EKS-OTG-00274

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-OTG-00274

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CMGC/DYRK	453.8	3.2E-136	199	527	329

Status

Unreviewed

Ensembl Protein

ENSOGAP00000012465

UniProt Accession

H0XA39;

Protein Name

Protein Synonyms/Alias

Gene Name

HIPK1

Gene Synonyms/Alias

HIPK1;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSOGAG00000013919	ENSOGAP00000012465	ENSOGAT00000013924

Organism

Otolemur garnettii

Functional Description

Protein Length

1218

Protein Sequence
(FASTA)

SFFLSFNVGM ASQLQVFSPP SVSSSAFCSA KKLKIEPSGW DVSGQSSSDK YYTHSKTLPA 60

TQGQANSSHQ VANFNIPAYD QGLLLPAPAV EHIVVTAADS SGSAATSTFQ SSQTLTHRSN 120

VSLLEPYQKC GLKRKSEEVD SNGSVQIIEE HPPLMLQNRT VVGAAATTTT VTTKSSSSSG 180

EGDYQLVQHE ILCSMTNSYE VLEFLGRGTF GQVAKCWKRS TKEIVAIKIL KNHPSYARQG 240

QIEVSILSRL SSENADEYNF VRSYECFQHK NHTCLVFEML EQNLYDFLKQ NKFSPLPLKY 300

IRPILQQVAT ALMKLKSLGL IHADLKPENI MLVDPVRQPY RVKVIDFGSA SHVSKAVCST 360

YLQSRYYRAP EIILGLPFCE AIDMWSLGCV IAELFLGWPL YPGASEYDQI RYISQTQGLP 420

AEYLLSAGTK TTRFFNRDPN LGYPLWRLKT PEEHELETGI KSKEARKYIF NCLDDMAQVN 480

MSTDLEGTDM LAEKADRREY IDLLKKMLTI DADKRITPLK TLNHQFVTMT HLLDFPHSNH 540

VKSCFQNMEI CKRRVHMYDT VSQIKSPFTT HVAPNTSTNL TMSFSNQLNT VHNQASVLAS 600

SSTAAAATLS LANSDVSLLN YQSALYPSSA APVPGVAQQG VSLQPGTTQI CTQTDPFQQT 660

FIVCPPAFQT GLQATTKHSG FPVRMDNAVP IVPQAPAAQP LQIQSGVLTQ GSCTPLMVAT 720

LHPQVATITP QYAVPFTLSC AAGRPALVEQ TAAVLQAWPG GTQQILLPST WQQLPGVALH 780

NSVQPTTMIP EAMGSGQQLA DWRNAHSHGN QYGTIMQQPS LLTNHVTLAT AQPLNVGVAH 840

VVRQQSSSLP SKKNKQSAPV SSKSSLDVLP SQVYSLVGSS PLRTTSSYNS LVPVQDQHQP 900

IIIPDTPSPP VSVITIRSDT DEEEDNKYKP NSSGLKPRSN VISYVTVNDS PDSDSSLSSP 960

YSTDTLSALR GNGASLLEGP SRVVADGTST RTIIVPPLKT QLSDCTVATQ ASGLLSNKTK 1020

PVASVSGQSS GCCITPTGYR AQRGVTSAAQ PLNLSQNQQS SAAPTSQERS SNPAPRRQQA 1080

FVAPLSQAPY AFQHGSPLHS TGHPHLAPAP AHLPSQAHLY TYAAPTSAAA LGSTSSIAHL 1140

FSPQGSSRHA AAYTTHPSTL VHQVPVSVGP SLLTSASVAP AQYQHQFATQ SYIGSSRGST 1200

IYTGYPLSPT KISQYSYL 1218

Nucleotide Sequence
(FASTA)

