EKS-OTG-00170

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-OTG-00170

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CAMK/RSKb	410.0	3.8E-123	386	648	263

Status

Unreviewed

Ensembl Protein

ENSOGAP00000012413

UniProt Accession

H0X9Z1;

Protein Name

Ribosomal protein S6 kinase

Protein Synonyms/Alias

Gene Name

RPS6KA5

Gene Synonyms/Alias

RPS6KA5;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSOGAG00000013852	ENSOGAP00000012413	ENSOGAT00000013862

Organism

Otolemur garnettii

Functional Description

Protein Length

760

Protein Sequence
(FASTA)

DRINVHNYDL IKKNYISAYG KVFLVRKISG HDTGKLYAMK VLKKATIVQK AKTTEHTRTE 60

RQVLEHIRQS PFLVTLHYAF QTETKLHLIL DYINGGELFT HLSQRERFTE HEVQIYVGEI 120

ILALEHLHKL GIIYRDIKLE NILLDSNGHV VLTDFGLSKE FVADETERAY SFCGTIEYMA 180

PDIVRGGDSG HDKAVDWWSL GVLMYELLTG ASPFTVDGEK NSQAEISRRI LKSEPPYPQE 240

MSALAKDLIQ RLLMKDPKKR LGCGPRDADE IKEHLFFQKI NWDDLAAKKV PAPFKPVIRD 300

ELDVSNFAEE FTEMDPTYSP AALPQSSEKL FQGYSFVAPS ILFKRNAAVI DPLQFHMGVE 360

RPGVTNVARS AMMKDSPFYQ HYDLDLKDKP LGEGSFSICR KCTHKKSNQA FAVKIISKRM 420

EANTQKEITA LKLCEGHPNI VKLHEVFHDQ LHTFLVMELL NGGELFERIK KKKHFSETEA 480

SYIMRKLVSA VSHMHDVGVV HRDLKPENLL FTDENDNLEI KIIDFGFARL KPPDNQPLKT 540

PCFTLHYAAP ELLNHNGYDE SCDLWSLGVI LHWMPSCFLP MASHLSLLTC NNAVEVVTVK 600

KVKKESFSFE GEAWKNVSQE AKDLIQGLLT VDPNKRLKMS GLRYNEWLQD GSQLSSNPLM 660

TPDILGSSGA AVHTCVKATF HAFNKYKREG FCLQNVDKAP LAKRRKMKKT STSTETRSSS 720

SESSHSSSSH SHGKTTPTKT LQPSNPADSS NPETLFQFTD 760

Nucleotide Sequence
(FASTA)

