1860
CAGCCGCCGT TCAAGCCCAA AGTGTGTGGC AAAGGAGCAG AAAACTTTGA CAAGTTCTTC 1920
ACGCGAGGAC AACCCGTCTT AACGCCGCCC GATCAGCTGG TCATCGCTAA CATAGACCAG 1980
TCTGACTTTG AAGGCTTCTC GTACGTCAAC CCCCAGTTCG TGCACCCCAT CCTTCAGAGC 2040
GCACCAACCT CCACCCTCCC ACTAACATTG TGC 2073
Domain Profile
S: 1     fellkvlGkGsfgkvllaelkktdelyaikvlkkdvvlqdddveltlvekrvlalaskkp  60
         f++l+vlGkGsfgkv+la++k+t+elyaik+lkkdvv+qdddve+t+vekrvlal +k+p
Q: 349   FNFLMVLGKGSFGKVMLADRKGTEELYAIKILKKDVVIQDDDVECTMVEKRVLALLDKPP  408
         99**********************************************************
S: 61    flvqlfscfqtedrlffvleyvnGGdlmfhiqkarklkeerarfyaaeiilalkflhekg  120
         fl+ql+scfqt drl+fv+eyvnGGdlm+hiq+++k+ke++a+fyaaei+++l+flh++g
Q: 409   FLTQLHSCFQTVDRLYFVMEYVNGGDLMYHIQQVGKFKEPQAVFYAAEISIGLFFLHKRG  468
         ************************************************************
S: 121   iiyrdlkldnvlldaeGhikladfGlckeeilegkttstfcGtPdyiaPeilkeeeygks  180
         iiyrdlkldnv+ld+eGhik+adfG+cke++++g tt+tfcGtPdyiaPei+++++ygks
Q: 469   IIYRDLKLDNVMLDSEGHIKIADFGMCKEHMMDGVTTRTFCGTPDYIAPEIIAYQPYGKS  528
         ************************************************************
S: 181   vdwwalGvllyemlagqsPfegededelfesilekevlyPkslskeaveilkglltkdpe  240
         vdwwa+Gvllyemlagq+Pf+gededelf+si+e++v+yPkslskeav+i+kgl+tk+p+
Q: 529   VDWWAYGVLLYEMLAGQPPFDGEDEDELFQSIMEHNVSYPKSLSKEAVSICKGLMTKHPA  588
         ************************************************************
S: 241   krlGvkeegeedikehaff  259
         krlG+ +ege+d++ehaff
Q: 589   KRLGCGPEGERDVREHAFF  607
         ******************9
Domain Sequence
(FASTA)
FNFLMVLGKG SFGKVMLADR KGTEELYAIK ILKKDVVIQD DDVECTMVEK RVLALLDKPP 60
FLTQLHSCFQ TVDRLYFVME YVNGGDLMYH IQQVGKFKEP QAVFYAAEIS IGLFFLHKRG 120
IIYRDLKLDN VMLDSEGHIK IADFGMCKEH MMDGVTTRTF CGTPDYIAPE IIAYQPYGKS 180
VDWWAYGVLL YEMLAGQPPF DGEDEDELFQ SIMEHNVSYP KSLSKEAVSI CKGLMTKHPA 240
KRLGCGPEGE RDVREHAFF 259
KeywordATP-binding; Complete proteome; Kinase; Metal-binding; Nucleotide-binding; Reference proteome; Repeat; Serine/threonine-protein kinase; Transferase; Zinc; Zinc-finger.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Procavia capensis"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Xiphophorus maculatus"; ?>
EKS-AIM-00161
EKS-ANC-00165
EKS-BOT-00169
EKS-CAE-00131
EKS-CAJ-00173
EKS-CAF-00176
EKS-CAP-00169
EKS-CII-00114
EKS-CIS-00205
EKS-DAR-00460
EKS-DRM-00084
EKS-EQC-00167
EKS-FEC-00159
EKS-GAM-00089
EKS-GAG-00145
EKS-GAA-00203
EKS-GOG-00167
EKS-HOS-00175
EKS-ICT-00164
EKS-LAC-00179
EKS-LOA-00168
EKS-MAM-00167
EKS-MEG-00134
EKS-MOD-00168
EKS-MUM-00174
EKS-MUP-00173
EKS-MYL-00178
EKS-NOL-00162
EKS-ORA-00149
EKS-ORC-00155
EKS-ORL-00198
EKS-PAT-00160
EKS-PES-00149
EKS-POA-00171
EKS-PRC-00045
EKS-RAN-00168
EKS-SAH-00163
EKS-TAG-00197
EKS-TAR-00221
EKS-XIM-00207
Gene Ontology
GO:0005622; C:intracellular
GO:0005524; F:ATP binding
GO:0004697; F:protein kinase C activity
GO:0008270; F:zinc ion binding
GO:0035556; P:intracellular signal transduction
KEGG
InterPros
IPR000961; AGC-kinase_C.
IPR000008; C2_Ca-dep.
IPR008973; C2_Ca/lipid-bd_dom_CaLB.
IPR020477; C2_dom.
IPR018029; C2_membr_targeting.
IPR020454; DAG/PE-bd.
IPR011009; Kinase-like_dom.
IPR017892; Pkinase_C.
IPR002219; Prot_Kinase_C-like_PE/DAG-bd.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR014375; Protein_kinase_C_a/b/g.
IPR002290; Ser/Thr_dual-sp_kinase_dom.
IPR008271; Ser/Thr_kinase_AS.
Pfam
PF00130; C1_1; 2.
PF00168; C2; 1.
PF00069; Pkinase; 1.
PF00433; Pkinase_C; 1.
SMARTs
SM00109; C1; 2.
SM00239; C2; 1.
SM00133; S_TK_X; 1.
SM00220; S_TKc; 1.
Prosites
PS51285; AGC_KINASE_CTER; 1.
PS50004; C2; 1.
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00108; PROTEIN_KINASE_ST; 1.
PS00479; ZF_DAG_PE_1; 2.
PS50081; ZF_DAG_PE_2; 2.
Prints
PR00360; C2DOMAIN.
PR00008; DAGPEDOMAIN.
Created Date20-Feb-2013