TCATTCTTCC TTTCTTTCAA TGTAGGTATG GCATCACAGT TGCAGGTGTT TTCCCCCCCA 60

TCAGTGTCGT CGAGTGCCTT CTGCAGTGCG AAGAAATTGA AAATAGAGCC CTCTGGTTGG 120

GATGTTTCAG GACAGAGCAG CAGCGACAAA TATTATACCC ACAGTAAAAC CCTCCCAGCT 180

ACACAAGGGC AAGCCAACTC CTCTCACCAG GTAGCAAATT TCAACATCCC TGCTTACGAC 240

CAGGGCCTCC TCCTCCCAGC TCCTGCAGTG GAGCATATTG TGGTAACAGC CGCGGATAGC 300

TCAGGCAGTG CTGCTACGTC AACTTTTCAA AGCAGCCAGA CCCTGACTCA CAGAAGCAAC 360

GTTTCTTTGC TTGAGCCATA TCAAAAATGT GGATTGAAAA GAAAAAGTGA GGAAGTTGAC 420

AGCAACGGTA GCGTGCAGAT CATAGAAGAA CATCCCCCTC TCATGCTGCA AAACAGGACT 480

GTGGTGGGTG CTGCTGCCAC GACCACCACT GTGACCACAA AGAGTAGCAG TTCCAGCGGA 540

GAAGGGGATT ACCAGCTGGT CCAGCATGAG ATCCTTTGCT CTATGACCAA CAGCTACGAA 600

GTCTTGGAGT TCCTAGGCCG GGGGACATTT GGACAGGTGG CTAAGTGCTG GAAGCGGAGC 660

ACCAAGGAAA TTGTGGCTAT TAAAATCTTG AAGAACCACC CCTCCTATGC CAGACAAGGA 720

CAGATTGAAG TGAGCATCCT TTCCCGCCTA AGCAGTGAAA ATGCTGATGA GTATAATTTT 780

GTCCGTTCTT ATGAATGCTT TCAGCATAAG AATCACACCT GCCTCGTGTT TGAGATGCTG 840

GAGCAGAACT TATACGATTT TCTAAAGCAA AACAAGTTTA GCCCACTGCC ACTCAAGTAC 900

ATTAGACCAA TCTTGCAGCA GGTGGCCACA GCTTTGATGA AGCTCAAGAG TCTTGGTCTG 960

ATTCATGCTG ACCTTAAGCC TGAGAACATA ATGCTGGTTG ATCCAGTTCG CCAACCCTAC 1020

CGAGTGAAGG TCATTGACTT TGGTTCTGCC AGTCATGTTT CCAAAGCTGT ATGCTCCACC 1080

TACTTACAGT CACGTTACTA CAGAGCCCCT GAAATTATTC TTGGATTACC ATTTTGTGAA 1140

GCTATTGATA TGTGGTCACT GGGCTGTGTG ATAGCTGAGC TGTTCCTGGG ATGGCCTCTT 1200

TACCCTGGTG CTTCAGAATA TGATCAGATT CGTTACATTT CACAAACACA AGGCTTGCCA 1260

GCTGAATATC TTCTCAGTGC CGGAACAAAA ACAACCAGGT TTTTCAACAG AGATCCTAAT 1320

TTGGGATACC CACTGTGGAG GCTTAAGACA CCCGAAGAAC ACGAACTGGA GACTGGAATA 1380

AAATCAAAAG AAGCTCGAAA ATACATTTTT AACTGTTTAG ATGACATGGC TCAGGTGAAT 1440

ATGTCTACAG ACTTAGAGGG AACAGATATG TTGGCAGAGA AGGCGGATCG AAGAGAATAC 1500

ATTGATTTGT TAAAAAAAAT GCTAACAATT GATGCAGATA AGAGAATTAC TCCTCTGAAA 1560

ACTCTAAACC ATCAGTTTGT GACAATGACT CACCTTCTGG ATTTTCCACA TAGCAATCAT 1620

GTTAAGTCCT GTTTTCAAAA CATGGAGATC TGCAAGCGGA GGGTTCACAT GTATGATACA 1680

GTGAGTCAGA TCAAGAGTCC CTTCACTACA CATGTTGCCC CAAATACAAG CACAAATCTA 1740

ACAATGAGCT TCAGCAACCA GCTCAATACA GTGCACAATC AGGCCAGTGT TCTAGCTTCC 1800

AGTTCTACTG CAGCAGCTGC TACTCTTTCT CTGGCTAATT CGGATGTCTC ACTGCTAAAC 1860

TACCAGTCAG CTCTGTACCC ATCATCTGCG GCCCCAGTTC CTGGAGTTGC CCAGCAGGGT 1920