GATAGAATTA ATGTACACAA TTATGATCTA ATTAAAAAAA ATTACATTTC AGCTTATGGA 60

AAAGTATTCC TGGTTCGTAA AATAAGTGGT CATGATACTG GAAAGCTGTA TGCCATGAAA 120

GTCTTGAAAA AGGCAACAAT AGTTCAGAAG GCCAAGACCA CGGAGCACAC GAGGACAGAA 180

CGACAAGTCT TGGAGCACAT TAGACAGTCG CCGTTCTTGG TGACACTGCA CTATGCTTTC 240

CAGACAGAAA CCAAACTTCA TCTCATTTTA GATTATATAA ATGGTGGAGA ACTTTTTACT 300

CACCTTTCTC AAAGAGAGCG TTTCACAGAG CATGAGGTGC AGATCTATGT TGGAGAGATC 360

ATCCTTGCCC TCGAACATCT CCACAAGTTG GGGATTATAT ACCGTGACAT TAAGCTTGAG 420

AATATTCTGC TTGATTCTAA TGGCCATGTG GTGCTGACAG ATTTTGGTCT GAGTAAGGAG 480

TTTGTGGCTG ATGAAACTGA AAGAGCATAT TCCTTTTGTG GAACTATTGA ATACATGGCA 540

CCAGATATTG TCAGAGGAGG AGATTCAGGA CATGACAAGG CCGTTGACTG GTGGAGTTTA 600

GGTGTTCTAA TGTATGAATT GCTAACTGGA GCCTCTCCTT TCACTGTTGA TGGAGAAAAA 660

AATTCCCAAG CTGAGATATC TAGGAGAATA TTAAAAAGTG AGCCTCCATA TCCCCAAGAA 720

ATGAGTGCTT TAGCTAAAGA CCTAATTCAG CGTCTTTTGA TGAAAGATCC CAAGAAGCGA 780

TTGGGATGTG GCCCACGTGA TGCAGATGAA ATCAAAGAAC ATCTCTTCTT TCAGAAAATA 840

AATTGGGATG ATTTAGCTGC CAAAAAAGTG CCTGCACCAT TTAAGCCAGT CATTCGAGAT 900

GAGTTGGATG TGAGTAACTT TGCGGAAGAG TTCACGGAAA TGGATCCCAC CTATTCTCCC 960

GCAGCCCTGC CCCAGAGCTC TGAGAAGCTG TTTCAGGGCT ATTCCTTTGT TGCTCCTTCT 1020

ATCCTCTTCA AGCGTAATGC AGCTGTCATA GATCCTCTTC AGTTTCACAT GGGAGTCGAA 1080

CGTCCTGGAG TGACAAACGT TGCCAGGAGT GCAATGATGA AGGACTCTCC ATTCTATCAG 1140

CACTATGACC TGGATCTGAA GGATAAACCA CTGGGAGAAG GAAGTTTTTC AATTTGTCGG 1200

AAGTGCACAC ACAAAAAAAG CAACCAAGCT TTCGCAGTCA AAATAATCAG CAAAAGGATG 1260

GAAGCCAATA CTCAGAAAGA AATAACAGCT CTGAAACTCT GTGAAGGACA CCCCAATATC 1320

GTGAAGTTGC ACGAAGTTTT TCATGATCAG CTTCACACAT TTCTAGTGAT GGAACTTCTG 1380

AATGGGGGAG AGCTATTTGA ACGCATTAAG AAAAAGAAAC ACTTCAGCGA GACGGAAGCC 1440

AGCTACATCA TGCGGAAGCT TGTTTCAGCT GTCAGCCACA TGCATGATGT TGGAGTGGTG 1500

CACAGAGATT TGAAACCTGA GAATTTACTG TTCACTGATG AAAATGACAA TTTGGAAATT 1560

AAAATAATTG ATTTTGGGTT TGCACGCCTA AAGCCACCTG ATAATCAGCC TCTAAAGACA 1620

CCCTGCTTTA CCCTTCATTA TGCGGCCCCC GAGCTCTTGA ATCATAACGG CTACGATGAG 1680

TCCTGTGACC TGTGGAGCTT GGGCGTCATT TTGCATTGGA TGCCATCATG TTTTCTCCCA 1740

ATGGCTAGTC ACTTATCCCT GTTAACGTGT AATAATGCTG TTGAAGTAGT CACAGTGAAG 1800

AAAGTGAAGA AAGAAAGTTT CTCTTTTGAA GGAGAAGCCT GGAAGAATGT ATCTCAAGAG 1860

GCTAAAGATT TAATCCAAGG ACTTCTCACA GTTGATCCAA ATAAAAGGCT TAAAATGTCT 1920

GGCTTGAGAT ACAATGAATG GCTTCAAGAT GGAAGTCAGC TGTCCTCAAA TCCTCTGATG 1980

ACTCCAGACA TCCTAGGGTC TTCAGGCGCT GCTGTGCATA CCTGTGTGAA AGCAACCTTC 2040

CACGCCTTTA ATAAATACAA GAGAGAAGGG TTTTGCCTTC AGAACGTCGA TAAGGCCCCT 2100

TTGGCTAAGA GAAGGAAAAT GAAGAAGACT AGCACCAGCA CGGAGACACG CAGCAGTTCG 2160

AGCGAGAGTT CCCACTCTTC TTCCTCTCAC TCTCACGGCA AAACCACACC CACCAAGACA 2220

