EKS-OTG-00242

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-OTG-00242

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CAMK/MAPKAPK	400.3	3.4E-120	37	321	285

Status

Unreviewed

Ensembl Protein

ENSOGAP00000012934

UniProt Accession

H0XB76;

Protein Name

Protein Synonyms/Alias

Gene Name

MKNK1

Gene Synonyms/Alias

MKNK1;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSOGAG00000014430	ENSOGAP00000012934	ENSOGAT00000014436

Organism

Otolemur garnettii

Functional Description

Protein Length

415

Protein Sequence
(FASTA)

MGSSEPLPIA EGDKRKKKKR KARATDSSPG KFEDVYKLTS ELLGEGAYAK VQGAVSLQNG 60

KEYAVKIIEK QAGHSRSRVF REVETLYQCQ GNKNILELIE FFEDDTRFYL VFEKLQGGSI 120

LAHIQKQKHF NEREASRVVR DVAAALDFLH TKGIAHRDLK PENILCESPE KVSPVKICDF 180

DLGSGVKLNN SSTPITTPEL TTPCGSAEYM APEVVEVFMD QATFYDKRCD LWSLGVVLYI 240

MLSGYPPFVG HCGADCGWDR GEVCRVCQDK LFESIQEGKY EFPDKDWAHI SSEAKDLISR 300

LLVRDAKQRL SAAQVLQHPW VQGQAPERGL PTPQVLQRNS STMDLTMFAA EAIALNRQLS 360

QHEENELAEE PQALAEGLCS VKLSPPSKSR LARRRAQAQA GRSADREPSP TPSAL 415

Nucleotide Sequence
(FASTA)

