EKS-OTG-00380
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-OTG-00380
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TKL/MLK342.61.4E-102100357258
StatusUnreviewed
Ensembl ProteinENSOGAP00000012510
UniProt AccessionH0XA78;
Protein Name
Protein Synonyms/Alias
Gene NameMAP3K10
Gene Synonyms/Alias MAP3K10;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSOGAG00000013974ENSOGAP00000012510ENSOGAT00000013977
OrganismOtolemur garnettii
Functional Description
Protein Length955
Protein Sequence
(FASTA)
MEEEEEGAAA KEWGTTPTGP VWTAVFDYEA AGDEELTLRR GDRVQVLSQD CAVSGDEGWW 60
TGQLPSGRVG VFPSNYVAPS TPAAPVGLQL PQEIPFHELQ LEEIIGVGGF GKVYRALWRG 120
EEVAVKAARL DPERDPAVTA EQVCQEARLF GALKHPNIIA LRGACLTPPH LCLVMEYARG 180
GALSRVLAGR RVPPHVLVNW AVQVARGMNY LHNDAPVPII HRDLKSINIL ILEAIENHNL 240
ADTVLKITDF GLAREWHKTT KMSAAGTYAW MAPEVIRLSL FSKSSDVWSF GVLLWELLTG 300
EVPYREIDAL AVAYGVAMNK LTLPIPSTCP EPFARLLEEC WDPEPHGRPD FSSILKRLEV 360
IEQSALFQMP LESFHSLQED WKLEIQHMFD DLRTKEKELR SREEELLRAA QEQRFQEEQL 420
RRREQELAER EMDIVERELH LLMCQLSQEK PRVRKRKGNF KRSRLLKLRE GGSHISLPSG 480
FEHKITVQAS PTLDKRKGSD GASPPASPSI IPRLRAIRLT PVDCGGGGSS GSSPSGSGTW 540
GRSAPPKKEE LVGGKKKGRT WGPSSTLQKE RAGGEERLKT LGEGSKQWSS SAPNLGKSPK 600
HTPMAPGFAS LNEMEEFAEA DGGSSMPPSP YTTPSYLTVP IPNEPSPGTR VPWESAPAAP 660
AVRPGHSVRR RCDLALLGCA TLLGAVGLGA DVAEARAADC EEQRRWLDGF FFPRAGRFPR 720
GLSPPARHPS RREDSATCPG LAPSATLVSL SSVSDCNSTR SLLRSDSDEA APAAPSPPPS 780
PPPPESLSSP STNPLVDLEL ESFKKDPRQS LTPTHVTAAR AVSRGHRRTP SDGALGQRGP 840
LEPMGHCPGP RDPLDFPRLP DPQALFPARR RPPEFPGRPT TLTFAPRPRP AASRPRLDPW 900
KLVSFGRTLS ISPPSRPDTP ESPGPSSMQP TLLDMDMEGQ SQDSTVPLCG VHGPH 955
Nucleotide Sequence
(FASTA)
ATGGAGGAGG AGGAGGAGGG GGCGGCGGCC AAGGAGTGGG GCACGACCCC CACGGGGCCC 60
GTCTGGACCG CAGTGTTCGA CTATGAGGCG GCGGGCGACG AAGAGCTGAC ACTGCGGAGG 120
GGTGACCGGG TCCAGGTGCT TTCCCAGGAT TGTGCTGTGT CTGGCGATGA GGGCTGGTGG 180
ACCGGACAGC TACCCAGCGG CCGTGTGGGT GTCTTCCCCA GCAACTACGT GGCCCCCAGC 240
ACCCCTGCCG CACCCGTGGG CCTCCAGCTG CCTCAAGAGA TCCCCTTCCA CGAGCTGCAG 300
CTCGAAGAGA TCATCGGTGT AGGGGGCTTT GGCAAGGTCT ATCGGGCCCT GTGGCGTGGT 360
GAGGAGGTGG CAGTCAAGGC CGCCCGACTG GACCCTGAGC GGGACCCAGC AGTAACAGCG 420
GAGCAGGTGT GCCAGGAAGC CCGGCTCTTT GGAGCCCTGA AGCACCCCAA CATCATTGCC 480
CTTAGGGGTG CCTGCCTCAC CCCCCCACAC CTTTGCCTGG TGATGGAGTA TGCCCGAGGG 540
GGCGCACTGA GCAGGGTGCT GGCAGGTCGC CGGGTGCCCC CTCACGTACT GGTCAACTGG 600
GCTGTGCAGG TGGCCCGGGG CATGAACTAC CTACACAATG ATGCCCCTGT GCCCATCATC 660
CACCGGGACC TCAAGTCCAT CAACATCCTT ATTCTGGAGG CTATCGAGAA CCACAACCTC 720
GCAGACACGG TGCTCAAGAT CACAGACTTT GGCCTCGCCC GAGAGTGGCA CAAGACCACC 780
AAGATGAGTG CCGCGGGGAC CTACGCCTGG ATGGCACCGG AGGTTATCCG TCTCTCCCTC 840
TTCTCCAAAA GCAGTGATGT CTGGAGCTTC GGAGTACTGC TCTGGGAGCT GCTGACGGGG 900