CTGCAGCCCA GCAATCCTGC CGACAGCAGT AACCCCGAGA CGCTCTTCCA GTTCACAGAC 2280

TGA 2283

Domain Profile

S: 2     evkedlGvGsysvckrcvhkatnqefavkiidks.krdtseeieillryeqhpnivtlkd  60

         +++++lG+Gs+s+c++c hk++nq+favkii+k+ +++t++ei++l+++e+hpniv+l++

Q: 386   LKDKPLGEGSFSICRKCTHKKSNQAFAVKIISKRmEANTQKEITALKLCEGHPNIVKLHE  445

         5789******************************9*************************

S: 61    vyddgkyvylvlellkGGelldrikkkkffsereasailrtlvkaveylheqGvvhrdlk  120

         v++d+++++lv+ell+GGel++rikkkk+fse+eas+i+r+lv+av+++h++Gvvhrdlk

Q: 446   VFHDQLHTFLVMELLNGGELFERIKKKKHFSETEASYIMRKLVSAVSHMHDVGVVHRDLK  505

         ************************************************************

S: 121   penilyvdesdnaesikiidfGfaklkraengllktpcytlnfvapevlkrqGydeacdl  180

         pen+l++de+dn+e ikiidfGfa+lk+++n++lktpc+tl+++ape+l+++Gyde+cdl

Q: 506   PENLLFTDENDNLE-IKIIDFGFARLKPPDNQPLKTPCFTLHYAAPELLNHNGYDESCDL  564

         **************.*********************************************

S: 181   wslGvllytmlaGyvpf....angpedtaeeil..akikeGkfslsGeawdsvseeakdl  234

         wslGv+l+ m + + p+    + +++++a+e++  +k+k+  fs++Geaw++vs+eakdl

Q: 565   WSLGVILHWMPSCFLPMashlSLLTCNNAVEVVtvKKVKKESFSFEGEAWKNVSQEAKDL  624

         *****************55555579999*99963379***********************

S: 235   vsklltvdpakrlkleqllkhswl  258

         +++lltvdp+krlk+++l++++wl

Q: 625   IQGLLTVDPNKRLKMSGLRYNEWL  648

         ***********************7

Domain Sequence
(FASTA)

LKDKPLGEGS FSICRKCTHK KSNQAFAVKI ISKRMEANTQ KEITALKLCE GHPNIVKLHE 60

VFHDQLHTFL VMELLNGGEL FERIKKKKHF SETEASYIMR KLVSAVSHMH DVGVVHRDLK 120

PENLLFTDEN DNLEIKIIDF GFARLKPPDN QPLKTPCFTL HYAAPELLNH NGYDESCDLW 180

SLGVILHWMP SCFLPMASHL SLLTCNNAVE VVTVKKVKKE SFSFEGEAWK NVSQEAKDLI 240

QGLLTVDPNK RLKMSGLRYN EWL 263

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Dipodomys ordii"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Pan troglodytes"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Sarcophilus harrisii"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0000287	; F:magnesium ion binding
GO:0004674	; F:protein serine/threonine kinase activity
GO:0007243	; P:intracellular protein kinase cascade

KEGG

InterPros

IPR000961	; AGC-kinase_C.
IPR011009	; Kinase-like_dom.
IPR017892	; Pkinase_C.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR016239	; Ribosomal_S6_kinase_II.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069	; Pkinase; 2.
PF00433	; Pkinase_C; 1.

SMARTs

SM00133	; S_TK_X; 1.
SM00220	; S_TKc; 2.

Prosites

PS51285	; AGC_KINASE_CTER; 1.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 2.
PS00108	; PROTEIN_KINASE_ST; 2.

Prints

Created Date

20-Feb-2013