ATGGGCAGCA GCGAGCCCCT TCCCATCGCA GAGGGTGACA AGAGGAAGAA GAAGAAGCGG 60

AAGGCCCGGG CCACTGACTC CTCACCAGGG AAGTTTGAAG ATGTGTATAA GCTGACCTCT 120

GAATTGCTGG GAGAGGGAGC CTACGCCAAA GTTCAAGGTG CCGTGAGCCT CCAGAATGGC 180

AAAGAGTATG CTGTCAAAAT CATTGAAAAA CAAGCAGGGC ACAGTCGGAG TAGGGTATTT 240

CGAGAGGTGG AGACGCTCTA TCAGTGTCAA GGAAACAAGA ACATTTTGGA GCTGATTGAG 300

TTCTTTGAAG ATGACACAAG GTTTTACTTG GTCTTTGAGA AATTGCAAGG AGGCTCCATC 360

CTTGCCCACA TCCAGAAGCA GAAGCACTTC AACGAGCGAG AAGCCAGCCG AGTGGTGCGG 420

GATGTTGCGG CTGCCCTTGA CTTCCTGCAT ACCAAAGGCA TTGCTCATCG TGACCTGAAG 480

CCAGAAAATA TATTGTGTGA ATCTCCAGAA AAGGTATCTC CAGTGAAAAT CTGTGACTTT 540

GACTTGGGCA GCGGGGTAAA ACTGAACAAC TCGTCTACCC CCATCACCAC ACCAGAGCTC 600

ACCACCCCGT GTGGCTCTGC AGAATACATG GCCCCCGAGG TGGTGGAGGT CTTCATGGAT 660

CAGGCCACTT TCTATGACAA GCGCTGTGAC CTGTGGAGCC TAGGTGTGGT CCTCTACATC 720

ATGCTCAGTG GCTACCCCCC GTTTGTGGGT CACTGCGGGG CCGACTGTGG CTGGGACCGG 780

GGCGAGGTCT GCAGGGTGTG CCAGGACAAG CTGTTTGAGA GCATCCAGGA AGGCAAGTAT 840

GAGTTTCCCG ACAAGGACTG GGCACACATC TCCAGCGAAG CCAAAGACCT CATCTCCAGG 900

CTCCTGGTTC GAGATGCAAA GCAGAGACTC AGCGCTGCCC AAGTTCTGCA GCACCCATGG 960

GTGCAGGGGC AAGCTCCAGA AAGGGGACTC CCCACACCAC AAGTCCTCCA GAGGAACAGC 1020

AGCACAATGG ACCTGACGAT GTTCGCGGCT GAGGCCATCG CCCTTAACCG CCAGCTATCT 1080

CAGCATGAGG AGAACGAACT GGCAGAGGAA CCCCAGGCAC TGGCTGAGGG CCTGTGCTCA 1140

GTGAAGCTTT CCCCTCCCTC CAAGTCACGC TTGGCCCGCA GGCGGGCCCA GGCCCAAGCA 1200

GGCCGCAGTG CAGACCGAGA ACCATCCCCC ACACCCTCAG CACTCTGA 1248

Domain Profile

S: 1     klteevlGeGisgkvlecvkkktgekyalkil.....kdrkkvrrevelhvqasghkniv  55

         klt+e+lGeG+++kv+ +v+ ++g++ya+ki+     ++r++v+reve+++q++g+kni+

Q: 37    KLTSELLGEGAYAKVQGAVSLQNGKEYAVKIIekqagHSRSRVFREVETLYQCQGNKNIL  96

         5799********************************************************

S: 56    elidvfensfedekrlllvlekleGGellsriqerkaftekeasevvkdiasalkflhsk  115

         eli++fe    d++r++lv+ekl+GG++l++iq++k+f+e+eas+vv+d+a+al+flh+k

Q: 97    ELIEFFE----DDTRFYLVFEKLQGGSILAHIQKQKHFNEREASRVVRDVAAALDFLHTK  152

         *******....*************************************************

S: 116   niahrDlkpenlLyeskeknapvklcDfglaket..eee.......eelktpcltaeyva  166

         +iahrDlkpen+L+es+ek++pvk+cDf+l++++  + +       +el+tpc++aey+a

Q: 153   GIAHRDLKPENILCESPEKVSPVKICDFDLGSGVklN-NsstpittPELTTPCGSAEYMA  211

         ********************************99643.25789999**************

S: 167   PevleaekeeallydksCDlWslGvilyillcGypPfyskkg...........raiskkl  215

         Pev+e++ ++a++ydk+CDlWslGv+lyi+l+GypPf++++g           r +++kl

Q: 212   PEVVEVFMDQATFYDKRCDLWSLGVVLYIMLSGYPPFVGHCGadcgwdrgevcRVCQDKL  271

         *****************************************99*****************

S: 216   keriqegkyefPeeeWsevseeakdlirklLkrdpkerltieevlnhpwv  265

         +e+iqegkyefP+++W+++s+eakdli++lL+rd+k+rl++++vl+hpwv

Q: 272   FESIQEGKYEFPDKDWAHISSEAKDLISRLLVRDAKQRLSAAQVLQHPWV  321

         *************************************************8

Domain Sequence
(FASTA)

KLTSELLGEG AYAKVQGAVS LQNGKEYAVK IIEKQAGHSR SRVFREVETL YQCQGNKNIL 60

ELIEFFEDDT RFYLVFEKLQ GGSILAHIQK QKHFNEREAS RVVRDVAAAL DFLHTKGIAH 120

RDLKPENILC ESPEKVSPVK ICDFDLGSGV KLNNSSTPIT TPELTTPCGS AEYMAPEVVE 180

VFMDQATFYD KRCDLWSLGV VLYIMLSGYP PFVGHCGADC GWDRGEVCRV CQDKLFESIQ 240

EGKYEFPDKD WAHISSEAKD LISRLLVRDA KQRLSAAQVL QHPWV 285

Keyword

ATP-binding; Complete proteome; Nucleotide-binding; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Dipodomys ordii"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Macropus eugenii"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tarsius syrichta"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069

; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013