GAGGTCCCCT ACCGTGAAAT CGACGCCTTG GCTGTGGCAT ATGGCGTGGC TATGAACAAG 960
CTGACTCTGC CCATCCCCTC CACGTGCCCC GAGCCCTTTG CCCGCCTACT GGAGGAATGC 1020
TGGGACCCAG AACCCCATGG ACGACCAGAT TTCAGCAGCA TTTTGAAGCG GCTTGAAGTC 1080
ATTGAACAGT CAGCTCTGTT CCAAATGCCA CTGGAGTCTT TCCATTCACT GCAAGAAGAC 1140
TGGAAGCTGG AGATTCAGCA CATGTTTGAT GATCTTCGGA CCAAGGAGAA GGAGCTGCGG 1200
AGCCGGGAGG AGGAGCTGCT GCGGGCAGCG CAGGAGCAGC GCTTCCAGGA GGAGCAACTG 1260
CGGCGGCGGG AGCAGGAGCT GGCCGAGCGT GAGATGGACA TCGTGGAGCG GGAGCTGCAC 1320
CTGCTTATGT GCCAGCTGAG CCAGGAGAAG CCCAGGGTCC GCAAACGCAA GGGAAACTTC 1380
AAGCGCAGCC GCCTGCTCAA GCTACGTGAA GGCGGCAGCC ACATCAGCCT GCCCTCGGGC 1440
TTCGAGCATA AGATCACAGT CCAGGCCTCT CCAACTCTGG ACAAGCGGAA AGGATCCGAT 1500
GGAGCCAGCC CCCCCGCAAG CCCCAGCATC ATCCCCCGGC TGAGGGCCAT CCGTTTGACT 1560
CCCGTGGACT GTGGTGGCGG TGGCAGTAGT GGCAGCAGCC CCAGTGGCAG TGGGACATGG 1620
GGCCGCAGTG CACCCCCAAA GAAAGAAGAG CTGGTTGGAG GCAAGAAGAA GGGCCGGACA 1680
TGGGGGCCCA GCTCTACCCT CCAAAAGGAG CGGGCTGGAG GAGAAGAGAG GCTGAAGACC 1740
CTCGGGGAAG GAAGCAAACA ATGGTCATCA AGTGCCCCCA ATCTGGGCAA ATCCCCCAAA 1800
CACACACCCA TGGCCCCGGG CTTTGCCAGC CTCAATGAGA TGGAGGAGTT CGCGGAGGCG 1860
GACGGAGGCA GCAGCATGCC CCCTTCCCCC TACACGACCC CGTCCTACCT CACGGTGCCG 1920
ATACCCAACG AGCCCTCCCC GGGGACGCGG GTGCCCTGGG AGTCGGCACC GGCAGCGCCC 1980
GCTGTCCGGC CGGGACATAG CGTCCGGCGG CGCTGCGACC TCGCGCTGCT GGGTTGCGCC 2040
ACGCTACTAG GCGCCGTGGG CCTGGGTGCC GACGTGGCGG AGGCGCGAGC GGCAGACTGC 2100
GAGGAACAGC GGCGCTGGCT CGACGGCTTC TTCTTCCCCC GCGCCGGCCG CTTCCCTCGG 2160
GGTCTCAGCC CGCCTGCTCG CCACCCCAGC CGCCGTGAAG ACTCGGCCAC CTGCCCGGGC 2220
CTGGCGCCCT CGGCCACCCT CGTGTCACTG TCGTCTGTCT CCGATTGCAA CTCCACGCGT 2280
TCACTGCTGC GCTCGGACAG CGACGAGGCC GCGCCGGCCG CGCCCTCCCC ACCGCCCTCC 2340
CCGCCCCCGC CCGAGTCCTT GTCTTCGCCC AGCACTAACC CCCTGGTGGA CCTGGAGCTG 2400
GAGAGCTTCA AGAAGGACCC GCGCCAGTCG CTCACTCCCA CTCACGTCAC TGCTGCGCGT 2460
GCAGTGAGCC GTGGGCACCG GCGGACGCCG TCGGACGGGG CGCTGGGACA GCGAGGGCCG 2520
CTCGAGCCCA TGGGCCACTG CCCTGGCCCT CGAGACCCCC TGGATTTCCC TCGCCTGCCT 2580
GACCCCCAGG CCCTGTTCCC AGCCCGCCGC CGGCCCCCTG AGTTCCCAGG CCGCCCCACC 2640
ACCCTGACCT TCGCCCCAAG GCCCCGGCCA GCTGCCAGTC GCCCTCGCTT AGACCCTTGG 2700
AAACTAGTCT CCTTCGGCCG GACACTCAGC ATCTCACCTC CCAGCAGGCC AGACACTCCG 2760
GAGAGCCCTG GGCCCTCTAG CATGCAGCCC ACGCTGCTCG ACATGGACAT GGAGGGGCAG 2820
AGCCAGGACA GCACAGTGCC CCTGTGTGGG GTGCATGGCC CCCACTGA 2868
Domain Profile
S: 2     eleeligsgafgkvykakwrkkevavKklreeaee..kekleklereakllsklshpnii  59
         +lee+ig g fgkvy+a wr++evavK++r + e+  + ++e++++ea+l+ +l+hpnii
Q: 100   QLEEIIGVGGFGKVYRALWRGEEVAVKAARLDPERdpAVTAEQVCQEARLFGALKHPNII  159
         789*******************************988999********************
S: 60    ellGvcleepnlllvmeyveggsLsnvlhekskreidlevlvswalqiArGmaYLhseap  119
