EKS-OTG-00308

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-OTG-00308

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TK/Alk	536.1	1.4E-161	692	961	270

Status

Unreviewed

Ensembl Protein

ENSOGAP00000012861

UniProt Accession

H0XB22;

Protein Name

Tyrosine-protein kinase receptor

Protein Synonyms/Alias

Gene Name

ALK

Gene Synonyms/Alias

ALK;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSOGAG00000014350	ENSOGAP00000012861	ENSOGAT00000014356

Organism

Otolemur garnettii

Functional Description

Protein Length

1200

Protein Sequence
(FASTA)

CLPGTTPGSK MALQSSFTCW NGTVLQLGQA CDFHQDCAQG EDEGQLCRKL PAGFYCNFEE 60

GFCGWTPGTL SPHTPQWQVR TLKDALFQDQ KGHALLLSTT DVPAAESATV TSTTFPAPMK 120

NSPCELRMSW LIRGVLRGNV SLVLVENKTG KEQSRTVWHV ATNEGLSLWQ WTVLPLLDVS 180

DRFWLQMVAW WGQGSRATVA FDNISISLDC YLTINGEDKV PQNAAPKSRN LFERNPNKEP 240

TPWENAPRQT PIFDPTVHWL FTTCGASGPY GPTQAQCNNA YQNSNLSVVV GSEGPLKGIQ 300

IWKVPATDTY SISGYGAAGG KGGKNTMMRS HGVSVLGLFN LEKDDTLYIL VGQQGEDACP 360

STNQLIQKVC IGENNVIEEE IRVNRSVHEW AGGGGGGGGA TYVFKMKDGV PVPLIIAAGG 420

GGRAYGAKTD TFHPERLENN SSVLGLNGNS GAAGGGGGWN DNTSLLWAGK SLLEGATGGH 480

SCPQAMKKWG WETRGGFGGG GGGCSSGGGG GGYIGGNTAS NNDPEMDGED GVSFISPLGI 540

LYTPALKVME GHGEVNIKHY LNCSHCEVDE CHMDPESHKV ICFCDHGTVL AEDGVSCIVS 600

PTSEPHLPLS LVLSVVTSAL VAALVLAFSG IMIVYRRKHQ ELQAMQMELQ SPEYKLSKLR 660

TSTIMTDYNP NYCFAGKTSS ISDLKEVPRK NITLLRGLGH GAFGEVYEGQ VSGMPNDPSP 720

LQVAVKTLPE VCSEQDELDF LMEALIISKF NHQNIVRCIG VSLQALPRFI LLELMAGGDL 780

KSFLRETRPR PSQPSSLAML DLLHVARDIA CGCQYLEENH FIHRDIAARN CLLTCPGPGR 840

VAKIGDFGMA RDIYRASYYR KGGCAMLPVK WMPPEAFMEG IFTSKTDTWS FGVLLWEIFS 900

LGYMPYPSKS NQEVLEFVTS GGRMDPPKNC PGPVYRIMTQ CWQHQPEDRP NFAIILERIE 960

YCTQQDPDVI NTALPVEYGP LIEEEEKVPM RPKDPEGIPP LLVSPQQAKR GDEERRPAAP 1020

PPPPASASGK AGRKPPTAEG SARGARAPAA EGGCVNMAFS QSNPPTELHK VHGSRNKPTS 1080

LWNPTYGSWF TEKPAKKNNP LAKKEPQERG SLGREGGCTV PPSVAATGRL PGASLLLEPS 1140

ALTANMKDVP LFRLRHFPCG NVNYGYQQQG LPLEATTAPG TGHYEDTILK SKNSVTQPGP 1200

Nucleotide Sequence
(FASTA)