GTTTCCTTGC AGCCTGGGAC CACCCAGATT TGCACTCAGA CAGATCCATT CCAACAAACA 1980

TTTATAGTAT GTCCACCTGC ATTTCAAACT GGACTACAAG CAACAACAAA GCATTCTGGA 2040

TTCCCTGTGA GGATGGATAA TGCTGTGCCA ATTGTACCCC AGGCACCGGC AGCTCAGCCA 2100

CTGCAGATTC AGTCAGGAGT TCTTACACAG GGAAGCTGTA CACCACTAAT GGTAGCAACT 2160

CTTCACCCTC AAGTAGCCAC CATCACACCG CAGTATGCGG TGCCCTTTAC TCTGAGCTGC 2220

GCAGCCGGCC GGCCGGCGCT GGTTGAACAG ACTGCCGCTG TACTGCAGGC ATGGCCTGGA 2280

GGAACTCAGC AAATTCTCCT GCCTTCAACT TGGCAACAGT TGCCTGGGGT AGCTCTACAC 2340

AACTCTGTAC AACCTACAAC AATGATTCCA GAGGCCATGG GGAGTGGCCA GCAACTAGCA 2400

GACTGGAGGA ATGCCCACTC TCATGGCAAC CAGTACGGCA CTATCATGCA ACAGCCATCC 2460

TTGCTGACTA ACCATGTGAC ATTGGCCACT GCTCAGCCCT TGAATGTTGG TGTTGCCCAT 2520

GTTGTCAGAC AACAATCCAG TTCCCTTCCT TCGAAGAAAA ATAAGCAGTC TGCTCCAGTG 2580

TCTTCTAAGT CTTCTCTGGA TGTTCTGCCT TCCCAAGTCT ATTCTCTGGT TGGGAGCAGT 2640

CCCCTCCGCA CCACGTCTTC TTATAATTCC CTAGTTCCTG TCCAAGATCA GCATCAGCCA 2700

ATCATCATTC CAGATACTCC CAGCCCTCCT GTGAGTGTCA TCACTATCCG AAGTGACACT 2760

GATGAGGAAG AGGACAACAA ATATAAGCCT AATAGCTCAG GCCTGAAGCC AAGATCTAAT 2820

GTCATTAGTT ATGTCACTGT CAATGATTCT CCAGACTCCG ACTCTTCTTT GAGCAGCCCT 2880

TACTCTACCG ATACTCTGAG TGCTCTCCGG GGCAATGGTG CATCTCTTTT GGAGGGGCCC 2940

AGCAGAGTTG TGGCAGATGG CACTAGCACT CGCACCATAA TTGTGCCTCC GCTGAAAACT 3000

CAGCTTAGTG ACTGCACTGT AGCAACCCAG GCCTCAGGTC TCCTGAGCAA TAAGACCAAG 3060

CCAGTGGCCT CAGTGAGTGG GCAGTCATCT GGATGCTGTA TCACCCCCAC AGGGTATCGA 3120

GCTCAGCGCG GGGTGACTAG TGCAGCCCAG CCACTCAACC TTAGCCAGAA CCAGCAGTCT 3180

TCGGCAGCTC CAACCTCGCA GGAGAGAAGC AGCAACCCTG CCCCCCGCAG GCAGCAGGCG 3240

TTTGTGGCCC CGCTCTCCCA AGCCCCCTAC GCTTTCCAGC ATGGCAGCCC ACTACACTCG 3300

ACGGGGCACC CACATCTGGC CCCAGCCCCC GCACACCTGC CAAGCCAGGC TCACCTGTAT 3360

ACGTATGCTG CCCCCACCTC TGCTGCTGCA TTGGGCTCCA CCAGTTCCAT TGCTCATCTT 3420

TTCTCCCCCC AGGGCTCCTC AAGGCACGCT GCAGCCTATA CCACTCACCC TAGCACTCTG 3480

GTGCACCAGG TCCCTGTCAG TGTTGGGCCC AGCCTCCTGA CTTCTGCCAG TGTAGCCCCT 3540

GCTCAGTACC AACACCAGTT TGCCACCCAG TCCTACATTG GGTCTTCCCG AGGCTCAACT 3600

ATTTACACTG GATACCCGCT GAGTCCTACA AAGATCAGCC AGTATTCCTA CTTGTAG 3657

Domain Profile

S: 1     yevlevigkGsfgqVvkaldkktkeivaikiiknkkrfarqaqeEveiLeklnkkdkeek  60

         yevle++g+G+fgqV+k+++++tkeivaiki+kn++++arq+q+Ev+iL++l++ +++++