         +l+G+cl +p+l+lvmey++gg+Ls+vl++   r+++++vlv+wa+q+ArGm+YLh++ap
Q: 160   ALRGACLTPPHLCLVMEYARGGALSRVLAG---RRVPPHVLVNWAVQVARGMNYLHNDAP  216
         ******************************...9**************************
S: 120   kkiihrdLksknvLl.......seekktlkicdFGtarelskstkmsaagtlawmaPEvl  172
         ++iihrdLks n+L+       + ++++lki+dFG are++k+tkmsaagt+awmaPEv+
Q: 217   VPIIHRDLKSINILIleaienhNLADTVLKITDFGLAREWHKTTKMSAAGTYAWMAPEVI  276
         ********************99999***********************************
S: 173   keekvseksDvwSygvvLWelltrevPykdlselaiaykvalkglrlpipsscpeklkkL  232
         + + +s++sDvwS+gv+LWellt+evPy++++ la+ay+va+++l+lpips+cpe++++L
Q: 277   RLSLFSKSSDVWSFGVLLWELLTGEVPYREIDALAVAYGVAMNKLTLPIPSTCPEPFARL  336
         ************************************************************
S: 233   mkecwnedpekRpsfseivks  253
         ++ecw+ +p+ Rp+fs+i+k 
Q: 337   LEECWDPEPHGRPDFSSILKR  357
         ******************987
Domain Sequence
(FASTA)
QLEEIIGVGG FGKVYRALWR GEEVAVKAAR LDPERDPAVT AEQVCQEARL FGALKHPNII 60
ALRGACLTPP HLCLVMEYAR GGALSRVLAG RRVPPHVLVN WAVQVARGMN YLHNDAPVPI 120
IHRDLKSINI LILEAIENHN LADTVLKITD FGLAREWHKT TKMSAAGTYA WMAPEVIRLS 180
LFSKSSDVWS FGVLLWELLT GEVPYREIDA LAVAYGVAMN KLTLPIPSTC PEPFARLLEE 240
CWDPEPHGRP DFSSILKR 258
KeywordComplete proteome; Kinase; Reference proteome; Serine/threonine-protein kinase; Transferase.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Felis catus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Pan troglodytes"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sus scrofa"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>
EKS-AIM-00351
EKS-ANC-00366
EKS-BOT-00379
EKS-CAJ-00382
EKS-CAF-00385
EKS-CAP-00410
EKS-DAR-00758
EKS-DRM-00176
EKS-FEC-00366
EKS-GAA-00461
EKS-GOG-00369
EKS-HOS-00385
EKS-ICT-00357
EKS-LAC-00393
EKS-LOA-00388
EKS-MOD-00368
EKS-MUM-00411
EKS-MUP-00371
EKS-MYL-00376
EKS-NOL-00352
EKS-ORN-00485
EKS-ORC-00355
EKS-ORL-00447
EKS-PAT-00359
EKS-POA-00368
EKS-RAN-00393
EKS-SUS-00331
EKS-TAR-00480
EKS-TEN-00479
EKS-TUT-00103
EKS-XET-00491
EKS-XIM-00474
Gene Ontology
GO:0005524; F:ATP binding
GO:0004709; F:MAP kinase kinase kinase activity
GO:0000186; P:activation of MAPKK activity
GO:0000165; P:MAPK cascade
KEGG
InterPros
IPR011009; Kinase-like_dom.
IPR016231; MAPKKK9/10/11.
IPR015785; MAPKKK9/10/11-like.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
IPR008271; Ser/Thr_kinase_AS.
IPR011511; SH3_2.
IPR001452; SH3_domain.
Pfam
PF07714; Pkinase_Tyr; 1.
PF07653; SH3_2; 1.
SMARTs
SM00326; SH3; 1.
Prosites
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00108; PROTEIN_KINASE_ST; 1.
PS50002; SH3; 1.
Prints
PR00452; SH3DOMAIN.
PR00109; TYRKINASE.
Created Date20-Feb-2013