TGCTTGCCAG GAACAACCCC AGGCTCCAAG ATGGCCCTGC AGAGCTCCTT CACTTGTTGG 60

AACGGGACAG TCCTCCAGCT TGGGCAGGCC TGTGACTTCC ACCAGGACTG CGCCCAGGGA 120

GAAGACGAGG GACAGCTATG CCGTAAACTC CCTGCTGGTT TTTATTGCAA CTTTGAGGAA 180

GGCTTCTGTG GCTGGACCCC AGGCACACTG TCACCCCACA CTCCTCAGTG GCAGGTCAGG 240

ACCCTCAAGG ATGCACTGTT CCAGGATCAG AAAGGCCATG CCCTGTTGCT CAGCACCACT 300

GATGTCCCCG CGGCTGAAAG CGCCACAGTG ACTAGCACCA CCTTTCCTGC ACCGATGAAG 360

AACTCTCCGT GTGAGCTCCG GATGTCCTGG CTTATCCGTG GAGTCTTGAG GGGAAATGTG 420

TCCTTGGTGC TGGTGGAGAA CAAAACAGGG AAGGAACAAA GCAGGACGGT CTGGCATGTT 480

GCCACCAACG AAGGCTTGAG CCTGTGGCAG TGGACAGTGC TGCCCCTTCT GGATGTGTCT 540

GACAGGTTCT GGCTACAGAT GGTCGCATGG TGGGGGCAAG GATCCAGAGC CACCGTGGCT 600

TTCGACAATA TCTCCATCAG CCTGGACTGC TACCTCACCA TCAATGGGGA GGACAAGGTG 660

CCACAGAATG CAGCACCCAA ATCAAGAAAT CTGTTTGAGA GAAACCCAAA CAAGGAGCCT 720

ACACCTTGGG AAAATGCACC CAGACAGACC CCCATCTTTG ACCCTACGGT TCACTGGCTG 780

TTCACCACGT GCGGCGCCAG TGGGCCCTAT GGCCCCACCC AGGCCCAGTG CAACAACGCC 840

TATCAGAACT CCAACCTGAG TGTGGTGGTG GGGAGCGAGG GCCCGCTGAA GGGCATCCAG 900

ATCTGGAAAG TGCCAGCCAC CGACACCTAC AGTATCTCTG GCTACGGTGC CGCTGGCGGG 960

AAAGGCGGGA AGAACACCAT GATGCGGTCC CATGGCGTGT CTGTGCTGGG CCTCTTCAAC 1020

CTGGAGAAGG ATGACACGCT GTACATCCTG GTCGGGCAGC AGGGGGAGGA TGCCTGTCCC 1080

AGCACAAATC AGTTAATCCA GAAAGTCTGC ATTGGCGAGA ACAACGTGAT AGAGGAAGAA 1140

ATCCGTGTGA ACAGGAGCGT GCATGAGTGG GCGGGAGGAG GCGGCGGTGG GGGCGGAGCC 1200

ACCTACGTAT TTAAGATGAA GGATGGCGTG CCCGTGCCCT TGATCATTGC AGCCGGGGGC 1260

GGTGGCAGGG CCTATGGGGC CAAGACAGAC ACATTCCACC CAGAAAGACT AGAGAATAAC 1320

TCCTCTGTTC TCGGGCTCAA TGGCAACTCC GGAGCCGCAG GTGGTGGAGG TGGCTGGAAT 1380

GATAACACTT CCTTGCTCTG GGCTGGAAAA TCTTTGCTGG AGGGTGCCAC CGGAGGACAT 1440

TCCTGCCCCC AGGCCATGAA GAAGTGGGGG TGGGAGACCA GAGGGGGTTT CGGAGGGGGT 1500

GGCGGGGGGT GCTCCTCCGG TGGAGGAGGC GGAGGATATA TAGGTGGCAA CACGGCCTCC 1560

AACAATGACC CTGAAATGGA CGGGGAGGAT GGGGTTTCCT TCATCAGTCC ACTGGGCATC 1620

CTGTACACCC CGGCTTTGAA AGTGATGGAG GGCCACGGGG AAGTGAACAT TAAGCATTAC 1680

CTAAACTGCA GTCACTGTGA GGTAGACGAA TGTCACATGG ACCCCGAGAG CCACAAGGTC 1740

ATCTGCTTCT GTGACCATGG GACCGTGTTG GCTGAGGACG GTGTCTCCTG CATTGTGTCA 1800

CCTACCTCAG AGCCCCACCT GCCGCTCTCC CTGGTCCTCT CCGTCGTGAC CTCTGCCCTT 1860

GTGGCCGCCC TGGTCCTTGC CTTCTCCGGC ATCATGATCG TATACCGCCG GAAGCACCAG 1920

GAGCTGCAGG CCATGCAGAT GGAGCTGCAG AGCCCTGAGT ACAAGCTGAG CAAGCTACGC 1980

ACTTCGACCA TCATGACCGA CTACAACCCC AACTACTGCT TCGCGGGCAA GACCTCGTCC 2040