Q: 199   YEVLEFLGRGTFGQVAKCWKRSTKEIVAIKILKNHPSYARQGQIEVSILSRLSS-ENADE  257

         9****************************************************9.999**

S: 61    ynvvrllelfvfrnhlclvfellsqnLyellkknkfsglslklvrklaqqilkaLklLke  120

         yn+vr +e+f+++nh+clvfe+l+qnLy++lk+nkfs+l+lk++r+++qq+++aL++Lk+

Q: 258   YNFVRSYECFQHKNHTCLVFEMLEQNLYDFLKQNKFSPLPLKYIRPILQQVATALMKLKS  317

         ************************************************************

S: 121   lkiiHaDlKPeNillvekkrse..vkviDFGsssavsqkeiytyiqsrfYraPEiilglk  178

         l++iHaDlKPeNi+lv++ r++  vkviDFGs+s+vs+++++ty+qsr+YraPEiilgl+

Q: 318   LGLIHADLKPENIMLVDPVRQPyrVKVIDFGSASHVSKAVCSTYLQSRYYRAPEIILGLP  377

         *********************999************************************

S: 179   ydeaiDmWSlGcvlaElftGkpLfpGenevdqlalivevlglppekllekakkakkff..  236

         ++eaiDmWSlGcv+aElf+G+pL+pG++e+dq+++i++++glp+e+ll++++k+++ff

Q: 378   FCEAIDMWSLGCVIAELFLGWPLYPGASEYDQIRYISQTQGLPAEYLLSAGTKTTRFFnr  437

         **********************************************************66

S: 237   .tkkeapkyilktk.........ksdrkkklvlnvkkaakkrkaplskelgealkekedk  286

           + ++p ++lkt          ks++++k+++n+ +++++++++++ e +++l+ek+d+

Q: 438   dPNLGYPLWRLKTPeeheletgiKSKEARKYIFNCLDDMAQVNMSTDLEGTDMLAEKADR  497

         556778889998889********************************************9

S: 287   l.fkdllkrmleldpakRitpkealkhpfv  315

         + ++dllk+ml++d++kRitp ++l+h+fv

Q: 498   ReYIDLLKKMLTIDADKRITPLKTLNHQFV  527

         99***************************7

Domain Sequence
(FASTA)

YEVLEFLGRG TFGQVAKCWK RSTKEIVAIK ILKNHPSYAR QGQIEVSILS RLSSENADEY 60

NFVRSYECFQ HKNHTCLVFE MLEQNLYDFL KQNKFSPLPL KYIRPILQQV ATALMKLKSL 120

GLIHADLKPE NIMLVDPVRQ PYRVKVIDFG SASHVSKAVC STYLQSRYYR APEIILGLPF 180

CEAIDMWSLG CVIAELFLGW PLYPGASEYD QIRYISQTQG LPAEYLLSAG TKTTRFFNRD 240

PNLGYPLWRL KTPEEHELET GIKSKEARKY IFNCLDDMAQ VNMSTDLEGT DMLAEKADRR 300

EYIDLLKKML TIDADKRITP LKTLNHQFV 329

Keyword

ATP-binding; Complete proteome; Nucleotide-binding; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Echinops telfairi"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Tursiops truncatus"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069

; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013