ATCAGCGACC TCAAGGAGGT GCCAAGGAAA AACATCACTC TCCTTCGGGG TCTGGGCCAT 2100

GGCGCATTTG GAGAGGTGTA TGAAGGCCAG GTGTCTGGAA TGCCCAACGA CCCAAGCCCC 2160

CTGCAAGTGG CTGTAAAGAC ACTGCCAGAG GTGTGCTCAG AACAGGACGA GCTGGATTTC 2220

CTCATGGAAG CCCTGATCAT CAGCAAATTC AATCACCAGA ACATCGTGCG CTGCATCGGG 2280

GTGAGCCTGC AGGCCCTGCC CCGGTTCATC CTGCTCGAGC TCATGGCGGG CGGAGACCTC 2340

AAGTCCTTCC TGCGAGAGAC CCGCCCGCGC CCGAGTCAGC CCTCCTCCCT GGCCATGCTG 2400

GACCTTCTGC ACGTGGCTCG GGACATTGCC TGCGGCTGTC AGTATTTAGA GGAAAACCAC 2460

TTCATCCACC GGGACATTGC TGCCAGGAAC TGCCTCTTGA CCTGTCCTGG CCCTGGAAGA 2520

GTGGCCAAGA TTGGAGACTT TGGAATGGCC CGAGATATCT ACAGAGCGAG CTACTACCGG 2580

AAGGGGGGCT GTGCAATGCT GCCAGTTAAG TGGATGCCCC CAGAGGCCTT CATGGAAGGA 2640

ATATTCACTT CTAAAACAGA CACGTGGTCC TTTGGAGTGC TGCTATGGGA AATATTTTCT 2700

CTTGGATATA TGCCATACCC TAGCAAAAGC AACCAGGAAG TTCTGGAGTT CGTCACCAGT 2760

GGAGGACGGA TGGACCCACC TAAGAACTGC CCTGGGCCTG TATACCGGAT AATGACTCAG 2820

TGCTGGCAAC ATCAGCCTGA AGACAGACCC AATTTTGCCA TAATTTTGGA GAGAATTGAA 2880

TACTGTACCC AGCAGGACCC AGACGTGATC AACACCGCTT TGCCGGTGGA GTACGGGCCA 2940

CTTATAGAAG AGGAAGAGAA AGTGCCCATG CGGCCCAAGG ACCCCGAGGG GATCCCTCCT 3000

CTGCTGGTGT CCCCGCAGCA GGCCAAGCGC GGGGACGAGG AGCGCCGTCC AGCCGCGCCG 3060

CCGCCTCCGC CCGCCTCTGC GTCCGGCAAA GCTGGGAGGA AACCCCCGAC GGCAGAGGGG 3120

TCGGCGCGGG GGGCCAGGGC GCCGGCCGCC GAGGGCGGGT GCGTCAACAT GGCCTTCTCC 3180

CAGTCCAACC CGCCGACCGA GCTGCACAAG GTCCACGGAT CCAGGAACAA ACCCACCAGC 3240

TTGTGGAACC CAACTTACGG CTCGTGGTTT ACAGAGAAAC CTGCCAAAAA GAACAACCCT 3300

CTGGCAAAGA AGGAGCCACA GGAGAGGGGA AGCCTGGGGC GCGAGGGCGG CTGTACTGTC 3360

CCGCCTAGTG TCGCGGCGAC TGGGAGGCTC CCGGGGGCCT CCCTGCTCCT GGAGCCGTCG 3420

GCGCTGACTG CCAACATGAA GGACGTACCC CTGTTCAGGC TCCGTCACTT CCCTTGTGGG 3480

AACGTCAACT ACGGCTACCA GCAACAAGGC TTACCGTTAG AGGCCACCAC TGCCCCTGGC 3540

ACTGGTCATT ATGAGGACAC CATTCTGAAA AGCAAGAATA GTGTGACCCA GCCTGGGCCG 3600

TGA 3603

Domain Profile

S: 1     ielvralGkGafGevyeglvsglpgdasklavavktlpesaseqdeldflkealiiskfn  60

         i+l+r+lG+GafGevyeg+vsg+p+d+s+l+vavktlpe++seqdeldfl+ealiiskfn

Q: 692   ITLLRGLGHGAFGEVYEGQVSGMPNDPSPLQVAVKTLPEVCSEQDELDFLMEALIISKFN  751

         799*********************************************************

S: 61    henivrliGvsleklprlillellaGGdlksflresrpkpeqlsslamkdllkvaldvak  120

         h+nivr+iGvsl++lpr+illel+aGGdlksflre+rp+p+q+sslam dll+va+d+a+

Q: 752   HQNIVRCIGVSLQALPRFILLELMAGGDLKSFLRETRPRPSQPSSLAMLDLLHVARDIAC  811

         ************************************************************

S: 121   GckyleenkfihrdiaarnillsskGpsrvakiadfGmardiyraeyyrkggrallpvkw  180

         Gc+yleen+fihrdiaarn+ll+++Gp+rvaki+dfGmardiyra+yyrkgg+a+lpvkw

Q: 812   GCQYLEENHFIHRDIAARNCLLTCPGPGRVAKIGDFGMARDIYRASYYRKGGCAMLPVKW  871

         ************************************************************

S: 181   mppeafleGiftsktdvwsfGvllwevfslGvvpypgksnqevlelvveGgrldspkeip  240

         mppeaf+eGiftsktd+wsfGvllwe+fslG++pyp+ksnqevle+v++Ggr+d+pk++p

Q: 872   MPPEAFMEGIFTSKTDTWSFGVLLWEIFSLGYMPYPSKSNQEVLEFVTSGGRMDPPKNCP  931

         ************************************************************

S: 241   gsvyrimtdcwkhepedrpkfvsilerlqa  270

         g+vyrimt+cw+h+pedrp+f++iler+++

Q: 932   GPVYRIMTQCWQHQPEDRPNFAIILERIEY  961

         ***************************986

Domain Sequence
(FASTA)

ITLLRGLGHG AFGEVYEGQV SGMPNDPSPL QVAVKTLPEV CSEQDELDFL MEALIISKFN 60

HQNIVRCIGV SLQALPRFIL LELMAGGDLK SFLRETRPRP SQPSSLAMLD LLHVARDIAC 120

GCQYLEENHF IHRDIAARNC LLTCPGPGRV AKIGDFGMAR DIYRASYYRK GGCAMLPVKW 180

MPPEAFMEGI FTSKTDTWSF GVLLWEIFSL GYMPYPSKSN QEVLEFVTSG GRMDPPKNCP 240

GPVYRIMTQC WQHQPEDRPN FAIILERIEY 270

Keyword

ATP-binding; Complete proteome; Kinase; Membrane; Nucleotide-binding; Phosphoprotein; Receptor; Reference proteome; Transferase; Transmembrane; Tyrosine-protein kinase.

Sequence Source

Ensembl

Orthology

Ortholog group

Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Macropus eugenii"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0016021	; C:integral to membrane
GO:0005524	; F:ATP binding
GO:0004714	; F:transmembrane receptor protein tyrosine kinase activity
GO:0000187	; P:activation of MAPK activity
GO:0048666	; P:neuron development
GO:0007169	; P:transmembrane receptor protein tyrosine kinase signaling pathway

KEGG

InterPros

IPR026830	; ALK.
IPR008985	; ConA-like_lec_gl_sf.
IPR011009	; Kinase-like_dom.
IPR002172	; LDrepeatLR_classA_rpt.
IPR000998	; MAM_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR008266	; Tyr_kinase_AS.
IPR020635	; Tyr_kinase_cat_dom.
IPR002011	; Tyr_kinase_rcpt_2_CS.

Pfam

PF00629	; MAM; 1.
PF07714	; Pkinase_Tyr; 1.

SMARTs

SM00192	; LDLa; 1.
SM00219	; TyrKc; 1.

Prosites

PS50060	; MAM_2; 1.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00109	; PROTEIN_KINASE_TYR; 1.
PS00239	; RECEPTOR_TYR_KIN_II; 1.

Prints

PR00109

; TYRKINASE.

Created Date

20-Feb-2013